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Reshaping immunometabolism in the tumour microenvironment to improve cancer immunotherapy

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Article Oncology

Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis

Yan Li et al.

Summary: This study identified the association of fatty acid synthase (FASN) with sorafenib resistance through regulation of ferroptosis, providing a novel treatment strategy to overcome sorafenib resistance in advanced hepatocellular carcinoma (HCC) patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Effects of lactate on metabolism and differentiation of CD4+T cells

Yu-Ting Zhang et al.

Summary: Lactate accumulation in tumor microenvironment can induce the formation of an inhibitory immune microenvironment. Treg cells can utilize lactate as an alternative energy source to maintain their inhibitory activity. Lactate can also promote the differentiation of CD4+T cells into Treg cells, but the mechanism is not completely clear.

MOLECULAR IMMUNOLOGY (2023)

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Article Oncology

Polyunsaturated Fatty Acid-Bound a-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

Paul Munson et al.

Summary: Hepatocellular cancer tumors express a-Fetoprotein (AFP), which inhibits dendritic cell differentiation and maturation, and blocks oxidative phosphorylation. Tumor-derived AFP increases glycolytic capacity and glucose dependence of dendritic cells, leading to increased glucose uptake and lactate secretion. Furthermore, AFP bound with polyunsaturated fatty acids (PUFAs) skews dendritic cell metabolism and promotes immune suppression.

CANCER RESEARCH (2023)

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Review Biochemistry & Molecular Biology

HIF: a master regulator of nutrient availability and metabolic cross-talk in the tumor microenvironment

Rindert Missiaen et al.

Summary: The role of hypoxia-inducible factors (HIFs) in regulating tumor cell metabolism under hypoxia has been extensively studied, but their role in regulating nutrient fates in tumor and stromal cells is not well understood. HIF and nutrients in the tumor microenvironment (TME) can influence the metabolism of stromal and immune cells, as well as tumor cells. This review discusses how HIF-mediated mechanisms regulate nutrient sensing and availability in the TME, the competition for nutrients, and the metabolic crosstalk between tumor and stromal cells.

EMBO JOURNAL (2023)

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Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

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Article Cell Biology

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

Mathias Wenes et al.

Summary: Mitochondrial pyruvate uptake instructs metabolic flexibility for guiding T cell differentiation and antitumor responses.

CELL METABOLISM (2022)

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Article Medicine, Research & Experimental

Effect of Postoperative ω-3 Fatty Acid Immunonutritional Therapy on NK Cell Gene Methylation in Elderly Patients with Gastric Cancer

Li-ning Xu et al.

Summary: This study found that immunonutritional therapy with omega-3 fatty acid can improve the activity of NK cells and reduce the methylation level of TNF-alpha gene promoter in elderly patients with gastric cancer.

CURRENT MEDICAL SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma

Jin Liu et al.

Summary: The accumulation of FABP5 in monocytes/macrophages in the tumor microenvironment promotes immune tolerance formation through metabolic reprogramming and IL-10 expression. Furthermore, elevated FABP5 levels are negatively associated with the overall survival time of hepatocellular carcinoma patients.

CANCER GENE THERAPY (2022)

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Article Cell Biology

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Ilaria Elia et al.

Summary: This study reveals the mechanism by which tumor-derived lactate in the tumor microenvironment inhibits the cytotoxicity of CD8(+) T cells, highlighting the role of metabolic pathways in regulating T cell cytotoxicity.

CELL METABOLISM (2022)

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Article Cell Biology

The Role of Amino Acid Metabolism of Tumor Associated Macrophages in the Development of Colorectal Cancer

Manman Jiang et al.

Summary: This study revealed the relationship between amino acid metabolism and cell death in macrophages, and found that changes in amino acid metabolism may regulate immune escape in colorectal cancer through cell death. The study also demonstrated that deficiency in ACADS polarizes macrophages to M2 phenotype.

CELLS (2022)

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Article Cell Biology

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-? signaling in regulatory T cells

Jian Gu et al.

Summary: The lactate in tumor microenvironment plays a crucial role in regulating Treg cells. It can improve Treg cell stability and function, while its degradation reduces Treg cell induction. Lactate modulates Treg cell generation through lactylation of MOESIN, leading to enhanced interaction with TGF-β receptor I and downstream SMAD3 signaling. Combining lactate dehydrogenase inhibitor with anti-PD-1 treatment shows stronger antitumor effects. MOESIN lactylation levels in Treg cells are associated with the response to anti-PD-1 treatment in hepatocellular carcinoma patients.

