Selenium Species in Diabetes Mellitus Type 2

Selenium is an important trace element for humans and animals as it plays a key role in several major metabolic pathways. Several studies were conducted to better understand the role of selenium against diabetes mellitus (DM), particularly type 2 (T2DM), but the obtained conclusions are contradictory. A simple linear relationship does not exist between the risk of T2DM and selenium levels but is best represented in a dose-dependent manner, getting often the U-graph. This relation also depends on selenium chemical forms that are present in a diet or supplements. Both too low and too high selenium intakes could increase the risk of diabetes. Moreover, the baseline status of Se should be taken into consideration to avoid over-supplementation. The focus of this brief overview is to report the recent updates concerning selenium participation in diabetes mellitus.

Automated summary

Selenium plays a key role in human and animal metabolism and is associated with diabetes mellitus. However, studies on the relationship between selenium intake and diabetes risk have yielded contradictory results, which may be influenced by selenium chemical forms, intake levels, and baseline status.