☆ 4.4 Review

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

BIOGERONTOLOGY (2023)

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Review Biochemistry & Molecular Biology

Targeting the molecular & cellular pillars of human aging with exercise

Jorming Goh et al.

Summary: Biological aging is the main driver of age-related chronic diseases. A meeting sponsored by the United States National Institute of Aging (NIA) identified seven biological pillars of aging, providing a useful framework for studying human aging. This review examines these pillars from the perspective of exercise and discusses how regular physical exercise can modulate them to prevent age-related chronic diseases and maintain functional capacity.

FEBS JOURNAL (2023)

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Review Environmental Sciences

The role of non-ionizing electromagnetic radiation on female fertility: A review

Pooja Jangid et al.

Summary: This study examines the effects of non-ionizing electromagnetic radiations on female fertility and finds that these radiations can have harmful effects on oocytes, embryonic development, and may lead to infertility.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2023)

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Review Gastroenterology & Hepatology

Endoplasmic reticulum stress in liver diseases

Amir Ajoolabady et al.

Summary: The endoplasmic reticulum stress and unfolded protein response play important roles in the pathophysiology of liver diseases. Understanding this process is crucial for developing interventions for the treatment of nonmalignant liver diseases.

HEPATOLOGY (2023)

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Article Chemistry, Medicinal

Dual inhibitors of ASK1 and PDK1 kinases: Design, synthesis, molecular docking and mechanism studies of N-benzyl pyridine-2-one containing derivatives as anti-fibrotic agents

Jia Qin et al.

Summary: Using fragment-based hybrid designing strategies, 24 N-benzyl pyridine-2-one containing derivatives were synthesized by incorporating 6-(4H-1,2,4-triazol-3-yl) pyridin-2-amine of scaffold of ASK1 inhibitor (GS-444217). These compounds were screened in cell-free ASK1 and PDK1 kinase assays, as well as cellular vitality assays. Compound 21c and 21d showed potent inhibition of ASK1 and PDK1 kinases, as well as anti-fibrotic and anti-inflammatory activities, indicating their potential as dual inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H2O2-induced oxidative stress

Chandan Muddahally Naganna et al.

Summary: The study found that vanillic acid can protect the viability and function of pancreatic beta-cells under oxidative stress conditions, while enhancing insulin secretion. This may be achieved through the activation of the Erk1/2 signaling pathway, increased expression of antioxidant enzymes, and reduced expression of apoptotic markers. These results demonstrate the potential therapeutic value of vanillic acid in preventing oxidative stress-related diseases such as diabetes.

MOLECULAR BIOLOGY REPORTS (2023)

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Article Medicine, Research & Experimental

ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats

Jiajia Duan et al.

Molecular Medicine Reports (2023)

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Review Endocrinology & Metabolism

Metabolism, homeostasis, and aging

Alibek Moldakozhayev et al.

Summary: We propose a two-mode model of metabolism, which includes pursuit (anabolism and catabolism) and maintenance, based on usable resource availability. Pursuit dominates when resources are abundant, generating metabolic waste, while maintenance is activated when resources are depleted and metabolic waste accumulates. Interactions with the environment cause pendulum-like swings between these metabolic states, attempting to maintain the least deleterious organismal state, known as ephemeral homeostasis. Imperfections during these attempts contribute to the accumulation of harmful effects, driving organismal aging. We discuss how environmental metabolic adjustments and resource stabilization can impact healthspan and lifespan.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2023)

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Article Multidisciplinary Sciences

Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK-SIRT1-PGC(1a) energy metabolism pathway

Zhijia Guo et al.

Summary: A large number of data suggest that caloric restriction has a protective effect on myocardial ischemia/reperfusion injury in the elderly, but the mechanism is still unclear. In this study, the I/R model was created in vivo and the results showed that caloric restriction significantly reduced infarct size in elderly mice after I/R injury, promoted glycolysis, and restored myocardial glucose uptake.

SCIENTIFIC REPORTS (2023)

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Article Environmental Sciences

Association between asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, and lung cancer in the US population

Humairat H. Rahman et al.

Summary: This study investigated the correlation between asthma, emphysema, chronic bronchitis, chronic obstructive lung disease (COPD) and lung cancer in the US adult population. The study found a significant correlation between emphysema, chronic bronchitis, COPD and lung cancer. However, no correlation was established between asthma and lung cancer.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

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Article Biochemistry & Molecular Biology

Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis

Yawan Zi et al.

Summary: Cigarette smoke-induced oxidative stress is a major factor in the development of respiratory diseases. Ferroptosis, a regulated cell death process, is closely related to cigarette smoke-induced airway injury, but the underlying mechanism is not well understood. Our study found that bronchial epithelial ferroptosis and iNOS expression were significantly higher in smoking patients, and inhibiting iNOS attenuated cigarette smoke-induced ferroptosis and mitochondrial dysfunction. Mechanistically, SIRT3 negatively regulated iNOS to mediate ferroptosis, and the Nrf-2/SIRT3 signal was deactivated by cigarette smoke-induced ROS. These findings provide new insights into the pathogenesis of cigarette smoke-induced tracheal injury diseases.

FREE RADICAL BIOLOGY AND MEDICINE (2023)

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Article Biochemistry & Molecular Biology

Oxidative stress, inflammation and hormesis: The role of dietary and lifestyle modifications on aging

Vinita Sharma et al.

Summary: Oxidative stress, caused by free radicals and reactive oxygen species, is a prominent factor in aging and age-related diseases. Investigating disease susceptibility during aging requires specific analysis of molecular damage and oxidative stress at the cellular level, extending outward to affect tissues, organs, and the organism as a whole. Various biomarkers at the biomolecular level are useful in understanding aging processes. Hormetic approaches such as caloric restriction, exercise, and nutrition can help reduce oxidative stress.

NEUROCHEMISTRY INTERNATIONAL (2023)

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Article Cell Biology

ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS

Andrea Magri et al.

Summary: Mitochondrial dysfunction and impaired mitophagy contribute to the onset of ALS. We found that reduced mitochondrial respiration, driven by complex I and II inhibition, is correlated with ALS motor symptoms. Additionally, we observed increased levels of TSPO and decreased expression of Atg12, suggesting impairments in mitophagy activation.

CELL DEATH & DISEASE (2023)

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Article Nutrition & Dietetics

Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells

Gabriele De Rubis et al.

Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease caused by chronic cigarette smoke exposure. Traditional treatments focus on reducing symptoms, but fail to regulate oxidative stress and inflammation, resulting in lung damage. This study explores the potential of agarwood essential oil nanoemulsion (agarwood-NE) as a promising treatment option for COPD by demonstrating its antioxidant and anti-inflammatory effects. The findings show that agarwood-NE successfully counters the pro-inflammatory effects of cigarette smoke extract by reducing the expression of pro-inflammatory cytokines and inducing the expression of anti-inflammatory mediators and antioxidant genes.

NUTRIENTS (2023)

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Article Cell Biology

PINK1/Parkin-mediated mitophagy in neurodegenerative diseases

Jie Li et al.

Summary: Mitochondria have crucial roles in bioenergetics, metabolism, and signaling, particularly in energy-intensive neuronal cells. In neurodegenerative diseases, accumulation of damaged mitochondria leads to cellular dysfunction and/or death. Mitophagy, a pathway that delivers defective mitochondria for degradation, is important for maintaining mitochondrial health. The PINK1/Parkin pathway regulates ubiquitin-dependent mitophagy and autophagic mechanisms. This review summarizes the current knowledge of mitophagy dysregulation in neurodegenerative diseases and potential therapeutic strategies.

AGEING RESEARCH REVIEWS (2023)

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Review Biochemistry & Molecular Biology

How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing

Beatriz Castejon-Vega et al.

