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The relationship between social isolation, social support, and loneliness with cardiovascular disease and shared risk factors: A narrative review

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2023)

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The association between loneliness and sleep quality among older adults: A systematic review and meta-analysis

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Summary: This study systematically reviewed existing studies and explored the association between loneliness and sleep quality among older adults. The results showed that lonely older adults were more likely to suffer from low sleep quality compared to those without loneliness. Therefore, reducing loneliness should be considered as an essential element in sleep management programs for older people.

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Summary: This systematic review and meta-analysis examined the relationship between loneliness and cognitive function, showing that loneliness is associated with subtle impairment across multiple cognitive domains in older adults. These findings are important for understanding how loneliness affects cognitive function and providing valuable information for risk reduction and early detection strategies.

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Summary: This study aims to investigate the unique impact of loneliness on health literacy and health-related factors in young adults, while controlling for social isolation, depressive symptomology, and social anxiety. Using a cross-sectional study design, 521 young adults completed an online survey, reporting their loneliness, social isolation, health-related factors, and health literacy. The results showed that increased loneliness was associated with decreased health literacy and increased health-related factors in young adults, even after controlling for other variables.

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Loneliness increases the risk of type 2 diabetes: a 20 year follow-up - results from the HUNT study

Roger E. Henriksen et al.

Summary: Loneliness may be a factor that increases the risk of type 2 diabetes, but there is no strong evidence that the effect of loneliness on type 2 diabetes is mediated by depression or insomnia.

DIABETOLOGIA (2023)

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Review Geriatrics & Gerontology

Association between social integration and risk of dementia: A systematic review and meta-analysis of longitudinal studies

Shanshan Wang et al.

Summary: The study reveals that strong social engagement and frequent social contact are positively associated with a lower risk of dementia, while loneliness is associated with a higher risk. The size of a person's social network may also have a promising impact on dementia risk. However, there is substantial heterogeneity among studies.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2023)

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Review Public, Environmental & Occupational Health

Effectiveness of social prescribing for chronic disease prevention in adults: a systematic review and meta-analysis of randomised controlled trials

Htet Lin Htun et al.

Summary: Social prescribing (SP) links patients with non-medical interventions in the community to address socioeconomic and behavioral determinants. A systematic review of randomized controlled trials found that SP exercise interventions were associated with a slight increase in physical activity, but no significant improvement in metabolic factors. Further rigorous studies are needed to determine the effectiveness of SP in modifying the determinants of chronic disease and promoting sustainable healthy behaviors.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2023)

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Article Multidisciplinary Sciences

Social isolation exacerbates diet-induced obesity and peripheral inflammation in young male mice under thermoneutrality

Nicholas J. Queen et al.

Summary: Social isolation is associated with increased risk of mortality and chronic diseases, including obesity, in humans. However, studies on mice have been inconsistent, partly due to a lack of consideration for housing temperature. This study establishes a mouse model that demonstrates the propensity for obesity induced by social isolation, providing insights into the influence of social isolation on health and disease.

ISCIENCE (2023)

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Does social isolation, social support or loneliness influence health or well-being after a cardiovascular disease event? A narrative thematic systematic review

Rosanne Freak-Poli et al.

Summary: This systematic review investigated the association between social health and mental health outcomes and patient needs among cardiac patients in Australia and New Zealand. The findings suggest that better social health is consistently associated with better mental health outcomes and meeting patient needs. Further research focusing on women and gender-disaggregated reporting is needed to fully understand the impact of social factors on health outcomes after a cardiovascular disease event.

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Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts

Rosanne Freak-Poli et al.

Summary: Loneliness is independently associated with cognitive decline and an increased risk of developing dementia. However, perceived and structural social support do not have a significant impact on cognitive function or dementia risk.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Can social support buffer the association between loneliness and hypertension? a cross-sectional study in rural China

Aki Yazawa et al.

Summary: The study aimed to investigate the relationship between loneliness and hypertension, as well as the buffering effect of social support on this association. The results showed that loneliness was associated with a higher prevalence of hypertension. However, contrary to the stress buffering theory, the positive association between loneliness and hypertension was more pronounced among individuals with higher social support.

