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Stem cell-derived exosomal MicroRNAs: Potential therapies in diabetic kidney disease

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Medicine, General & Internal

Role of Obesity in Female Reproduction

Wei Yong et al.

Summary: Contemporary scientists are well aware of the increasing prevalence of obesity and its complications. Obesity is strongly associated with type 2 diabetes, hypertension, vascular disease, tumors, and reproductive disorders. It affects female reproduction by reducing fertility, increasing miscarriage rates, and affecting the success of in vitro fertilization. Moreover, obesity-induced inflammation has a chronic inflammatory response, affecting the complete process of female reproduction.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2023)

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Review Biochemistry & Molecular Biology

What's New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances

Kimio Watanabe et al.

Summary: Diabetic kidney disease (DKD) is the main cause of chronic kidney disease and increases the risk of cardiovascular mortality. Treatment options for DKD have advanced, but their efficacy is limited. A deeper understanding of the molecular mechanisms of DKD is necessary for the development of new treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Immunology

NF-KB dynamics in the language of immune cells

Mohammad Aqdas et al.

Summary: Biological discovery has been driven by advances in analysis technologies, but there is a bias towards snapshot-based knowledge. Although recent methods like multi-omics single-cell assays have improved immunological investigations, they still have limitations in reconstructing dynamic events across individual cells. This study presents a rationale for how NF-KB conveys contextual information through quantitative features of its signaling dynamics, which may help solve the paradox of accurate responses to different immune challenges.

TRENDS IN IMMUNOLOGY (2023)

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Review Endocrinology & Metabolism

Renal Protection with SGLT2 Inhibitors: Effects in Acute and Chronic Kidney Disease

Clifford J. Bailey et al.

Summary: This review evaluates the nephroprotective effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors in people with type 2 diabetes, highlighting their ability to slow down the decline in glomerular filtration rate, reduce microalbuminuria, and slow or reverse proteinuria. These effects are not limited to diabetes patients and extend to non-diabetic, lean, and normotensive individuals as well. The mechanisms behind these effects include tubuloglomerular feedback, improved tubular oxygenation and metabolism, and reduced inflammation and fibrosis. The use of SGLT2 inhibitors has not shown increased risk of urinary tract infections or acute kidney injury.

CURRENT DIABETES REPORTS (2022)

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Review Cell & Tissue Engineering

Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management

Lei Peng et al.

Summary: Diabetic nephropathy remains the most common cause of end-stage renal disease, and early diagnosis and treatment can slow down its progression. Circulating levels of kidney-released exosomes and biomolecules have shown potential in predicting the occurrence and progression of diabetic nephropathy. Stem cell therapy and medications targeting inflammatory, oxidant, or pro-fibrotic pathways are being investigated as potential treatments.

STEM CELL RESEARCH & THERAPY (2022)

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Review Pharmacology & Pharmacy

Role of nitric oxide in type 1 diabetes-induced osteoporosis

Sajad Jeddi et al.

Summary: Type 1 diabetes-induced osteoporosis is characterized by decreased bone quality and increased fracture risk. The mechanisms include insulin deficiency, high blood sugar, oxidative stress, and inflammation. Decreased nitric oxide availability plays a role in T1D-induced osteoporosis.

BIOCHEMICAL PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

IL-6 and its role in IgA nephropathy development

Yaroslava Groza et al.

Summary: IL-6 is a cytokine with homeostatic, pro-inflammatory, and anti-inflammatory activities, involved in regulating cell proliferation, survival, differentiation, and metabolism changes. Abnormal levels of IL-6 and its signaling response are associated with autoimmune diseases like IgA nephropathy. This review summarizes the role of IL-6 in the pathogenesis of IgA nephropathy through the production of Gd-IgA1 and regulation of mesangial cell proliferation.

CYTOKINE & GROWTH FACTOR REVIEWS (2022)

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Article Pharmacology & Pharmacy

Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway

Wei Gu et al.

