☆ 4.7 Review

The gut microbes in inflammatory bowel disease: Future novel target option for pharmacotherapy

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Pathology

Vitamin D and Microbiome Molecular Interaction in Inflammatory Bowel Disease Pathogenesis

Ioanna Aggeletopoulou et al.

Summary: Studies show that there are characteristic microbial patterns in various systemic autoimmune diseases, including inflammatory bowel disease (IBD). Vitamin D deficiency, which predisposes to autoimmune diseases and IBD, can lead to changes in the gut microbiome and disruption of intestinal epithelial barrier integrity. This review explores the role of the gut microbiome in IBD and discusses how vitamin D and vitamin D receptor (VDR)-associated signaling pathways contribute to the development and progression of IBD by affecting gut barrier function, microbial community, and immune system function. Understanding the cellular functions of vitamin D-VDR signaling in intestinal epithelial cells may lead to the development of new treatment strategies for IBD in the future.

AMERICAN JOURNAL OF PATHOLOGY (2023)

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Review Microbiology

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Stephanie L. Collins et al.

Summary: This Review discusses host-microbiota interactions and their impact on bile acid metabolism and composition. The gut microbiota plays a crucial role in bile acid metabolism, with diverse biological roles for bile acids being discovered. External factors such as antibiotics and diet also influence bile acid composition. Understanding the impact of bile acid signaling networks in different organs is increasingly important for the development of targeted therapeutics.

NATURE REVIEWS MICROBIOLOGY (2023)

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Review Nutrition & Dietetics

Immunomodulatory Properties of Vitamin D in the Intestinal and Respiratory Systems

Fatheia N. N. Hamza et al.

Summary: Vitamin D plays a crucial role in modulating the innate immune response by interacting with its intracellular receptor, VDR. It contributes to the regulation of intestinal and respiratory microbiota and the modulation of components of the innate immune system. Vitamin D/VDR signaling mounts an antimicrobial response through the transduction of microbial signals and the production of antimicrobial peptides. Vitamin D supplementation may have potentially beneficial effects on diseases such as inflammatory bowel disease and acute respiratory distress syndrome.

NUTRIENTS (2023)

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Article Biotechnology & Applied Microbiology

Functional analysis of metalloenzymes from human gut microbiota and their role in ulcerative colitis

Pratik Balwant Shinde et al.

Summary: Metalloenzymes produced by gut microbiota play a vital role in maintaining gastrointestinal tract homeostasis and various physiological processes. Analysis of metagenomics and metatranscriptomics data from the Inflammatory Bowel Disease Multiomics Database revealed significant differences in bacterial taxonomy and altered gene expression of ulcerative colitis (UC)-associated enzymes. Docking and simulation studies suggested changes in catalytic efficiency and ligand interacting residues of screened UC-associated enzymes. The beta-diversity analysis of microbes containing metalloenzymes highlights the importance of specific genes or enzymes in understanding the diversity between UC and healthy individuals. The study indicates the potential role of metalloenzymes and specific UC-associated enzymes in the severity of UC.

JOURNAL OF APPLIED MICROBIOLOGY (2023)

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Review Biotechnology & Applied Microbiology

Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics

Manoj Kumar Yadav et al.

Summary: Probiotics are an economical and safe alternative for treating chronic diseases and improving human health. They modulate the host immunity and protect against infectious and non-infectious diseases. Additionally, prebiotics and non-digestible food substances promote the growth of probiotics and human health through modulation of gut microbiota and immune system.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022)

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Review Gastroenterology & Hepatology

Methotrexate in inflammatory bowel disease: A primer for gastroenterologists

Turki AlAmeel et al.

Summary: Methotrexate is an important drug for the treatment of inflammatory bowel disease and has potential as an alternative to other medications due to its lower risk profile. It can be used alone or in combination with other drugs to maintain efficacy and prevent immunogenicity.

SAUDI JOURNAL OF GASTROENTEROLOGY (2022)

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Review Immunology

The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease

John P. Thomas et al.

Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Clinical Neurology

Sphingosine-1-phosphate receptor modulators versus interferon beta for the treatment of relapsing-remitting multiple sclerosis: findings from randomized controlled trials

Siyuan Yang et al.

Summary: S1PR modulators have shown good efficacy and safety in the treatment of relapsing-remitting multiple sclerosis (RRMS), reducing relapse rate and lesion numbers significantly, and improving patients' quality of life.

NEUROLOGICAL SCIENCES (2022)

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Article Gastroenterology & Hepatology

Fecal microbiota and bile acids in IBD patients undergoing screening for colorectal cancer

Aonghus Lavelle et al.

Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.

GUT MICROBES (2022)

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Review Medicine, Research & Experimental

Emerging Nanotechnologies and Microbiome Engineering for the Treatment of Inflammatory Bowel Disease

Omar A. Abed et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammation that affects almost 7 million people worldwide. Current treatments are effective in managing symptoms, but fail to target the root cause. Self-assembled nanoparticles have shown great potential as drug delivery systems for treating IBD by surviving harsh gastric conditions and reaching inflamed areas of the gastrointestinal tract. These nanoparticles can localize drugs to the affected regions, reduce off-target toxicities, and restore symbiotic microbes while reducing harmful ones. However, challenges such as scale-up synthesis, potential side effects, and financial obstacles in clinical trials need to be addressed. Research on nanoparticles is crucial for the development of more effective therapeutics for IBD.

MOLECULAR PHARMACEUTICS (2022)

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Review Medicine, General & Internal

Hot topics on fecal microbiota transplantation for the treatment of inflammatory bowel disease

Xiaochen Zhang et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal mucosa with a complex etiology. The altered gut microbiota in IBD patients is associated with dysbiosis, leading to disease. Fecal microbiota transplantation (FMT) has shown promising efficacy and safety in the treatment of IBD, but further optimization is needed for its implementation.

FRONTIERS IN MEDICINE (2022)

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Article Food Science & Technology

Stimulation of the intestinal microbiota with prebiotics enhances hepatic levels of dietary polyphenolic compounds, lipid metabolism and antioxidant status in healthy rats

Bartosz Fotschki et al.

Summary: This study investigated the effects of stimulating the intestinal microbiota with fructooligosaccharides (FOSs) and a polyphenol preparation (PP) on liver function in healthy rats. The results showed that the combination of FOSs and PP increased the levels of polyphenolic metabolites in the liver, improved lipid metabolism and antioxidative status, and elevated total antioxidant status and activity of superoxide dismutase in the blood.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Safety and Efficacy of an AIEC-targeted Bacteriophage Cocktail in a Mice Colitis Model

Marie Titecat et al.

Summary: Adherent invasive Escherichia coli (AIEC) are believed to contribute to the pathogenesis of Crohn's disease, and bacteriophage therapy targeting AIEC has been proposed. The study shows that the EcoActive phage cocktail has an efficacy of over 95% against AIEC strains in vitro and no deleterious impact on commensal microbiota. In a mouse model, daily administration of the EcoActive cocktail for 15 days protected mice from inflammation symptoms and manifestations. These results support the use of AIEC-targeted phage therapy as a safe and effective treatment for reducing AIEC levels in the gut of IBD patients.

JOURNAL OF CROHNS & COLITIS (2022)

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Article Genetics & Heredity

Expression Analysis and the Roles of the Sec1 Gene in Regulating the Composition of Mouse Gut Microbiota

Zhanshi Ren et al.

Summary: This study reveals that the Sec1 gene is expressed at different stages during mouse development and that Sec1 knockout mice exhibit significant weight gain, abdominal fat accumulation, and changes in gut microbial composition.

GENES (2022)

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Review Gastroenterology & Hepatology

Intestinal phages interact with bacteria and are involved in human diseases

Han Shuwen et al.