CELL REPORTS (2022)

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Article Genetics & Heredity

Lactate score predicts survival, immune cell infiltration and response to immunotherapy in breast cancer

Ting-Ting Yin et al.

Summary: In this study, the potential roles of lactate-related genes (LRGs) in the diversity and prognosis of the tumor microenvironment (TME) were analyzed. The results of this study will contribute to a better understanding of the characteristics of TME immune cell infiltration and guide the development of more effective immunotherapy strategies.

FRONTIERS IN GENETICS (2022)

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Article Multidisciplinary Sciences

Oncometabolite D-2HG alters T cell metabolism to impair CD8(+) T cell function

Giulia Notarangelo et al.

Summary: Gain-of-function mutations in IDH result in the production of oncometabolite D-2HG, which promotes tumorigenesis by affecting the metabolism and antitumor functions of CD8(+) T cells.

SCIENCE (2022)

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Article Multidisciplinary Sciences

Lactate increases stemness of CD8+T cells to augment anti-tumor immunity

Qiang Feng et al.

Summary: Lactate increases stemness of CD8(+) T cells and enhances anti-tumor immunity. It inhibits histone deacetylase activity, leading to increased expression of Tcf7 gene, and affects the stemness of T cells.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion

Zenan Wang et al.

Summary: The authors demonstrate that doxorubicin promotes IL-18 secretion by tumor associated macrophages, leading to the upregulation of CD47 in osteosarcoma cells. By inhibiting LAT2, CD47 expression can be downregulated, enhancing macrophage infiltration and phagocytosis of tumor cells. These findings highlight the critical role of mutual regulation between macrophages and tumor cells in tumor immune evasion.

NATURE COMMUNICATIONS (2022)

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Review Medicine, Research & Experimental

Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy

Qi Liu et al.

Summary: This article discusses the expression and role of HIF-1 alpha in TNBC, including its regulation of various biological processes and its potential significance in immunotherapy, chemotherapy, anti-angiogenic therapy, and photodynamic therapy. The upstream regulatory factors and future directions of targeting HIF-1 alpha are also studied.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Immunology

High-Fat Diet-Induced Obesity Alters Dendritic Cell Homeostasis by Enhancing Mitochondrial Fatty Acid Oxidation

I-Chun Chen et al.

Summary: Obesity caused by high-fat diet disrupts the metabolic and functional status of splenic dendritic cells (SpDCs), leading to severe changes in gene expression. SpDCs from obese mice demonstrate enhanced mitochondrial respiration and reactive oxygen species accumulation, impairing antigen presentation to T cells. The use of FAO inhibitors and antioxidants can restore the antigen-presenting capacity of SpDCs from obese mice.

JOURNAL OF IMMUNOLOGY (2022)

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Article Cell Biology

Regulation of ROS in myeloid-derived suppressor cells through targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy

Adeleye Oluwatosin Adeshakin et al.

Summary: The success of cancer immunotherapy using PD-L1 blockade may be enhanced by targeting FATP2 in MDSCs to reduce lipid accumulation and inhibit immunosuppressive activity. This approach shows promising results in enhancing anti-PD-L1 tumor immunotherapy.

CELLULAR IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

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Article Immunology

Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors

Jang Hyun Park et al.

Summary: Glioblastoma presents a hypoxic microenvironment that affects gamma delta T cell-mediated antitumor immune responses. The tumor's high demand for oxygen leads to suppression of gamma delta T cell function, which can be alleviated by reducing hypoxia. This study highlights the importance of gamma delta T cells in antitumor immunity against brain tumors.

NATURE IMMUNOLOGY (2021)

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Article Oncology

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma

Hui Li et al.

Summary: Icaritin inhibits AFP expression in liver cancer cells at both mRNA and protein levels. It targets AFP as the downstream gene of the p53 transcription factor, improving p53 stability by inhibiting its ubiquitination degradation through Mdm2/p53 pathways. This ultimately leads to the inhibition of cellular proliferation and promotion of cellular apoptosis in hepatocellular carcinoma.

BMC CANCER (2021)

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Article Cell Biology

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

Yao He et al.

Summary: Recent studies suggest that gut microbial metabolite butyrate can enhance the efficacy of oxaliplatin by modulation of CD8(+) T cell immunity through an ID2-dependent mechanism. This finding has important implications for cancer therapy in patients responding to oxaliplatin.