PLOS ONE (2022)

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Article Health Care Sciences & Services

Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians

Aung Zaw Zaw Phyo et al.

Summary: This study identified four physical HRQoL trajectories among older people, with economic factors, social health, and stressful life events impacting these trajectories. Specific stressful life events had a greater impact on adverse physical HRQoL trajectories in older people than other factors. Volunteering may prevent physical HRQoL decline and requires further investigation.

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Evaluation of Social Isolation, Loneliness, and Cardiovascular Disease Among Older Women in the US

Natalie M. Golaszewski et al.

Summary: Social isolation and loneliness are associated with increased risk of cardiovascular disease among older women, and social support does not moderate these associations.

JAMA NETWORK OPEN (2022)

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Review Psychology, Multidisciplinary

Social isolation: An underappreciated determinant of physical health

Julianne Holt-Lunstad et al.

Summary: While much recent focus has been on loneliness, research suggests that the actual presence of social connections is essential for health and well-being, with structural indicators playing a powerful role alongside relationship functions and quality.

CURRENT OPINION IN PSYCHOLOGY (2022)

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Social isolation, social support and loneliness as independent concepts, and their relationship with health-related quality of life among older women

Rosanne Freak-Poli et al.

Summary: This study found that social isolation, social support, and loneliness have independent associations with health-related quality of life (HRQoL), with loneliness showing the strongest negative impact. Women with high social support and not feeling lonely had the best HRQoL outcomes.

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Psychosocial factors in adherence to pharmacological treatment and diabetes mellitus control in patients over 65

Alfredo Lara-Morales et al.

Summary: The aim of this study was to explore the influence of anxiety/depression symptoms and social risk on non-adherence to pharmacological treatment (Non-AdhT) and poor control of type 2 diabetes mellitus (T2DM) in patients older than 65 years. The results showed that male patients had a higher risk of non-adherence if they had symptoms of anxiety/depression, while female patients had a higher risk if they had social risk. Additionally, male patients had a higher risk of poor control of T2DM if they did not adhere to treatment.

ATENCION PRIMARIA (2022)

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Social Determinants of Cardiovascular Disease

Tiffany M. Powell-Wiley et al.

Summary: Social determinants of health have a significant impact on the development of cardiovascular disease and its outcomes, but their influence is not fully understood. This review aims to further investigate the relationship between social determinants of health and cardiovascular disease, and provide a framework for future research and interventions.

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Psychometric assessment of scales for measuring loneliness and social isolation: an analysis of the household, income and labour dynamics in Australia (HILDA) survey

Karine E. Manera et al.

Summary: Loneliness and social isolation are global public health threats. This study aimed to develop robust and practical scales for measuring these conditions using items from a national survey. The results showed that a three-factor model could be derived from ten items, reflecting different aspects of loneliness and social isolation. These derived scales provide reliable and practical measures for population-based research.

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Rosanne Freak-Poli et al.

Summary: This study provides new evidence on social isolation, social support, and loneliness for older widows before and after spousal death. The findings show that spousal death is strongly associated with increased loneliness for both men and women, but also an increase in interactions with friends and family. Financial resources provide some protection against loneliness for men. Interestingly, spousal death is not associated with changes in social support or participation in community activities.

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Daniel F. Morse et al.

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Ziyao Zhou et al.

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JOURNAL OF ADOLESCENCE (2022)

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Are social isolation, lack of social support or loneliness risk factors for cardiovascular disease in Australia and New Zealand? A systematic review and meta-analysis

Rosanne Freak-Poli et al.

Summary: The international systematic review found that poor social health is associated with an increased risk of coronary heart disease and stroke, but Australian studies did not show this association. Further research using medical diagnosis of CVD and considering the influence of residential factors is needed to clarify the relationship between social health and CVD incidence in Australia and New Zealand.

HEALTH PROMOTION JOURNAL OF AUSTRALIA (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risks Collaboration, 1990-2021

Megan Lindstrom et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Endocrinology & Metabolism

Associations of polysocial risk score, lifestyle and genetic factors with incident type 2 diabetes: a prospective cohort study

Yimin Zhao et al.

