Organic Catalytic Activity as a Method for Agnostic Life Detection

Article Multidisciplinary Sciences

Design of a minimal di-nickel hydrogenase peptide

Jennifer Timm et al.

Summary: A 13-amino acid nickel-binding peptide has been designed to produce molecular hydrogen from protons under various conditions. This suggests that modern enzymes may have evolved from simple peptide precursors on early Earth.

SCIENCE ADVANCES (2023)

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Review Biochemistry & Molecular Biology

A material-based panspermia hypothesis: The potential of polymer gels and membraneless droplets

Mahendran Sithamparam et al.

Summary: The Panspermia hypothesis suggests that life's building blocks or life itself may have been transferred between planets, facilitating the origins of life. It is uncertain whether organisms can effectively seed a new planet through interplanetary transfer, thus, using abiotic chemicals as seeds, known as molecular Panspermia, has been proposed. In this study, a theoretical concept called polymeric material-based Panspermia seed (M-BPS) is introduced and reviewed, with polymeric gels as a potential example, to explore the plausibility of chemical evolution leading to the origin of life events on foreign planets.

BIOPOLYMERS (2022)

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Article Astronomy & Astrophysics

Urability: A Property of Planetary Bodies That Can Support an Origin of Life

David Deamer et al.

Summary: This article introduces the concept of "urability," which refers to the conditions that allow the origin of life, rather than the habitable environments for existing life. The author tests the utility of this concept by applying it to combinations of geophysical and geochemical factors that might support localized zones conducive to the origin of life.

ASTROBIOLOGY (2022)

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Review Astronomy & Astrophysics

In situ organic biosignature detection techniques for space applications

Victor Abrahamsson et al.

Summary: This review article provides an overview of the instrument techniques used in the search for life on Mars and Ocean Worlds, as well as the ongoing developments in these techniques and ion mobility spectrometry. It also reviews the current developments in next-generation instruments for organic biosignature detection, such as capillary electrophoresis, liquid chromatography, biosensors, and nanopore sensing.

FRONTIERS IN ASTRONOMY AND SPACE SCIENCES (2022)

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Review Astronomy & Astrophysics

Comparative study of methods for detecting extraterrestrial life in exploration mission of Mars and the solar system

Keigo Enya et al.

Summary: The detection and analysis of extraterrestrial life are important issues in space science. This paper presents a comparative study of methods for detecting extraterrestrial life and emphasizes the importance of using a combination of complementary methods.

LIFE SCIENCES IN SPACE RESEARCH (2022)

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Article Geochemistry & Geophysics

Sulfides and hollows formed on Mercury's surface by reactions with reducing S-rich gases

C. J. Renggli et al.

Summary: The surface of Mercury is enriched in sulfur, and novel experiments suggest that the reaction of Mercury composition glasses with reduced S-rich gas forms sulfides, explaining the formation of hollows on Mercury. The BepiColombo mission will test this hypothesis.

EARTH AND PLANETARY SCIENCE LETTERS (2022)

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Article Astronomy & Astrophysics

Biomarkers in the Atacama Desert along the moisture gradient and the depth in the hyperarid zone: Phosphatase activity as trace of microbial activity

Kensei Kobayashi et al.

Summary: Microbiological activities in extreme environments on Earth suggest the possibility of hosting life in extraterrestrial environments like Mars. Phosphatase activity was evaluated as a potential biomarker to assess biological activities in extreme environments, using soils from the Atacama Desert as a study model. The study found a positive correlation between phosphatase activity and amino acid concentration and colony-forming units, while it was negatively correlated with precipitation amount. Phosphatase activity could be a reliable indicator for evaluating biological activities in extreme environments.

INTERNATIONAL JOURNAL OF ASTROBIOLOGY (2022)

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Article Astronomy & Astrophysics

A Short History of Panspermia from Antiquity Through the Mid-1970s

Simon Mitton

Summary: Panspermia is a philosophical proposition that suggests life's precursors exist in space and can initiate life when reaching a suitable environment. Over the past century, it has evolved into a testable and observable science, intertwining with the plurality of worlds, origin of life, and theory of evolution.

