PVT1 alleviates hypoxia-induced endothelial apoptosis by enhancing autophagy via the miR-15b-5p/ATG14 and miR-424-5p/ATG14 axis

Review Biochemistry & Molecular Biology

The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence

Mohammad Heydarnezhad Asl et al.

Summary: Long noncoding RNAs (lncRNAs) play regulatory roles in important biological processes such as apoptosis, cell cycle, and cellular senescence. Dysregulation of lncRNAs is implicated in tumor formation and other diseases.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

The Role of Autophagy and Apoptosis in Neuropathic Pain Formation

Ming-Feng Liao et al.

Summary: Recent studies have shown that both autophagic and apoptotic activities play important roles in the neural changes after nerve damage. Enhancing autophagic activities while suppressing apoptotic activities can effectively treat neuropathic pain.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood-Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight Junction Protein Reduction in Rat Stroke Model

Lin-Yan Huang et al.

Summary: Exosomes extracted from healthy rat serum were found to provide neuroprotection against ischemic stroke by reducing infarct volumes and enhancing neurological function. The treatment inhibited endothelial cell apoptosis and autophagy, thus preventing blood-brain barrier breakdown.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Cell Biology

Hypoxia-induced PVT1 promotes lung cancer chemoresistance to cisplatin by autophagy via PVT1/miR-140-3p/ATG5 axis

Jiying Wang et al.

Summary: Lung cancer chemoresistance during chemotherapy is a challenge, with hypoxia being one of the contributing factors. This study aimed to analyze the regulatory relationship between hypoxia and PVT1 and the mechanism of PVT1 in hypoxia-induced chemoresistance in lung cancer. The results showed that the expression of PVT1 is regulated by HIF-1 alpha and participates in hypoxia-induced chemoresistance.

CELL DEATH DISCOVERY (2022)

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Review Biochemistry & Molecular Biology

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

Rohan Gupta et al.

Summary: Autophagy and apoptosis are two essential self-destructive processes that regulate cellular homeostasis through signal transduction mechanisms, playing crucial roles in various diseases including neurodegenerative diseases and cancer. These cell death pathways share common molecular mechanisms, with some key signaling molecules triggering apoptotic and autophagic processes in cells.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Cell Biology

Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress

Peipei Meng et al.

Summary: This review explores the mechanisms of astragaloside IV in improving endothelial dysfunction caused by oxidative stress related to cardiovascular diseases. The results suggest that astragaloside IV can prevent or reverse the uncoupling of eNOS, increase eNOS and NO, and enhance various activating enzymes to activate the antioxidant system. Further validation and quantitative experiments are needed for a comprehensive understanding of its effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Immunology

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status

John Sieh Dumbuya et al.

Summary: HIE is a significant cause of central nervous system damage in newborns, leading to death or long-term neurological disorders. Therapies such as hypothermia and G-CSF have shown promise in treating HIE, with G-CSF playing a crucial role in neuroprotection through inhibition of apoptosis and inflammation.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Medicine, Research & Experimental

The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression

Kai Su et al.

Summary: Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play crucial roles in regulating gene expression and influencing cancer development. The regulatory network between them affects cell growth and development, disruption of which can lead to various diseases, especially cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell Biology

The lncRNA PVT1 regulates autophagy in regulatory T cells to suppress heart transplant rejection in mice by targeting miR-146a

Jian Lu et al.

Summary: In this study, the interaction of lncRNA PVT1 and miR-146a was found to influence Treg autophagy, playing a role in alleviating transplant rejection. Higher expression of PVT1 was associated with increased autophagy in Tregs, leading to stronger inhibitory effects on CD4+ T cells in vitro and prolonged allograft survival in animal models. This research reveals a novel regulatory pathway involving PVT1, miR-146a, and TRAF6 which may offer new therapeutic strategies for transplant rejection.

CELLULAR IMMUNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

LncRNA PVT1 knockdown alleviated ox-LDL-induced vascular endothelial cell injury and atherosclerosis by miR-153-3p/GRB2 axis via ERK/p38 pathway

Junxia Guo et al.

