Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1

Article Plant Sciences

Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway

Fang Zhao et al.

Summary: Chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications in obstructive sleep apnea (OSA). Ginsenoside Rg1 may alleviate CIH-induced vascular endothelial dysfunction through the calpain-1 pathway.

JOURNAL OF GINSENG RESEARCH (2023)

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Article Medicine, Research & Experimental

Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice

Duoduo Zhang et al.

Summary: Ginsenoside Rg1 has a protective effect against chronic renal injury induced by low-dose lipopolysaccharide (LPS), possibly by reducing oxidative stress and inhibiting inflammasome activation.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Treatment of Chronic Kidney Disease with Extracellular Vesicles from Mesenchymal Stem Cells and CD133+ Expanded Cells: A Comparative Preclinical Analysis

Dayane Mayumi Miyasaki et al.

Summary: This study evaluated the effects of extracellular vesicles (EVs) from human umbilical cord tissue and human umbilical cord blood on rats with chronic kidney disease. The results demonstrated that EVs have the potential to improve renal function, suggesting their use as a cell-free treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Multidisciplinary Sciences

Role of non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review

Suifen Xie et al.

Summary: Cardiotoxicity caused by anticancer drugs can pose life-threatening risks or long-term morbidity by interfering with optimal treatment. The heart is a complex organ composed of cardiomyocytes and non-cardiomyocytes, with non-cardiomyocytes playing an increasingly recognized dynamic and essential role in drug-induced cardiotoxicity. This review provides an overview of the involvement of non-cardiomyocytes in cardiotoxicity, including direct damage, paracrine-induced cardiomyocyte injury, transient cell-induced myocardial inflammation, and protective agents targeting non-cardiomyocytes.

ISCIENCE (2022)

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Review Biochemistry & Molecular Biology

Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension

Anastasia Gorelova et al.

Summary: Endothelial-to-mesenchymal transition (EndMT) is a process that involves transcriptional reprogramming of endothelial cells towards mesenchymal phenotypes, contributing to various pathologies in adults, particularly in cardiovascular diseases and pulmonary hypertension. This review provides an overview of the current knowledge on the role of EndMT in pulmonary hypertension and discusses potential therapeutic strategies for disease management.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Cell Biology

NR4A1 knockdown confers hepatoprotection against ischaemia-reperfusion injury by suppressing TGFβ1 via inhibition of CYR61/NF-κB in mouse hepatocytes

Jun Cao et al.

Summary: NR4A1 exacerbates hepatic ischemia-reperfusion injury by up-regulating CYR61/NF-kappa B/TGF beta 1 pathway, leading to hepatocellular damage. Silencing NR4A1 can alleviate hepatic I/R injury through inhibiting this pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Plant Sciences

Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway

Mei-Li Lu et al.

Summary: The study shows that Rg1 can alleviate cardiac hypertrophy and fibrosis, and improve cardiac diseases induced by mechanical stress. Rg1 protects the heart from injury by inhibiting the CaSR signaling pathway and the expression of calcineurin.

JOURNAL OF GINSENG RESEARCH (2021)

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Article Neurosciences

Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension

Nikki L. Jernigan et al.

Summary: Pulmonary hypertension is characterized by sustained vasoconstriction and remodeling of the small pulmonary arteries. Acid-sensing ion channel 1 (ASIC1) plays a role in chronic hypoxia-induced pulmonary hypertension and contributes to the depolarization of pulmonary arterial smooth muscle cells. Na+ influx, mediated by ASIC1, is essential for the persistent depolarization in PASMCs during chronic hypoxia.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

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Review Pharmacology & Pharmacy

Ginsenosides in vascular remodeling: Cellular and molecular mechanisms of their therapeutic action

Guang-Xuan Zhu et al.

