4.3 Review

Complete mesocolic excision for colon cancer: current status and controversies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Role of preoperative CT angiography with multimodality imaging reconstruction to perform laparoscopic Complete Mesocolic Excision (CME) and Central Vascular Ligation (CVL) in right-sided colon cancer: Is it really useful? A prospective clinical study

Giorgio Romano et al.

Summary: Preoperative radiological assessment using CT angiography and advanced imaging techniques can reduce surgical difficulty and intraoperative complications, resulting in improved short-term outcomes in right colonic resections.
Review Surgery

Definition and reporting of lymphadenectomy and complete mesocolic excision for radical right colectomy: a systematic review

Giuseppe S. Sica et al.

Summary: This study aimed to assess the variations in definition and reporting of radical right colectomy (RRC). The results showed significant heterogeneity and overlap among different RRC techniques, which may jeopardize the interpretation of study outcomes. Consistent use of definitions and reporting of procedures is crucial for obtaining reliable conclusions in future trials.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2023)

Article Oncology

Primary tumour immune response and lymph node yields in colon cancer

Nikhil Lal et al.

Summary: High lymph node (LN) yield is predictive of overall and disease-free survival in non-metastatic colon cancer. There is no association between higher LN yield and increasing nodal positivity, but it is strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response, especially in node-negative cancers. These findings were validated in an independent dataset.

BRITISH JOURNAL OF CANCER (2022)

Article Gastroenterology & Hepatology

Multidimensional evaluation of the learning curve for laparoscopic complete mesocolic excision for right colon cancer: a risk-adjusted cumulative summation analysis

Alessandro Giani et al.

Summary: Experienced colorectal surgeons can achieve proficiency in laparoscopic complete mesocolic excision (CME) for right-sided colon cancer (RCC) after performing 24-33 cases.

COLORECTAL DISEASE (2022)

Article Gastroenterology & Hepatology

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer

Jon D. Vogel et al.

DISEASES OF THE COLON & RECTUM (2022)

Article Surgery

Robotic complete mesocolic excision versus conventional robotic right colectomy for right-sided colon cancer: a comparative study of perioperative outcomes

Jose Tomas Larach et al.

Summary: This study compared the short-term outcomes of RCME and RRC for right-sided colon cancer, finding no significant differences in operative time, complications, reoperation rates, or length of hospital stay, but a higher lymph node harvest with RCME. Additional studies are needed to confirm these results and evaluate long-term oncologic outcomes.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2022)

Review Oncology

Incidence of lymph node recurrence after primary surgery for non- metastatic colon cancer: A systematic review

Mathieu Struys et al.

Summary: The incidence of locoregional, potentially preventable lymph node recurrence after surgery for colon cancer is low and is not affected by the extent of lymphadenectomy.
Article Pathology

The association between tumour sub-site and local nodal and/or distant metastasis at the time of resection of colorectal cancer: a prospective study of 3,360 consecutive cases

Ronald Newland et al.

Summary: The findings suggest that multivariable modeling can be used to identify associations between sub-sites and molecular characteristics.

HUMAN PATHOLOGY (2022)

Review Oncology

Complete mesocolic excision with central venous ligation/D3 lymphadenectomy for colon cancer - A comprehensive review of the evidence

Isaac Seow-En et al.

Summary: Complete mesocolic excision (CME) is a beneficial surgical approach that improves lymph node yield, survival outcomes, and reduces the risk of local and distant recurrence. It is associated with longer surgical duration but reduced operative blood loss, with no significant difference in overall complication rates compared to conventional colectomy. Routine CME is recommended for all patients except those with early-stage colon cancer. Standardized training is necessary to achieve mastery of the technique.

SURGICAL ONCOLOGY-OXFORD (2022)

Article Surgery

Complete mesocolic excision for right colonic cancer: prospective multicentre study

Stefan R. Benz et al.

Summary: The use of complete mesocolic excision (CME) in right colonic cancer surgery is still controversial. This prospective multicentre study found no significant difference in overall survival between CME and non-CME surgery in a 5-year follow-up. However, there may be a survival benefit for CME in stage III disease, which requires further investigation.

