期刊
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
卷 247, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.autneu.2023.103094
关键词
Pos acute sequelae of SARS-CoV2; Long-COVID-19; Orthostatic hypertension; Neurogenic hypertension
This study investigated the effect of COVID-19 on blood pressure during the orthostatic challenge after recovery. It found that about one-third of PASC patients had abnormal blood pressure responses during the challenge, which supports the hypothesis of neurogenic hypertension as a phenotype.
Objective:Post-acute sequelae of SARS-COV-2 (PASC) are emerging as a major health challenge. Orthostatic intolerance secondary to autonomic failure has been found in PASC patients. This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge. Research design and methods:Thirty-one out of 45 patients hospitalized due to COVID-19-related pneumonia that developed PASC and did not have hypertension at discharge were studied. They underwent a head-up tilt test (HUTT) at 10.8 & PLUSMN; 1.9 months from discharge. All met the PASC clinical criteria, and an alternative diagnosis did not explain the symptoms. This population was compared with 32 historical asymptomatic healthy controls. Results:Exaggerated orthostatic blood pressure response (EOPR)/orthostatic hypertension (OHT) was detected in 8 out of 23 (34.7 %) patients, representing a significantly increased prevalence (7.67-fold increase p = 0.009) compared to 2 out of 32 (6.4 %) asymptomatic healthy controls matched by age, who underwent HUTT and were not infected with SARS-CoV-2. Conclusions:This prospective evaluation in patients with PASC revealed abnormal blood pressure rise during the orthostatic challenge, suggesting of autonomic dysfunction in a third of the studied subjects. Our findings support the hypothesis that EOPR/OHT may be a phenotype of neurogenic hypertension. Hypertension in PASC patients may adversely affect the cardiovascular burden in the world.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据