期刊
MEDICAL PHYSICS
卷 43, 期 2, 页码 939-950出版社
WILEY
DOI: 10.1118/1.4940355
关键词
positron emission tomography (PET); time-of-flight(TOF); depth-of-interaction (DOI); scintillator; phosphor coating
资金
- UC Davis Research Investment in Science and Engineering
- NIH [R01 CA170874]
- Natural Sciences and Engineering Research Council of Canada
Purpose: In support of a project to build a total-body PET scanner with an axial field-of-view of 2 m, the authors are developing simple, cost-effective block detectors with combined time-of-flight (TOF) and depth-of-interaction (DOI) capabilities. Methods: This work focuses on investigating the potential of phosphor-coated crystals with conventional PMT-based block detector readout to provide DOI information while preserving timing resolution. The authors explored a variety of phosphor-coating configurations with single crystals and crystal arrays. Several pulse shape discrimination techniques were investigated, including decay time, delayed charge integration (DCI), and average signal shapes. Results: Pulse shape discrimination based on DCI provided the lowest DOI positioning error 2 mm DOI positioning error was obtained with single phosphor-coated crystals while 3-3 5 mm DOI error was measured with the block detector module. Minimal timing resolution degradation was observed with single phosphor-coated crystals compared to uncoated crystals, and a timing resolution of 442 ps was obtained with phosphor-coated crystals in the block detector compared to 404 ps without phosphor coating. Flood maps showed a slight degradation in crystal resolvability with phosphor-coated crystals; however, all crystals could be resolved. Energy resolution was degraded by 3%-7% with phosphor-coated crystals compared to uncoated crystals. Conclusions: These results demonstrate the feasibility of obtaining TOF DOI capabilities with simple block detector readout using phosphor-coated crystals. (C) 2016 American Association of Physicists in Medicine.
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