Summary: This study found an association between cumulative social risks and incident type 2 diabetes. Adherence to a healthy lifestyle can reduce the risk of diabetes caused by social vulnerability. Genetic susceptibility and disadvantaged social status may interact synergistically, leading to additional risks for type 2 diabetes.

DIABETOLOGIA (2022)

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Associations of Social Isolation and Loneliness With Later Dementia

Chun Shen et al.

Summary: Social isolation and loneliness are independently associated with the occurrence of dementia. Social isolation may be an early indicator of increased risk of dementia and is related to brain structure and gene expression.

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Gender Differences in Correlates of Loneliness among Community-Dwelling Older Koreans

Young Bum Kim et al.

Summary: This study explored the gender differences in loneliness among community-dwelling older adults. The findings revealed that men were more likely to feel lonely than women, and that a social network of family ties and being married were negatively correlated with loneliness in men, but not in women.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Effects of Objective and Perceived Social Isolation on Cardiovascular and Brain Health: A Scientific Statement From the American Heart Association

Crystal W. Cene et al.

Summary: Social isolation and loneliness are associated with worse cardiovascular and brain health outcomes, particularly coronary heart disease and stroke mortality. However, more research is needed to understand the associations with heart failure, dementia, and cognitive impairment, as well as the underlying mechanisms.

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The relationships between social support and loneliness: A meta-analysis and review

Xing Zhang et al.

Summary: The meta-analysis found a negative correlation between levels of social support and loneliness, with the relationship moderated by various variables. In Chinese samples, the association between loneliness and social support was stronger among rural populations compared to urban populations; perceived social support had a greater impact on loneliness compared to other forms of social support.

ACTA PSYCHOLOGICA (2022)

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Shirley Musich et al.

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Effects of social isolation on quality of life in elderly adults

Roger D. Newman-Norlund et al.

Summary: Social isolation has significant negative effects on the health and quality of life of older adults, and the COVID-19 pandemic has further exacerbated these effects. Higher levels of physical activity and better physical/mental health may moderate these effects.

PLOS ONE (2022)

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Effects of lifestyle risk behaviour clustering on cardiovascular disease among UK adults: latent class analysis with distal outcomes

Teketo Kassaw Tegegne et al.

Summary: This study examined the clustering effect of lifestyle risk behaviors on cardiovascular disease (CVD) and CVD risk among adults in the UK. The results showed that the clustering of multiple risk behaviors increased the risk of CVD, and individuals with more risk behaviors had higher odds of having CVD. Interventions targeting multiple lifestyle behaviors and social circumstances should be prioritized to reduce the burden of CVD.

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Social support and recovery from mental health problems: a scoping review

Knut Ivar Bjorlykhaug et al.

Summary: There is a connection between social support and mental health or recovery. Integrating social support in services and policy can help reduce health inequalities and enhance recovery. This article provides a literature review on the associations between social support, mental health, and recovery, as well as the features of community mental health services that incorporate social support.

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Associations between social connections and cognition: a global collaborative individual participant data meta-analysis

Suraj Samtani et al.

Summary: This study found that good social connections, including living with others, weekly community group engagement, weekly interaction with family and friends, and rarely feeling lonely, are associated with slower cognitive decline.

LANCET HEALTHY LONGEVITY (2022)

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Relationship of smoking with current and future social isolation and loneliness: 12-year follow-up of older adults in England

Keir E. J. Philip et al.

Summary: Smoking is associated with increasing social isolation and loneliness in older adults, suggesting it is detrimental to psychosocial health.

LANCET REGIONAL HEALTH-EUROPE (2022)

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Osteosarcopenia, the co-existence of osteoporosis and sarcopenia, is associated with social frailty in older adults

Tatsuro Inoue et al.

Summary: This study revealed a significant association between osteosarcopenia and social frailty, with a higher prevalence of social frailty among individuals with osteosarcopenia. Comprehensive assessment of these conditions is necessary for disability prevention in older adults.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

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Psychosocial Factors Associated with Sleep Quality and Duration Among Older Adults with Chronic Pain

Catherine Zaidel et al.