Summary: Abnormal vascular remodeling (VR) precedes many cardiovascular diseases, highlighting the potential of ginsenoside as a pivotal target for treatment and prevention. Research suggests that ginsenosides can improve VR caused by vasodilation dysfunction, abnormal structure, and blood pressure.

PHARMACOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Qing Zhang et al.

Summary: This study summarized natural compounds that exert protective effects against oxidative stress in vascular endothelial cells (ECs), including phenylpropanoids, flavonoids, terpenoids, and alkaloids. These compounds alleviate EC apoptosis by activating the Nrf2/HO-1 signaling pathway, showing potential for the treatment of atherosclerosis.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

Jia-qi Liu et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Chemistry, Medicinal

Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

Min Yu et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Medicine, Research & Experimental

Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets

Yafeng Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Respiratory System

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

Gerald Simonneau et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Respiratory System

Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management

Erika B. Rosenzweig et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

Emily R. Watts et al.

TRENDS IN MOLECULAR MEDICINE (2019)

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Review Respiratory System

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases

Alice Huertas et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Immunology

Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes

Jonathan Florentin et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Plant Sciences

Cardioprotection of Sheng Mai Yin a classic formula on adriamycin induced myocardial injury in Wistar rats

Kai Zhang et al.

PHYTOMEDICINE (2018)

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Article Multidisciplinary Sciences

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells

Francesca Cuomo et al.

SCIENTIFIC REPORTS (2018)

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Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

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Review Medicine, General & Internal

Pulmonary arterial hypertension: pathogenesis and clinical management

Thenappan Thenappan et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

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Review Immunology

Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

Jin Gu Cho et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Cysteine-rich angiogenic inducer 61 (Cyr61): a novel soluble biomarker of acutemyocardial injury improves risk stratification after acute coronary syndromes

Roland Klingenberg et al.

EUROPEAN HEART JOURNAL (2017)

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Article Oncology

NF-κB mediated miR-130a modulation in lung microvascular cell remodeling: Implication in pulmonary hypertension

Li Li et al.

EXPERIMENTAL CELL RESEARCH (2017)

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Article Medicine, General & Internal

Cysteine-rich 61 (Cyr61) upregulated in pulmonary arterial hypertension promotes the proliferation of pulmonary artery smooth muscle cells

Lan Gao et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2017)

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Article Integrative & Complementary Medicine

Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

Lin-Bo Yuan et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2017)

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Article Multidisciplinary Sciences

Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension

Wei-Chun Huang et al.

PLOS ONE (2016)

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Article Critical Care Medicine

Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways

Simon C. Rowan et al.

LANCET RESPIRATORY MEDICINE (2016)

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Editorial Material Medicine, Research & Experimental

New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis

Haiyang Tang et al.

EMBO MOLECULAR MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Management of Pulmonary Arterial Hypertension

Vallerie V. McLaughlin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

CCN1 suppresses pulmonary vascular smooth muscle contraction in response to hypoxia

Seon-jin Lee et al.

PULMONARY CIRCULATION (2015)

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Article Biochemistry & Molecular Biology

NFkappaB activation is essential for miR-21 induction by TGFβ1 in high glucose conditions

Radha Madhyastha et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Biochemistry & Molecular Biology

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling

Erawan Borkham-Kamphorst et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

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Article Medicine, Research & Experimental

The effects and mechanism of ginsenoside Rg1 on myocardial remodeling in an animal model of chronic thromboembolic pulmonary hypertension

Chang-yi Li et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2013)

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Article Pharmacology & Pharmacy

Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vessel dilatation

Chunshui Pan et al.

VASCULAR PHARMACOLOGY (2012)

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Review Medicine, General & Internal

Mechanisms of Disease: Hypoxia and Inflammation.

Holger K. Eltzschig et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Immunology

Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages

Tao Bai et al.

JOURNAL OF IMMUNOLOGY (2010)

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Review Cell Biology

Divergence and convergence of TGF-β/BMP signaling

K Miyazono et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2001)

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Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1

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