期刊
MEDICAL MYCOLOGY
卷 54, 期 7, 页码 677-683出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myw020
关键词
Histoplasmosis; Children; Diagnosis
资金
- Strategy for Sustainability for Research Groups, University of Antioquia (CODI), Medellin, Colombia
Histoplasmosis is an importantmycosis in the Americas; and in children with no immune system abnormalities, histoplasmosis is typically a self-limited process. In contrast, in children with immune problems, disease manifestations are frequently more severe and include dissemination. From 1984 to 2010, a retrospective study of paediatric patients who had been diagnosed with histoplasmosiswas performed. A total of 45 pediatric cases of histoplasmosis were identified. The most important risk factor wasmalnutrition (37%), followed by environmental exposure (33%). The patients exhibited pulmonary infiltrates (83%), fever (76%), cough, constitutional symptoms (38%), headache (35%), and lymph node hypertrophy (33%). Concerning the clinical forms, 64% of the patients presented with the progressive disseminated form that frequently affected the central nervous system (48%). Diagnostic laboratory tests indicated that the cultures were positive for 80% of the patients, the agar gel immunodiffusion was reactive in 95%, the M band of the precipitate was more commonly observed (81%), and the complement fixation tests were reactive in 88% of the patients. The timely diagnosis of histoplasmosis is important, and for this reason, it is hoped that the results of this study will lead pediatricians toward a better understanding of this mycosis in children.
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