Summary: Diabetic kidney disease is a common complication of diabetes, and lipid deposits in the kidneys contribute to kidney damage. This study found that abnormal lipid metabolism is closely related to diabetic kidney disease in patients. Additionally, the administration of resveratrol in mice with high-fat diet-induced renal abnormalities reduced lipid deposition, improved renal function, and regulated lipid synthesis pathways.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Review Urology & Nephrology

Molecular mechanisms and therapeutic targets for diabetic kidney disease

Katherine R. Tuttle et al.

Summary: Diabetic kidney disease is a global burden that increases the risk of kidney failure and cardiovascular events. There is a need to understand the molecular mechanisms of the disease and find new therapies. Inflammatory and fibrotic mediators play important roles in the pathophysiology of the disease. Recent clinical trials have shown promising drug therapies and dietary strategies for treating diabetic kidney disease.

KIDNEY INTERNATIONAL (2022)

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Review Genetics & Heredity

Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation

Ryan L. Kan et al.

Summary: Epigenetic modifications play a crucial role in gene expression regulation through modifications on genomic DNA, histones, and more recently, mRNA. These modifications, especially the common N6-methyladenosine (m6A) methylation, not only influence RNA stability and translation efficiency, but also interact with histone/DNA epigenetic mechanisms to specify transcriptional outputs and recruit chromatin modifiers. This review focuses on dissecting the feedback circuits orchestrated by m6A, which regulate histone modifications and the activity of regulatory RNAs, such as long noncoding RNA and chromosome-associated regulatory RNA. The evidence suggests that m6A acts as a versatile checkpoint linking different layers of gene regulation.

TRENDS IN GENETICS (2022)

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Article Cell Biology

Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

Haojia Wu et al.

Summary: This study analyzed the response of a murine model of diabetic kidney disease (DKD) to five different treatment regimens using single-cell RNA sequencing. The results revealed a heterogeneous response of all kidney cell types to DKD and its treatment. Both monotherapy and combination therapies targeted different cell types and induced distinct transcriptional changes. Sodium-glucose cotransporter-2 inhibitors were found to regulate alternative splicing in the proximal tubule, suggesting a potential mechanism of action for this drug class in treating DKD.

CELL METABOLISM (2022)

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Review Endocrinology & Metabolism

Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan

Takashi Kadowaki et al.

Summary: There is a interaction between metabolic disorders, cardiovascular disease, and kidney dysfunction, known as cardio-renal-metabolic (CRM) disease. Understanding the molecular mechanisms and pathophysiological processes of CRM disease is crucial for improving patient outcomes, and there may be differences in CRM diseases between different regions.

DIABETES OBESITY & METABOLISM (2022)

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Article Plant Sciences

Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway

Di Jin et al.

Summary: The therapeutic effect of Jiedu Tongluo Baoshen formula (JTBF) on diabetic kidney disease (DKD) was investigated in this study. It was found that JTBF can effectively reduce proteinuria and protect kidney function in a rat model of DKD. The mechanism of action involves the enhancement of podocyte autophagy, which helps alleviate podocyte damage.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Urology & Nephrology

Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease

Khurrum Shahzad et al.

Summary: This study found that activation of the NLRP3 inflammasome in podocytes is both necessary and sufficient for diabetic kidney disease (DKD), indicating that podocytes have immune cell-like functions. Targeting NLRP3 may be a promising therapeutic approach for DKD.

KIDNEY INTERNATIONAL (2022)

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Review Immunology

NF-?B: blending metabolism, immunity, and inflammation

Daria Capece et al.

Summary: This review discusses the central role of NF-KB transcription factors in the immune and metabolic systems, and how their understanding can lead to better diagnostics and therapeutics for human diseases.

TRENDS IN IMMUNOLOGY (2022)

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Article Physiology

The relationship between insulin and glucagon concentrations in non-diabetic humans

Marcello C. Laurenti et al.

Summary: Abnormal postprandial suppression of glucagon in Type 2 diabetes has been attributed to impaired insulin secretion. However, dysregulation of alpha-cell function in prediabetes occurs early and independently of changes in beta-cells, suggesting insulin's less significant role on glucagon control. Research on hepatic vein hormone concentrations suggests that the interaction between insulin and glucagon is not driven by either hormone.

