4.6 Article

IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Haichuan Peng et al.

Summary: Secondary spinal cord injury (SSCI) is the subsequent stage of spinal cord injury (SCI) that involves various physiological processes. Hydrogels have emerged as a promising delivery system for bioactive additives in the treatment of SSCI. In this review, the current state and functional modifications of hydrogel delivery systems for SSCI therapy are discussed comprehensively.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

Article Biochemistry & Molecular Biology

Delayed inhibition of collagen deposition by targeting bone morphogenetic protein 1 promotes recovery after spinal cord injury

Yifan Huang et al.

Summary: Fibrotic scars composed of fibroblasts and excess extra-cellular matrix (ECM) are observed after spinal cord injury (SCI). The role of collagen and ECM in SCI is not fully understood. This study found elevated levels of procollagen type I C-terminal propeptide (PICP) and bone morphogenetic protein 1 (BMP1) in the cerebrospinal fluid of SCI patients, which were associated with spinal cord compression and neurological symptoms. Inhibition of BMP1 at the subacute stage improved nerve function, suggesting it as a potential target for scar reduction.

MATRIX BIOLOGY (2023)

Review Cell Biology

Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration

Tanner Clifford et al.

Summary: Spinal cord injury (SCI) leads to permanent and degenerating damage to the central nervous system (CNS). The formation of glial scar plays a role in segregating neural lesion and protecting surrounding healthy tissue, but it also inhibits regeneration. Therapeutic strategies have been developed to overcome the negative effects, including scar prevention, scar resolution, cell transplantation, and cell reprogramming. This review focuses on the molecular and cellular aspects of glial scar formation and discusses the advantages and disadvantages of different regeneration-promoting strategies after SCI.
Article Biophysics

Improved functional recovery of rat transected spinal cord by peptide-grafted PNIPAM based hydrogel

Yunhui Chai et al.

Summary: In this study, a temperature-sensitive hydrogel scaffold grafted with IKVAV peptide was used to treat spinal cord injury. Results showed that the peptide hydrogel scaffold exhibited good biological activity, promoted angiogenesis, and inhibited the formation of glial scar tissue.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

Article Chemistry, Physical

Biochemical functionalization of graphene oxide for directing stem cell differentiation

Andrea F. Verre et al.

Summary: Graphene scaffolds have been chemically functionalized to direct stem cell differentiation for potential therapeutic applications in peripheral nerve injuries. Functionalized GO substrates, particularly IKVAV, are more effective in guiding stem cell differentiation towards neuroglial phenotypes compared to standard glass, showing increased neuronal attachment and neurite growth.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Materials Science, Biomaterials

The hydrogels based on peptide/collagen as potential multifunctional materials for soft tissue filling and inhibition of tumor growth

Xian Li et al.

Summary: The study designed injectable peptide hydrogels by crosslinking peptides and HA with BDDE, incorporating ACBP, PB, FBC, and BBC for evaluation. The peptide hydrogels demonstrated anti-inflammatory and anti-biodegradation properties, with the ACBP-fabricated hydrogel potentially inhibiting tumor growth in vivo.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2022)

Article Neurosciences

Ethamsylate Attenuates Mutilated Secondary Pathogenesis and Exhibits a Neuroprotective Role in Experimental Model of Spinal Cord Injury

Sonam Dolma et al.

Summary: The secondary pathogenesis in spinal cord injury involves inflammation, lesion formation, and fibrotic scar formation, which hinder axonal regeneration and cause motor impairment. Injury-induced blood spinal cord barrier rupture leads to the release of inflammatory factors and activation of signaling pathways, resulting in excessive fibroblast proliferation and collagen deposition. Ethamsylate, an anti-hemorrhagic drug, may reduce neuronal apoptosis, maintain blood spinal cord barrier integrity, and decrease secondary damage severity, thus demonstrating a neuroprotective role in SCI.

NEUROSCIENCE (2022)

Review Public, Environmental & Occupational Health

Epidemiology of Traumatic Spinal Cord Injury in Developing Countries from 2009 to 2020: A Systematic Review and Meta-Analysis

Ali Golestani et al.

Summary: This study updated a systematic review and meta-analysis of traumatic spinal cord injury (TSCI) in developing countries. The results showed that TSCI is more common in young adults and males, and the main causes are motor vehicle crashes and falls. These findings can inform the development of cost-effective preventive strategies to reduce the incidence and burden of TSCI.