CELL METABOLISM (2021)

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Article Biochemistry & Molecular Biology

The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Zhijian Jin et al.

Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.

REDOX BIOLOGY (2021)

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Article Cell Biology

CXCR4 promotes B cell viability by the cooperation of nuclear factor (erythroid-derived 2)-like 2 and hypoxia-inducible factor-1α under hypoxic conditions

Ju-Won Jang et al.

Summary: The study shows that under hypoxic conditions, CXCR4 may regulate B cell viability by binding of HIF-1 alpha and Nrf2 to the CXCR4 gene promoter cooperatively. This suggests that CXCR4 could be a therapeutic target to control B cells with roles at disease sites under hypoxic conditions.

CELL DEATH & DISEASE (2021)

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Review Biochemistry & Molecular Biology

Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis

Hui Wang et al.

Summary: Colorectal cancer (CRC) is a highly prevalent and lethal malignant tumor in the digestive system. Tumor-associated macrophages (TAMs) play a crucial role in various mechanisms of CRC progression, such as promoting tumor proliferation, invasion, angiogenesis, and immunosuppression, although their exact role is still debated in clinical evidence.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Oncology

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

Zhaowei Wang et al.

Summary: This study highlights the role of GDF15 in promoting Treg cell expansion and enhancing their suppressive function in HCC, with CD48 identified as a receptor for GDF15 in the immune system. Inhibiting GDF15 shows promising results in reversing HCC-related immunosuppression. The findings suggest a potential new target for immunotherapy in HCC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

MitoTracker Deep Red (MTDR) Is a Metabolic Inhibitor for Targeting Mitochondria and Eradicating Cancer Stem Cells (CSCs), With Anti-Tumor and Anti-Metastatic Activity In Vivo

Camillo Sargiacomo et al.

Summary: MTDR can be used to target and eradicate cancer stem cells by selectively interfering with mitochondrial metabolism in breast cancer cells. It significantly inhibits tumor growth and metastasis with little to no toxicity observed in a preclinical animal model.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

The metabolism of cancer cells during metastasis

Gabriele Bergers et al.

Summary: This review discusses the metabolic rewiring in cancer cells during the metastatic cascade and the distinct metabolic features of primary tumors and metastases. Metastasis is the leading cause of death in most cancer patients, and targeting metastatic seeding and colonization remains a significant challenge. Adjusting metabolism may provide therapeutic opportunities to prevent or reduce metastasis, and targeting the new metabolic traits in established metastases could lead to their eradication.

NATURE REVIEWS CANCER (2021)

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Review Immunology

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Alireza Labani-Motlagh et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer

Fang Bai et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Cell Biology

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

Tianke Chen et al.

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Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

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Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma

Suchismita Mohanty et al.

CELL DEATH & DISEASE (2019)

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The Tumor Microenvironment Innately Modulates Cancer Progression

Dominique C. Hinshaw et al.

CANCER RESEARCH (2019)

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Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Yuxin Lin et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages

Hao Wu et al.

EMBO MOLECULAR MEDICINE (2019)

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The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells

Chiara Bellio et al.

CANCERS (2019)

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Article Cell Biology

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

Lingyun Xia et al.

CELL METABOLISM (2019)

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Phagocytosis checkpoints as new targets for cancer immunotherapy

Mingye Feng et al.

NATURE REVIEWS CANCER (2019)

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Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation

Jing Ge et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

Linchong Sun et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

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JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

Tianyi Wang et al.

CELL METABOLISM (2018)

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Targeting the tumour stroma to improve cancer therapy

Kenneth C. Valkenburg et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Patrice D. Cani et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

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Lipid droplet density alters the early innate immune response to viral infection

Ebony A. Monson et al.

PLOS ONE (2018)

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Lipid Droplets as Immune Modulators in Myeloid Cells

Martijn H. den Brok et al.

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Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Xavier Michelet et al.

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Free fatty acids clog up cytotoxic machinery

Anna Kriebs

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Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy

Ashley Orillion et al.

CLINICAL CANCER RESEARCH (2018)

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Tumour microenvironment factors shaping the cancer metabolism landscape

Dimitrios Anastasiou

BRITISH JOURNAL OF CANCER (2017)

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Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma

Jiaze An et al.

ONCOTARGET (2017)

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Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells

Hao Wu et al.