Summary: The study found that short sleep duration was the most commonly reported sleep issue among older adults with chronic pain, followed by poor sleep quality and long sleep duration. Factors such as perceived stress, depression, and pain or sleep medications were independently associated with poor sleep quality and short or long sleep durations. On the other hand, higher resilience and a diverse social network were independently associated with good sleep quality and optimal sleep duration, highlighting the significance of positive psychosocial factors on sleep outcomes in this population.

POPULATION HEALTH MANAGEMENT (2021)

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Social connections and hypertension in women and men: a population-based cross-sectional study of the Canadian Longitudinal Study on Aging

Zeinab Hosseini et al.

Summary: The study found that single women with limited social participation or small social networks were more likely to have hypertension, while lone-living men had a lower risk of hypertension. Understanding social factors can help healthcare professionals assess the risk of hypertension and cardiovascular disease.

JOURNAL OF HYPERTENSION (2021)

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Relationship between loneliness, social isolation and modifiable risk factors for cardiovascular disease: a latent class analysis

Feifei Bu et al.

Summary: This study identified latent clustering of cardiovascular risk factors among adults aged 50+, showing how risk factors cluster together and how the risk patterns are related to social factors. Loneliness was found to be associated with a higher risk of certain classes, while social disengagement and living alone were also differentially associated with latent class memberships. The findings offer important implications for clinical practice and preventive interventions in cardiovascular disease.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2021)

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Loneliness and social isolation is associated with sleep problems among older community dwelling women and men with complex needs

Laurie McLay et al.

Summary: Sleep problems, loneliness, and social isolation are common among older adults, with loneliness and social isolation contributing to insufficient sleep, while excessive sleep is related to living with others. Further research is needed to explore the impact of these factors on the restorative properties of sleep in older adults.

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Cognitive health risks posed by social isolation and loneliness in older Korean Americans

Yuri Jang et al.

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BMC GERIATRICS (2021)

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Self-isolation negatively impacts self-management of diabetes during the coronavirus (COVID-19) pandemic

Shahina Pardhan et al.

Summary: The study revealed that self-isolation significantly affected various aspects of diabetes self-management, leading to greater fluctuation in blood glucose levels, reduced access to diabetes medicine, and reduced access to a healthy diet. Targeted interventions to improve access to necessary resources for individuals in self-isolation are essential to ensure effective self-management of diabetes.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality

Rosanne Freak-Poli et al.

Summary: Poor social health is associated with increased risk of cardiovascular disease, with social isolation and low social support being more important predictors than loneliness in healthy older adults. The study suggests that different social health domains should be considered in future cardiovascular risk prediction models.

BMC GERIATRICS (2021)

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Social isolation, physical inactivity and inadequate diet among European middle-aged and older adults

Alice Delerue Matos et al.

Summary: The study found that in most countries, highly socially isolated individuals are more likely to be physically inactive and consume less fruit or vegetables daily compared to low/intermediate isolated individuals. Highly socially isolated European middle-aged and older adults are more prone to physical inactivity and inadequate diet.

BMC PUBLIC HEALTH (2021)

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Association between social isolation and depression onset among older adults: a cross-national longitudinal study in England and Japan

Taiji Noguchi et al.

Summary: This study examined the association of social isolation with depression onset among older adults in England and Japan. Despite variations in cultural background, social isolation was significantly associated with depression onset in both countries. Addressing social isolation is crucial for safeguarding older adults' mental health globally.

BMJ OPEN (2021)

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Loneliness and Risk for Cardiovascular Disease: Mechanisms and Future Directions

Elise Paul et al.

Summary: Loneliness is associated with an increased risk of early mortality and cardiovascular disease, similar to well-known risk factors like obesity and smoking. This association is likely mediated by health-related behaviors, biological mechanisms, and psychological factors that can negatively impact health.

CURRENT CARDIOLOGY REPORTS (2021)

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Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study

Aung Zaw Zaw Phyo et al.

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INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Social isolation, social support, loneliness and cardiovascular disease risk factors: A cross-sectional study among older adults

Jessie Hu et al.

Summary: The study found diverse relationships between social health and cardiovascular disease (CVD) risk factors, emphasizing the importance of distinguishing between these constructs. Men were more socially isolated, less socially supported, and less lonely than women.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2021)

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Glucocorticoid resistance and β2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species

Catherine P. Walsh et al.

