Alternating chiral selectivity of aldol reactions under the confined space of mesoporous silica

The chiral selectivities were altered and high diastereo-and enantio-selectivities of the products were obtained in water medium without adding acid co-catalysts when a primary-tertiary diamine catalystwas immobilized onmesoporous SBA-15 to forma recyclable catalyst for the direct asymmetric aldol reaction of cyclohexanone with p-nitrobenzaldehyde.