SCIENTIFIC REPORTS (2017)

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The Warburg Effect and the Hallmarks of Cancer

Laurent Schwartz et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2017)

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Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer

Fan Feng et al.

BMC CANCER (2017)

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Lactate Metabolism in Human Lung Tumors

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CELL (2017)

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Local Activation of p53 in the Tumor Microenvironment Overcomes Immune Suppression and Enhances Antitumor Immunity

Gang Guo et al.

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Hunger Pains: Stimulating the Appetite of the Immune System for Cancer

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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Federico Pietrocola et al.

CANCER CELL (2016)

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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Stefano Di Biase et al.

CANCER CELL (2016)

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Obesity and Cancer: The Oil that Feeds the Flame

Joan Font-Burgada et al.

CELL METABOLISM (2016)

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The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

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Optical imaging of gastric cancer with near-infrared heptamethine carbocyanine fluorescence dyes

Ningning Zhao et al.

ONCOTARGET (2016)

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Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5

Vittoria D'Esposito et al.

ONCOTARGET (2016)

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Xudong Fu et al.

CELL METABOLISM (2015)

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Targeting T cell metabolism for therapy

David O'Sullivan et al.

TRENDS IN IMMUNOLOGY (2015)

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The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies

Leisha A. Emens et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Near-infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes

Jianlin Yuan et al.

MOLECULAR MEDICINE REPORTS (2015)

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ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

Hayato Nakagawa et al.

CANCER CELL (2014)

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Review Immunology

HIF Transcription Factors, Inflammation, and Immunity

Asis Palazon et al.

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Bcl-6 directly represses the gene program of the glycolysis pathway

Kenneth J. Oestreich et al.

NATURE IMMUNOLOGY (2014)

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Review Immunology

Molecular regulation of effector and memory T cell differentiation

John T. Chang et al.

NATURE IMMUNOLOGY (2014)

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Article Oncology

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

Sarah Schwitalla et al.

CANCER CELL (2013)

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Article Biochemistry & Molecular Biology

Non-Cell-Autonomous Tumor Suppression by p53

Amaia Lujambio et al.

CELL (2013)

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Article Urology & Nephrology

Optical Imaging of Kidney Cancer with Novel Near Infrared Heptamethine Carbocyanine Fluorescent Dyes

Xiaojian Yang et al.

JOURNAL OF UROLOGY (2013)

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Article Immunology

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Linda V. Sinclair et al.

NATURE IMMUNOLOGY (2013)

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Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

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Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

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Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Chintan K. Kikani et al.

SCIENCE SIGNALING (2012)

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Article Biochemistry & Molecular Biology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Weibo Luo et al.

CELL (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Immunology

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

Ruoning Wang et al.

IMMUNITY (2011)

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Frank Weinberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Biochemistry & Molecular Biology

Lipid droplets in inflammation and cancer

Patricia T. Bozza et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2010)

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Leukocyte lipid bodies - Biogenesis and functions in inflammation

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

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CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

David G. DeNardo et al.

CANCER CELL (2009)

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Article Oncology

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

N. V. Khromova et al.

CANCER LETTERS (2009)

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Tumor suppressors and cell metabolism: a recipe for cancer growth

Russell G. Jones et al.

GENES & DEVELOPMENT (2009)

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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma

Qi Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

Cancer cell metabolism: Warburg and beyond

Peggy P. Hsu et al.

CELL (2008)

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Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

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Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

Andrew G. Renehan et al.

LANCET (2008)

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Article Multidisciplinary Sciences

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

Jeremy B. Swann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Immunology

Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development

Caroline Aspord et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

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Review Biochemistry & Molecular Biology

Hypoxia-inducible factors, stem cells, and cancer

Brian Keith et al.

CELL (2007)

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Article Hematology

L-arginine availability regulates T-lymphocyte cell-cycle progression

Paulo C. Rodriguez et al.

BLOOD (2007)

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Article Hematology

Elevated plasma membrane cholesterol content alters macrophage signaling and function

CB Qin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Article Immunology

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

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IMMUNITY (2005)

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Review Oncology

Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms

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Article Immunology

Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division

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IMMUNOLOGY (2002)

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Article Biochemistry & Molecular Biology

Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

SY Huang et al.

ONCOGENE (2001)

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Article Cell Biology

Human leptin signaling in human peripheral blood mononuclear cells: Activation of the JAK-STAT pathway

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CELLULAR IMMUNOLOGY (2001)

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