Summary: This review presents the interactions between phages and bacteria in the human intestinal tract, as well as their roles in disease pathogenesis and treatment.

GUT MICROBES (2022)

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Review Infectious Diseases

The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

Fen Zhang et al.

Summary: The gut mycobiome is a crucial component of the gut microbiome that regulates host homeostasis, physiological processes, and the assembly of the gut bacterial microbiome. Understanding its composition and functional diversity is important for studying health and diseases, as well as developing microbiome-based therapies.

LANCET MICROBE (2022)

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Article Microbiology

Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Gottingen Minipig model

Ditte Olsen Lutzhoft et al.

Summary: This study investigates the impact of a choline-deficient amino acid defined high fat diet (CDAHFD) on gut microbiota and selected pathways related to non-alcoholic steatohepatitis (NASH) development in a male Gottingen Minipig model. The results suggest that gut microbiota dysbiosis and elevated levels of the metabolite imidazole propionate may be relevant factors in the development of NASH. Furthermore, the study highlights the importance of considering the gut microbiota and its products when developing animal models for NASH.

BMC MICROBIOLOGY (2022)

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Letter Medicine, General & Internal

Probiotic mixture VSL#3 prevents ulcerative colitis-associated carcinogenesis in mice and cells by regulating the inflammatory and Wnt/β-catenin pathway

Wenbin Li et al.

CHINESE MEDICAL JOURNAL (2022)

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Review Gastroenterology & Hepatology

Post-operative prevention and monitoring of Crohn's disease recurrence

Kate E. Lee et al.

Summary: Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. Although surgery can cure ulcerative colitis, it is rarely curative for Crohn's disease. Research has identified risk factors for post-operative Crohn's disease recurrence, allowing for patient risk stratification and preventive treatment.

GASTROENTEROLOGY REPORT (2022)

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Review Biotechnology & Applied Microbiology

Gut-organ axis: a microbial outreach and networking

S. Ahlawat et al.

Summary: Human gut microbiota is a complex and dynamic population crucial for health and survival, with a bidirectional relationship with associated diseases and other vital organs.

LETTERS IN APPLIED MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Understanding connections and roles of gut microbiome in cardiovascular diseases

Ethendhar Rajendiran et al.

Summary: The gut microbiome, composed of trillions of residing bacteria, plays a crucial role in maintaining the physiological and metabolic health of the host, and has been associated with diseases like cardiovascular disease. Evidence suggests that altered gut environment and microbiome-derived metabolites are linked to CVD events. By manipulating the gut microbiome through dietary intervention, novel therapy targets, dietary recommendations, and preventive measures can be identified to reduce CVD risk in humans.

CANADIAN JOURNAL OF MICROBIOLOGY (2021)

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Review Microbiology

Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium

Shruti Ahlawat et al.

Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Yersinia enterocolitica and Lactobacillus fermentum induces differential cellular and behavioral responses during diclofenac biotransformation in rat gut

Shruti Ahlawat et al.

Summary: The study found that diclofenac had different effects on the rat gut when administered with Yersinia enterocolitica strain 8081 or Lactobacillus fermentum strain 9338, impacting the expression of gut proteins and histopathology differently.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Review Immunology

Roles of Gut Bacteriophages in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Lingling Qv et al.

Summary: Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory disorder, with Crohn's disease and ulcerative colitis as its main forms. The pathogenesis of IBD is believed to be influenced by genetic predisposition, host immune response, and environmental factors such as the intestinal microbiome, with a recent focus on the role of gut bacteria over enteroviruses. Of the enteroviruses, bacteriophages (phages) are the most abundant, having the potential to regulate the bacterial population and influence the host immune response in IBD.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Interplay between Immune System and Microbiota in Inflammatory Bowel Disease: A Narrative Review

Laila Aldars-Garcia et al.