Summary: This study investigated the role of PVT1 in high fat diet-induced atherosclerosis. The results showed that PVT1 knockdown alleviated ox-LDL-induced vascular endothelial cell injury through the miR-153-3p/GRB2 axis via ERK1/2 and p38 pathway. Inhibiting PVT1 could reduce atherosclerotic plaques, lipid deposition, inflammation, oxidative stress, and apoptosis in AS mice.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Review Pharmacology & Pharmacy

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

Huxinyue Duan et al.

Summary: Endothelial cell apoptosis is the initial step in the development of atherosclerosis, with risk factors inducing excessive apoptosis. Natural medicines have great potential in treating atherosclerosis by inhibiting endothelial cell apoptosis.

PHARMACOLOGICAL RESEARCH (2021)

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Review Oncology

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib

Laurence A. Booth et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Medicine, Research & Experimental

Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma

Jin-yan Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Pharmacology & Pharmacy

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

Ting Liu et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Long non-coding RNA PVT1 contributes to cell growth and metastasis in non-small-cell lung cancer by regulating miR-361-3p/SOX9 axis and activating Wnt/β-catenin signaling pathway

Guanbin Qi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Cefan Zhou et al.

MOLECULAR CANCER (2020)

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Review Oncology

Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Le Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Long noncoding RNAs: functions and mechanisms in colon cancer

Sian Chen et al.

MOLECULAR CANCER (2020)

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Article Multidisciplinary Sciences

A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

Viorel Simion et al.

NATURE COMMUNICATIONS (2020)

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Review Biotechnology & Applied Microbiology

Long Noncoding RNA/Circular RNA-miRNA-mRNA Axes in Ischemia-Reperfusion Injury

Chengwu Gong et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/-Catenin Signaling Pathway in Glioma Cells

Cheng-Wei Chu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Genetics & Heredity

Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma

Liang Yang et al.

GENE (2019)

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Review Oncology

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

Yan Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity

Cheng-Fei Li et al.

APOPTOSIS (2019)

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Review Biochemistry & Molecular Biology

Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis

Stephanie Paone et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

LncRNA MALAT1 promotes oxidized low-density lipoprotein-induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway

Shu Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

LncRNA MT1JP functions as a ceRNA in regulating FBXW7 through competitively binding to miR-92a-3p in gastric cancer

Gang Zhang et al.

MOLECULAR CANCER (2018)

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Review Biochemistry & Molecular Biology

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

Guangbo Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Cell Biology

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

Shuling Song et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Review Oncology

The role of miRNA and lncRNA in gastric cancer

Ning-Bo Hao et al.

ONCOTARGET (2017)

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Article Biochemistry & Molecular Biology

6-Gingerol induces autophagy to protect HUVECs survival from apoptosis

Shaopeng Wang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

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Review Urology & Nephrology

Autophagy in acute kidney injury

Gur P. Kaushal et al.

KIDNEY INTERNATIONAL (2016)

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Review Genetics & Heredity

Endogenous microRNA sponges: evidence and controversy

Daniel W. Thomson et al.

NATURE REVIEWS GENETICS (2016)

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Review Pharmacology & Pharmacy

Neuroprotective agents for neonatal hypoxic-ischemic brain injury

Qiaofeng Wu et al.

DRUG DISCOVERY TODAY (2015)

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Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Review Biochemistry & Molecular Biology

Apoptosis, autophagy, necroptosis, and cancer metastasis

Zhenyi Su et al.

MOLECULAR CANCER (2015)

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Review Biochemistry & Molecular Biology

Crosstalk between apoptosis, necrosis and autophagy

Vassiliki Nikoletopoulou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

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Article Gastroenterology & Hepatology

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

Virginia Hernandez-Gea et al.

GASTROENTEROLOGY (2012)

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Article Biochemistry & Molecular Biology

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

Assaf D. Rubinstein et al.

MOLECULAR CELL (2011)

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Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Article Cell Biology

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Shida Yousefi et al.

NATURE CELL BIOLOGY (2006)

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PVT1 alleviates hypoxia-induced endothelial apoptosis by enhancing autophagy via the miR-15b-5p/ATG14 and miR-424-5p/ATG14 axis

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