Summary: In the past, mtROS were seen as byproducts of cellular metabolism and drivers of ageing and age-related diseases. Now, we know that mtROS serve as important cellular messengers, playing a role in maintaining cellular homeostasis and influencing cellular differentiation, proliferation, and survival. However, dysregulated mtROS signaling can contribute to degenerative diseases. This review focuses on the signaling pathways involving mtROS and their role in ageing.

ANTIOXIDANTS (2023)

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Review Toxicology

Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Li You et al.

Summary: Mycotoxins induce oxidative stress, hypoxia, and cellular senescence, which are involved in immunosuppressive effects. Activation of senescence markers and cell cycle arrest pathways by mycotoxins further contribute to immunomodulatory effects.

ARCHIVES OF TOXICOLOGY (2023)

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Review Biochemistry & Molecular Biology

Hallmarks of aging: An expanding universe

Carlos Lopez-Otin et al.

Summary: Aging is driven by hallmarks that manifest with age, accelerate aging when accentuated experimentally, and can be decelerated, stopped, or reversed with therapeutic interventions. The twelve proposed hallmarks of aging include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected with each other and with the recently proposed hallmarks of health.

CELL (2023)

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Review Cell Biology

mTORC2: a multifaceted regulator of autophagy

Yanan Sun et al.

Summary: Autophagy is a highly regulated catabolic process involving the degradation and recycling of cellular components. The mechanistic target of rapamycin (mTOR) plays a central role in autophagy regulation. While mTORC1 is well-studied and known to be acutely inhibited by rapamycin, less is known about mTORC2. Recent research suggests that mTORC2's role in autophagy is mainly through its downstream effector proteins and varies under different conditions and cellular contexts. Understanding the involvement of mTORC2 in autophagy could potentially lead to new treatment strategies for autophagy-related diseases.

CELL COMMUNICATION AND SIGNALING (2023)

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Article Biology

Evaluation of oxidative stress markers in ethanol users

L. Moraes et al.

Summary: This study aimed to compare oxidative stress parameters between alcohol users and non-drinkers. It was found that the activity of superoxide dismutase and the concentration of malondialdehyde were significantly increased in alcohol users, while the ferric reducing/antioxidant power gradually reduced, indicating that alcohol users were under oxidative stress.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2023)

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Review Immunology

DNA damage and repair in age-related inflammation

Yang Zhao et al.

Summary: Genomic instability is a key factor in the process of aging, with accumulated DNA damage leading to cell death, senescence, tissue dysfunction, and inflammation. This review explores the link between DNA damage, inflammation, and aging, particularly in the context of premature aging syndromes and age-related diseases. The study highlights the mechanisms by which DNA damage induces inflammation and discusses potential therapeutic targets.

NATURE REVIEWS IMMUNOLOGY (2023)

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Article Biochemistry & Molecular Biology

The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

Lakhan Kma et al.

Summary: Autophagy is regulated by the PI3K pathway and Akt protein in response to changing ROS levels. Flavonoids and ionizing radiation can modulate autophagy by affecting PTEN and Akt protein levels, depending on the levels of ROS induced.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

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Article Oncology

The intricate nature of senescence in development and cell plasticity

Hilah Gal et al.

Summary: Cellular senescence, a stable form of cell cycle arrest with pronounced secretory activity, plays functional roles in both physiological and pathological conditions. Recent studies have shown its contribution to development, regeneration and reprogramming. Transient presence of senescent cells may be beneficial for tissue regeneration.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Keap-NRF2 signaling contributes to the Notch1 protected heart against ischemic reperfusion injury via regulating mitochondrial ROS generation and bioenergetics

Hua Xu et al.

Summary: Myocardial ischemia/reperfusion (I/R) injury is a leading cause of death worldwide. The combined action of Notch1 and Keap1-NRF2 signaling pathway can protect the heart against I/R injury.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future

Joao Paulo Margiotti dos Santos et al.

Summary: Non-alcoholic steatohepatitis (NASH) is a disease characterized by fatty degeneration, lobular inflammation, and enlargement of hepatocytes (ballooning hepatocytes) with or without fibrosis. It affects 20% of patients with non-alcoholic fatty liver disease (NAFLD). Altered secretion of organokines, due to liver dysfunction and associated metabolic changes, may contribute to the development and progression of NASH. Therefore, further research on the regulation of organokines in endocrine organs (such as skeletal muscle, adipose tissue, bone, and liver tissue) is essential for better understanding the pathogenesis of NASH and advances in its treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Chemistry, Analytical

Biomarkers of Oxidative Stress and Antioxidant Defense

Sema Demirci-Cekic et al.

Summary: Reactive oxygen and nitrogen species produced during normal metabolism in the human body play important roles in signal transmission and the immune system, but an imbalance between oxidants and antioxidants can lead to oxidative stress and diseases. Maintaining a balanced antioxidant defense system is crucial for overall health and disease prevention.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Nutrition & Dietetics

Intermittent Fasting and Metabolic Health

Izzah Vasim et al.

Summary: Given the strain of the obesity epidemic on public health outcomes, new approaches to weight control are necessary. Intermittent fasting, with its beneficial metabolic effects, is an option to consider for individuals with unhealthy weight gain patterns. However, further research is needed for long-term outcomes and it should be avoided in specific health conditions.

NUTRIENTS (2022)

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Review Genetics & Heredity

Bacterial Response to Oxidative Stress and RNA Oxidation

Andre F. Seixas et al.

Summary: Bacteria face oxidative stress caused by Reactive Oxygen Species (ROS), and have developed strategies to protect cells and combat RNA oxidation. RNA oxidation can lead to structural and functional damage, resulting in harmful consequences for cell survival. However, bacteria have evolved RNA quality control pathways to eliminate oxidized RNA.

FRONTIERS IN GENETICS (2022)

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Review Medicine, General & Internal

Review: Serum Biomarkers of Lung Fibrosis in Interstitial Pneumonia with Autoimmune Features-What Do We Already Know?

Ewa Miadlikowska et al.

Summary: Interstitial pneumonia with autoimmune features (IPAF) is a type of interstitial lung disease with varied prognosis and course. Currently, there is a lack of specific and sensitive biomarkers for predicting disease progression, monitoring natural history, and stratifying patients for treatment. Several studies have focused on circulating biomarkers and assessed their diagnostic and prognostic value in interstitial lung diseases. However, a meta-analysis of pulmonary fibrosis biomarkers in IPAF is still lacking due to the heterogeneity in research methodology and analyzed groups.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Cell Biology

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Younis Ahmad Hajam et al.

Summary: This article discusses the mechanism of oxidative stress and its relationship with aging and related diseases.

CELLS (2022)

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Article Oncology

Critical DNA damaging pathways in tumorigenesis

Jake A. Kloeber et al.

Summary: The acquisition of DNA damage is an early driving event in tumorigenesis, and DNA damage is also a targetable vulnerability in cancer cells. Researchers are exploring the cellular and molecular mechanisms governing DNA integrity, discussing the relationship between DNA repair and tumorigenesis, and how oncogenes promote DNA damage through replication stress.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Physiology

THE SUPEROXIDE RADICAL SWITCH IN THE BIOLOGY OF NITRIC OXIDE AND PEROXYNITRITE

Lucia Piacenza et al.

Summary: The free radical nitric oxide (NO) plays a key role in physiological processes, but its bioavailability is compromised in certain disease conditions due to increased production of superoxide radical. This leads to the inactivation of nitric oxide and the formation of peroxynitrite, which is implicated in various human diseases and the aging process. Understanding the complex biochemistry of peroxynitrite is crucial for developing therapeutic interventions.

PHYSIOLOGICAL REVIEWS (2022)

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Review Nutrition & Dietetics

Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review

Maryla Mlynarczyk et al.

Summary: Glaucoma is a common cause of irreversible vision loss worldwide, with progress in treatment methods but potential for prevention and lifestyle modifications to slow disease progression. Further research is needed to assess the influence of nutrition on glaucoma and develop nutritional management strategies for patients.

NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases

Gurjit Kaur Bhatti et al.

Summary: Mitochondria, the powerhouses of cells, play a vital role in maintaining normal cell functioning and human health. Dysfunctional mitochondria can lead to various diseases, affecting organs with high energy demand. Drugs or compounds targeting mitochondria are considered effective and safe for treating these diseases.

BIOMEDICAL JOURNAL (2022)

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Editorial Material Biochemistry & Molecular Biology

Antioxidants, Oxidative Stress, and Non-Communicable Diseases

Luis Crisostomo et al.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite

Orazio Cantoni et al.

Summary: Long-term ingestion of arsenicals is associated with various diseases, mainly through binding to proteins and ROS formation. Different forms of arsenic have different effects on cells and tissues. It is important to study the molecular mechanisms of specific arsenic compounds under controlled conditions.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

Inflammatory and Oxidative Stress Markers Related to Adherence to the Mediterranean Diet in Patients with Metabolic Syndrome

Maria Magdalena Quetglas-Llabres et al.

Summary: Studies have found that MetS patients with low adherence to MDP have higher levels of glycated haemoglobin A1c and triglycerides, as well as lower levels of HDL cholesterol. Those with low adherence to MDP also have higher plasma levels of pro-inflammatory markers, lower antioxidant enzyme activity, and more severe cellular oxidative stress responses. Patients with higher adherence to MDP showed less altered anthropometric parameters, blood biochemical profile, and better oxidative and inflammatory status.

ANTIOXIDANTS (2022)

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Editorial Material Biochemistry & Molecular Biology

The Pharma-Nutritional Role of Antioxidant Phytochemicals in Health and Disease

Sergio Davinelli et al.

ANTIOXIDANTS (2022)

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Article Geriatrics & Gerontology

Melatonin-related signaling pathways and their regulatory effects in aging organisms

Mehmet Can Atayik et al.

Summary: Melatonin is a molecule derived from bacteria that plays a vital role in the evolution and aging processes of eukaryotic organisms. It acts as a radical scavenger and has multiple receptor-mediated actions. However, as organisms age, the levels of melatonin decrease, leading to impaired redox modulation and increased susceptibility to age-related diseases.

BIOGERONTOLOGY (2022)

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Review Geriatrics & Gerontology

Mitochondria-targeted senotherapeutic interventions

Mehmet Can Atayik et al.

Summary: Healthy aging is a delicate balance, with age-related disorders playing a significant role in making life difficult with aging. Developing senotherapeutic strategies, particularly targeting mitochondrial dysfunction, could provide effective solutions for age-related disorders. The interplay between mitochondrial dysfunction and the development of senescence-associated secretory phenotype (SASP) is closely linked to weakened immunity, a common phenomenon in aging. Targeting senescent cells with senolytics or suppressing their SASP secretions with senomorphics/senostatics could potentially extend both health and lifespan.

BIOGERONTOLOGY (2022)

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Review Medicine, Research & Experimental

Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes

Basista Rabina Sharma et al.

Summary: This review provides an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the gut microbiota for the prevention and management of type 2 diabetes mellitus.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

Thobekile S. Leyane et al.

Summary: Ageing and chronic degenerative pathologies share characteristics such as oxidative stress, chronic inflammation, and mitochondrial abnormalities. The body produces antioxidants to counteract cell damage caused by excessive reactive oxygen species (ROS) production. Strengthening the antioxidant defense system and inhibiting the harmful effects of ROS and nitrogen species (RONS) are crucial in preventing the progression of ageing and chronic degenerative diseases. Various therapeutic methods have been developed, but their efficacy needs to be further investigated.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Reproductive Biology

Melatonin supplementation preserves testicular function by attenuating lactate production and oxidative stress in high fat diet-induced obese rat model

Azeezat O. Saidi et al.

Summary: The study found that high fat diet can lead to testicular dysfunction, and melatonin supplementation can mitigate this impact with the involvement of upregulation of PPAR-gamma.

THERIOGENOLOGY (2022)

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Review Immunology

NF-?B: blending metabolism, immunity, and inflammation

Daria Capece et al.

Summary: This review discusses the central role of NF-KB transcription factors in the immune and metabolic systems, and how their understanding can lead to better diagnostics and therapeutics for human diseases.

TRENDS IN IMMUNOLOGY (2022)

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Review Neurosciences

Cell Non-autonomous Proteostasis Regulation in Aging and Disease

Joao Vasco Ferreira et al.

Summary: Aging is associated with the accumulation of proteotoxic material inside cells, which may contribute to neurodegenerative diseases such as Alzheimer's and Parkinson's. Despite efforts to develop therapies targeting proteotoxic accumulation, progress has been limited, as evidenced by the failure of clinical trials for Alzheimer's disease treatments. It is increasingly recognized that regulation of proteostasis involves complex transcellular networks and may shed new light on aging and disease mechanisms.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

Ameyalli M. Rodriguez-Cano et al.

Summary: This study found that consumption of ultra-processed food (UPF) during pregnancy may increase oxidative stress and is inversely associated with levels of oxidative stress markers in the body. Additionally, fiber intake was positively associated with protein carbonylation.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

Evangelia Eirini Tsermpini et al.

Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

The role and regulation of apoptosis signal-regulated kinase 1 in liver disease

Yining Lu et al.

Summary: This article summarizes the role of ASK1 in liver disease and the differential regulation of ASK1 through phosphorylation, ubiquitination, and methylation, providing new insights for finding ASK1-targeting drugs.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Biochemistry & Molecular Biology

Selenium: An Antioxidant with a Critical Role in Anti-Aging

Geir Bjorklund et al.

Summary: Selenium plays an important role in improving antioxidant defense, immune functions, and metabolic homeostasis. Inadequate selenium status can accelerate the aging process and increase the risk of diseases. This review introduces the role of selenium in aging mechanisms and its potential clinical implications.

MOLECULES (2022)

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Article Neurosciences

Age-dependent neurodegeneration and neuroinflammation in a genetic A30P/A53T double-mutated α-synuclein mouse model of Parkinson's disease

Lisa Rauschenberger et al.

Summary: The pathogenesis of Parkinson's disease is closely related to aging, and inflammation is also an additional factor in disease development. In a mouse model of Parkinson's disease, age and inflammation are found to be associated with dopaminergic neurodegeneration, and the response of T cells and glial cells is involved in the process of neurodegeneration.

NEUROBIOLOGY OF DISEASE (2022)

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Review Cell Biology

ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Arthur Jose Pontes Oliveira de Almeida et al.

Summary: Reactive oxygen species (ROS) are molecules with oxidizing properties that play a key role in cellular signaling. Understanding the balance of ROS is important for determining cellular fate through redox signaling.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Substance Abuse

Fetal growth restriction, low birth weight, and preterm birth: Effects of active or passive smoking evaluated by maternal expired CO at delivery, impacts of cessation at different trimesters

Conchita Delcroix-Gomez et al.

Summary: This study evaluated the impact of smoking cessation during different trimesters of pregnancy on the risk of reduced birth weight and prematurity, as well as the effects of passive smoking. The results showed that quitting smoking in the first and second trimesters can reduce the risk of intrauterine growth restriction and low birth weight. Active smoking and passive smoking both have deleterious effects on fetal development, with passive smoking having an intermediate impact between active smoking and non-smoking.

TOBACCO INDUCED DISEASES (2022)

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Review Cell Biology

Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms

Umer Farooq et al.

Summary: 9p21 locus is a highly reproducible region in genome-wide association studies (GWAS) and is associated with various diseases and cancers. The genes within this region, including CDKN2A/B genes, play critical roles in cell cycle regulation and are linked to cellular regeneration, stemness, aging, and cancers. Understanding the regulation of these genes through promoter-driven and distal mechanisms could provide insights for targeting this locus in pathologies and aging.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

A host-guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator

Kun-Xu Teng et al.