Summary: The gut microbiota plays a crucial role in human health, contributing to the development of the immune system, digestion, metabolism, and barrier against pathogens. Inflammatory bowel disease (IBD) is characterized by an exaggerated immune reaction against intestinal microbiota, with changes in abundance of specific microorganisms associated with the disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD

Adrian Martyniak et al.

Summary: The increasing incidence of inflammatory bowel diseases necessitates new methods of therapy, with the gut microbiome being studied extensively as a key factor. The composition of intestinal microbiota can be modified by diet and probiotics, and enhanced by the use of paraprobiotics and postbiotics. This study summarizes recent works on various microbiome-altering methods in IBD.

BIOMOLECULES (2021)

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Article Nanoscience & Nanotechnology

Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

Fengqian Chen et al.

Summary: Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are highly debilitating due to the imbalance of inflammatory mediators within the inflamed bowel. Conventional drugs for IBD treatment suffer from bioavailability issues and systemic side effects, while nanoparticle (NP)-derived therapy has shown improvements in therapeutic efficacy and targeting specificity. Recent studies have highlighted the fast-growing field of nanomedicines tailored to the pathophysiology of bowel diseases, offering potential for prolonged circulation period and reduced side effects through improved drug encapsulation and targeted delivery.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Plant Sciences

Total glucosides of Paeony restores intestinal barrier function through inhibiting Lyn/Snail signaling pathway in colitis mice

Xin-Yue Cao et al.

Summary: The study found that TGP effectively improves symptoms and pathological changes, reduces levels of inflammatory cytokines in the colon tissues and serum in a dose-dependent manner, and restores intestinal barrier function by regulating tight junction and adherens junction proteins. Additionally, TGP inhibits Lyn/Snail signaling pathway and maintains tight and adherens junctions, indicating its potential as a therapeutic agent for IBD.

PHYTOMEDICINE (2021)

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Article Microbiology

Intestinal Inflammation and Altered Gut Microbiota Associated with Inflammatory Bowel Disease Render Mice Susceptible to Clostridioides difficile Colonization and Infection

Lisa Abernathy-Close et al.

Summary: Clostridioides difficile (C. difficile) infection poses significant risks to patients with inflammatory bowel disease (IBD), leading to increased morbidity and mortality. The development of IBD alters the gut microbiome and decreases colonization resistance to C. difficile, making animals susceptible to C. difficile colonization and infection. Inflammation induced by IBD plays a critical role in overcoming colonization resistance and promoting C. difficile colonization in the host.

MBIO (2021)

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Review Environmental Sciences

Role of Quality of Life as Endpoint for Inflammatory Bowel Disease Treatment

Cristina Calvino-Suarez et al.

Summary: Inflammatory bowel diseases (IBDs) are chronic conditions that are unpredictable and often affect young people, requiring lifelong treatment. Recently, health-related quality of life (HRQoL) has been suggested as an important endpoint for IBD management and included in many studies.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Immunology

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice

Stefano Bruscoli et al.

Summary: Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease (CD) and involves immune cell alteration and chronic inflammatory cascade activation against unknown environmental triggers. Therapy focuses on supporting measures and use of anti-inflammatory and immunosuppressive drugs, with glucocorticoids (GCs) being a cornerstone treatment for moderate-to-severe IBD. However, their use is limited by important adverse drug effects, leading researchers to explore newer, safer alternatives.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Dietary vitamin K is remodeled by gut microbiota and influences community composition

Jessie L. Ellis et al.

Summary: The experiment revealed that dietary vitamin K deficiency can alter the gut microbial composition, and further studies are needed to determine if menadione generated by host metabolism serves as an intermediate in dietary vitamin K remodeling in vivo.

GUT MICROBES (2021)

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Letter Medicine, General & Internal

Pathophysiology of Inflammatory Bowel Diseases

Chung-Jen Chen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Gastroenterology & Hepatology

Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn's disease

Harry Sokol et al.

GUT (2020)

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Review Gastroenterology & Hepatology

The epidemiology of inflammatory bowel disease: East meets west

Wing Yan Mak et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice

Craig Haifer et al.

