Alterations in regional homogeneity and functional connectivity in the cerebellum of patients with sporadic amyotrophic lateral sclerosis

Article Neurosciences

Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis

Qianwen Li et al.

Summary: The study found that the local activity and network functional connectivity in the PSMA region can explain disease severity differently in fast and slow progression groups of ALS patients.

HUMAN BRAIN MAPPING (2022)

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Review Cell Biology

Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration

Rangariroyashe H. Chipika et al.

Summary: Amyotrophic lateral sclerosis is a multi-system disease characterized by degeneration of upper and lower motor neurons. Recent studies have shown that cerebellar pathology also plays a role in the disease. However, most research has focused on supratentorial disease, and there is a lack of post-mortem validation. Clinical symptoms of amyotrophic lateral sclerosis, such as dysarthria, dysphagia, cognitive and behavioral deficits, saccade abnormalities, gait impairment, respiratory weakness and pseudobulbar affect may be exacerbated by co-existing cerebellar pathology.

NEURAL REGENERATION RESEARCH (2022)

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Article Neuroimaging

Dynamic alterations of spontaneous neural activity in patients with amyotrophic lateral sclerosis

Xujing Ma et al.

Summary: ALS is a multi-system disease characterized by movement disorder. Studies on ALS using static neuroimaging indexes have shown inconsistent results, but recent research suggests that intrinsic brain activity is time-varying. In this study, ALS patients exhibited altered dynamics in intrinsic brain activity compared to healthy controls, indicating the potential use of such changes as a biomarker for diagnosing ALS.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Neural Correlates of Motor Imagery of Gait in Amyotrophic Lateral Sclerosis

Malek Abidi et al.

Summary: This study aimed to assess gait-specific cognitive networks and functional adaptation in ALS patients, with results showing increased imagery time during imagined gait in UMNp patients, along with altered brain activation patterns.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2021)

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Article Clinical Neurology

The protective impact of education on brain structure and function in Alzheimer's disease

Wanqiu Zhu et al.

Summary: The study found a negative correlation between education years and brain structure and function in AD patients, particularly in the early stages of the disease.

BMC NEUROLOGY (2021)

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Article Neurosciences

The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual

Aihuiping Xue et al.

Summary: This study used functional connectivity MRI to examine the cerebellum of two intensively sampled individuals, revealing connections between different regions and a hierarchical organization within the cerebellum. The research showed the importance of the cerebellum in processing somatomotor and visual information, as well as its role in higher-order cognitive functions, with each individual displaying unique organizational features.

JOURNAL OF NEUROPHYSIOLOGY (2021)

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Article Geriatrics & Gerontology

Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson's Disease

Xia Deng et al.

Summary: This study explored the potential damaged pathogenesis of other brain regions associated with the multiple and complex clinical symptoms of mid-stage sporadic Parkinson's disease (sPD) through magnetic resonance imaging (MRI). Results showed significant alteration of cortical structural connectivity in multiple brain regions at the mid-stage of sPD, suggesting that extensive alteration of cortical structural connectivity may be one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Neurosciences

Cognitive Profiles of Amyotrophic Lateral Sclerosis Differ in Resting-State Functional Connectivity: An fMRI Study

Anna G. M. Temp et al.

Summary: This study found that resting-state functional connectivity differs between ALS patients with different cognitive profiles, and is directly associated with clinical presentation, particularly with motor function and cognitive shifting.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Neuroimaging

Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study

Robert L. Barry et al.

Summary: The study identified disruptions in functional connectivity in ALS patients at cerebellar lobule VI, a transition zone between anterior motor networks and posterior non-motor networks in the cerebellum, which is associated with complex motor and cognitive processing tasks. This observation adds to the growing body of research implicating the cerebellum in ALS, and suggests potential for leveraging high-resolution imaging to visualize differences in functional connectivity disturbances in various genotypes and phenotypes along the ALS-frontotemporal dementia spectrum.

NEUROIMAGE-CLINICAL (2021)

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Article Clinical Neurology

Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes

M. Abidi et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Current concepts of cross-sectional and functional anatomy of the cerebellum: a pictorial review and atlas

Vance T. Lehman et al.

BRITISH JOURNAL OF RADIOLOGY (2020)

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Article Anatomy & Morphology

Anatomy and White Matter Connections of the Superior Frontal Gyrus

Robert G. Briggs et al.

CLINICAL ANATOMY (2020)

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Article Neurosciences

Patterns of brain regional functional coherence in cognitive impaired ALS

Tao Hu et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2020)

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Article Clinical Neurology

Structural and functional brain connectome in motor neuron diseases A multicenter MRI study

Silvia Basaia et al.