ASTROBIOLOGY (2022)

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Article Astronomy & Astrophysics

Picogram-Scale Interstellar Probes via Bioinspired Engineering

George Church

Summary: For exploring nearby stars, the challenges of a picogram- to nanogram-scale probe landing, replicating, and producing a communications module based on biominerals at the destination are considered. A billion such probes could be launched for a similar cost as a single gram-scale probe.

ASTROBIOLOGY (2022)

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Article Astronomy & Astrophysics

Science Goals and Mission Architecture of the Europa Lander Mission Concept

K. P. Hand et al.

Summary: Europa is a significant target for planetary science and astrobiology, as well as comparative oceanography. The potential habitable subsurface ocean and thin ice shell of Europa may contain signs of life and offer opportunities to study various mechanisms and compositions. This article details the goals and architecture of the Europa Lander mission concept, developed from 2015 through 2020.

PLANETARY SCIENCE JOURNAL (2022)

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Article Astronomy & Astrophysics

Phosphine gas in the cloud decks of Venus

Jane S. Greaves et al.

Summary: Measurements of phosphine gas in Venus's atmosphere have been reported, with the presence of the gas currently unexplained. Possible origins include unknown photochemical or geochemical processes, or even the presence of life, resembling the biological production of phosphine on Earth. Further research is needed to investigate the sources and nature of this gas on Venus.

NATURE ASTRONOMY (2021)

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Review Astronomy & Astrophysics

Planetary Mass Spectrometry for Agnostic Life Detection in the Solar System

Luoth Chou et al.

Summary: For the past fifty years, mass spectrometry has provided insights on planetary characteristics during space exploration, deepening our understanding of exploration targets and enabling sensitive detection of chemical biosignatures. The continuing exploration of Mars, Europa, Enceladus, Titan, and Venus involves assessing habitability and searching for life, which can be advanced by mass spectrometry. Future missions can help ensure search strategies are inclusive of unfamiliar life forms by examining extraterrestrial biosignatures and utilizing agnostic approaches in astrobiology.

FRONTIERS IN ASTRONOMY AND SPACE SCIENCES (2021)

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Review Astronomy & Astrophysics

Critical review of chirality indicators of extraterrestrial life

David Avnir

Summary: This review analyzes the strengths, limits, and potential weaknesses of relying on chirality and homochirality as biomarkers, along with practical recommendations on how to use them effectively.

NEW ASTRONOMY REVIEWS (2021)

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Article Astronomy & Astrophysics

Science Goals and Objectives for the Dragonfly Titan Rotorcraft Relocatable Lander

Jason W. Barnes et al.

Summary: NASA's Dragonfly mission will send a rotorcraft lander to Titan in the mid-2030s to investigate prebiotic chemistry, habitability, and potential biosignatures from water-based and hydrocarbon-based life forms. The mission aims to sample organic sediments and water ice in Titan's equatorial dunes, ultimately targeting the Selk Crater for signs of mixed liquid water and surface organics. Dragonfly will also study Titan's tropical deserts' role in the global methane cycle and search for chemical biosignatures indicative of past or current biological processes, making it the first NASA mission since the 1976 Viking landers to explicitly incorporate the search for signs of life into its mission goals.

PLANETARY SCIENCE JOURNAL (2021)

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Review Chemistry, Multidisciplinary

The Search for Chiral Asymmetry as a Potential Biosignature in our Solar System

Daniel P. Glavin et al.

CHEMICAL REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Temperature, Dynamics, and Enzyme-Catalyzed Reaction Rates

Vickery L. Arcus et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 49, 2020 (2020)

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Editorial Material Chemistry, Physical

Nano-Apples and Orange-Zymes

Susannah Scott et al.

ACS CATALYSIS (2020)

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Review Chemistry, Multidisciplinary

The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides

Travis Walton et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Astronomy & Astrophysics

Hydrogen sensing in Titan's atmosphere: Motivations and techniques

Ralph D. Lorenz et al.

