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Review
Biochemistry & Molecular Biology
Ghofraan Abdulsalam Atallah et al.
Summary: Ovarian cancer is a deadly reproductive tumor affecting women worldwide. Chemoresistance and the need for biomarkers to predict platinum resistance in order to improve survival and quality of life are important factors in the treatment of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min Zhang et al.
Summary: Ovarian cancer is the second leading cause of death in women with gynecological malignancy in China. Circular RNAs, specifically hsa_circ_0007444, play a role in inhibiting ovarian cancer progression by interacting with AGO2 and sponging miR-23a-3p, ultimately upregulating DICER1 expression, which is a tumor suppressor in ovarian cancer. The downregulation of hsa_circ_0007444 in ovarian cancer tissues and cell lines leads to enhanced cell proliferation, invasion, migration, and decreased apoptosis. In vivo experiments also confirm that hsa_circ_0007444 inhibits tumor growth and lung metastasis in mouse models.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell Biology
Lijia Zhang et al.
Summary: In this study, it was found that the natural product ASII inhibited cell growth and promoted apoptosis of DDP-resistant OC cells, possibly by regulating protein expression and inducing autophagy.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Cheng Dai et al.
Summary: This study identifies the role of circular RNA circ_0078607 in cisplatin resistance of ovarian cancer cells and demonstrates its involvement in up-regulating GAS7 to inhibit resistance. The research reveals that circ_0078607 attenuates platinum resistance by modulating the miR-196b-5p/GAS7 axis, highlighting its therapeutic potential in overcoming drug resistance in ovarian cancer.
Review
Biochemistry & Molecular Biology
Aleksandra Zon et al.
Summary: Cisplatin is a widely used anticancer drug with multidirectional mechanisms, primarily damaging the DNA of cancer cells. However, it has serious disadvantages including toxicity to important organs and the development of resistance mechanisms. Strategies to improve its effectiveness in ovarian cancer treatment include developing less toxic analogs and combination therapy with other drugs or treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hong Wang et al.
Summary: Ovarian cancer is a highly lethal malignant gynecological cancer. This study found that circRNAs play a critical role in the development of ovarian cancer, and the upregulation of hsa_circ_0001741 inhibits the proliferation of ovarian cancer through modulating the miR-188-5p/FOXN2 signaling pathway.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yun Zhou et al.
Summary: Chemotherapy is less effective in treating ovarian cancer due to drug resistance, making it challenging. Baohuoside I, derived from Herba Epimedii, has antitumor properties in various malignancies. This study found that Baohuoside I decreased the viability and proliferation of ovarian cancer cells and increased their sensitivity to cisplatin (DDP). It was also discovered that Baohuoside I suppressed autophagy by downregulating the HIF-1a/ATG5 axis, enhancing the chemotherapeutic efficacy of DDP in ovarian cancer.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Pengfei Xu et al.
Summary: Analyses of several databases showed that the lncRNA RNF157-AS1 is overexpressed in epithelial ovarian cancer tissues. Suppression or overexpression of RNF157-AS1 significantly affects the proliferation, invasion, and migration of EOC cells. RNF157-AS1 interacts with HMGA1 and EZH2 proteins, regulating the expression of ULK1 and DIRAS3 and influencing autophagy.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Hui Sheng et al.
Summary: Circ-PIP5K1A is highly expressed in DDP-resistant OC tissues and cells, and its knockdown can inhibit the proliferation, migration, and invasion, increase apoptosis, and enhance sensitivity to DDP. Circ-PIP5K1A acts as a sponge for miR-942-5p to positively regulate NFIB expression. Exosomes containing circ-PIP5K1A can be internalized by surrounding cells, mediating intercellular communication between OC cells.
Article
Oncology
Rebecca L. Siegel et al.
Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Biochemistry & Molecular Biology
Ikram ul Haq et al.
Summary: Circular RNAs (circRNAs) are endogenous noncoding RNAs formed by exon back splicing events, widely distributed in eukaryotic cells. They function as microRNA sponges, protein scaffolds, and regulators of transcription and splicing, and can even serve as templates for peptide production. Abnormal circRNA expression is associated with various cancers, promoting cellular proliferation, invasiveness, and bypassing cellular senescence and death. Understanding the functional mechanisms and biomarker potential of circRNAs will aid in the discovery of new biomarkers and therapeutic targets.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2023)
Article
Reproductive Biology
Hongxia Wang et al.
