Risk factors for fractures following liver transplantation: a population-based cohort study

Summary: This study identified risk factors for post-transplant fractures in liver transplant recipients, especially those who were aged ≥65 years, female, hepatitis C carriers, had a history of fractures within 1 year prior to transplant, alcoholism, and higher daily prednisolone dose. The use of tacrolimus and sirolimus/everolimus was associated with a decreased risk of fractures. The findings highlight the importance of identifying high-risk individuals and implementing preventive measures.

Summary: A positive association was found between higher blood pressure variability (BPV) and incidence of fractures in this retrospective cohort study involving over 3 million participants. BPV was identified as an independent predictor for developing fractures, with consistent results noted for vertebral fractures and hip fractures in various subgroup analyses.