PLANETARY AND SPACE SCIENCE (2019)

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Article Geosciences, Multidisciplinary

The Rise of A Habitable Planet: Four Required Conditions for the Origin of Life in the Universe

Vladimir Kompanichenko

GEOSCIENCES (2019)

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Article Biochemistry & Molecular Biology

Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites

Antonio J. M. Ribeiro et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Astronomy & Astrophysics

Fingerprinting Non-Terran Biosignatures

Sarah S. Johnson et al.

ASTROBIOLOGY (2018)

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Article Astronomy & Astrophysics

The Ladder of Life Detection

Marc Neveu et al.

ASTROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Disequilibrium biosignatures over Earth history and implications for detecting exoplanet life

Joshua Krissansen-Totton et al.

SCIENCE ADVANCES (2018)

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Article Astronomy & Astrophysics

Functional Properties of Amino Acid Side Chains as Biomarkers of Extraterrestrial Life

Christos D. Georgiou

ASTROBIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Quantifying enzyme activity in living cells

Agnes Zotter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Multidisciplinary Sciences

A probabilistic framework for identifying biosignatures using Pathway Complexity

Stuart M. Marshall et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2017)

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Article Astronomy & Astrophysics

Detecting Darwinism from Molecules in the Enceladus Plumes, Jupiter's Moons, and Other Planetary Water Lagoons

Steven A. Benner

ASTROBIOLOGY (2017)

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Article Astronomy & Astrophysics

Habitability on Early Mars and the Search for Biosignatures with the ExoMars Rover

Jorge L. Vago et al.

ASTROBIOLOGY (2017)

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Article Astronomy & Astrophysics

The Mars Organic Molecule Analyzer (MOMA) Instrument: Characterization of Organic Material in Martian Sediments

Fred Goesmann et al.

ASTROBIOLOGY (2017)

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Article Astronomy & Astrophysics

Radiation-Driven Formation of Reactive Oxygen Species in Oxychlorine-Containing Mars Surface Analogues

Christos D. Georgiou et al.

ASTROBIOLOGY (2017)

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Article Astronomy & Astrophysics

Alien Mindscapes-A Perspective on the Search for Extraterrestrial Intelligence

Nathalie A. Cabrol

ASTROBIOLOGY (2016)

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Review Chemistry, Analytical

Chromatographic methods for the isolation, separation and characterisation of dissolved organic matter

Sara Sandron et al.

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2015)

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Article Astronomy & Astrophysics

Lipids as Universal Biomarkers of Extraterrestrial Life

Christos D. Georgiou et al.

ASTROBIOLOGY (2014)

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Article Chemistry, Multidisciplinary

An intercomparison of three methods for the large-scale isolation of oceanic dissolved organic matter

Nelson W. Green et al.

MARINE CHEMISTRY (2014)

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Article Astronomy & Astrophysics

The Icebreaker Life Mission to Mars: A Search for Biomolecular Evidence for Life

Christopher P. McKay et al.

ASTROBIOLOGY (2013)

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Article Astronomy & Astrophysics

Perchlorate Radiolysis on Mars and the Origin of Martian Soil Reactivity

Richard C. Quinn et al.

ASTROBIOLOGY (2013)

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Article Biochemistry & Molecular Biology

What is the total number of protein molecules per cell volume? A call to rethink some published values

Ron Milo

BIOESSAYS (2013)

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Article Biochemistry & Molecular Biology

Escherichia coli achieves faster growth by increasing catalytic and translation rates of proteins

Kaspar Valgepea et al.

MOLECULAR BIOSYSTEMS (2013)

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Article Geochemistry & Geophysics

Evidence for perchlorates and the origin of chlorinated hydrocarbons detected by SAM at the Rocknest aeolian deposit in Gale Crater

Daniel P. Glavin et al.

JOURNAL OF GEOPHYSICAL RESEARCH-PLANETS (2013)

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Review Chemistry, Multidisciplinary

Prebiotic-like chemistry on Titan

Francois Raulin et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Article Biochemistry & Molecular Biology

Analyses of trace metals, peptide ligands of trace metals and mercury speciation in home prepared bread

Oto Mestek et al.

