NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells

The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional regulator of activated T cells. The NFAT family is involved in the development of tumors. Furthermore, recent evidence reveals that NFAT proteins regulate the development of inflammatory and immune responses. New discoveries have also been made about the mechanisms by which NFAT regulates cancer progression through cancer stem cells (CSC). Here, we discuss the role of the NFAT family in the immune system and various cancer types.

Automated summary

The nuclear factor of activated T cells (NFAT) is a transcriptional regulator initially identified in activated T cells. The NFAT family is involved in tumor development and recent studies have shown its role in regulating inflammatory and immune responses. Additionally, NFAT has been found to regulate cancer progression through cancer stem cells (CSC). This article discusses the involvement of NFAT family in immune system functioning and various types of cancer.