Summary: Chronic stress is associated with decreased cellular GR sensitivity, alterations in intracellular beta-AR signaling, and upregulation of pro-inflammatory biomarkers in peripheral blood. These findings suggest that chronic stress may affect cellular sensitivity to glucocorticoids and catecholamines.

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The Association Between Obesity and Social Isolation as Well as Loneliness in the Adult Population: A Systematic Review

Andre Hajek et al.

Summary: The studies found that there may be an association between obesity and increased levels of loneliness, but the results are mixed. While the study quality was quite high, the literature remains inconclusive and incomplete. Further research is needed in countries outside of Europe, using longitudinal data and objective assessments of obesity, with a focus on exploring gender differences.

DIABETES METABOLIC SYNDROME AND OBESITY (2021)

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Loneliness, Social Isolation, and Chronic Disease Outcomes

Julie Christiansen et al.

Summary: Loneliness and social isolation were independently associated with cardiovascular disease and Type 2 diabetes within a 5 year follow-up period. However, there were no significant associations between loneliness or social isolation and COPD and cancer. The associations of loneliness and social isolation with CVD and T2D were fully explained by baseline psychological and behavioral factors.

ANNALS OF BEHAVIORAL MEDICINE (2021)

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Article Nursing

Factors associated with loneliness in patients with diabetes mellitus

Ewa Kobos et al.

Summary: Patients with diabetes generally experience moderate loneliness, with almost one-fifth (16%) of patients experiencing intense loneliness. Risk factors for increased loneliness include lower education, being single, and the presence of chronic complications of diabetes mellitus.

NURSING OPEN (2021)

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Article Geriatrics & Gerontology

Social Isolation and Memory Decline in Later-life

Sanna Read et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2020)

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Article Geriatrics & Gerontology

Depressive symptoms predict increased social and emotional loneliness in older adults

Joanna McHugh Power et al.

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Article Geriatrics & Gerontology

Loneliness and Risk of Dementia

Angelina R. Sutin et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2020)

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Article Cardiac & Cardiovascular Systems

Association of sleep disturbance with risk of cardiovascular disease and all-cause mortality in patients with new-onset type 2 diabetes: data from the Korean NHIS-HEALS

Young Choi et al.

CARDIOVASCULAR DIABETOLOGY (2020)

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Review Medicine, General & Internal

Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework

Sam Hodgson et al.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2020)

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The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness

Huige Li et al.

REDOX BIOLOGY (2020)

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A Meta-Analysis of the Relationship Between Sleep Problems and Loneliness

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Understanding loneliness in the twenty-first century: an update on correlates, risk factors, and potential solutions

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PSYCHIATRY RESEARCH (2020)

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Are Loneliness and Social Isolation Associated with Quality of Life in Older Adults? Insights from Northern and Southern Europe

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Loneliness and sleep: A systematic review and meta-analysis

Sarah C. Griffin et al.

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Gender Differences in Social Support on Social Network Sites: A Meta-Analysis

Sigal Tifferet

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Social Risk Factors for Medication Nonadherence: Findings from the CARDIA Study

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Race and Objective Social Isolation: Older African Americans, Black Caribbeans, and Non-Hispanic Whites

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Anna Bludau et al.

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Are loneliness and social isolation associated with cognitive decline?

Elvira Lara et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2019)

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Loneliness as a risk factor for metabolic syndrome: results from the HUNT study

Roger Ekeberg Henriksen et al.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2019)

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Review Psychiatry

The impact of perceived and objective social isolation on hospital readmission in patients with heart failure: A systematic review and meta-analysis of observational studies

M. A. Heidari Gorji et al.

GENERAL HOSPITAL PSYCHIATRY (2019)

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Review Cardiac & Cardiovascular Systems

Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

Eleonora Iob et al.

CURRENT CARDIOLOGY REPORTS (2019)

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Article Public, Environmental & Occupational Health

Associations between social isolation, loneliness, and objective physical activity in older men and women

Stephanie Schrempft et al.

BMC PUBLIC HEALTH (2019)

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Article Psychology, Social

Gender Differences in Loneliness Across the Lifespan: A Meta-Analysis

Marlies Maes et al.