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Article Cell Biology

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

Petra Hyrossova et al.

Summary: Under glucose restriction, cells undergo entosis, a cannibalistic process, to withstand metabolic stress. Reduced protein glycosylation and the involvement of PEPCK-M in this survival program play crucial roles. These findings have implications for tumor metabolism and treatment strategies.

CELL DEATH & DISEASE (2022)

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Review Medicine, General & Internal

The role of circular RNA in Diabetic Nephropathy

Chao Tu et al.

Summary: This article summarizes the origin, classification, biogenesis, and regulatory mechanisms of circular RNA (CircRNA), and introduces the role of CircRNA as competing endogenous RNA in the pathogenesis and clinical significance of diabetic nephropathy. It is of great significance for us to fully understand the pathological mechanism of diabetic nephropathy and develop new therapeutic targets or treatment options to improve the prognosis of patients.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

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Article Medicine, Research & Experimental

Roles of melatonin in the field of reproductive medicine

Wei Yong et al.

Summary: Melatonin is a multifunctional hormone regulated by the circadian rhythm, with roles in sleep-wake cycle rhythms, ageing retardation, antioxidant and anti-inflammatory functions, as well as significant impact on reproductive functions.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Urology & Nephrology

Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

Radica Z. Alicic et al.

Summary: Incretin-based therapies, such as GLP1R agonists and DPP4 inhibitors, have shown protective effects in diabetic kidney disease patients, with potential mechanisms including immunomodulation and anti-inflammatory actions. These drugs not only lower blood glucose levels effectively but also reduce the risk of developing chronic kidney disease and cardiovascular events, in addition to potentially attenuating oxidative stress and cellular apoptosis in the kidney.

NATURE REVIEWS NEPHROLOGY (2021)

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Review Nutrition & Dietetics

Effects of High Glucose and Lipotoxicity on Diabetic Podocytes

Ran Nakamichi et al.

Summary: Podocytes are highly differentiated cells that cover the outside of glomerular capillaries, and damage to podocytes leads to proteinuria and glomerulosclerosis. Diabetes is a main cause of CKD, making it crucial to understand its effects on podocytes for preventing CKD progression.

NUTRIENTS (2021)

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Review Pharmacology & Pharmacy

Mesenchymal Stem Cell-Derived Exosomes: A Promising Biological Tool in Nanomedicine

Wumei Wei et al.

Summary: The article discusses the significant role of exosomes derived from mesenchymal stem cells in biomedicine, including their function as nanocarriers, drug loading, and tissue engineering. Exosomes have advantages and potential disadvantages compared to stem cells and synthetic nanoparticles.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Fei Teng et al.

Summary: Extracellular vesicles (EVs) are nano-sized secreted vesicles containing various biomolecules, which have low immunogenicity and can functionally modify recipient cells by transferring bioactive constituents. Therefore, they are considered as an excellent candidate for the next generation drug delivery system.

ADVANCED SCIENCE (2021)

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Article Nutrition & Dietetics

The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes

Domenico Sergi et al.

Summary: The study demonstrates that EPA can prevent low-grade inflammation and mitochondrial dysfunction induced by nutrient excess, while improving insulin signaling pathway. This suggests that EPA may help preserve skeletal muscle metabolic health.

JOURNAL OF NUTRITION (2021)

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Article Medicine, General & Internal

Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, doubleblind, double-dummy, placebo-controlled, phase 3 trial

Melanie Davies et al.

Summary: In this study, once-weekly subcutaneous semaglutide 2.4 mg was shown to achieve a significantly greater and clinically meaningful weight reduction compared to placebo in adults with overweight or obesity and type 2 diabetes. Adverse events, particularly gastrointestinal events, were more common with semaglutide compared to placebo.

LANCET (2021)

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Article Medicine, Research & Experimental

被撤回的出版物: BMSCs-derived exosomal microRNA-let-7a plays a protective role in diabetic nephropathy via inhibition of USP22 expression (Retracted article. See vol. 318, 2023)

Ruiyang Mao et al.