NEUROEPIDEMIOLOGY (2022)

Review Cell Biology

Cell-3D matrix interactions: recent advances and opportunities

Kenneth M. Yamada et al.

Summary: Cell-ECM interactions are essential in development, diseases, and tissue remodeling. Recent advances in research have provided detailed descriptions of ECM molecules, identified distinct modes of cell migration in different ECM environments, and offered new insights into organ formation mechanisms. The dynamic nature of these interactions and the feedback loops involved can contribute to disease progression.

TRENDS IN CELL BIOLOGY (2022)

Article Neurosciences

Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway

Zhengxin Jin et al.

Summary: This study investigated the effect of apigenin on fibrous scar formation after spinal cord injury (SCI) in mice. Results showed that apigenin inhibited fibrous scar formation and promoted motor function recovery. It achieved this by reducing the expression of fibrosis-related factors through the TGF beta/SMADs signaling pathway.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

Review Cell Biology

Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation

Maryam Ayazi et al.

Summary: Reviewed the formation of fibrotic scars in central nervous system trauma and their unique characteristics, and discussed therapeutic targets that may enhance CNS regeneration.
Article Materials Science, Biomaterials

An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing

Tianqi Feng et al.

Summary: This study developed a multi-functional wound dressing based on a thermosensitive hydrogel, which has rapid sol-gel transition, the capacity to fill irregular wounds, good biocompatibility, and antibacterial properties. The experimental results showed that this dressing accelerates wound healing by promoting epithelialization, angiogenesis, and collagen fiber generation.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Biotechnology & Applied Microbiology

Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress

Jiarui Han et al.

Summary: The study found that Ginkgo biloba extract EGB761 can improve renal function, reduce tubular injury, and ameliorate ECM accumulation and EMT in DKD kidney tubules, and the mechanism may be related to the inhibition of ERS.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Chemistry, Multidisciplinary

Collagen Film Activation with Nanoscale IKVAV-Capped Dendrimers for Selective Neural Cell Response

Jessica J. Kim et al.

Summary: The study suggests that incorporating dendrimers with IKVAV motifs onto collagen films can promote rat Schwann cell growth and inhibit human dermal fibroblast proliferation. Pre-crosslinked collagen films can direct specific cellular responses, while post-crosslinked films do not have the same effect.

NANOMATERIALS (2021)

Article Materials Science, Biomaterials

Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment

Yixia Yin et al.

Summary: The development of a novel neural stem cell scaffold material has shown promising results in supporting the growth and differentiation of neural stem cells, offering a new potential avenue for spinal cord injury repair.

BIOMATERIALS SCIENCE (2021)

Review Immunology

Transforming growth factor-beta in tissue fibrosis

Nikolaos G. Frangogiannis

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Cell Biology

Mechanisms, regulation and functions of the unfolded protein response

Claudio Hetz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

TGF-β1 Activates Nasal Fibroblasts through the Induction of Endoplasmic Reticulum Stress

Jae-Min Shin et al.

BIOMOLECULES (2020)

Article Materials Science, Biomaterials

Enhanced proliferation and differentiation of neural stem cells by peptide-containing temperature-sensitive hydrogel scaffold

Yanpiao Long et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Materials Science, Biomaterials

A novel poly-ε-lysine based implant, Proliferate®, for promotion of CNS repair following spinal cord injury

Sara Hosseinzadeh et al.

BIOMATERIALS SCIENCE (2020)

Review Clinical Neurology

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

Arsalan Alizadeh et al.

FRONTIERS IN NEUROLOGY (2019)

Article Physiology

Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

Saeid Ghavami et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

David Oliveira Dias et al.

Review Biochemistry & Molecular Biology

Fibrotic scarring following lesions to the central nervous system

David Oliveira Dias et al.

MATRIX BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Dl-3-n-butylphthalide prevents the disruption of blood-spinal cord barrier via inhibiting endoplasmic reticulum stress following spinal cord injury

Binbin Zheng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Medicine, Research & Experimental

Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing

Femke Heindryckx et al.

EMBO MOLECULAR MEDICINE (2016)

Article Multidisciplinary Sciences

Astrocyte scar formation aids central nervous system axon regeneration

Mark A. Anderson et al.

NATURE (2016)

Review Pharmacology & Pharmacy

Polyethylene glycol (PEG)-Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications

Amit Alexander et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)