GUT (2020)

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Article Allergy

The microbiome and inflammatory bowel disease

Kerri L. Glassner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Gastroenterology & Hepatology

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment

Xiao Yan Guo et al.

JOURNAL OF DIGESTIVE DISEASES (2020)

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Article Microbiology

Fecal microbiota transplantation to maintain remission in Crohn's disease: a pilot randomized controlled study

Harry Sokol et al.

MICROBIOME (2020)

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Review Gastroenterology & Hepatology

Interactions of commensal and pathogenic microorganisms with the mucus layer in the colon

Rui Cai et al.

GUT MICROBES (2020)

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Article Multidisciplinary Sciences

Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity

Lianmin Chen et al.

NATURE COMMUNICATIONS (2020)

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Review Nutrition & Dietetics

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review

Dominika Jakubczyk et al.

NUTRIENTS (2020)

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Review Medicine, Research & Experimental

Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models

Roberto de Paula do Nascimento et al.

LIFE SCIENCES (2020)

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Article Multidisciplinary Sciences

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Wenjing Yang et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease: An Update

Pufang Tan et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, General & Internal

Ulcerative colitis

Taku Kobayashi et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Review Immunology

Antibiotics as Major Disruptors of Gut Microbiota

Jaime Ramirez et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Microbiology

Streptococcus Thermophilus UASt-09 Upregulates Goblet Cell Activity in Colonic Epithelial Cells to a Greater Degree than other Probiotic Strains

Madhur D. Shastri et al.

MICROORGANISMS (2020)

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Article Gastroenterology & Hepatology

Sarcoidosis is associated with lower risks of penetrating disease and colectomy in hospitalized patients with inflammatory bowel disease

Yi Jiang et al.

JGH OPEN (2020)

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Review Gastroenterology & Hepatology

Novel Therapeutic Options for People with Ulcerative Colitis: An Update on Recent Developments with Janus Kinase (JAK) Inhibitors

Edoardo Troncone et al.

CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

The weekend effect does not influence management of inflammatory bowel disease

Alana Persaud et al.

JGH OPEN (2020)

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Article Gastroenterology & Hepatology

Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]

Tadakazu Hisamatsu et al.

JOURNAL OF CROHNS & COLITIS (2019)

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Review Immunology

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

Matthias Friedrich et al.

IMMUNITY (2019)

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Article Biochemistry & Molecular Biology

Host genetic determinants of the gut microbiota of wild mice

Taichi A. Suzuk et al.

MOLECULAR ECOLOGY (2019)

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Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

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Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Immunology

A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn's disease

Ingvar Bjarnason et al.

INFLAMMOPHARMACOLOGY (2019)

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Review Gastroenterology & Hepatology

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

Mary Ellen Sanders et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Medicine, Research & Experimental

Probiotic Mixture VSL#3 Alleviates Dextran Sulfate Sodium-induced Colitis in Mice by Downregulating T Follicular Helper Cells

Xiao-jing Liu et al.

CURRENT MEDICAL SCIENCE (2019)

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Article Gastroenterology & Hepatology

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

Christopher Andrew Lamb et al.

GUT (2019)

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Review Physiology

THE MICROBIOTA-GUT-BRAIN AXIS

John F. Cryan et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Microbiology

Cooking shapes the structure and function of the gut microbiome

Rachel N. Carmody et al.

NATURE MICROBIOLOGY (2019)

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Review Microbiology

Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome

Israr Khan et al.

PATHOGENS (2019)

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Article Medicine, Research & Experimental

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice

Wang Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Medicine, General & Internal

Systematic review and meta-analysis of the incidence and prevalence and 30-year trend of inflammatory bowel diseases in Asia: a study protocol

Ali Reza Safarpour et al.

BMJ Open (2019)

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Article Gastroenterology & Hepatology

Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis

Sudarshan Paramsothy et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease

Linyan Zhou et al.