Summary: The study showed that BMSCs-derived exosomal miR-let-7a can protect against diabetic nephropathy by repressing renal cell apoptosis through downregulating USP22.

LIFE SCIENCES (2021)

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Review Urology & Nephrology

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors

Ralph A. DeFronzo et al.

Summary: Diabetic kidney disease is a leading cause of kidney failure globally, with over 50% of individuals entering dialysis or transplant programmes in the USA affected by it. Hyperglycaemia is the primary factor in its development, leading to various pathophysiological disturbances that contribute to progressive glomerular sclerosis and declining renal function. Multiple agents used in combination are likely to be needed to effectively slow the progression of the disease.

NATURE REVIEWS NEPHROLOGY (2021)

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Review Urology & Nephrology

Update on diagnosis, pathophysiology, and management of diabetic kidney disease

Mai Sugahara et al.

Summary: Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus that is difficult to cure completely due to its heterogeneous nature. Recent studies have shown that different patients exhibit varying clinical manifestations, progression rates, and pathophysiological mechanisms, making it challenging to develop effective treatments.

NEPHROLOGY (2021)

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Review Pharmacology & Pharmacy

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Guoyi Tang et al.

Summary: Chinese medicine has shown promising clinical benefits in the treatment and management of diabetic nephropathy, with its multi-target function affecting crucial mechanisms such as glucose/lipid metabolism regulation, antioxidation, anti-inflammation, anti-fibrosis, and podocyte protection. Studies have emphasized the clinical efficacy of Chinese medicines and their bioactive components, with a focus on identifying the underlying mechanisms and molecular targets.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Endocrinology & Metabolism

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials

Naveed Sattar et al.

Summary: The meta-analysis showed that GLP-1 receptor agonists can reduce the risk of major adverse cardiovascular events, all-cause mortality, hospital admission for heart failure, and worsening kidney function in patients with type 2 diabetes, regardless of structural homology.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

Non-Coding RNA and Diabetic Kidney Disease

Huiwen Ren et al.

Summary: Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes with a complex pathological process involving multiple factors. Non-coding RNAs, such as micro RNA (miRNA), play a role in disease regulation and may serve as potential biomarkers for disease prediction. The research on long coding RNA (lncRNA) and circular RNA (circRNA) is still challenging and in early stages.

DNA AND CELL BIOLOGY (2021)

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Review Urology & Nephrology

Tubuloglomerular Feedback Synchronization in Nephrovascular Networks

Tayyaba Zehra et al.

Summary: The kidneys maintain stable blood perfusion by autoregulating blood flow through myogenic response and tubuloglomerular feedback (TGF) mechanisms, with nephrons communicating electrically over long distances to form the nephrovascular unit (NVU). This distributed autoregulation across the renal microvascular network optimizes oxygenation-perfusion matching and prevents transmission of high systemic pressure to the glomeruli, thus preventing progressive glomerular and vascular injury.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Endocrinology & Metabolism

Mesenchymal Stem Cell-Derived Exosomes Carry MicroRNA-125a to Protect Against Diabetic Nephropathy by Targeting Histone Deacetylase 1 and Downregulating Endothelin-1

Yan Hao et al.

Summary: The study showed that exosomes derived from adipose tissue-derived MSCs inhibited the progression of diabetic nephropathy by carrying miR-125a, which led to the inhibition of HDAC1 and ET-1. This novel finding may offer insights into the treatment of DN.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Review Cell Biology

Application of mesenchymal stem cell-derived exosomes in kidney diseases

Deng Gang et al.

Summary: Exosomes have the potential to be a promising treatment for kidney injury by promoting tissue repair and immune regulation through the action of proteins and RNA on target cells. While there are still some key issues that remain unaddressed, exosomes show potential benefits in the treatment of kidney injury.

CELLULAR IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

The IL-8-CXCR1/2 axis contributes to diabetic kidney disease

Cristian Loretelli et al.

Summary: In diabetic kidney disease, the IL-8-CXCR1/2 axis plays a significant role in inducing kidney damage, suggesting that targeting this axis may be beneficial in reducing the burden of diabetic kidney disease.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Endocrinology & Metabolism

Insulin resistance, cardiovascular stiffening and cardiovascular disease

Michael A. Hill et al.

