A nuclear NKRF interacting long noncoding RNA controls EBV eradication and suppresses tumor progression in natural killer/T-cell lymphoma

Article Oncology

LncRNA Uc003xsl.1-Mediated Activation of the NFKB/IL8 Axis Promotes Progression of Triple-Negative Breast Cancer

Ying Xu et al.

Summary: This study identifies an epigenetic-driven NF kappa B/IL8 cascade initiated by a lncRNA, whose aberrant activation contributes to tumor metastasis and poor survival in patients with triple-negative breast cancer.

CANCER RESEARCH (2022)

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Review Cell Biology

LncRNAs in human cancers: signal from noise

Sara Adnane et al.

Summary: Recent studies have shown that long noncoding RNAs play a crucial role in cancer by regulating LLPS. This discovery may lead to the development of new diagnostic tools and treatment methods.

TRENDS IN CELL BIOLOGY (2022)

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Review Virology

Long non-coding RNAs in virus-related cancers

Yushan Huang et al.

Summary: This review summarizes the dysregulation and mechanism of long non-coding RNAs (lncRNAs) in virus-related cancers, with a focus on Hepatitis B virus, Epstein-Barr virus, and Human Papillomavirus. The potential implications of lncRNAs in COVID-19 are also discussed.

REVIEWS IN MEDICAL VIROLOGY (2022)

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Review Immunology

NF-?B: blending metabolism, immunity, and inflammation

Daria Capece et al.

Summary: This review discusses the central role of NF-KB transcription factors in the immune and metabolic systems, and how their understanding can lead to better diagnostics and therapeutics for human diseases.

TRENDS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Epstein-Barr virus: Biology and clinical disease

Blossom Damania et al.

Summary: This review discusses the life cycle of EBV, its impact on host immune responses, and the neoplastic and autoimmune diseases associated with EBV infection.

CELL (2022)

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Article Gastroenterology & Hepatology

Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma

Mengge Li et al.

Summary: This study revealed that HBV integration is a common event in HBV-related ICC and identified several recurrent HBV integration genes, such as TERT, which provide new clues for further exploring the relationship between HBV infection and ICC.

HEPATOLOGY RESEARCH (2021)

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Review Pharmacology & Pharmacy

Long non-coding RNAs: From disease code to drug role

Yuanyuan Chen et al.

Summary: Extensive studies have shown that long non-coding RNAs (lncRNAs) play crucial roles in physiological processes and are closely linked to various diseases. Using lncRNAs as biomarkers or intervention targets can provide new perspectives for disease diagnosis and treatment. Research is shifting towards utilizing lncRNAs as pharmacological targets, with a focus on preclinical research and clinical trial progress.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Virology

The Role of Ubiquitination in NF-κB Signaling during Virus Infection

Kun Song et al.

Summary: NF-κB family transcription factors play a crucial role in regulating cell functions and viral infection, with viruses modulating NF-κB signaling pathways through ubiquitination to facilitate infection.

VIRUSES-BASEL (2021)

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Article Biochemistry & Molecular Biology

CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis

Chen-xing Zhao et al.

Summary: In this study, a novel circRNA circEAF2 was identified, which was found to be downregulated in EBV + DLBCL and negatively correlated with EBV infection and DLBCL progression. CircEAF2 counteracted EBV + DLBCL progression via the miR-BART19-3p/APC/beta-catenin axis, suggesting circEAF2 as a potential prognostic biomarker. Therapeutic targeting of EBV-encoded miRNA may prove to be a promising strategy in treating EBV-associated lymphoid malignancies.

MOLECULAR CANCER (2021)

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Article Medicine, General & Internal

SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential

Jie Xiong et al.

Summary: Metabolic reprogramming plays a crucial role in lymphoma progression, with aberrant glutamine metabolism identified in NKTCL patients. SLC1A1 serves as a central regulator in altering glutaminolysis, leading to glutamine addiction and accelerated tumor growth. Overexpression of SLC1A1 is associated with PD-L1 downregulation and impaired T cell immunity, which can be restored by asparaginase treatment.

EBIOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis

Yao-Hui Huang et al.

Summary: Epigenetic alterations, especially mutations in genes related to histone modification, play a crucial role in tumor progression of DLBCL by influencing the tumor microenvironment, leading to increased tumor cell proliferation and polarization of M2 macrophages.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma

Liang Wang et al.

Summary: The study found that BCYRN1 is overexpressed in ENKTCL compared to normal NK cells, and its high expression is significantly correlated with poorer progression-free survival in patients. BCYRN1 promotes resistance to ASP by inducing autophagy, which can be reversed by inhibition of autophagy.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

Christiane E. Olivero et al.