GUT AND LIVER (2019)

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Article Immunology

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Graham J. Britton et al.

IMMUNITY (2019)

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Article Gastroenterology & Hepatology

Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function

Ying Cai et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Medicine, General & Internal

Mechanisms of Disease: Inflammatory Bowel Diseases

Guilherme Piovezani Ramos et al.

MAYO CLINIC PROCEEDINGS (2019)

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Review Gastroenterology & Hepatology

Fecal microbiota transplantation: great potential with many challenges

Richard Kellermayer

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Insights into the role of fecal microbiota transplantation for the treatment of inflammatory bowel disease

Alexander N. Levy et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

A comparison of diverticulitis in Crohn's disease versus ulcerative colitis

Alana Persaud et al.

JGH OPEN (2019)

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Review Dermatology

Treatment-resistant prurigo nodularis: challenges and solutions

Eric H. Kowalski et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2019)

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Article Gastroenterology & Hepatology

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

Floris Imhann et al.

GUT (2018)

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Review Pharmacology & Pharmacy

All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance

Grace B. Hatton et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Review Gastroenterology & Hepatology

Effect of Faecal Microbiota Transplantation for Treatment of Clostridium difficile Infection in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Tuo Chen et al.

JOURNAL OF CROHNS & COLITIS (2018)

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Review Neurosciences

The interplay between microbes and the immune response in inflammatory bowel disease

Ashleigh Goethel et al.

JOURNAL OF PHYSIOLOGY-LONDON (2018)

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Article Cell Biology

Probiotic Mixture Protects Dextran Sulfate Sodium-Induced Colitis by Altering Tight Junction Protein Expressions and Increasing Tregs

Yingdi Zhang et al.

MEDIATORS OF INFLAMMATION (2018)

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Article Immunology

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Ye Zhao et al.

MUCOSAL IMMUNOLOGY (2018)

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Review Immunology

Aryl hydrocarbon receptor and intestinal immunity

Bruno Lamas et al.

MUCOSAL IMMUNOLOGY (2018)

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Review Nutrition & Dietetics

Time for food: The impact of diet on gut microbiota and human health

Na Zhang et al.

NUTRITION (2018)

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Article Multidisciplinary Sciences

Gut microbiomes of wild great apes fluctuate seasonally in response to diet

Allison L. Hicks et al.

NATURE COMMUNICATIONS (2018)

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Article Pharmacology & Pharmacy

Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon

Huantian Cui et al.

FRONTIERS IN PHARMACOLOGY (2018)

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American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain

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MUCOSAL IMMUNOLOGY (2017)

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Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

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IMMUNOLOGICAL REVIEWS (2017)

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Lactobacillus plantarum Enhanced IL-22 Production in Natural Killer (NK) Cells That Protect the Integrity of Intestinal Epithelial Cell Barrier Damaged by Enterotoxigenic Escherichia coli

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High Fat Diet Alters Gut Microbiota and the Expression of Paneth Cell-Antimicrobial Peptides Preceding Changes of Circulating Inflammatory Cytokines

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MEDIATORS OF INFLAMMATION (2017)

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Thalidomide results in diminished ovarian reserve in reproductive age female IBD patients

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MEDICINE (2017)

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Review Gastroenterology & Hepatology

Gut microbiota and IBD: causation or correlation?

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Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology

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Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

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FRONTIERS IN MICROBIOLOGY (2017)

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FRONTIERS IN IMMUNOLOGY (2017)

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The human microbiome in evolution

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BMC BIOLOGY (2017)

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Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease

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Increased corneal sub-basal nerve density in patients with Sjogren syndrome treated with topical cyclosporine A

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MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate- Induced Colitis

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INFECTION AND IMMUNITY (2017)

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Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety

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GUT (2016)

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The gut microbiota and host health: a new clinical frontier

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GUT (2016)

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Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

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JOURNAL OF GASTROENTEROLOGY (2016)

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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

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Genetic Determinants of the Gut Microbiome in UK Twins

