期刊
BIOFACTORS
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/biof.2000
关键词
bathophenanthroline; catalase; cobalt; curcumin; development; Drosophila melanogaster; iron; polyamines; trace metals
Recent studies have shown that curcumin, a phytochemical, possesses iron-chelating activity. Feeding experiments using fruit flies demonstrated that dietary curcumin decreased iron and cobalt levels and had a lesser effect on manganese and zinc levels. Curcumin supplementation during the larval stage was sufficient to induce these changes in adult animals. Curcumin's metal-chelating property should be considered in feeding studies.
Recent reports indicated that the phytochemical curcumin possesses iron-chelating activity. Here, by employing the fruit fly Drosophila melanogaster, we conducted feeding studies supplementing curcumin or, as a control, the iron chelator bathophenanthroline (BPA). First, the absorption and further metabolization of dietary curcuminoids were proved by metabolomics analyses. Next, we found that 0.2% dietary curcumin, similar to BPA, lowered the iron but also the cobalt content, and to a lesser extent affected the manganese and zinc status. Supplementation during larval stages was required and sufficient for both compounds to elicit these alterations in adult animals. However, curcumin-induced retarded larval development was not attributable to the changed trace metal status. In addition, a reduction in the iron content of up to 70% by curcumin or BPA supplementation did not reduce heme-dependent catalase activity and tolerance toward H2O2 in D. melanogaster. Moreover, polyamines were not influenced by curcumin treatment and decreased iron levels. This was confirmed for selected organs from 0.2% curcumin-treated mice, except for the spleen. Here, elevated spermidine level and concomitant upregulation of genes involved in polyamine production were associated with a putatively anemia-derived increased spleen mass. Our data underline that the metal-chelating property of curcumin needs to be considered in feeding studies.
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