Genomic analysis and characterization of bacteriophage vB_SpuS_ NX263 infecting Salmonella enterica subsp. enterica serovar Pullorum

In this study, a new Salmonella phage, NX263, was isolated from sewage. This phage could lyse 90.57% (48/53) of the bacterial strains tested and showed good activity over a wide range of temperature (up to 60 degrees C) and pH (5-10). Phylogenetic analysis showed that it should be classified as a member of the genus Skatevirus. The genome of phage NX263 is 46,574 bp in length with a GC content of 45.52%. It contains 89 open reading frames and two tRNA genes. No lysogeny, drug resistance, or virulence-associated genes were identified in the genome sequence, suggesting that this phage could potentially be used to treat Salmonella Pullorum infections.

Automated summary

In this study, a new Salmonella phage, NX263, was isolated from sewage. The phage showed high lytic activity against a wide range of bacterial strains tested, as well as good stability at different temperatures and pH levels. Genomic analysis revealed its potential as a therapeutic agent for Salmonella Pullorum infections.