NEUROLOGY (2020)

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Article Neuroimaging

Involvement of the dentate nucleus in the pathophysiology of amyotrophic lateral sclerosis: A multi-center and multi-modal neuroimaging study

Komal Bharti et al.

NEUROIMAGE-CLINICAL (2020)

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Article Neuroimaging

Progression of brain functional connectivity and frontal cognitive dysfunction in ALS

Veronica Castelnovo et al.

NEUROIMAGE-CLINICAL (2020)

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Article Neurosciences

Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis

Ting Qiu et al.

HUMAN BRAIN MAPPING (2019)

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Review Clinical Neurology

Imaging in amyotrophic lateral sclerosis: MRI and PET

Jan Kassubek et al.

CURRENT OPINION IN NEUROLOGY (2019)

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Article Medicine, General & Internal

Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement

Aya Ogura et al.

EBIOMEDICINE (2019)

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Article Neurosciences

Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

Ana Paula Arantes Bueno et al.

BRAIN CONNECTIVITY (2019)

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Article Clinical Neurology

Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration

Peter Bede et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2018)

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Article Neuroimaging

Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis

Foteini Christidi et al.

BRAIN IMAGING AND BEHAVIOR (2018)

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Article Neurosciences

White Matter Structural Network Abnormalities Underlie Executive Dysfunction in Amyotrophic Lateral Sclerosis

Dennis Dimond et al.

HUMAN BRAIN MAPPING (2017)

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Review Clinical Neurology

Cerebellar atrophy in neurodegeneration-a meta-analysis

Helena M. Gellersen et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

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Article Geriatrics & Gerontology

Frequency-Specific Abnormalities of Intrinsic Functional Connectivity Strength among Patients with Amyotrophic Lateral Sclerosis: A Resting-State fMRI Study

Fangjun Li et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis

M-S. Buhour et al.

EJNMMI RESEARCH (2017)

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Article Clinical Neurology

18F-FDG-PET correlates of cognitive impairment in ALS

Antonio Canosa et al.

NEUROLOGY (2016)

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Article Clinical Neurology

Cerebellar atrophy in Parkinson's disease and its implication for network connectivity

Claire O'Callaghan et al.

BRAIN (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Abnormal regional homogeneity in Parkinson's disease: a resting state fMRI study

Y. Li et al.

CLINICAL RADIOLOGY (2016)

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Letter Clinical Neurology

Patterns of cerebral and cerebellar white matter degeneration in ALS

P. Bede et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2015)

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Review Clinical Neurology

Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

Adriano Chio et al.

LANCET NEUROLOGY (2014)

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Review Clinical Neurology

The phenotypic variability of amyotrophic lateral sclerosis

Bart Swinnen et al.

NATURE REVIEWS NEUROLOGY (2014)

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Review Clinical Neurology

The involvement of the cerebellum in amyotrophic lateral sclerosis

Tino Prell et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)

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Article Clinical Neurology

Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion

Johannes Brettschneider et al.

ACTA NEUROPATHOLOGICA (2012)

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Article Neurosciences

Functional topography of the cerebellum for motor and cognitive tasks: An fMRI study

Catherine J. Stoodley et al.

NEUROIMAGE (2012)

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Article Neurosciences

Sensorimotor Functional Connectivity Changes in Amyotrophic Lateral Sclerosis

F. Agosta et al.

CEREBRAL CORTEX (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis

Takashi Yoshiura et al.

EUROPEAN RADIOLOGY (2011)

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Article Neurosciences

Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity

Jill X. O'Reilly et al.

CEREBRAL CORTEX (2010)

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Article Neurosciences

Distinct Cerebellar Contributions to Intrinsic Connectivity Networks

Christophe Habas et al.

JOURNAL OF NEUROSCIENCE (2009)

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Article Clinical Neurology

Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis

Felix Geser et al.

ARCHIVES OF NEUROLOGY (2008)

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Article Psychiatry

The cerebellum in mild cognitive impairment and Alzheimer's disease - A structural MRI study

Philipp A. Thomann et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2008)

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Article Clinical Neurology

An autopsy case of frontotemporal dementia with severe dysarthria and motor neuron disease showing numerous basophilic inclusions

Kenji Ishihara et al.

NEUROPATHOLOGY (2006)

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Article Neurosciences

Regional homogeneity approach to fMRI data analysis

YF Zang et al.

NEUROIMAGE (2004)

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Article Clinical Neurology

El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

BR Brooks et al.

AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2000)

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Alterations in regional homogeneity and functional connectivity in the cerebellum of patients with sporadic amyotrophic lateral sclerosis

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