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CELL HOST & MICROBE (2016)

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The Sus operon: a model system for starch uptake by the human gut Bacteroidetes

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Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals

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Interactions of gut microbiota with dietary polyphenols and consequences to human health

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CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2016)

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Correction Immunology

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome (vol 45, pg 802, 2016)

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Understanding the mechanisms of faecal microbiota transplantation

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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

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The Human Intestinal Microbiome in Health and Disease

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Cross-species comparisons of host genetic associations with the microbiome

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Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

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WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

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WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Role of antibiotics for treatment of inflammatory bowel disease

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Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

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FRONTIERS IN MICROBIOLOGY (2016)

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Gut microbiota, metabolites and host immunity

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NATURE REVIEWS IMMUNOLOGY (2016)

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ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

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EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2015)

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Efficacy and Safety of Natalizumab and Vedolizumab for the Management of Crohn's Disease: A Systematic Review and Meta-analysis

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INFLAMMATORY BOWEL DISEASES (2015)

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Review Biotechnology & Applied Microbiology

The Role of Probiotic Lactic Acid Bacteria and Bifidobacteria in the Prevention and Treatment of Inflammatory Bowel Disease and Other Related Diseases: A Systematic Review of Randomized Human Clinical Trials

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BIOMED RESEARCH INTERNATIONAL (2015)

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Targeting Leukocyte Trafficking for the Treatment of Inflammatory Bowel Disease

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Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway

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MUCOSAL IMMUNOLOGY (2015)

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Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner

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PLOS ONE (2015)

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Nonsteroidal anti-inflammatory drugs and exacerbations of inflammatory bowel disease

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SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2015)

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Lactobacillus rhamnosus CNCM 1-3690 and the commensal bacterium Faecalibacterium prausnitzii A2-165 exhibit similar protective effects to induced barrier hyper-permeability in mice

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Important impacts of intestinal bacteria on utilization of dietary amino acids in pigs

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AMINO ACIDS (2014)

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Innate and adaptive immunity in inflammatory bowel disease

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AUTOIMMUNITY REVIEWS (2014)

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Human Genetics Shape the Gut Microbiome

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The Treatment-Naive Microbiome in New-Onset Crohn's Disease

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DNA methylation-associated colonic mucosal immune and defense responses in treatment-naive pediatric ulcerative colitis

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EPIGENETICS (2014)

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The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

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Commercial probiotic bacteria and prebiotic carbohydrates: a fundamental study on prebiotics uptake, antimicrobials production and inhibition of pathogens

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Relating the metatranscriptome and metagenome of the human gut

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Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease

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Review Gastroenterology & Hepatology

Probiotics and synbiotics may improve liver aminotransferases levels in non-alcoholic fatty liver disease patients

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A novel SCFA receptor, the microbiota, and blood pressure regulation

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GUT MICROBES (2014)

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Vedolizumab for the Treatment of IBD: A Selective Therapeutic Approach Targeting Pathogenic a4b7 Cells

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CURRENT DRUG TARGETS (2013)

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CURRENT OPINION IN BIOTECHNOLOGY (2013)

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The human microbiome is a source of therapeutic drug targets

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CURRENT OPINION IN CHEMICAL BIOLOGY (2013)

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Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

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A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn's Disease and Ulcerative Colitis

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Role of the gut microbiota in human nutrition and metabolism

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Control of pathogens and pathobionts by the gut microbiota

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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

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SCIENCE (2013)

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Use of antibiotics in the treatment of Crohn's disease

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WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Aspirin, Nonsteroidal Anti-inflammatory Drug Use, and Risk for Crohn Disease and Ulcerative Colitis A Cohort Study

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CARCINOGENESIS (2012)

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Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers

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IMMUNOLOGY (2012)

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Regulation of intestinal homeostasis by innate and adaptive immunity

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INTERNATIONAL IMMUNOLOGY (2012)

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Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

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Review Multidisciplinary Sciences