CHEMICAL SPECIATION AND BIOAVAILABILITY (2012)

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Article Astronomy & Astrophysics

Influence of methane concentration on the optical indices of Titan's aerosols analogues

A. Mahjoub et al.

ICARUS (2012)

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Article Multidisciplinary Sciences

The search for life in our Solar System and the implications for science and society

Christopher P. Mckay

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2011)

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Review Biotechnology & Applied Microbiology

Measuring enzyme activity in single cells

Michelle L. Kovarik et al.

TRENDS IN BIOTECHNOLOGY (2011)

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Article Astronomy & Astrophysics

Defining Life

Steven A. Benner

ASTROBIOLOGY (2010)

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Article Biology

Homochirality in Life: Two Equal Runners, One Tripped

Mark M. Green et al.

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES (2010)

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Article Biochemistry & Molecular Biology

Generalized rate equation for single-substrate enzyme catalyzed reactions

Fikret Kargi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

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Article Multidisciplinary Sciences

Detection of Perchlorate and the Soluble Chemistry of Martian Soil at the Phoenix Lander Site

M. H. Hecht et al.

SCIENCE (2009)

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Article Multidisciplinary Sciences

Substrate arrays for fluorescence-based enzyme fingerprinting and high-throughput screening

Jean-Louis Reymond

FLUORESCENCE METHODS AND APPLICATIONS: SPECTROSCOPY, IMAGING, AND PROBES (2008)

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Article Chemistry, Applied

TAC-Scaffolded Tripeptides as Artificial Hydrolytic Receptors: A Combinatorial Approach Toward Esterase Mimics

H. Bauke Albada et al.

JOURNAL OF COMBINATORIAL CHEMISTRY (2008)

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Article Biochemical Research Methods

Enzyme assay and activity fingerprinting of hydrolases with the red-chromogenic adrenaline test

Viviana S. Fluxa et al.

NATURE PROTOCOLS (2008)

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Article Multidisciplinary Sciences

Prevolutionary dynamics and the origin of evolution

Martin A. Nowak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Optics

Single-molecule detection sensitivity using planar integrated optics on a chip

Dongliang Yin et al.

OPTICS LETTERS (2006)

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Article Chemistry, Analytical

Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays

Dino Di Carlo et al.

ANALYTICAL CHEMISTRY (2006)

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Article Geochemistry & Geophysics

Phosphatase and microbial activity with biochemical indicators in semi-permafrost active layer sediments over the past 10,000 years

Y Takano et al.

APPLIED GEOCHEMISTRY (2006)

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Article Astronomy & Astrophysics

Possibilities for methanogenic life in liquid methane on the surface of Titan

CP McKay et al.

ICARUS (2005)

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Article Environmental Sciences

Sources of dissolved organic matter (DOM) in a Rocky Mountain stream using chemical fractionation and stable isotopes

E Hood et al.

BIOGEOCHEMISTRY (2005)

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Article Chemistry, Multidisciplinary

Enzyme activity fingerprinting with substrate cocktails

JP Goddard et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

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Review Biochemical Research Methods

Enzyme assays for high-throughput screening

JP Goddard et al.

CURRENT OPINION IN BIOTECHNOLOGY (2004)

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Article Chemistry, Applied

Fluorogenic cyanohydrin esters as chiral probes for esterase and lipase activity

E Leroy et al.

ADVANCED SYNTHESIS & CATALYSIS (2003)

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Article Biochemistry & Molecular Biology

Analysis of catalytic residues in enzyme active sites

GJ Bartlett et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

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Review Chemistry, Organic

Amino acids and peptides as asymmetric organocatalysts

ER Jarvo et al.

TETRAHEDRON (2002)

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Article Multidisciplinary Sciences

The universal nature of biochemistry

NR Pace

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Organic Catalytic Activity as a Method for Agnostic Life Detection

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