A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers

Article Engineering, Biomedical

Size-optimized nuclear-targeting phototherapy enhances the type I interferon response for cold tumor immunotherapy

Xiliu Zhang et al.

Summary: This study demonstrates that using 5nm nuclear-targeting nanoparticles can activate the innate immune response and convert cold tumors into hot tumors.

ACTA BIOMATERIALIA (2023)

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Article Multidisciplinary Sciences

Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy

Yuanyuan Guo et al.

Summary: This study presents a rational design and assembly of a nanocarrier that can package multiple drugs, including small-molecule drugs and macromolecular biologics. The nanogel not only achieves photodynamic therapy but also targets gene silencing, leading to enhanced antitumor immune response in a synergistic manner.

SCIENCE ADVANCES (2022)

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Article Engineering, Biomedical

Therapeutic supramolecular tubustecan hydrogel combined with checkpoint inhibitor elicits immunity to combat cancer

Feihu Wang et al.

Summary: The localized chemoimmunotherapy system using aSP hydrogel enables sustained release of bioactive camptothecin and aPD1 into the tumor microenvironment, leading to robust infiltration of tumor-associated T cells and a response to immune checkpoint blockade. This approach provokes a long-term and systemic anticancer T cell immune response, resulting in tumor regression and inhibition of recurrence and metastasis.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor

Sean D. Allen et al.

Summary: The study demonstrates the effective use of encapsulated GSK3 inhibitor AZD1080 in improving drug delivery to tumor sites and promoting cytotoxicity against tumor cells by CD8(+) T-cells. The therapeutic efficacy of encapsulated AZD1080 was similar or even better than anti-PD-1 antibody, with the added benefit of lacking treatment toxicity.

BIOMATERIALS (2021)

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Review Engineering, Biomedical

Nanobiomaterial-based vaccination immunotherapy of cancer

Fangmin Chen et al.

Summary: Cancer vaccines, including antigen peptide/adjuvant-based nanovaccines, nucleic acid-based nanovaccines, and biomimetic nanobiomaterials-based nanovaccines, have shown significant efficacy in inhibiting tumor growth and preventing relapse and metastasis. However, challenges remain in the clinical translation of these vaccines. The use of various nanobiomaterials has great potential to enhance the efficacy of cancer vaccines and reduce off-target effects.

BIOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun et al.

Summary: Metalloimmunotherapy utilizes metal ions to amplify the anti-tumour immune response promoted by STING agonists, forming nanoparticles that effectively deliver STING agonists and achieve remarkable therapeutic efficacy in multiple tumour models. This work highlights the great potential of coordination nanomedicine for metalloimmunotherapy.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Ming Chen et al.

Summary: In this study, researchers found that limited-stage small-cell lung cancer (LS-SCLC) tumors have a relatively homogeneous mutational landscape but a cold and heterogeneous TCR repertoire. Higher mutational burden, higher T cell infiltration, and positive PD-L1 expression are associated with longer overall survival, while higher chromosomal copy number aberration (CNA) burden is associated with shorter overall survival in patients with LS-SCLC.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade

Ravi B. Patel et al.

Summary: The study demonstrates that delivering radiation semiselectively to tumors through targeted radionuclide therapy (TRT) can enhance response to immune checkpoint inhibitors (ICIs), leading to therapeutic efficacy and tumor-specific T cell memory in murine models. Combination of TRT and ICI activates production of proinflammatory cytokines, promotes tumor infiltration by CD8(+) T cells, and reduces metastases, suggesting a promising approach to improve response to ICIs for various tumor types.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Article Multidisciplinary Sciences

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Qianqian Ni et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

Katherine A. Michaelis et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

Qian Chen et al.

ADVANCED MATERIALS (2019)

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Article Engineering, Biomedical

In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence

Xiao Han et al.

BIOMATERIALS (2019)

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Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Engineering, Biomedical

Self-indicating, fully active pharmaceutical ingredients nanoparticles (FAPIN) for multimodal imaging guided trimodality cancer therapy

Xiangdong Xue et al.

BIOMATERIALS (2018)

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Article Oncology

Genome-wide identification of transcription factors that are critical to non-small cell lung cancer

Da-Lin Zhang et al.

CANCER LETTERS (2018)

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Review Chemistry, Multidisciplinary

Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy

Qin Fan et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Multidisciplinary Sciences

Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment

Xiangdong Xue et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

Assaf Marcus et al.

IMMUNITY (2018)

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Article Chemistry, Multidisciplinary

Molecular Recognition Under Interfacial Conditions: Calix[4]pyrrole-Based Cross-linkable Micelles for Ion Pair Extraction

Xiaodong Chi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Chemistry, Multidisciplinary

Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer

Jun Xu et al.

ACS NANO (2017)

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Article Multidisciplinary Sciences

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

Qian Chen et al.

NATURE COMMUNICATIONS (2016)

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Article Chemistry, Multidisciplinary

Probe-Inspired Nano-Prodrug with Dual-Color Fluorogenic Property Reveals Spatiotemporal Drug Release in Living Cells

Xiangdong Xue et al.

ACS NANO (2015)

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Article Multidisciplinary Sciences

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor et al.

NATURE (2015)

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Review Immunology

STING: infection, inflammation and cancer

Glen N. Barber

NATURE REVIEWS IMMUNOLOGY (2015)

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Article Chemistry, Multidisciplinary

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

Edward A. Sykes et al.

ACS NANO (2014)

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Article Chemistry, Multidisciplinary

Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission

Xiangdong Xue et al.

ADVANCED MATERIALS (2014)

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Article Chemistry, Multidisciplinary

Combination of Small Molecule Prodrug and Nanodrug Delivery: Amphiphilic Drug-Drug Conjugate for Cancer Therapy

Ping Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

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Review Biochemistry & Molecular Biology

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

Xin Cai et al.

MOLECULAR CELL (2014)

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Article Chemistry, Multidisciplinary

Ablation of Hypoxic Tumors with Dose-Equivalent Photothermal, but Not Photodynamic, Therapy Using a Nanostructured Porphyrin Assembly

Cheng S. Jin et al.

ACS NANO (2013)

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Review Chemistry, Multidisciplinary

Aggregation-induced emission

Yuning Hong et al.

CHEMICAL SOCIETY REVIEWS (2011)

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Article Biochemistry & Molecular Biology

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

Theocharis Panaretakis et al.

EMBO JOURNAL (2009)

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Review Immunology

Toll-like receptor agonists in cancer therapy

Sylvia Adams

IMMUNOTHERAPY (2009)

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Review Physiology

The endothelial glycocalyx: composition, functions, and visualization

Sietze Reitsma et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)

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Article Biochemistry & Molecular Biology

Calreticulin exposure dictates the immunogenicity of cancer cell death

Michel Obeid et al.

NATURE MEDICINE (2007)

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Article Immunology

TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848)

RD Weeratna et al.

VACCINE (2005)

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A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers

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