Summary: In this work, an effective strategy for converting the conventional type-II photosensitizer (PS) to a type-I PS by host-guest complexation is reported. The supramolecular PS demonstrates high photodynamic therapy efficacy even under hypoxic conditions.

CHEMICAL SCIENCE (2022)

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Article Toxicology

Physiological hormesis and hormetins in biogerontology

Suresh I. S. Rattan

Summary: Research on the biology of aging has progressed by exploring the concept of mild stress-induced physiological hormesis, which activates adaptive and protective pathways in cells and organisms, resulting in health promotion and lifespan extension.

CURRENT OPINION IN TOXICOLOGY (2022)

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Review Cell & Tissue Engineering

Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses

Sakhawat Ali et al.

Summary: This study summarizes the reactivation of tumor suppressor genes p53 and PTEN in glioblastoma (GB) treatment and the use of mesenchymal stem cells (MSCs) as a Trojan horse to deliver oncolytic viral cargo to disseminated tumor beds. The integration of MSCs and OVs could potentially become a new paradigm in cancer treatment.

STEM CELL REVIEWS AND REPORTS (2022)

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Article Biochemistry & Molecular Biology

The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus

Nihal Efe Atila et al.

Summary: This study found that elevated levels of cadmium, manganese, and chromium, as well as reduced levels of selenium in serum, may play an important role in the etiopathogenesis of tinnitus.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Molecular insights ofNADPHoxidases and its pathological consequences

Bhargav N. Waghela et al.

Summary: NOX family proteins generate ROS as their prime product and play important roles in various cellular functions. Dysregulation of NOX activation leading to enhanced ROS levels is associated with various pathophysiologies, highlighting the importance of maintaining NOX balance for cellular homeostasis.

CELL BIOCHEMISTRY AND FUNCTION (2021)

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Article Cell Biology

NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving

Ze-qing Pu et al.

Summary: The study demonstrates that NR4A1 attenuates JNK phosphorylation incurred by ER-stress or ROS partially by enhancing MKP7 expression, potentially decreases pancreatic beta cell apoptosis induced by ROS or ER-stress.

CELL DEATH DISCOVERY (2021)

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Review Neurosciences

Sepsis and Cerebral Dysfunction: BBB Damage, Neuroinflammation, Oxidative Stress, Apoptosis and Autophagy as Key Mediators and the Potential Therapeutic Approaches

Ming Gu et al.

Summary: Sepsis-associated cerebral dysfunction is a complex pathology resulting from primary infections, affecting vulnerable populations like neonates, elderly individuals, and chronically ill patients. Various methods, including electrophysiological recordings and imaging techniques, are used for detection and diagnosis. Mechanisms involve blood-brain barrier permeability, metalloprotease activity, and other factors leading to cerebrovascular damage.

NEUROTOXICITY RESEARCH (2021)

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Article Chemistry, Analytical

Aging Diagnostic Probe for Research on Aging and Evaluation of Anti-aging Drug Efficacy

Zihong Li et al.

Summary: Aging is a biological process that leads to increased morbidity and mortality. Studies on aging and anti-aging drugs are significant for human health. The new probe YDGAL for beta-galactosidase is highly sensitive and can visualize aging and evaluate the efficacy of anti-aging drugs.

ANALYTICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1

Chaoyu Zhu et al.

Summary: The study identified that the lack of Sirt6 in the liver leads to more severe fatty liver disease and affects the activities of carbohydrate response element binding protein and sterol regulatory element binding protein 1. It was found that Sirt6 can suppress metabolic regulators in the liver through direct deacetylation.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Review Biochemistry & Molecular Biology

Build-UPS and break-downs: metabolism impacts on proteostasis and aging

Franziska Ottens et al.

Summary: Metabolic perturbation leads to cellular stress, affecting protein homeostasis and requiring adaptive mechanisms. Protein homeostasis is controlled by mechanisms such as translational control, chaperone-assisted folding, and protein degradation.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Genetics & Heredity

The multifaceted roles of DNA repair and replication proteins in aging and obesity

Alexandra M. D'Amico et al.

Summary: Efficient genomic maintenance is crucial for cell survival, and dysregulation due to aging and obesity can lead to various diseases. Mutations in genes related to DNA repair and replication can exacerbate aging- and obesity-related disorders, contributing to the development of progeroid diseases.

DNA REPAIR (2021)

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Review Chemistry, Medicinal

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Aurelia Magdalena Pisoschi et al.

Summary: This review paper examines the chemistry of oxidative stress mitigation by antioxidants, highlighting the crucial role of balancing pro-oxidant and antioxidant species. It discusses the association between oxidative stress and various diseases, elucidating the types, mechanisms, and defense strategies of antioxidants.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Integrative & Complementary Medicine

TCM Regulates PI3K/Akt Signal Pathway to Intervene Atherosclerotic Cardiovascular Disease

Jiali Liu et al.

Summary: The PI3K/Akt signaling pathway plays a crucial role in the pathogenesis of atherosclerosis, and traditional Chinese medicine has shown promising results in regulating this pathway, providing a theoretical basis for the treatment and pathological mechanism research of atherosclerosis.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

Veronika Obsilova et al.

Summary: ASK1, a crucial cellular stress sensor, activates JNKs and p38 MAPKs which when excessively activated can lead to cell death, inflammation and fibrosis. Targeted inhibition of ASK1, the upstream activator of these kinases, is a promising therapeutic strategy for treating various severe conditions including neurological disorders, cardiovascular diseases, diabetes and cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling

Kashi Raj Bhattarai et al.

Summary: The endoplasmic reticulum (ER) plays crucial roles in protein synthesis and folding in eukaryotic cells. The unfolded protein response (UPR) is triggered by disturbances in ER function, aiming to restore cellular homeostasis but possibly leading to apoptotic signaling under prolonged stress. The complex interactions between ER stress, redox imbalance, and oxidative stress can have profound negative impacts on cellular physiology and targeting these stress mechanisms may be a promising approach for disease treatment.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes

Natsuki Eguchi et al.

Summary: Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose levels due to impaired pancreatic beta cell function and insulin resistance. Studies have shown that endoplasmic reticulum stress, mitochondrial dysfunction, and oxidative stress play central roles in promoting beta cell dysfunction, with oxidative stress particularly important as beta cells exhibit lower antioxidative capacity. Efforts are being made to understand and counteract the effects of oxidative stress on beta cell health and survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nutrition & Dietetics

Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance

Edwin E. Martinez Leo et al.

Summary: The consumption of ultra-processed food is on the rise globally, leading to cellular alterations and oxidative stress, which in turn affects immune function and increases the risk of infections. This review explores the connection between ultra-processed diets, oxidative stress, and immune tolerance, highlighting the importance of dietary patterns in immune responses and health outcomes.

NUTRITION (2021)

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Article Cell Biology

Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women

Martha A. Sanchez-Rodriguez et al.

Summary: The study found that a sedentary lifestyle increases oxidative stress in Mexican women during the aging process. Multiple markers were used to measure oxidative stress, with sedentary women showing significantly higher levels of oxidative stress after two years.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

Jun Ren et al.

Summary: This review summarizes the role of endoplasmic reticulum stress and protein response in cardiovascular diseases, discussing potential therapeutic strategies for restoring ER proteostasis.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Pharmacology & Pharmacy

(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD

Xue Tian et al.

Summary: This study demonstrated the protective effect of EC on experimental COPD rats and elucidated the mechanism of EC promoting Nrf2 activity, which might provide a novel therapeutic strategy for COPD.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Bcl-2 Is Involved in Cardiac Hypertrophy throu PI3K-Akt Pathway

Xianwei Meng et al.

