4.7 Review

Non-coding RNAs: Emerging roles in the characterization of immune microenvironment and immunotherapy of prostate cancer

期刊

BIOCHEMICAL PHARMACOLOGY
卷 214, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2023.115669

关键词

Non-coding RNA; Tumor immune microenvironment; immune; checkpoints; Immunotherapy; Prostate cancer; mCRPC

向作者/读者索取更多资源

Prostate cancer is the most common tumor among men, and advanced prostate cancer often leads to death due to resistance to existing treatments. Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has shown great progress in solid tumor treatment, but has limited effectiveness in metastatic castration-resistant prostate cancer (mCRPC). Non-coding RNAs (ncRNAs) have been identified as an ideal class of molecules for cancer treatment, and targeting related ncRNAs presents an opportunity to improve the effectiveness of immunotherapy in mCRPC.
Prostate cancer is the most common tumor among men. Although the prognosis for early-stage prostate cancer is good, patients with advanced disease often progress to metastatic castration-resistant prostate cancer (mCRPC), which usually leads to death owing to resistance to existing treatments and lack of long-term effective therapy. In recent years, immunotherapy, especially immune checkpoint inhibitors (ICIs), has made great progress in the treatment of various solid tumors, including prostate cancer. However, the ICIs have only shown modest outcomes in mCRPC compared with other tumors. Previous studies have suggested that the suppressive tumor immune microenvironment (TIME) of prostate cancer leads to poor anti-tumor immune response and tumor resistance to immunotherapy. It has been reported that non-coding RNAs (ncRNAs) are capable of regulating upstream signaling at the transcriptional level, leading to a cascade of changes in downstream molecules. As a result, ncRNAs have been identified as an ideal class of molecules for cancer treatment. The discovery of ncRNAs provides a new perspective on TIME regulation in prostate cancer. ncRNAs have been associated with establishing an immunosuppressive microenvironment in prostate cancer through multiple pathways to modulate the immune escape of tumor cells which can promote resistance of prostate cancer to immunotherapy. Targeting these related ncRNAs presents an opportunity to improve the effectiveness of immunotherapy in this patient population.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据