EUROPEAN JOURNAL OF PERSONALITY (2019)

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Article Social Work

Depression, Loneliness, and Suicide Risk among Latino College Students: A Test of a Psychosocial Interaction Model

Edward C. Chang et al.

SOCIAL WORK (2019)

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Review Medicine, General & Internal

Loneliness and social isolation causal association with health-related lifestyle risk in older adults: a systematic review and meta-analysis protocol

Martin Malcolm et al.

SYSTEMATIC REVIEWS (2019)

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Article Psychology, Multidisciplinary

Genetic Contributions to Loneliness and Their Relevance to the Evolutionary Theory of Loneliness

A. W. M. Spithoven et al.

PERSPECTIVES ON PSYCHOLOGICAL SCIENCE (2019)

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Review Biochemistry & Molecular Biology

Loneliness, Social Isolation, and Cardiovascular Health

Ning Xia et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Review Psychiatry

Associations between loneliness and perceived social support and outcomes of mental health problems: a systematic review

Jingyi Wang et al.

BMC PSYCHIATRY (2018)

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Article Health Care Sciences & Services

Perceived social support and health-related quality of life (HRQoL) in Tehranian adults: Tehran lipid and glucose study

Sara Jalali-Farahani et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2018)

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Article Geriatrics & Gerontology

The link between depression and atherosclerosis through the pathways of inflammation and endothelium dysfunction

Christina Chrysohoou et al.

MATURITAS (2018)

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Article Cardiac & Cardiovascular Systems

Perceived Social Isolation and Outcomes in Patients With Heart Failure

Sheila M. Manemann et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Article Multidisciplinary Sciences

Validation of an abbreviated version of the Lubben Social Network Scale (LSNS-6) and its associations with suicidality among older adults in China

Qingsong Chang et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

Social isolation and multiple chronic diseases after age 50: A European macro-regional analysis

David Cantarero-Prieto et al.

PLOS ONE (2018)

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Article Medicine, General & Internal

Quality of life, loneliness and health-related characteristics among older people in Liaoning province, China: a cross-sectional study

Yaxin Zhu et al.

BMJ OPEN (2018)

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Article Psychology, Clinical

Depressive symptoms prior to and after incident cardiovascular disease and long-term survival. A population-based study of older persons

Rosanne Freak-Poli et al.

DEPRESSION AND ANXIETY (2018)

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Article Geriatrics & Gerontology

The discrepancy between social isolation and loneliness as a clinically meaningful metric: findings from the Irish and English longitudinal studies of ageing (TILDA and ELSA)

J. E. McHugh et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2017)

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Review Neurosciences

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Naomi I. Eisenberger et al.

NEUROPSYCHOPHARMACOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Coronary disease risk assessment in men: Comparison between ASCVD Risk versus Framingham

Natalia Maria Maciel Guerra-Silva et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)

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Article Psychiatry

Social support from the closest person and sleep quality in later life: Evidence from a British birth cohort study

Mai Stafford et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2017)

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Article Rheumatology

Chronic musculoskeletal pain and its impact on older people

Fiona M. Blyth et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2017)

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Article Psychiatry

Loneliness in the general population: prevalence, determinants and relations to mental health

Manfred E. Beutel et al.

BMC PSYCHIATRY (2017)

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Article Medicine, General & Internal

Multiple Chronic Conditions and Psychosocial Limitations in Patients Hospitalized with an Acute Coronary Syndrome

Mayra Tisminetzky et al.

AMERICAN JOURNAL OF MEDICINE (2016)

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Editorial Material Public, Environmental & Occupational Health

Social Isolation, Loneliness, and Living Alone: Identifying the Risks for Public Health

Eric Klinenberg

AMERICAN JOURNAL OF PUBLIC HEALTH (2016)

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Review Rehabilitation

A systematic review of the impact of stroke on social support and social networks: associated factors and patterns of change

Sarah Northcott et al.

CLINICAL REHABILITATION (2016)

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Article Public, Environmental & Occupational Health

Do stress, health behavior, and sleep mediate the association between loneliness and adverse health conditions among older people?

Julie Christiansen et al.

SOCIAL SCIENCE & MEDICINE (2016)

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Article Psychology, Clinical

Loneliness Over Time: The Crucial Role of Social Anxiety

Michelle H. Lim et al.

