The discovery of 9/8-ribbons, β/γ-peptides with curved shapes governed by a combined configuration-conformation code

The de novo design of a beta/gamma-peptidic foldamer motif has led to the discovery of an unprecedented 9/8-ribbon featuring an uninterrupted alternating C9/C8 hydrogen-bonding network. The ribbons adopt partially curved topologies determined synchronistically by the beta-residue configuration and the gamma-residue conformation sets.