Functionalized europium-doped hollow mesoporous silica nanospheres as a cell imaging and drug delivery agents

In an effort to enhance the antitumor efficacy of breast cancer treatment, the chemotherapeutic agent Paclitaxel (PTX) was encapsulated within hyaluronic acid (HA) modified hollow mesoporous silica (HMSNs). In vitro drug release assays showed that the resulting formulation, Eu-HMSNs-HA-PTX, exhibited enzyme-responsive drug release. In addition, cell cytotoxicity and hemolysis assays demon-strated the favorable biocompatibility of both Eu-HMSNs and Eu-HMSNs-HA. Notably, compared to Eu-HMSNs alone, Eu-HMSNs-HA showed enhanced accumulation within CD44-expressing cancer cells (MDA-MB-231). As anticipated, apoptosis experiments indicated that Eu-HMSNs-HA-PTX displayed significantly greater cytotoxicity toward MDA-MB-231 cells than non-targeted Eu-HMSNs-PTX and free PTX. In conclusion, Eu-HMSNs-HA-PTX demonstrated excellent anticancer effects and holds promise as a potent candidate for the efficient therapy of breast cancer. & COPY; 2023 Elsevier Inc. All rights reserved.

Automated summary

In order to improve the efficacy of breast cancer treatment, Paclitaxel was encapsulated in hyaluronic acid modified hollow mesoporous silica. The resulting formulation exhibited enzyme-responsive drug release and showed enhanced accumulation within cancer cells. It also demonstrated significantly greater cytotoxicity and holds promise as a potent candidate for breast cancer therapy.