4.8 Article

A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Supramolecular Copolymers of Peptides and Lipidated Peptides and Their Therapeutic Potential

Ruomeng Qiu et al.

Summary: Supramolecular peptide chemistry provides a versatile strategy for creating new biomaterials that can deliver various peptide therapeutics or integrate other types of bioactivity. This study focuses on the co-assembly of lipidated beta-sheet-forming peptides with soluble short peptides, resulting in supramolecular copolymers with different degrees of internal order. The copolymers exhibit thermodynamic metastability, leading to the spontaneous release of peptide monomers, which could serve as a potential mechanism for drug delivery.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Multidisciplinary Sciences

Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury

Z. Alvarez et al.

Summary: Researchers have successfully utilized peptide amphiphile supramolecular polymers containing two distinct signals to achieve cell signaling and tissue regeneration in a mouse model of severe spinal cord injury. By mutating the peptide sequence of the monomers, they intensified the motions of molecules within scaffold fibrils, resulting in notable effects such as vascular growth, axonal regeneration, and functional recovery. The study suggests that optimizing cell signaling through ensembles of molecules could be achieved by tuning their internal motions.

SCIENCE (2021)

Article Multidisciplinary Sciences

Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion

Priscilla S. Briquez et al.

Summary: A new translational protein engineering-based approach has been developed to reduce the required dosage of rhBMP-2 in clinical spinal fusion, increasing safety when delivered in a collagen sponge. This method has shown improved efficacy at low doses of rhBMP-2 in two mouse models of bone regeneration and may have applications in various regenerative medicine fields.

SCIENCE ADVANCES (2021)

Review Orthopedics

Investigational growth factors utilized in animal models of spinal fusion: Systematic review

Ethan Cottrill et al.

WORLD JOURNAL OF ORTHOPEDICS (2019)

Review Chemistry, Multidisciplinary

Peptide supramolecular materials for therapeutics

Kohei Sato et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Cell & Tissue Engineering

Tendon-bone interface healing using an injectable rhBMP-2-containing collagen gel in a rabbit extra-articular bone tunnel model

Kwang Won Lee et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Editorial Material Multidisciplinary Sciences

CLOSING THE GAP

David Holmes

NATURE (2017)

Article Nanoscience & Nanotechnology

Sulfated glycopeptide nanostructures for multipotent protein activation

Sungsoo S. Lee et al.

NATURE NANOTECHNOLOGY (2017)

Review Clinical Neurology

Lumbar Fusion for Degenerative Disease: A Systematic Review and Meta-Analysis

Daniel Yavin et al.

NEUROSURGERY (2017)

Review Peripheral Vascular Disease

The role of vasculature in bone development, regeneration and proper systemic functioning

Joanna Filipowska et al.

ANGIOGENESIS (2017)

Review Developmental Biology

Blood vessel formation and function in bone

Kishor K. Sivaraj et al.

DEVELOPMENT (2016)

Article Chemistry, Physical

Energy landscapes and functions of supramolecular systems

Faifan Tantakitti et al.

NATURE MATERIALS (2016)

Article Engineering, Biomedical

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

Charles M. Rubert Perez et al.

ANNALS OF BIOMEDICAL ENGINEERING (2015)

Article Chemistry, Multidisciplinary

Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons

Nicholas Stephanopoulos et al.

NANO LETTERS (2015)

Article Engineering, Biomedical

Gel Scaffolds of BMP-2-Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis

Sungsoo S. Lee et al.

ADVANCED HEALTHCARE MATERIALS (2015)

Article Cell & Tissue Engineering

FULL REGENERATION OF SEGMENTAL BONE DEFECTS USING POROUS TITANIUM IMPLANTS LOADED WITH BMP-2 CONTAINING FIBRIN GELS

J. van der Stok et al.

EUROPEAN CELLS & MATERIALS (2015)

Article Chemistry, Multidisciplinary

25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

Job Boekhoven et al.

ADVANCED MATERIALS (2014)

Article Engineering, Biomedical

Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels

Eric J. Berns et al.

BIOMATERIALS (2014)

Article Engineering, Biomedical

Bone substitutes in orthopaedic surgery: from basic science to clinical practice

V. Campana et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2014)

Review Pharmacology & Pharmacy

Studies of bone morphogenetic protein-based surgical repair

Kevin W. -H. Lo et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Engineering, Biomedical

Effects of protein dose and delivery system on BMP-mediated bone regeneration

Joel D. Boerckel et al.

BIOMATERIALS (2011)

Article Orthopedics

Recombinant Human Bone Morphogenetic Protein-2: A Randomized Trial in Open Tibial Fractures Treated with Reamed Nail Fixation

Hannu T. Aro et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2011)

Article Neurosciences

Self-Assembling Peptide Amphiphile Promotes Plasticity of Serotonergic Fibers Following Spinal Cord Injury

Vicki M. Tysseling et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2010)

Article Chemistry, Physical

A self-assembly pathway to aligned monodomain gels

Shuming Zhang et al.

NATURE MATERIALS (2010)

Article Clinical Neurology

Complications in the Use of rhBMP-2 in PEEK Cages for Interbody Spinal Fusions

Rahul Vaidya et al.

JOURNAL OF SPINAL DISORDERS & TECHNIQUES (2008)

Article Cell Biology

A rapid and sensitive bioassay to measure bone morphogenetic protein activity

Lior Zilberberg et al.

BMC CELL BIOLOGY (2007)

Article Chemistry, Multidisciplinary

Presentation and recognition of biotin on nanofibers formed by branched peptide amphiphiles

MO Guler et al.

NANO LETTERS (2005)

Article Engineering, Biomedical

Spinal fusion surgery: animal models for tissue-engineered bone constructs

SN Khan et al.

BIOMATERIALS (2004)

Article Biotechnology & Applied Microbiology

Repair of bone defects using synthetic mimetics of collagenous extracellular matrices

MR Lutolf et al.

NATURE BIOTECHNOLOGY (2003)

Article Multidisciplinary Sciences

Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials

JD Hartgerink et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Self-assembly and mineralization of peptide-amphiphile nanofibers

JD Hartgerink et al.

SCIENCE (2001)