Summary: This study identified key pathways and downstream effectors related to cardiac hypertrophy through gene expression profile analysis. It revealed that the PI3K-Akt signaling pathway plays a crucial role in cardiac hypertrophy, with Bcl-2 identified as a key downstream effector. These findings suggest Bcl-2 as a potential therapeutic target in the clinical management of cardiac hypertrophy.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Immune cell-produced ROS and their impact on tumor growth and metastasis

Kilian B. Kennel et al.

Summary: Reactive oxygen species (ROS) play crucial roles in immune cells and have both physiological and pathological effects. In the tumor microenvironment, ROS can suppress immune cell function while also serving as targets for cancer immunotherapy.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Protein oxidation-Formation mechanisms, detection and relevance as biomarkers in human diseases

Richard Kehm et al.

Summary: Generation of reactive oxygen species and related oxidants during life processes can lead to irreversible modifications of proteins, potentially contributing to pathological conditions and diseases.

REDOX BIOLOGY (2021)

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Review Immunology

Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases

Chien-Chung Yang et al.

Summary: The pathogenesis of inflammatory diseases is associated with pro-inflammatory factors, ROS, bacterial toxins, and viruses. Oxidative stress plays a role in maintaining cellular redox balance, but excessive ROS production is often induced by excessive stimulation of the mitochondrial electron transport chain and xanthine oxidase, leading to inflammation.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

The association between homocysteine levels and cardiovascular disease risk among middle-aged and elderly adults in Taiwan

Chin-Chuan Shih et al.

Summary: This study in a community in northern Taiwan found that elevated homocysteine levels in middle-aged and elderly adults were associated with higher cardiovascular disease risk. Positive correlation between homocysteine levels and Framingham cardiovascular risk score was observed, with the high homocysteine level group showing higher CVD risk.

BMC CARDIOVASCULAR DISORDERS (2021)

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Review Medicine, General & Internal

Parkinson's disease

Bastiaan R. Bloem et al.

Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.

LANCET (2021)

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Review Chemistry, Medicinal

Mechanisms, Pathophysiology and Currently Proposed Treatments of Chronic Obstructive Pulmonary Disease

Sarah de Oliveira Rodrigues et al.

Summary: COPD, primarily caused by cigarette smoke, is a major global cause of morbidity and mortality characterized by progressive airflow obstruction. Existing treatments such as inhaled corticosteroids and bronchodilators are ineffective in halting disease progression, highlighting the need for specific and effective therapeutic alternatives targeting oxidative imbalance.

PHARMACEUTICALS (2021)

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Review Multidisciplinary Sciences

The central role of DNA damage in the ageing process

Bjoern Schumacher et al.

Summary: Ageing is a complex process that affects every organ and tissue in the body, but the causal mechanism behind it remains unclear. Accumulating evidence suggests that DNA damage may play a central role in driving ageing, providing a potential unified approach to combat age-related diseases.

NATURE (2021)

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Article Cell Biology

Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways

Xi Chen et al.

Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.

CELL DEATH & DISEASE (2021)

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Review Medicine, General & Internal

Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

Maria Magallon et al.

Summary: Rare respiratory diseases like AATD, IPF, CF, and PCD have been shown to exhibit oxidative stress and endoplasmic reticulum stress. This review discusses their involvement in the pathologies and the potential use of antioxidants as therapeutic agents to mitigate the effects of oxidative stress.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Cell Biology

From Flies to Men: ROS and the NADPH Oxidase in Phagocytes

Zohreh Mansoori Moghadam et al.

Summary: ROS formation is an ancient defense system against microorganisms, originating from NADPH oxidases and the mitochondrial electron transport chain. Microorganisms have defense mechanisms against ROS, leading to an arms race. NOX plays a role in cellular signaling, and deficiency of NOX components can result in infections and dysregulated inflammatory responses.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology

Michel Fasnacht et al.

Summary: Since the great oxidation event, Earth's cellular life forms have had to deal with reactive oxygen species (ROS) affecting biomolecules and cellular metabolism. Increased ROS levels in the biosphere represent growing stress and shape species evolution. Systems have evolved to remove ROS and repair damage, but oxidative stress occurs if ROS surpass the cell's capacity.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biochemistry & Molecular Biology

Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease

Cristina Mas-Bargues et al.

Summary: Oxidative stress, caused by an imbalance between prooxidants and antioxidants, can lead to biomolecular damage and development of diseases. Lipids are sensitive to oxidant attack, with MDA, 4-HNE, and F2-isoprostane being the main biomarkers for lipid peroxidation assessment. The profile of PUFAs in tissues determines the proportion of each biomarker.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Article Geriatrics & Gerontology

Oxidative stress, antioxidants, hormesis and calorie restriction: The current perspective in the biology of aging

Mohammad Murtaza Mehdi et al.

Summary: Aging is defined as the result of oxidative stress affecting cells, leading to cellular dysfunction and slowing down of the system. Slowing down the aging process involves reducing the rate of cellular oxidative damage, which is related to genetic factors, lifestyle, and diet. Understanding aging theories and molecular damage caused by oxidative stress is crucial for anti-aging strategies.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2021)

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Article Hematology

Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes

Elena Tonc et al.

Summary: The study reveals the essential role of c-MYC in B cell proliferation and its involvement in tumor suppression through TFAP4, providing protection against the transformation of developing B cells.

BLOOD (2021)

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Article Oncology

Balancing DNA repair to prevent ageing and cancer

Eleanor Rachel Stead et al.

Summary: DNA damage and mutations constantly stress the cell, with impaired DNA repair mechanisms leading to accelerated aging and increased cancer risk. While stem cells maintain low mutation rates, their clonal expansion due to mutations can contribute to tissue dysfunction and heightened cancer risk associated with aging.

EXPERIMENTAL CELL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis

Mary Adebayo et al.

Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.

FASEB JOURNAL (2021)

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Article Chemistry, Applied

Is oven bag really advantageous in terms of heterocyclic aromatic amines and bisphenol-A? Chicken meat perspective

Adem Savas et al.

Summary: The study investigated the effects of different brands of oven bags on the formation of HAA and migration of BPA in cooked chicken meats, finding that total HAA content ranged from 6.53 to 42.32 ng/g, with higher levels in breast meat. The use of oven bags reduced total HAA amount by 12% to 68.82%, but caused BPA migration, although the levels of HAA and BPA in all samples were not at a level to pose a risk to human health.

FOOD CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Protein carbonylation: molecular mechanisms, biological implications, and analytical approaches

Mitsugu Akagawa

Summary: Proteins can undergo oxidative modifications, leading to protein carbonylation which is considered a major hallmark of oxidative damage. Detection and quantification of protein carbonyls can be used to assess oxidative stress levels and cellular damage. Studying the molecular mechanisms and biological implications of protein carbonylation is important for understanding oxidative damage and identifying therapeutic targets.

FREE RADICAL RESEARCH (2021)

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Article Clinical Neurology

Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination

John W. Prineas et al.

Summary: The study showed that microglia and monocytes play important roles in myelin destruction in early multiple sclerosis patients, with newly identified cell types and a new gray matter lesion observed in MS.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2021)

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Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Biochemical Research Methods

Optimizing mitochondrial maintenance in extended neuronal projections

Anamika Agrawal et al.

Summary: Neurons rely on localized mitochondria to meet varying spatial demands, with mitochondrial aging occurring faster than the neuronal lifespan. Maintaining optimal mitochondrial distribution involves interactions between stationary and motile pools, with occasional exchange through fusion or replacement events. Infrequent servicing between pools, selective recycling through mitophagy, and robust maintenance via transient fusion are key for mitochondrial homeostasis in neurons, impacting neurological disorders.

PLOS COMPUTATIONAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

The redox-senescence axis and its therapeutic targeting

Natalie Y. L. Ngoi et al.

Summary: The article discusses the impact of cellular senescence on cancer and redox pathways, as well as the role of chemotherapy-induced senescence in cellular carcinogenesis, highlighting the importance of Bcl-2 family proteins in inducing drug resistance.

