相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。PROTAC targeted protein degraders: the past is prologue
Miklos Bekes et al.
NATURE REVIEWS DRUG DISCOVERY (2022)
Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity
Laura Sinatra et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation
Kairui Yue et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Development of the first non-hydroxamate selective HDAC6 degraders
Tim Keuler et al.
CHEMICAL COMMUNICATIONS (2022)
PROTAC degraders as chemical probes for studying target biology and target validation
Vaclav Nemec et al.
CHEMICAL SOCIETY REVIEWS (2022)
Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6
Zhuoxian Cao et al.
ACS CHEMICAL BIOLOGY (2021)
Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway
Shuang Xu et al.
ATHEROSCLEROSIS (2021)
HDAC6 as privileged target in drug discovery: A perspective
Sravani Pulya et al.
PHARMACOLOGICAL RESEARCH (2021)
The Role of HDAC6 in Autophagy and NLRP3 Inflammasome
Panpan Chang et al.
FRONTIERS IN IMMUNOLOGY (2021)
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway
Qian Chen et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Alesa Bricelj et al.
FRONTIERS IN CHEMISTRY (2021)
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases
Margherita Brindisi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells
Gerrit Mueller et al.
AUTOPHAGY (2020)
Control of the inflammasome by the ubiquitin system
Gloria Lopez-Castejon
FEBS JOURNAL (2020)
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
George M. Burslem et al.
CELL (2020)
A short guide to histone deacetylases including recent progress on class II enzymes
Suk-Youl Park et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor
Sida Shen et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Lysosomotropic drugs enhance pro-inflammatory responses to IL-1β in macrophages by inhibiting internalization of the IL-1 receptor
Charlotte Luebow et al.
BIOCHEMICAL PHARMACOLOGY (2020)
Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase
Ka Yang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson's Disease
Shaoqi Yan et al.
FRONTIERS IN AGING NEUROSCIENCE (2020)
Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models
Yves Depetter et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
HDAC6 inhibition blocks inflammatory signaling and caspase-1 activation in LPS-induced acute lung injury
Li Liu et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
Hao Wu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6
Jeremy D. Osko et al.
BIOCHEMISTRY (2019)
Developing potent PROTACs tools for selective degradation of HDAC6 protein
Zixuan An et al.
PROTEIN & CELL (2019)
PROTACs: great opportunities for academia and industry
Xiuyun Sun et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
Plasticity in designing PROTACs for selective and potent degradation of HDAC6
Haiyan Yang et al.
CHEMICAL COMMUNICATIONS (2019)
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Karen V. Swanson et al.
NATURE REVIEWS IMMUNOLOGY (2019)
Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
Ka Yang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Targeting the NLRP3 inflammasome in inflammatory diseases
Matthew S. J. Mangan et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Canonical and Non-Canonical Activation of NLRP3 inflammasome at the Crossroad between immune Tolerance and intestinal inflammation
Carolina Pellegrini et al.
FRONTIERS IN IMMUNOLOGY (2017)
NF-kappa B signaling in inflammation
Ting Liu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)
Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages
Gi Soo Youn et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Immunomodulatory drugs inhibit TLR4-induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway
David Millrine et al.
INTERNATIONAL IMMUNOLOGY (2016)
Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation
Inhwa Hwang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Histone deacetylase 6 in health and disease
Carole Seidel et al.
EPIGENOMICS (2015)
THP-1 cell line: An in vitro cell model for immune modulation approach
Wasaporn Chanput et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2014)
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Katrina J. Falkenberg et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability
Jeanine Jochems et al.
NEUROPSYCHOPHARMACOLOGY (2014)
HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages
Bing Yan et al.
PLOS ONE (2014)
A Comprehensive Mathematical Model for Three-Body Binding Equilibria
Eugene F. Douglass et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages
Mihai G. Netea et al.
BLOOD (2009)
Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-α production via down-regulation of MyD88 expression
Abu Shadat M. Noman et al.
Innate Immunity (2009)
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Michael Haberland et al.
NATURE REVIEWS GENETICS (2009)
A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells
LK Gediya et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65
R Kiernan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The inflammasome:: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
F Martinon et al.
MOLECULAR CELL (2002)
The language of covalent histone modifications
BD Strahl et al.
NATURE (2000)
分享论文