MOLECULAR CELL (2020)

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Article Oncology

Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma

Jie Xiong et al.

CANCER CELL (2020)

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Editorial Material Hematology

Improved outcomes for extranodal natural killer T-cell lymphoma Comment

Bradley M. Haverkos et al.

LANCET HAEMATOLOGY (2020)

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Article Oncology

Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B-cell lymphoma

Rong Shen et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2020)

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Article Oncology

Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

Eleni Anastasiadou et al.

LEUKEMIA (2019)

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Article Cell Biology

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

Liang Wei Wang et al.

CELL METABOLISM (2019)

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Article Biochemistry & Molecular Biology

Epstein-Barr virus tegument protein BGLF2 inhibits NF-κB activity by preventing p65 Ser536 phosphorylation

Tao Chen et al.

FASEB JOURNAL (2019)

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Article Virology

Differential expression profiling of lncRNAs related to Epstein-Barr virus infection in the epithelial cells

Jing Zhang et al.

JOURNAL OF MEDICAL VIROLOGY (2019)

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Article Immunology

miR-301a Regulates Inflammatory Response to Japanese Encephalitis Virus Infection via Suppression of NKRF Activity

Bibhabasu Hazra et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Oncology

Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma

Rou-Jun Peng et al.

LEUKEMIA (2019)

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Review Cell Biology

The functions and unique features of long intergenic non-coding RNA

Julia D. Ransohoff et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp et al.

CELL (2018)

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Article Multidisciplinary Sciences

Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients

Cheng Wang et al.

NATURE COMMUNICATIONS (2018)

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Review Oncology

Advances in multiple omics of natural-killer/T cell lymphoma

Jie Xiong et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Review Immunology

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

Glutamine supplementation suppresses herpes simplex virus reactivation

Kening Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Multidisciplinary Sciences

TRIM29 promotes DNA virus infections by inhibiting innate immune response

Junji Xing et al.

NATURE COMMUNICATIONS (2017)

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Article Hematology

PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing L-asparaginase

Yok-Lam Kwong et al.

BLOOD (2017)

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Review Hematology

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Steven H. Swerdlow et al.

BLOOD (2016)

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Article Oncology

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

Xi-wen Bi et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

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Article Multidisciplinary Sciences

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

Hyung-Joon Kwon et al.

NATURE COMMUNICATIONS (2016)

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Article Biochemical Research Methods

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

Guangchuang Yu et al.

BIOINFORMATICS (2015)

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Article Gastroenterology & Hepatology

MicroRNA 29 Targets Nuclear Factor-κB-Repressing Factor and Claudin 1 to Increase Intestinal Permeability

QiQi Zhou et al.

GASTROENTEROLOGY (2015)

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Article Genetics & Heredity

Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

Lu Jiang et al.

NATURE GENETICS (2015)

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Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

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Editorial Material Multidisciplinary Sciences

RNA and dynamic nuclear organization

John Rinn et al.

SCIENCE (2014)

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Article Immunology

EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: Implications for viral immune escape

Martina Severa et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Article Biochemical Research Methods

Optimized RNA ISH, RNA FISH and protein-RNA double labeling (IF/FISH) in Drosophila ovaries

Sandra G. Zimmerman et al.

NATURE PROTOCOLS (2013)

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Article Urology & Nephrology

Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells

Kirstin M. Heutinck et al.

KIDNEY INTERNATIONAL (2012)

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Article Biochemical Research Methods

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Ben Langmead et al.

NATURE METHODS (2012)

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Article Microbiology

The Nuclear Chaperone Nucleophosmin Escorts an Epstein-Barr Virus Nuclear Antigen to Establish Transcriptional Cascades for Latent Infection in Human B Cells

Cheng-Der Liu et al.

PLOS PATHOGENS (2012)

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Article Oncology

International peripheral T-cell and natural killer/T-cell lymphoma study: Pathology findings and clinical outcomes

Julie M. Vose et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

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Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

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Review Immunology

NFκB:: Linking inflammation and immunity to cancer development and progression

M Karin et al.

NATURE REVIEWS IMMUNOLOGY (2005)

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Article Multidisciplinary Sciences

NF-κB functions as a tumour promoter in inflammation-associated cancer

E Pikarsky et al.

NATURE (2004)

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Article Biochemistry & Molecular Biology

IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

FR Greten et al.

CELL (2004)

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A nuclear NKRF interacting long noncoding RNA controls EBV eradication and suppresses tumor progression in natural killer/T-cell lymphoma

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