BRITISH JOURNAL OF SURGERY (2022)

Review Oncology

Comparing complete mesocolic excision versus conventional colectomy for colon cancer: A systematic review and meta-analysis

Zachariah Gene Wing Ow et al.

Summary: This study, through systematic review and meta-analysis, demonstrates that CME/LND3 surgery provides superior long-term survival outcomes in patients with colon cancer compared to NCME/LND2.
Review Surgery

Oncological reasons for performing a complete mesocolic excision: a systematic review and meta-analysis

Joseph C. Kong et al.

Summary: Based on the systematic review comparing CME with conventional colonic surgery for colon cancer, CME shows improved oncologic outcomes but comes with higher complication rates, including vascular injury. Compared to conventional surgery, CME has advantages in terms of increased lymph node yield, lower recurrence rates, and higher overall survival rates.

ANZ JOURNAL OF SURGERY (2021)

Article Oncology

D3-lymphadenectomy enhances oncological clearance in patients with right colon cancer. Results of a meta-analysis

Zutoia Balciscueta et al.

Summary: This systematic review with meta-analysis showed that right-sided hemicolectomy with CME + D3 is associated with improved survival rates and reduced local recurrence in patients with right colon cancer, without increasing morbidity. The prevalence of lymphatic metastases in D3-territory was relatively low.
Article Oncology

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial

Lai Xu et al.

Summary: This study compared the safety of complete mesocolic excision (CME) and D2 dissection in laparoscopic right hemicolectomy for right colon cancer patients. Early results showed fewer postoperative complications but more frequent intraoperative vascular injury in the CME group. The procedure appears safe and feasible for experienced surgeons.

LANCET ONCOLOGY (2021)

Review Gastroenterology & Hepatology

Complete mesocolic excision versus conventional surgery for colon cancer: A systematic review and meta-analysis

Jasmine Crane et al.

Summary: The meta-analysis suggests that CME/D3 may have a better overall and disease-free survival compared to conventional surgery, with no significant difference in perioperative complications. Randomized control trials are needed to provide stronger evidence on this topic.

COLORECTAL DISEASE (2021)

Article Gastroenterology & Hepatology

Routine CT evaluation of central vascular ligation in patients undergoing complete mesocolic excision for sigmoid colon cancer

Rasmus Peuliche Vogelsang et al.

Summary: This study measured the inferior mesenteric stump length following CME for sigmoid colon cancer and found that a stump length >= 10 mm was associated with key clinical quality measures. Routine follow-up CT measurement of arterial stump length may serve as a quality indicator of vascular ligation in CME surgery.

COLORECTAL DISEASE (2021)

Review Gastroenterology & Hepatology

Right-side colectomy with complete mesocolic excision vs conventional right-side colectomy in the treatment of colon cancer: a systematic review and meta-analysis

Valentina Ferri et al.

Summary: The meta-analysis on complete mesocolic excision (CME) for right-side colon cancer treatment showed improved five-year disease-free survival and overall survival compared to standard right-side hemicolectomy, with comparable mortality and morbidity rates between the two groups. Additionally, CME resulted in a higher mean number of harvested lymph nodes.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2021)

Review Surgery

Complete mesocolic excision and D3 lymphadenectomy with central vascular ligation in right-sided colon cancer: a systematic review of postoperative outcomes, tumor recurrence and overall survival

Gennaro Mazzarella et al.

Summary: Complete mesocolic excision (CME) surgery does not increase the risk of postoperative complications for patients with right-sided colon cancer, while significantly improving long-term oncological impact. Survival rates and tumor recurrence rates at 5 years are closely related to the stage of the disease.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2021)

Review Oncology

Complete Mesocolic Excision and D3 Lymphadenectomy versus Conventional Colectomy for Colon Cancer: A Systematic Review and Meta-Analysis

Tamara Diaz-Vico et al.

Summary: Based on the meta-analysis, complete mesocolon excision (CME) for primary colon cancer offers benefits such as increased lymph nodes harvested, higher postoperative adverse events, better overall and disease-free survival rates, and reduced rates of local and distant recurrences compared to conventional surgery (CS).

