期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 67, 期 8, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/aac.00368-23
关键词
plasmid sequencing; KPC-31; carbapenems; ceftazidime-avibactam; antimicrobial resistance; ST307; high-risk clone; Klebsiella pneumoniae; plasmid
In 2021, Klebsiella pneumoniae ST307 strains causing pulmonary and bloodstream infections in a hospital in Rome, Italy, exhibited high levels of resistance to ceftazidime-avibactam (CZA). One of these strains showed resistance to both CZA and carbapenems and carried two copies of bla(KPC-3) and one copy of bla(KPC-31) on plasmid pKpQIL.
In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains reached high levels of resistance to both CZA and carbapenems and carried two copies of bla(KPC-3) and one copy of bla(KPC-31) located on plasmid pKpQIL. The genomes and plasmids of CZA-resistant ST307 strains were analyzed to identify the molecular mechanisms leading to the evolution of resistance and compared with ST307 genomes at local and global levels. A complex pattern of multiple plasmids in rearranged configurations, coresident within the CZA-carbapenem-resistant K. pneumoniae strain, was observed. Characterization of these plasmids revealed recombination and segregation events explaining why K. pneumoniae isolates from the same patient had different antibiotic resistance profiles. This study illustrates the intense genetic plasticity occurring in ST307, one of the most worldwide-diffused K. pneumoniae high-risk clones. In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy, reached high levels of resistance to ceftazidime-avibactam (CZA). One of these strains reached high levels of resistance to both CZA and carbapenems and carried two copies of bla(KPC-3) and one copy of bla(KPC-31) located on plasmid pKpQIL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据