期刊
ARCHIVES OF CARDIOVASCULAR DISEASES
卷 116, 期 11, 页码 498-505出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.acvd.2023.08.003
关键词
Bicuspid aortic valve; Ascending aorta aneurysm; Mechanical properties
This study found differences in the adaptability of the aortic wall to dilatation mechanism between patients with bicuspid aortic valve (BAV) and those with tricuspid aortic valve (TAV). The aortic wall thickness was thinner in BAV patients, and dilatation > 51 mm was a significant predictor of severely reduced aortic wall thickness in BAV patients.
Background: Bicuspid aortic valve (BAV) is frequently associated with dilatation of the thoracic aorta. Peculiar anatomical, histological and mechanical changes of the aortic wall in BAV aortopathy have been hypothesized to suggest an increased risk of acute aortic complications in patients with BAV.Aim: In this study we tried to clarify any differences in the adaptability of the aortic wall to the mechanism of dilatation between patients with BAV and those with TAV.Methods: In total, 354 samples were taken from 71 patients undergoing elective aortic surgery and divided into two groups: BAV group (n = 16; 101 samples); and TAV group (n = 55; 253 samples). Aortic wall thickness was measured with a dedicated caliper. The relationship between aortic wall thickness and aortic dilatation and demographic variables was evaluated cumulatively and comparatively (BAV versus TAV). In patients with more than three samples available, intrapatient variability was also studied. Finally, potential risk factors for severely reduced aortic wall thickness were also assessed.Results: Analysis of preoperative characteristics revealed significant differences in patient age (54 +/- 16 years for BAV and 66 +/- 11 years for TAV; P = 0.0011), with no differences in variables related to aortic dilatation (including phenotype). Cumulative aortic wall thickness was significantly thinner in the anterior than in the posterior wall. In the comparative analysis, aortic wall thickness was significantly thinner in patients with BAV in both the anterior and posterior regions. Furthermore, in patients with BAV, dilatation > 51 mm was a significant predictor of severely reduced aortic wall thickness.Conclusions: In our experience, patients with BAV aortopathy reached the cut-off for the surgical indication at an early age. Careful monitoring in patients with BAV is mandatory when aortic dilatation has reached 51 mm, as it is related to significant anatomical changes.(c) 2023 Elsevier Masson SAS.All rights reserved.
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