ANNALS OF SURGICAL ONCOLOGY (2021)

Review Gastroenterology & Hepatology

Right hemicolectomy with complete mesocolic excision is safe, leads to an increased lymph node yield and to increased survival: results of a systematic review and meta-analysis

G. Anania et al.

Summary: Comparing right hemicolectomy with complete mesocolic excision (CME) to traditional surgery, it was found that right hemicolectomy with CME is not inferior in terms of safety, has a higher lymph node yield, shorter operating time, and lower conversion rate, while traditional surgery is associated with better oncologic outcomes in terms of overall and disease-free survival.

TECHNIQUES IN COLOPROCTOLOGY (2021)

Article Surgery

Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer Short-term Outcomes. A Randomized Clinical Study

Giuseppe Di Buono et al.

Summary: In this study, laparoscopic CME was found to be a safe and feasible technique, with improved lymph node harvesting and length of surgical specimens, without increasing surgical complications both during and after the operation.

ANNALS OF SURGERY (2021)

Review Gastroenterology & Hepatology

Complete mesocolic excision versus conventional hemicolectomy in patients with right colon cancer: a systematic review and meta-analysis

Ottavia De Simoni et al.

Summary: A systematic review and meta-analysis showed that compared to conventional right hemicolectomy (CRH), complete mesocolic excision (CME) had similar postoperative complication rates and improved survival outcomes for patients with right colon cancer. Subgroup analysis for stage III colon cancer patients did not show a significant impact of CME on 3-year and 5-year overall survival.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2021)

Article Oncology

Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer

Yojiro Hashiguchi et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Oncology

Post-operative computed tomography scan - reliable tool for quality assessment of complete mesocolic excision

Cristian Livadaru et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2019)

Article Gastroenterology & Hepatology

Clinicopathological Factors Influencing Lymph Node Yield in Colorectal Cancer: A Retrospective Study

Elena Orsenigo et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2019)

Article Gastroenterology & Hepatology

Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3d English Edition [Secondary Publication]

Kenjiro Kotake

JOURNAL OF THE ANUS RECTUM AND COLON (2019)

Article Oncology

NCCN Guidelines® Insights Colon Cancer, Version 2.2018 Featured Updates to the NCCN Guidelines

Al B. Benson et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2018)

Article Surgery

Laparoscopic right hemicolectomy with CME: standardization using the critical view concept

Christoph Werner Strey et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2018)

Article Surgery

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon

Wouter Willaert et al.

EUROPEAN SURGICAL RESEARCH (2018)

Review Gastroenterology & Hepatology

Right colic artery anatomy: a systematic review of cadaveric studies

M. Haywood et al.

TECHNIQUES IN COLOPROCTOLOGY (2017)

Article Gastroenterology & Hepatology

Variations in the Vascular Anatomy of the Right Colon and Implications for Right-Sided Colon Surgery

Mehmet Ayhan Kuzu et al.

DISEASES OF THE COLON & RECTUM (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Accuracy of CT for Local Staging of Colon Cancer: A Systematic Review and Meta-Analysis

Elias Nerad et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2016)

Article Gastroenterology & Hepatology

Vascular Anatomy in Laparoscopic Colectomy for Right Colon Cancer

Sang Jae Lee et al.

DISEASES OF THE COLON & RECTUM (2016)

Review Oncology

Non-surgical factors influencing lymph node yield in colon cancer

Patrick Wood et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2016)

Article Gastroenterology & Hepatology

Lymph Node Yield After Colectomy for Cancer: Is Absence of Mismatch Repair a Factor?

Tushar Samdani et al.

DISEASES OF THE COLON & RECTUM (2015)

Article Surgery

Cranial-to-caudal approach for radical lymph node dissection along the surgical trunk in laparoscopic right hemicolectomy

Takeru Matsuda et al.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2015)

Article Anatomy & Morphology

Variability in superior hypogastric plexus morphology and its clinical applications: a cadaveric study

G. Paraskevas et al.

SURGICAL AND RADIOLOGIC ANATOMY (2008)

Article Gastroenterology & Hepatology

Surgical technique and survival in patients having a curative resection for colon cancer

EL Bokey et al.

DISEASES OF THE COLON & RECTUM (2003)