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IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis

ANNALS OF THE RHEUMATIC DISEASES (2023)

Effects of cigarette smoking and human T-cell leukaemia virus type 1 infection on anti-citrullinated peptide antibody production in Japanese community-dwelling adults: the Nagasaki Islands Study

S-y Kawashiri et al.

Summary: The study revealed a significant association between cigarette-smoking status and ACPA production in a general population, while HTLV-1 positivity showed no correlation with ACPA production.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2021)

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Article Immunology

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Caroline Gronwall et al.

Summary: The study identified different autoantibody reactivities in patients with rheumatoid arthritis, including various modified protein autoantibodies. Reactivities to carbamylated and acetylated proteins were primarily seen in patients positive for citrullinated protein reactivity, while anti-acetylated histone reactivity was specific to RA. Anti-malondialdehyde acetaldehyde antibodies were associated with disease activity and were not significantly increased in individuals at risk of RA.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Rheumatology

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Sanne Reijm et al.

Summary: The study reveals that AMPA-IgM displays cross-reactivity towards different PTMs, indicating that PTM (cross-)reactivity is not confined to IgG and does not necessarily depend on extensive somatic hypermutation. Additionally, AMPA-IgM is more potent in complement activation compared to AMPA-IgG.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Rheumatology

Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis

Maria Juarez et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Rheumatology

Specific autoantibodies precede the symptoms of rheumatoid arthritis - A study of serial measurements in blood donors

MMJ Nielen et al.

ARTHRITIS AND RHEUMATISM (2004)

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IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis

相关参考文献

Effects of cigarette smoking and human T-cell leukaemia virus type 1 infection on anti-citrullinated peptide antibody production in Japanese community-dwelling adults: the Nagasaki Islands Study

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis

Specific autoantibodies precede the symptoms of rheumatoid arthritis - A study of serial measurements in blood donors

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