期刊
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
卷 205, 期 4, 页码 321-332出版社
SPRINGER
DOI: 10.1007/s00430-016-0449-y
关键词
Sex difference; Immune response; NKT cells; Human; alpha GalCer; Entamoeba histolytica; Cytokines; Glycolipid
资金
- Collaborative Research Center, Bonn, Germany [841]
- Bernhard Nocht Institute for Tropical Medicine
- Werner-Otto Stiftung
- Vereinigung der Freunde des Tropeninstituts Hamburg, E.V., Hamburg, Germany
Sex-related variations in natural killer T (NKT) cells may influence immunoregulation and outcome of infectious and autoimmune diseases. We analyzed sex-specific differences in peripheral blood NKTs and peripheral blood mononuclear cells (PBMCs) from men and women and determined the frequencies of NKT cells and their subpopulations [CD4(+); CD8(+); double negative (DN)] and the levels of cytokine production following stimulation with the NKT cell ligands alpha-Galactosylceramide (alpha GalCer) and Entamoeba histolytica lipopeptidephosphoglycan (Lotter et al. in PLoS Pathog 5(5):e1000434, 2009). Total and DN NKT cells were more abundant in women than in men. In women, alpha GalCer induced higher production of intracellular IFN gamma, IL-4, IL-17 and TNF by CD4(+) and DN+NKT cells. Both ligands induced expression of multiple cytokines in PBMCs and influenced the ratio of NKT cell subpopulations during long-term culture. Although the sex-specific differences in frequencies of NKT cells and their subpopulations were marginal, the significant sex-specific differences in cytokine production might influence disease outcomes.
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