CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis

Article Oncology

Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection

Ali Rajabi et al.

Summary: The study found that FOXD2-AS1 is significantly upregulated in gastric tumors and is significantly associated with lymph node metastasis and Helicobacter pylori infection, making it a potential prognostic biomarker for patients with GC.

JOURNAL OF GASTROINTESTINAL CANCER (2022)

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Article Gastroenterology & Hepatology

CircRNA-ABCB10 promotes gastric cancer progression by sponging miR-1915-3p to upregulate RaC1

Junhui Liu et al.

Summary: This study revealed that circ-ABCB10 promotes GC progression by targeting the miR-1915-3p/Rac1 axis, suggesting that circ-ABCB10 could be a potential target for the diagnosis and treatment of GC.

DIGESTIVE AND LIVER DISEASE (2022)

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Article Cell Biology

Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis

Yawei Xing et al.

Summary: Circ0007360 has been found to inhibit the progression of gastric cancer, and the activation of circ0007360/miR-762/IRF7 axis may serve as a novel mechanism for attenuation of gastric cancer progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Oncology

The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis

Penghui Xu et al.

Summary: In this study, it was found that circST3GAL6 was downregulated in gastric cancer and was associated with poor prognosis. Overexpression of circST3GAL6 inhibited malignant behaviors of gastric cancer cells, potentially through inducing apoptosis and autophagy. Furthermore, it was demonstrated that circST3GAL6 regulated gastric cancer through the miR-300/FOXP2 axis and regulated apoptosis and autophagy through FOXP2-mediated inhibition of the MET pathway.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Oncology

CircTMC5 promotes gastric cancer progression and metastasis by targeting miR-361-3p/RABL6

Peng Xu et al.

Summary: In this study, circTMC5 was found to be highly expressed in gastric cancer and promoted cancer cell proliferation, invasion, and metastasis by sponging miR-361-3p to up-regulate RABL6 expression, while inhibiting apoptosis. RABL6, highly expressed in gastric cancer, is involved in immune regulation and infiltration.

GASTRIC CANCER (2022)

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Article Cell Biology

CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer

Ruiting Guo et al.

Summary: This study found that Helicobacter pylori can induce the upregulation of circMAN1A2 in gastric cancer cells, and the downregulation of circMAN1A2 can inhibit the growth and invasion of gastric cancer cells. Furthermore, circMAN1A2 promotes the progression of H. pylori-induced gastric cancer by regulating the expression of MTA2. This study suggests that circMAN1A2 may be a potential diagnostic marker and therapeutic target for gastric cancer.

CELL DEATH & DISEASE (2022)

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Article Cell Biology

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner

Shengkui Qiu et al.

Summary: This study identified circTHBS1 as an oncogenic circRNA that enhances the malignancy of gastric cancer by elevating the expression of INHBA. It provides new insights and a feasible target for the diagnosis and treatment of gastric cancer.

CELL DEATH & DISEASE (2022)

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Article Multidisciplinary Sciences

The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients

Jing Zhang et al.

Summary: The study demonstrates that a higher level of circFNDC3B leads to increased expression of CD44 and CDH1 by modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. The up-regulation of CD44 and CDH1 results in a higher recurrence rate of EGC patients treated by ESD.

SCIENTIFIC REPORTS (2022)

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Article Cell Biology

Circular RNA circPGD contributes to gastric cancer progression via the sponging miR-16-5p/ABL2 axis and encodes a novel PGD-219aa protein

Yun Liu et al.

Summary: circPGD promotes proliferation and migration of gastric cancer cells by interacting with miR-16-5p and ABL2, thereby modulating the SMAD2/3 and YAP signaling pathways.

CELL DEATH DISCOVERY (2022)

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Article Oncology

Overexpression of HOXA-AS2 LncRNA in Patients with Gastric Cancer and Its Association with Helicobacter pylori Infection

Ali Rajabi et al.

Summary: This study evaluated the difference in HOXA-AS2 gene expression between cancerous and marginal noncancerous tissues in gastric cancer patients, and found that HOXA-AS2 was significantly upregulated in cancerous tissues. The expression of HOXA-AS2 was closely associated with clinicopathological features such as tumor size, lymph node metastasis, and H. pylori infection. ROC analysis indicated that HOXA-AS2 could potentially serve as a biomarker for diagnosing gastric cancer.

JOURNAL OF GASTROINTESTINAL CANCER (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

Dong-Liang Chen et al.

Summary: The study highlights the upregulation of circDLG1 in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy, correlating with aggressive tumor phenotype and poor prognosis. Ectopic circDLG1 expression promotes proliferation, migration, invasion, and immune evasion of gastric cancer cells. Mechanistically, circDLG1 interacts with miR-141-3p as a miRNA sponge to increase CXCL12 expression, promoting gastric cancer progression and resistance to anti-PD-1 therapy.

MOLECULAR CANCER (2021)

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Review Pathology

Contribution of circRNAs in gastric cancer

Soudeh Ghafouri-Fard et al.

Summary: Gastric cancer is closely related to environmental factors such as chronic infection with Helicobacter pylori, and high-throughput genome and transcriptome analysis has provided insights into its molecular mechanisms. However, data on circRNA expression in gastric cancer remains inconsistent, requiring further investigation. CircRNA could potentially serve as biomarkers and therapeutic targets for gastric cancer, yet more experiments are needed for clinical application.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Article Gastroenterology & Hepatology

Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation

Zhenxing Zhang et al.

Summary: This study demonstrated that Helicobacter pylori inhibits the expression of miRNA-375 in the stomach, leading to the activation of the JAK2-STAT3 pathway. This pathway promotes the secretion of IL-6, IL-10, and VEGF, resulting in immature differentiation of DCs and the induction of gastric cancer.

HELICOBACTER (2021)

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Article Oncology

The Correlation BetweenHelicobacter pyloriInfection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population

Alemeh Mohammadzadeh et al.

Summary: The study found significantly higher expression of Lnc_OC1 in gastric cancer tissues compared to normal tissues, with no significant correlation with clinical features. Additionally, Lnc_OC1 expression was significantly higher in H. pylori-positive patients compared to H. pylori-negative patients.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

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Article Oncology

Expression Profile of miRNA-17-3p and miRNA-17-5p Genes in Gastric Cancer Patients with Helicobacter pylori Infection

Nazanin Khayam et al.

Summary: The study found that the expression levels of miRNA-17-3p and miRNA-17-5p are associated with H. pylori infection in gastric cancer patients and non-gastric cancer patients. These miRNAs play an important role in detecting patients with H. pylori infection who are at risk of developing cancer.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

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Article Oncology