JOURNAL OF ABNORMAL PSYCHOLOGY (2016)

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Editorial Material Cardiac & Cardiovascular Systems

Social Determinants of Risk and Outcomes for Cardiovascular Disease A Scientific Statement From the American Heart Association

Edward P. Havranek et al.

CIRCULATION (2015)

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Review Clinical Neurology

The association between social relationships and depression: A systematic review

Ziggi Ivan Santini et al.

JOURNAL OF AFFECTIVE DISORDERS (2015)

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Article Pediatrics

Epigenetics and Understanding the Impact of Social Determinants of Health

Daniel A. Notterman et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2015)

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Article Substance Abuse

A Systematic Review of Loneliness and Smoking: Small Effects, Big Implications

Stephanie R. Dyal et al.

SUBSTANCE USE & MISUSE (2015)

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Review Cardiac & Cardiovascular Systems

Depression and cardiovascular disease: a clinical review

David L. Hare et al.

EUROPEAN HEART JOURNAL (2014)

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Article Cardiac & Cardiovascular Systems

The impact of advanced heart failure on social, psychological and existential aspects and personhood

Amy Leeming et al.

EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING (2014)

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Article Cardiac & Cardiovascular Systems

2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

David C. Goff et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

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Article Psychology

Toward a Neurology of Loneliness

Stephanie Cacioppo et al.

PSYCHOLOGICAL BULLETIN (2014)

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Article Health Care Sciences & Services

The role of social isolation in frequent and/or avoidable hospitalisation: rural community-based service providers' perspectives

Jo Longman et al.

AUSTRALIAN HEALTH REVIEW (2013)

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Editorial Material Critical Care Medicine

Loneliness and Social Isolation: Risk Factors Long Overdue for Surveillance

JoAnn Grif Alspach

CRITICAL CARE NURSE (2013)

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Article Multidisciplinary Sciences

The Center for Epidemiologic Studies Depression Scale: A Review with a Theoretical and Empirical Examination of Item Content and Factor Structure

R. Nicholas Carleton et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Social isolation, loneliness, and all-cause mortality in older men and women

Andrew Steptoe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Social Work

Validation of the DSSI-10 to Measure Social Support in a General Population

Jana Wardian et al.

RESEARCH ON SOCIAL WORK PRACTICE (2013)

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Article Medicine, General & Internal

Loneliness in Older Persons A Predictor of Functional Decline and Death

Carla M. Perissinotto et al.

ARCHIVES OF INTERNAL MEDICINE (2012)

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Article Medicine, General & Internal

Loneliness, isolation and the health of older adults: do we need a new research agenda?

Nicole Valtorta et al.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2012)

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Article Psychology, Clinical

Loneliness, Social Isolation, and Behavioral and Biological Health Indicators in Older Adults

Aparna Shankar et al.

HEALTH PSYCHOLOGY (2011)

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Article Health Care Sciences & Services

The impact of social isolation on the health status and health-related quality of life of older people

Annie Hawton et al.

QUALITY OF LIFE RESEARCH (2011)

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Article Psychiatry

Social support concepts and measures

Benjamin H. Gottlieb et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2010)

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Review Psychiatry

Lack of Social Support in the Etiology and the Prognosis of Coronary Heart Disease: A Systematic Review and Meta-Analysis

Juergen Barth et al.

PSYCHOSOMATIC MEDICINE (2010)

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Article Psychology, Multidisciplinary

Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms

Louise C. Hawkley et al.

ANNALS OF BEHAVIORAL MEDICINE (2010)

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Article Gerontology

Perceived Social Isolation Makes Me Sad: 5-Year Cross-Lagged Analyses of Loneliness and Depressive Symptomatology in the Chicago Health, Aging, and Social Relations Study

John T. Cacioppo et al.

PSYCHOLOGY AND AGING (2010)

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Article Gerontology

Loneliness Predicts Increased Blood Pressure: 5-Year Cross-Lagged Analyses in Middle-Aged and Older Adults

Louise C. Hawkley et al.

PSYCHOLOGY AND AGING (2010)

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Article Pediatrics

Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease Depression, Inflammation, and Clustering of Metabolic Risk Markers

Andrea Danese et al.

ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE (2009)

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Review Cardiac & Cardiovascular Systems

Work-Related Psychosocial Factors and the Development of Ischemic Heart Disease A Systematic Review

Nanna H. Eller et al.

CARDIOLOGY IN REVIEW (2009)

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Article Cardiac & Cardiovascular Systems

Perceived loneliness and social support in patients with chronic heart failure

Caroline Lofvenmark et al.

EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING (2009)

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Article Psychology, Clinical

Loneliness Predicts Reduced Physical Activity: Cross-Sectional & Longitudinal Analyses

Louise C. Hawkley et al.

HEALTH PSYCHOLOGY (2009)

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Article Nursing

Social isolation in older adults: an evolutionary concept analysis

Nicholas R. Nicholson

JOURNAL OF ADVANCED NURSING (2009)

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Article Cardiac & Cardiovascular Systems

Others Had Similar Problems and You Were Not Alone Evaluation of an Open-Group Mutual Aid Model in Cardiac Rehabilitation

Maryse Arndt et al.

JOURNAL OF CARDIOVASCULAR NURSING (2009)

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Review Behavioral Sciences

Perceived social isolation and cognition

John T. Cacioppo et al.

TRENDS IN COGNITIVE SCIENCES (2009)

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Article Psychology, Social

Alone in the Crowd: The Structure and Spread of Loneliness in a Large Social Network

John T. Cacioppo et al.

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY (2009)

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Article Public, Environmental & Occupational Health

Social Disconnectedness, Perceived Isolation, and Health among Older Adults

Erin York Cornwell et al.

JOURNAL OF HEALTH AND SOCIAL BEHAVIOR (2009)

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Article Psychology, Multidisciplinary

Social Isolation and Stress-related Cardiovascular, Lipid, and Cortisol Responses

Nina Grant et al.

ANNALS OF BEHAVIORAL MEDICINE (2009)

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Article Health Care Sciences & Services

Social isolation and loneliness among older people: issues and future challenges in community and residential settings

Linda Grenade et al.

AUSTRALIAN HEALTH REVIEW (2008)

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Review Cardiac & Cardiovascular Systems

Beyond established and novel risk factors - Lifestyle risk factors for cardiovascular disease

Dariush Mozaffarian et al.

CIRCULATION (2008)

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Article Cardiac & Cardiovascular Systems

General cardiovascular risk profile for use in primary care - The Framingham Heart Study

Ralph B. D'Agostino et al.

CIRCULATION (2008)

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Article Health Care Sciences & Services

The relationship between gender, social support, and health-related quality of life in a community-based study in Washington County, Maryland

Lisa Gallicchio et al.

QUALITY OF LIFE RESEARCH (2007)

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Article Psychiatry

Loneliness and risk of Alzheimer disease

Robert S. Wilson et al.

ARCHIVES OF GENERAL PSYCHIATRY (2007)

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Article Psychology, Social

Loneliness within a nomological net: An evolutionary perspective

John T. Cacioppo et al.

JOURNAL OF RESEARCH IN PERSONALITY (2006)

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Article Gerontology

Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations

James Lubben et al.

GERONTOLOGIST (2006)

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Article Pediatrics

Socially isolated children 20 years later -: Risk of cardiovascular disease

Avshalom Caspi et al.

ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE (2006)

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Article Gerontology

The relation of social isolation, loneliness, and social support to disease outcomes among the elderly

Joe Tomaka et al.

JOURNAL OF AGING AND HEALTH (2006)

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Article Geriatrics & Gerontology

Predictors and subjective causes of loneliness in an aged population

N Savikko et al.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2005)

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Article Neurosciences

Depression and cardiovascular disease: Mechanisms of interaction

KE Joynt et al.

BIOLOGICAL PSYCHIATRY (2003)

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Article Psychiatry

Loneliness and health: Potential mechanisms

JT Cacioppo et al.

PSYCHOSOMATIC MEDICINE (2002)

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Article Public, Environmental & Occupational Health

From social integration to health: Durkheim in the new millennium

LF Berkman et al.

SOCIAL SCIENCE & MEDICINE (2000)

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