REDOX BIOLOGY (2021)

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Review Oncology

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

Hyuk Moon et al.

Summary: The MAPK/ERK signaling pathway is frequently activated in liver cancer, with alternative mechanisms other than genetic mutations driving its activation. Recent studies have focused on understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway in HCC, suggesting potential therapeutic strategies targeting this pathway.

CANCERS (2021)

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Review Oncology

The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review

Federica Rascio et al.

Summary: The PI3K/Akt pathway plays a crucial role in drug resistance in cancer by impacting tumor cell growth and metastasis through different signaling pathways. Its multi-level deregulation contributes to resistance in various cancer types. Understanding the pathway is essential in developing potential inhibition strategies for overcoming drug resistance.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Targeting PI3K/Akt signal transduction for cancer therapy

Yan He et al.

Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Cell Biology

Molecular damage in aging

Vadim N. Gladyshev et al.

Summary: This Review discusses the concept of molecular damage in aging, from theoretical models to experimental approaches, highlighting the central role of damage accumulation in the aging process. It emphasizes the importance of measuring multiple types of damage and the development of omics approaches to study the role of molecular damage in aging.

NATURE AGING (2021)

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Review Cell Biology

Autophagy in healthy aging and disease

Yahyah Aman et al.

Summary: This Review discusses the recent research on the mechanisms and roles of autophagy in health, aging, and disease, and how drugs modulating autophagy process could be used to suppress age-associated diseases. It examines emerging features of autophagy and proposes the potential links to aging and disease progression. The review also highlights the importance of understanding the interplay between autophagy and age-related pathologies for the development of clinical applications promoting long-term health.

NATURE AGING (2021)

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Review Biochemistry & Molecular Biology

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Ruixue Huang et al.

Summary: Genomic instability is a characteristic of various cancers, with radiotherapy and chemotherapy in cancer treatment based on this property but also accompanied by adverse effects. Targeted cancer therapy has the potential to suppress cancer cells' DNA damage response by tailoring therapy to individual patients lacking specific DNA damage response functions, which is crucial for the emergence of promising druggable targets in the future.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Regulation of inflammation as an anti-aging intervention

Joana Neves et al.

FEBS JOURNAL (2020)

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Review Pathology

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

Megan A. Evans et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

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Article Pharmacology & Pharmacy

JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells

K. A. Heslop et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Current nutritional and pharmacological anti-aging interventions

Manuel Ros et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Review Neurosciences

3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases

Maria Bandookwala et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2020)

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Review Biochemistry & Molecular Biology

Understanding oxidants and antioxidants: Classical team with new players

Syed Saqib Ali et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

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Article

Biomarkers of inflammation and oxidative stress in ophthalmic disorders

Anas Ahmad et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2020)

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Review Genetics & Heredity

ASK1 inhibition: a therapeutic strategy with multi-system benefits

Jacqueline M. Ogier et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

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Review Cardiac & Cardiovascular Systems

The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease JACC Focus Seminar

Dimitrios A. Stakos et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Medicine, Research & Experimental

Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers

Dhanasekhar Reddy et al.

LIFE SCIENCES (2020)

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Review Neurosciences

Cellular Senescence in Neurodegenerative Diseases

Carmen Martinez-Cue et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Structure-antioxidant activity relationship of methoxy, phenolic hydroxyl, and carboxylic acid groups of phenolic acids

Jinxiang Chen et al.

SCIENTIFIC REPORTS (2020)

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Review Biochemistry & Molecular Biology

Redox signalling and ageing: insights from Drosophila

Claudia Lennicke et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

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Article Medicine, Research & Experimental

Magnoflorine inhibits human gastric cancer progression by inducing autophagy, apoptosis and cell cycle arrest by JNK activation regulated by ROS

Xiao-li Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging

Marta Kowalska et al.

DNA AND CELL BIOLOGY (2020)

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Review Geriatrics & Gerontology

Impact of calorie restriction on energy metabolism in humans

Jasper Most et al.

EXPERIMENTAL GERONTOLOGY (2020)

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Review Neurosciences

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

Liquan Wu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Review Nutrition & Dietetics

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

Dae-Sung Hwangbo et al.

NUTRIENTS (2020)

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Article Food Science & Technology

Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages

Annayara Celestina Ferreira Fernandes et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

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Review Physiology

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Mehdi Sharifi-Rad et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Inflammasome and Mitophagy Connection in Health and Disease

Jae-Min Yuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes

Chih-Hao Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

NADPH oxidases: Current aspects and tools

Katrin Schroeder

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Oxidative stress-based therapeutics in COPD

Peter J. Barnes

REDOX BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Dominic S. A. Simpson et al.

ANTIOXIDANTS (2020)

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Review Cell Biology

Inflammaging, hormesis and the rationale for anti-aging strategies

Aurelia Santoro et al.

AGEING RESEARCH REVIEWS (2020)

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Article Pharmacology & Pharmacy

Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway

Qianwen Zheng et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article

Apoptosis (programmed cell death) and its signals - A review

E. Obeng

BRAZILIAN JOURNAL OF BIOLOGY (2020)

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Article

Oxidative stress, antioxidant defense and depressive disorders: A systematic review of biochemical and molecular markers

Maiza Lacerda Barbosa et al.

NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks

Han Yang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effect of Antioxidants in the Brain

Kyung Hee Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Pathophysiology of Type 2 Diabetes Mellitus

Unai Galicia-Garcia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Cell Biology

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Andy W. C. Man et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cell Biology

Association of Oxidative Stress on Pregnancy

Kinga Tobola-Wrobel et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Cell Biology

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Xing Chang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Neurosciences

Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

Haziq Kamal et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Review Cell Biology

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Rui Liu et al.

CELL DEATH & DISEASE (2020)

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Review Biochemistry & Molecular Biology

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

Yu Sun et al.

REDOX BIOLOGY (2020)

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Review Oncology

NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer

Margherita Sonnessa et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Cardiovascular Diseases

Emilie Dubois-Deruy et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

Sarmistha Saha et al.

MOLECULES (2020)

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A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer

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Oxidative Stress and Aging and Medicinal Plants as Antiaging Agents

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Alcohol Use in Pregnancy

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Lipid peroxidation and protein oxidation in broiler breast fillets with white striping myopathy

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Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

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Obesity May Accelerate the Aging Process

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Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth

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Astragaloside IV Protects Ethanol-Induced Gastric Mucosal Injury by Preventing Mitochondrial Oxidative Stress and the Activation of Mitochondrial Pathway Apoptosis in Rats

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Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia

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Effects of Intermittent Fasting on Health, Aging, and Disease

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Pristimerin induces apoptosis and autophagy via activation of ROS/ASK1/JNK pathway in human breast cancer in vitro and in vivo

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Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature

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The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

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Mitophagy links oxidative stress conditions and neurodegenerative diseases

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CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis

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Renal and testicular up-regulation of pro-inflammatory chemokines (RANTES and CCL2) and cytokines (TNF-α, IL-1β, IL-6) following acute edible camphor administration is through activation of NF-κB in rats

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Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept

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Neoplastic Pathogenesis Associated with Cigarette Carcinogens

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A Review Of Current And Upcoming Treatment Modalities In Non-Alcoholic Fatty Liver Disease And Non-Alcoholic Steatohepatitis

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Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics

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A shared comparison of diabetes mellitus and neurodegenerative disorders

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Mitochondrial dysfunctions contribute to energy deficits in rodent model of hepatic encephalopathy

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METABOLIC BRAIN DISEASE (2018)

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Heat shock protein 72 regulates hepatic lipid accumulation

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-κB and p38 MAPK signaling pathways

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Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances

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Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

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The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?

