期刊
BIOINORGANIC CHEMISTRY AND APPLICATIONS
卷 2023, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2023/6669394
关键词
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The cytotoxic activity of a series of piano-stool-{CpRu} complexes containing different ligands against breast cancer cells was evaluated, and their mechanism of action and ruthenium uptake were studied. Two new piano-stool-{CpRu} complexes were synthesized and characterized, and their catalytic properties were investigated.
Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. The evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-kappa S)(HdmoPTA)(PPh3)](CF3SO3)2 (8) and [RuCp(PPh3)2-mu-dmoPTA-1 kappa P-2 kappa 2N,N '-PdCl2](CF3SO3) (11), which have been synthesized and characterized by NMR, IR, and single-crystal X-ray diffraction. The cytotoxic activity of compounds was evaluated against MDA-MB-231 breast cancer cells, and the three most active complexes were further tested against the hormone-dependent MCF-7 breast cancer cell line. Their cell death mechanism and ruthenium uptake were also evaluated, as well as their binding ability to human serum albumin.
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