Functional interactions between the gut microbiota and host metabolism

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Editorial Material Genetics & Heredity

Epigenetics: filling in the 'heritability gap' and identifying gene-environment interactions in ulcerative colitis

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Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

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GENOME BIOLOGY (2012)

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Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)

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Article Gastroenterology & Hepatology

Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis

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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

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Lactobacillus casei prevents impaired barrier function in intestinal epithelial cells

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APMIS (2011)

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Review Gastroenterology & Hepatology

Importance of Disrupted Intestinal Barrier in Inflammatory Bowel Diseases

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INFLAMMATORY BOWEL DISEASES (2011)

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Review Immunology

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

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MUCOSAL IMMUNOLOGY (2011)

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Article Genetics & Heredity

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Composition, variability, and temporal stability of the intestinal microbiota of the elderly

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Multidisciplinary Sciences

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

Brian D. Muegge et al.

SCIENCE (2011)

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L-Lysine Pro-Prodrug Containing trans-Ferulic Acid for 5-Amino Salicylic Acid Colon Delivery: Synthesis, Characterization and in Vitro Antioxidant Activity Evaluation

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Article Gastroenterology & Hepatology

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

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GASTROENTEROLOGY (2010)

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Article Multidisciplinary Sciences

Probiotics promote gut health through stimulation of epithelial innate immunity

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Gastroenterology & Hepatology

Effect of probiotics on pro-inflammatory cytokines and NF-κB activation in ulcerative colitis

Sahar K. Hegazy et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

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Article Nutrition & Dietetics

Comparative effects of very low-carbohydrate, high-fat and high-carbohydrate, low-fat weight-loss diets on bowel habit and faecal short-chain fatty acids and bacterial populations

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BRITISH JOURNAL OF NUTRITION (2009)

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Review Gastroenterology & Hepatology

On the Use of Herbal Medicines in Management of Inflammatory Bowel Diseases: A Systematic Review of Animal and Human Studies

Roja Rahimi et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

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Review Gastroenterology & Hepatology

Prebiotics in Chronic Intestinal Inflammation

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INFLAMMATORY BOWEL DISEASES (2009)

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Article Gastroenterology & Hepatology

Diversity of mucosa-associated microbiota in active and inactive ulcerative colitis

Jun Nishikawa et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2009)

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Article Gastroenterology & Hepatology

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors

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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

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Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

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Article Genetics & Heredity

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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NATURE GENETICS (2008)

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Article Multidisciplinary Sciences

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Unravelling the pathogenesis of inflammatory bowel disease

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Article Gastroenterology & Hepatology

Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease

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GASTROENTEROLOGY (2007)

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Article Genetics & Heredity

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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NATURE GENETICS (2007)

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Review Gastroenterology & Hepatology

Antibiotics and probiotics in treatment of inflammatory bowel disease

Paolo Gionchetti et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2006)

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Review Gastroenterology & Hepatology

Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: Their mechanisms of action and role in the treatment of IBD

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INFLAMMATORY BOWEL DISEASES (2006)

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Article Biotechnology & Applied Microbiology

Differences in fecal microbiota in different European study populations in relation to age, gender, and country:: A cross-sectional study

S Mueller et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)

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Diversity of the human intestinal microbial flora

PB Eckburg et al.

SCIENCE (2005)

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Article Gastroenterology & Hepatology

Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study

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GUT (2004)

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Review Cell Biology

Immunomodulatory benefits of cyclosporine A in inflammatory bowel disease

J Kountouras et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2004)

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Review Gastroenterology & Hepatology

Review article: antibiotics and probiotics in inflammatory bowel disease

W Kruis

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)

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Increased expression of interleukin 17 in inflammatory bowel disease

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GUT (2003)

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Review Biochemistry & Molecular Biology

Recent trends in functional food science and the industry in Japan

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BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2002)

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Article Nutrition & Dietetics

Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids

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BRITISH JOURNAL OF NUTRITION (2002)

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