Summary: This study analyzed the expression profiles of circular RNAs (circRNAs) in human ovarian carcinoma (OC) and found that circ-PHC3 was significantly upregulated in OC cell lines and tissues. Functionally, circ-PHC3 promoted OC proliferation and metastasis through the miR-497-5p/SOX9 axis. These findings suggest that circ-PHC3 may serve as a potential therapeutic target for OC.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Oncology
Ying Zheng et al.
Summary: Gastric cancer is a common malignancy worldwide, and patients with advanced disease require palliative care. Circular RNAs play a crucial role in gastric cancer and are involved in drug resistance. This review provides a comprehensive summary of the functions and mechanisms of circular RNAs in gastric cancer drug resistance, particularly in chemoresistance, and highlights their potential as promising targets for improving drug resistance and therapeutic efficacy.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Review
Oncology
Ling Yang et al.
Summary: This article summarizes the latest understanding of mechanisms underlying platinum-based chemotherapy resistance in ovarian cancer and discusses current and emerging approaches for targeting these patients. Challenges associated with these approaches are also presented, with a focus on the importance of development and overcoming resistance.
Article
Oncology
Han Li et al.
Summary: This study reveals the role of circITGB6 in promoting platinum resistance in ovarian cancer (OC). It demonstrates that circITGB6 may serve as a potential prognostic marker and therapeutic target for patients with OC. Mechanistically, circITGB6 interacts with IGF2BP2 and FGF9 mRNA to induce polarization of tumor-associated macrophages (TAMs) into M2 phenotype.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Aferin Beilerli et al.
Summary: This study aimed to explore the diagnostic and prognostic value of circulating cirRS-7 in patients with epithelial ovarian cancer (EOC). The results showed that the expression levels of circulating ciRS-7 were associated with the severity and prognosis of EOC patients.
NON-CODING RNA RESEARCH
(2022)
Article
Oncology
Li Ning et al.
Summary: CircN4BP2L2 may serve as a promising diagnostic biomarker for both type I and type II EOC. It was associated with advanced tumor stage in type I EOC and lymph node metastasis in type II EOC. CircN4BP2L2 could significantly separate type I or type II from benign or normal cohort.
Article
Biochemistry & Molecular Biology
Yang Meng et al.
Summary: This study demonstrates a new mechanism where CRL4(CUL4A/DDB1) manipulates ovarian cancer cell chemoresistance by regulating mitochondrial dynamics and mitophagy, providing novel insights into potential therapeutic strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Yuwei Chen et al.
Summary: In the development of ovarian cancer, the long non-coding RNA HOXA11-AS plays an important role by regulating autophagy. HOXA11-AS is expressed at higher levels in ovarian cancer cells compared to normal cells, and even higher in cisplatin-resistant cells. Knockdown of HOXA11-AS inhibits cell viability, migration, and invasion while promoting apoptosis. Additionally, HOXA11-AS knockdown increases cellular autophagy.
Article
Biotechnology & Applied Microbiology
Yi Cai et al.
Summary: MiR-30a mediates cisplatin resistance in ovarian cancer by inhibiting autophagy via the TGF-beta/Smad4 pathway. Overexpression of miR-30a reduces the expression of Smad4 and TGF-beta, inhibits DDP-induced autophagy, and promotes apoptosis in DDP-resistant cells.
Review
Biochemistry & Molecular Biology
Wei-Yi Zhou et al.
Review
Oncology
Jiao Li et al.
Article
Biotechnology & Applied Microbiology
Wei Wang et al.
ONCOTARGETS AND THERAPY
(2019)
Review
Oncology
Ashwin Chandra et al.
Review
Obstetrics & Gynecology
N. Spears et al.
HUMAN REPRODUCTION UPDATE
(2019)
Review
Oncology
Belinda van Zyl et al.
ENDOCRINE-RELATED CANCER
(2018)
Review
Pharmacology & Pharmacy
Rachel M. McQuade et al.
PHARMACOLOGICAL RESEARCH
(2018)
Review
Pharmacology & Pharmacy
Lauren Amable
PHARMACOLOGICAL RESEARCH
(2016)
Article
Oncology
William E. Winter et al.
JOURNAL OF CLINICAL ONCOLOGY
(2008)
Review
Cell Biology
N Mizushima et al.
CELL STRUCTURE AND FUNCTION
(2002)