Summary: Insulin resistance is typically accompanied by metabolic insulin resistance and cardiovascular disease, including the correlation of reduced nitric oxide production leading to increased blood flow. Insulin resistance and hyperinsulinemia promote cardiovascular diseases by increasing vascular stiffness.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Urology & Nephrology

The Mesangial cell - the glomerular stromal cell

Shimrit Avraham et al.

Summary: Mesangial cells are essential stromal cells in maintaining kidney glomerular homeostasis and responding to injury. Other mesenchymal stromal cells play roles in tissue architecture, developmental processes, vascularization, and cell fate determination. These stromal cells can also regulate a variety of processes through crosstalk with neighboring cells and matrix remodeling, potentially impacting immunity, inflammation, regeneration, and fibrosis. Insights into the molecular phenotype of kidney mesangial cells provide a better understanding of kidney disease pathogenesis and the development of new therapies for chronic kidney disease.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Urology & Nephrology

Targeting the Pathobiology of Diabetic Kidney Disease

Merlin C. Thomas

Summary: The pathobiology of diabetic kidney disease involves the interplay between different cell types within the kidney in response to chronic hyperglycemia. The characteristic morphological changes accelerate the progression of lesions, ultimately leading to kidney function decline.

ADVANCES IN CHRONIC KIDNEY DISEASE (2021)

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Review Biology

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Qiuping Guo et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

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Review Neurosciences

The future of stem cell therapies for Parkinson disease

Malin Parmar et al.

NATURE REVIEWS NEUROSCIENCE (2020)

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Review Cell Biology

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CELLS (2020)

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Article Biochemistry & Molecular Biology

Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy

Yurui Duan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Cell & Tissue Engineering

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CELL STEM CELL (2020)

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Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cell Biology

Hyperglycemia Induces Endoplasmic Reticulum Stress in Atrial Cardiomyocytes, and Mitofusin-2 Downregulation Prevents Mitochondrial Dysfunction and Subsequent Cell Death

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Review Cell & Tissue Engineering

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Article Cell & Tissue Engineering

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

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ACS NANO (2019)

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Medicine, General & Internal

Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons

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JOURNAL OF CLINICAL MEDICINE (2019)

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ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

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BIOMEDICINE & PHARMACOTHERAPY (2019)

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The roles of microRNAs in epigenetic regulation

Qian Yao et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2019)

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Article Medicine, Research & Experimental

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

Yu‐Rui Duan et al.

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CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

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The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes

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DIABETOLOGIA (2017)

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Article Physiology

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

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Review Pharmacology & Pharmacy

Stem cell-based therapies for HIV/AIDS

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ADVANCED DRUG DELIVERY REVIEWS (2016)

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The Players: Cells Involved in Glomerular Disease

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CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Article Urology & Nephrology

Incidence, Severity, and Outcomes of AKI Associated with Dual Renin-Angiotensin System Blockade

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CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

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Article Cell & Tissue Engineering

Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell

Li Sun et al.

CYTOTHERAPY (2016)

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Article Biotechnology & Applied Microbiology

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

Bo Wang et al.

MOLECULAR THERAPY (2016)

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Editorial Material Medicine, General & Internal

Nephron Protection in Diabetic Kidney Disease

Hans-Joachim Anders et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Cell & Tissue Engineering

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

Zhen-zhen Jiang et al.

STEM CELL RESEARCH & THERAPY (2016)

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Article Multidisciplinary Sciences

Stem Cell-Derived, microRNA-Carrying Extracellular Vesicles: A Novel Approach to Interfering with Mesangial Cell Collagen Production in a Hyperglycaemic Setting

Sara Gallo et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes

Kanna Nagaishi et al.

SCIENTIFIC REPORTS (2016)

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Article Genetics & Heredity

Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1

Rui Peng et al.

GENE (2015)

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Article Cardiac & Cardiovascular Systems

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

Yingjie Wang et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Tyson Smyth et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Review Oncology

Exosomes in cancer: small particle, big player

Xu Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

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Article Biochemistry & Molecular Biology

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

Sara Lovisa et al.