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Meeting Abstract Biochemistry & Molecular Biology

H2O2 as a central redox signaling molecule in physiological oxidative stress

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FREE RADICAL BIOLOGY AND MEDICINE (2018)

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ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

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Targeting incretin hormones and the ASK-1 pathway as therapeutic options in the treatment of non-alcoholic steatohepatitis

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HEPATOLOGY INTERNATIONAL (2018)

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The Nrf2 Signaling in Retinal Ganglion Cells under Oxidative Stress in Ocular Neurodegenerative Diseases

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The Influences of Soybean Agglutinin and Functional Oligosaccharides on the Intestinal Tract of Monogastric Animals

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The case of GWAS of obesity: does body weight control play by the rules?

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ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

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The Unfolded Protein Response and Cell Fate Control

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MOLECULAR CELL (2018)

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Nutrients and Oxidative Stress: Friend or Foe?

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Factors influencing eating behavior and dietary intake among resident students in a public university in Bangladesh: A qualitative study

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Cryo-EM structure of a mitochondrial calcium uniporter

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Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

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TRENDS IN BIOCHEMICAL SCIENCES (2018)

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Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy

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Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases

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Oncotarget (2018)

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Physical Activity, Lifestyle Factors and Oxidative Stress in Middle Age Healthy Subjects

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CLINICAL INTERVENTIONS IN AGING (2018)

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Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease

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Editorial: optimizing Exercise for the Prevention and treatment of type 2 diabetes

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Endoplasmic Reticulum Stress in Metabolic Disorders

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Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

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Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases

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CIRCULATION RESEARCH (2018)

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Effect of maternal antioxidant supplementation and/or exercise practice during pregnancy on postnatal overnutrition induced by litter size reduction: Brain redox homeostasis at weaning

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Cardiovascular Benefits of Exercise Training in Postmenopausal Hypertension

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Parkin and PINK1 mitigate STING-induced inflammation

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Increased pro-inflammatory cytokine-secreting regulatory T cells are correlated with the plasticity of T helper cell differentiation and reflect disease status in asthma

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RESPIRATORY MEDICINE (2018)

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Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

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cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease

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Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

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Coping with Reactive Oxygen Species to Ensure Genome Stability in Escherichia coli

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Sirtuins and Insulin Resistance

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FRONTIERS IN ENDOCRINOLOGY (2018)

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Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity

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Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint

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ANTIOXIDANTS (2018)

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Redox imbalance stress in diabetes mellitus: Role of the polyol pathway

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ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2018)

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Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer

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Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

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Neuroinflammation pathways: a general review

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Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

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Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

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Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD-induced obese mice

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T cells from patients with Parkinson's disease recognize α-synuclein peptides

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NEURON (2017)

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Unraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review

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REDOX REPORT (2017)

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TRENDS IN CELL BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

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TRENDS IN MOLECULAR MEDICINE (2017)

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Targeting Free Radicals in Oxidative Stress-Related Human Diseases

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TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

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Article

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Oncotarget (2017)

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Review Oncology

Skeletal muscle aging: influence of oxidative stress and physical exercise

Mariana Janini Gomes et al.

ONCOTARGET (2017)

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Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

Giang T. Nguyen et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

Adam Horn et al.

SCIENCE SIGNALING (2017)

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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Helmut Sies

REDOX BIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Proteostasis, oxidative stress and aging

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REDOX BIOLOGY (2017)

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Redox control of senescence and age-related disease

Akshaya Chandrasekaran et al.

REDOX BIOLOGY (2017)

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Amyotrophic lateral sclerosis

Orla Hardiman et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes

Kristian Karstoft et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

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Cytokine networks in neuroinflammation

Burkhard Becher et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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NF-kappa B signaling in inflammation

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SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

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Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts

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PLANTS-BASEL (2017)

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Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Kyoung-Han Kim et al.

CELL RESEARCH (2017)

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How does hormesis impact biology, toxicology, and medicine?

Edward J. Calabrese et al.

NPJ AGING AND MECHANISMS OF DISEASE (2017)

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Sirtuins, a promising target in slowing down the ageing process

Wioleta Grabowska et al.

BIOGERONTOLOGY (2017)

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AKT/PKB Signaling: Navigating the Network

Brendan D. Manning et al.

CELL (2017)

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Review Biochemistry & Molecular Biology

Cell death induced by endoplasmic reticulum stress

Raffaella Iurlaro et al.

FEBS JOURNAL (2016)

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Oxidative Stress in Neurodegenerative Diseases

Ewa Niedzielska et al.

MOLECULAR NEUROBIOLOGY (2016)

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ALCOHOL (2016)

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Review Medicine, Research & Experimental

The PI3K/AKT Pathway as a Target for Cancer Treatment

Ingrid A. Mayer et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

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Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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Oxidative stress and ageing

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BRITISH JOURNAL OF DERMATOLOGY (2016)

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Molecular and biological hallmarks of ageing

J. R. Aunan et al.

BRITISH JOURNAL OF SURGERY (2016)

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Oxidative Stress Modulation Through Habitual Physical Activity

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CURRENT PHARMACEUTICAL DESIGN (2016)

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Oxidative Stress, Sarcopenia, Antioxidant Strategies and Exercise: Molecular Aspects

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CURRENT PHARMACEUTICAL DESIGN (2016)

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Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Thomas E. Dever et al.

GENETICS (2016)

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Endoplasmic Reticulum Stress and Associated ROS

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Neuroinflammation: the devil is in the details

Damon J. DiSabato et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Exercise-induced oxidative stress: past, present and future

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The economic burden of physical inactivity: a global analysis of major non-communicable diseases

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LANCET (2016)

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Hypertension and physical exercise: The role of oxidative stress

Monica Korsager Larsen et al.

MEDICINA-LITHUANIA (2016)

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Role of neuroinflammation in neurodegenerative diseases

Wei-Wei Chen et al.

MOLECULAR MEDICINE REPORTS (2016)

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Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair

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NUCLEIC ACIDS RESEARCH (2016)

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Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naive, first episode, non-smoker major depression patients and healthy controls

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Advances in therapeutic CRISPR/Cas9 genome editing

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TRANSLATIONAL RESEARCH (2016)

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Mitochondrial Dynamics and Metabolic Regulation

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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2016)

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Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer

T. P. Das et al.

CELL DEATH & DISEASE (2016)

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Sirtuin functions and modulation: from chemistry to the clinic

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CLINICAL EPIGENETICS (2016)

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Review Genetics & Heredity

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Thomas E. Dever et al.

GENETICS (2016)

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Editorial: Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

Angel Catala et al.

FRONTIERS IN PHYSIOLOGY (2016)

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Hypertension and physical exercise: The role of oxidative stress

Monica Korsager Larsen et al.

MEDICINA-LITHUANIA (2016)

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Article Food Science & Technology

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

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CURRENT OPINION IN FOOD SCIENCE (2016)

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Fluoride Intensifies Hypercaloric Diet-Induced ER Oxidative Stress and Alters Lipid Metabolism

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PLOS ONE (2016)

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Impact of aerobic and anaerobic exercise training on oxidative stress and antioxidant defense in athletes

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Oxidative stress in pregnancy and reproduction

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OBSTETRIC MEDICINE (2016)

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Modulatory effect of Tinospora cordifolia extract on Cd-induced oxidative stress in Wistar rats

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INTEGRATIVE MEDICINE RESEARCH (2016)

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Editorial Material Chemistry, Multidisciplinary

DNA Repair

Thomas Carell

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

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The Role of Endoplasmic Reticulum Stress in Human Pathology

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ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10 (2015)

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Protein Oxidation in Aging: Does It Play a Role in Aging Progression?

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ANTIOXIDANTS & REDOX SIGNALING (2015)

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Review Dentistry, Oral Surgery & Medicine

The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review

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ARCHIVES OF ORAL BIOLOGY (2015)

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The detection and role of heat shock protein 70 in various nondisease conditions and disease conditions: a literature review

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

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Article Geriatrics & Gerontology

How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?

Jorge Pinto Soares et al.

EXPERIMENTAL GERONTOLOGY (2015)

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Risk factors and early origins of chronic obstructive pulmonary disease

Dirkje S. Postma et al.

