期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 -, 期 -, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/aac.00547-23
关键词
tebipenem; oral penem; faropenem; sulopenem; ceftibuten; taniborbactam; susceptibility testing; beta-lactamase; avibactam
This study evaluated the impact of beta-lactamases on the susceptibility to oral penems/carbapenems and other carbapenem molecules. The results showed that tebipenem and sulopenem had a similar activity spectrum in Escherichia coli and exhibited lower MIC values against beta-lactamase-producing strains.
The impact of beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and other carbapenem molecules was evaluated in Escherichia coli, alone and in combination with avibactam or taniborbactam beta-lactamase inhibitors. Tebipenem and sulopenem exhibited a similar spectrum of activity compared to the intravenous carbapenems and displayed lower MIC values than ceftibuten-avibactam against E. coli producing extended-spectrum beta-lactamases or AmpC enzymes. Combined with taniborbactam, tebipenem and sulopenem exhibited low MIC values against almost all tested recombinant E. coli, including metallo-beta-lactamase producers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据