NATURE MEDICINE (2015)

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Article Medicine, General & Internal

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

Bernard Zinman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Medicine, General & Internal

Diabetic kidney disease

Merlin C. Thomas et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Review Medicine, General & Internal

Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly

Robyn Cunard

JOURNAL OF CLINICAL MEDICINE (2015)

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Article Urology & Nephrology

VEGF-A Inhibition Ameliorates Podocyte Apoptosis via Repression of Activating Protein 1 in Diabetes

Xiaoyan Bai et al.

AMERICAN JOURNAL OF NEPHROLOGY (2014)

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Review Biochemistry & Molecular Biology

Modeling human neurological disorders with induced pluripotent stem cells

Yoichi Imaizumi et al.

JOURNAL OF NEUROCHEMISTRY (2014)

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Review Cell Biology

After the banquet Mitochondrial biogenesis, mitophagy, and cell survival

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AUTOPHAGY (2013)

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Review Oncology

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

Vladimir N. Anisimov et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2013)

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Article Medicine, General & Internal

Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy

Linda F. Fried et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Oncology

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells

Eun-Hee Nam et al.

CARCINOGENESIS (2012)

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Article Urology & Nephrology

The role of autophagy in unilateral ureteral obstruction rat model

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NEPHROLOGY (2012)

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Article Transplantation

Therapeutic potential of mesenchymal stem cell-derived microvesicles

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NEPHROLOGY DIALYSIS TRANSPLANTATION (2012)

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Dysregulated Nephrin in Diabetic Nephropathy of Type 2 Diabetes: A Cross Sectional Study

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PLOS ONE (2012)

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Review Urology & Nephrology

TGF-β/BMP Pathways and the Podocyte

Irini Tossidou et al.

SEMINARS IN NEPHROLOGY (2012)

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Review Urology & Nephrology

VEGF and Podocytes in Diabetic Nephropathy

Alda Tufro et al.

SEMINARS IN NEPHROLOGY (2012)

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Review Urology & Nephrology

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

Juan F. Navarro-Gonzalez et al.

NATURE REVIEWS NEPHROLOGY (2011)

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Article Endocrinology & Metabolism

The metabolic syndrome in type 2 diabetic patients in Gorgan: According to NCEP ATPIII and IDF definitions

Abdoljalal Marjani et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2011)

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Review Cardiac & Cardiovascular Systems

Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

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Review Biotechnology & Applied Microbiology

Epigenetic modifications and human disease

Anna Portela et al.

NATURE BIOTECHNOLOGY (2010)

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Review Oncology

Tumour necrosis factor and cancer

Frances Balkwill

NATURE REVIEWS CANCER (2009)

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Article Endocrinology & Metabolism

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease

Fangfang Peng et al.

DIABETES (2008)

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Article Medicine, General & Internal

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study):: a multicentre, randomised, double-blind, controlled trial

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LANCET (2008)

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Review Physiology

MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

G. H. Tesch

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

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Article Urology & Nephrology

Cellular and molecular mechanisms of proteinuria in diabetic nephropathy

Gunter Wolf et al.

NEPHRON PHYSIOLOGY (2007)

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Review Biochemistry & Molecular Biology

The role of TNF-α in diabetic nephropathy:: Pathogenic and therapeutic implications

Juan F. Navarro et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2006)

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Article Biochemistry & Molecular Biology

Signalling and regulation of collagen I synthesis by ET-1 and TGF-β1

A Horstmeyer et al.

FEBS JOURNAL (2005)

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Article Urology & Nephrology

Additive antiproteinuric effect of pentoxifylline in patients with type 2 diabetes under angiotensin II receptor blockade:: A short-term, randomized, controlled trial

JF Navarro et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)

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Article Endocrinology & Metabolism

Elevated levels of interleukin-18 and tumor necrosis factor-α in serum of patients with type 2 diabetes mellitus:: Relationship with diabetic nephropathy

Y Moriwaki et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2003)

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Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)

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Article Medicine, General & Internal

Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

EJ Lewis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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