LANCET (2015)

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Role of homocysteine in the development of cardiovascular disease

Paul Ganguly et al.

NUTRITION JOURNAL (2015)

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Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Standardized methods for the regulation of cigarette-smoke constituents

Chris Wright

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2015)

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Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

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SCIENTIFIC REPORTS (2015)

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DNA Damage, DNA Repair, Aging, and Neurodegeneration

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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

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Cataract

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NATURE REVIEWS DISEASE PRIMERS (2015)

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MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart

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JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Article Genetics & Heredity

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

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JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Review Biochemistry & Molecular Biology

4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation Product

Rudolf J. Schaur et al.

BIOMOLECULES (2015)

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Article Biochemistry & Molecular Biology

Free Radical Scavenging Properties of Skin and Pulp Extracts of Different Grape Cultivars In Vitro and Attenuation of H2O2-Induced Oxidative Stress in Liver Tissue Ex Vivo

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INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2015)

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Biological Activities of Reactive Oxygen and Nitrogen Species: Oxidative Stress versus Signal Transduction

Adelheid Weidinger et al.

BIOMOLECULES (2015)

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Protein Oxidation in Processed Meat: Mechanisms and Potential Implications on Human Health

O. P. Soladoye et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2015)

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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

Kerstin Nowotny et al.

BIOMOLECULES (2015)

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Article Obstetrics & Gynecology

mTOR Signaling in Endometrial Cancer: From a Molecular and Therapeutic Point of View

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CURRENT OBSTETRICS AND GYNECOLOGY REPORTS (2015)

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Letter Biochemistry & Molecular Biology

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

Vadim N. Gladyshev

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Review Oncology

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

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CANCER LETTERS (2014)

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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CELL (2014)

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Mitohormesis

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CELL METABOLISM (2014)

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Antioxidants and human diseases

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CLINICA CHIMICA ACTA (2014)

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ROS Function in Redox Signaling and Oxidative Stress

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CURRENT BIOLOGY (2014)

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Metformin Pharmacogenomics: Current Status and Future Directions

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DIABETES (2014)

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Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice

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INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2014)

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Review Neurosciences

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

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JOURNAL OF ALZHEIMERS DISEASE (2014)

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Production of heterocyclic aromatic amines in meat: Chemistry, health risks and inhibition. A review

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LWT-FOOD SCIENCE AND TECHNOLOGY (2014)

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Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

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TRENDS IN GENETICS (2014)

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Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

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BIOMED RESEARCH INTERNATIONAL (2014)

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A Comprehensive Review on Metabolic Syndrome

Jaspinder Kaur

CARDIOLOGY RESEARCH AND PRACTICE (2014)

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Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

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BIOLOGY LETTERS (2013)

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The Hallmarks of Aging

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CELL (2013)

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Review Food Science & Technology

Protein Oxidation: Basic Principles and Implications for Meat Quality

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2013)

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Environmental factors and unhealthy lifestyle influence oxidative stress in humans-an overview

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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2013)

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Protective potential of Black grapes against lead induced oxidative stress in rats

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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)

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Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

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IMMUNITY (2013)

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LEUKEMIA & LYMPHOMA (2013)

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Review Geriatrics & Gerontology

Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a chi

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IMMUNITY & AGEING (2013)

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Review Cell Biology

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

Evi M. Mercken et al.

AGEING RESEARCH REVIEWS (2012)

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Review Toxicology

Oxidative stress in apoptosis and cancer: an update

Jose M. Mates et al.

ARCHIVES OF TOXICOLOGY (2012)

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Review Oncology

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

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CANCER LETTERS (2012)

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Review Cardiac & Cardiovascular Systems

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging Mechanisms and Therapeutic Opportunities

Debapriya Dutta et al.

CIRCULATION RESEARCH (2012)

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Editorial Material Biochemistry & Molecular Biology

Unfolded protein response

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CURRENT BIOLOGY (2012)

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Article Endocrinology & Metabolism

Thyrotropin-Releasing Hormone Controls Mitochondrial Biology in Human Epidermis

Jana Knuever et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

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Article Endocrinology & Metabolism

Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion

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JOURNAL OF MOLECULAR ENDOCRINOLOGY (2012)

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Review Cell Biology

Sirtuins as regulators of metabolism and healthspan

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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Article Clinical Neurology

Ocimum sanctum attenuates oxidative damage and neurological deficits following focal cerebral ischemia/reperfusion injury in rats

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NEUROLOGICAL SCIENCES (2012)

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Correction Microbiology

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases (vol 75, pg 50, 2011)

Marie Cargnello et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

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Review Cell Biology

Oxidants, Antioxidants, and the Beneficial Roles of Exercise-Induced Production of Reactive Species

Elisa Couto Gomes et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)

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Article Biotechnology & Applied Microbiology

Metformin pathways: pharmacokinetics and pharmacodynamics

Li Gong et al.

PHARMACOGENETICS AND GENOMICS (2012)

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Review Endocrinology & Metabolism

Transcriptional integration of mitochondrial biogenesis

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TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

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Editorial Material Cell Biology

The JAK/STAT Pathway

Douglas A. Harrison

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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What is Aging?

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Frontiers in Genetics (2012)

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The Keap 1-Nrf2 system in cancers: stress response and anabolic metabolism

Yoichiro Mitsuishi et al.

FRONTIERS IN ONCOLOGY (2012)

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Hormesis and epigenetics: Is there a link?

Alexander M. Vaiserman

AGEING RESEARCH REVIEWS (2011)

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Determining the Effects of Antioxidants on Oxidative Stress Induced Carbonylation of Proteins

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ANALYTICAL CHEMISTRY (2011)

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Review Genetics & Heredity

Genome Engineering With Zinc-Finger Nucleases

Dana Carroll

GENETICS (2011)

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Review Dentistry, Oral Surgery & Medicine

Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

H. Y. Chung et al.

JOURNAL OF DENTAL RESEARCH (2011)

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Review Cell Biology

p53, ROS and senescence in the control of aging

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AGING-US (2010)

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Article Cell Biology

P66SHC and Ageing: ROS and TOR?

Giovambattista Pani

AGING-US (2010)

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Article Nutrition & Dietetics

Brain and high metabolic rate organ mass: contributions to resting energy expenditure beyond fat-free mass

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AMERICAN JOURNAL OF CLINICAL NUTRITION (2010)

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Editorial Material Biochemistry & Molecular Biology

Protein Carbonylation

Yuichiro J. Suzuki et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Editorial Material Cell Biology

Activation of senescence and aging characteristics by mitochondrially generated ROS How are they linked?

John Papaconstantinou et al.

CELL CYCLE (2010)

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Review Cell Biology

Exogenous antioxidants-Double-edged swords in cellular redox state Health beneficial effects at physiologic doses versus deleterious effects at high doses

Jaouad Bouayed et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)

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Review Obstetrics & Gynecology

Oxidative Stress and DNA Methylation in Prostate Cancer

Krishna Vanaja Donkena et al.

OBSTETRICS AND GYNECOLOGY INTERNATIONAL (2010)

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Article Nutrition & Dietetics

Sex differences in inflammatory markers: what is the contribution of visceral adiposity?

Amelie Cartier et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

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Article Cardiac & Cardiovascular Systems

Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children

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ATHEROSCLEROSIS (2009)

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Article Oncology

Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial

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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

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Article Biotechnology & Applied Microbiology

Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part II. Oxidative damage

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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)

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Review Biotechnology & Applied Microbiology

Oxidative stress in environmental-induced carcinogenesis

Salvador Mena et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2009)

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Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

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Review Cell Biology

Hormesis in aging

Suresh I. S. Rattan

AGEING RESEARCH REVIEWS (2008)

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Review Cell Biology

Hormesis defined

Mark P. Mattson

AGEING RESEARCH REVIEWS (2008)

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Review Biochemistry & Molecular Biology

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

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