期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 -, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20221410
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The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP synthase (CTPS). It has been discovered in recent years that CTPS can form snake-shaped mesoscale cytoophidia in fruit fly cells, which are undetectable under light microscopy. This review summarizes the current understanding of cytoophidia and filaments formed by CTPS, including their conservation, morphology, and functions.
The nucleotide CTP can be synthesized de novo from UTP via the metabolic enzyme CTP synthase (CTPS). As a textbook enzyme, CTPS has been extensively studied for seven decades. However, it came as a surprise when CTPS was found to form snake shaped mesoscale cytoophidia in fruit fly cells. Since 2010, more and more studies have demonstrated that CTPS can form cytoophidia within the cells across all three domains of life. Oligomers of CTPS form filaments that are undetectable under light microscopy. This review summarizes our current understanding of cytoophidia and filaments, highlighting some basic features such as conservation, morphology and functions of the two levels of CTPS structures.
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