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Article
Biochemistry & Molecular Biology
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy
Namrita Kaur et al.
Summary: Cells use noncanonical autophagy, called CASM, to label damaged intracellular compartments with ATG8 family proteins to signal danger. TECPR1-containing E3 complexes are key mediators of CASM activated by various drugs. TECPR1 retains E3 activity when ATG16L1 CASM activity is obstructed by SopF and is activated by damage-induced SM exposure.
EMBO JOURNAL (2023)
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