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Type 2 biomarkers and quality of life in chronic rhinosinusitis with nasal polyps

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis

Samuel D. Racette et al.

Summary: This study found a significant correlation between the CRS-PRO total score and T2 biomarkers, especially post-ESS and among CRSwNP patients. Additionally, the rhinologic subdomain of SNOT-22 and rhinopsychologic subdomain of CRS-PRO showed better correlation with T2 biomarkers.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2022)

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Article Allergy

EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: Definitions and management

Claus Bachert et al.

Summary: Uncontrolled severe CRSwNP can be challenging due to its association with asthma, NSAID-exacerbated respiratory disease, and allergies. The European Forum proposes structured definitions to facilitate communication among clinicians and offers a practical algorithm for defining type 2 inflammation in CRSwNP. Suggestions for evaluating treatment options, including surgery and biologics, are provided to inform patients for decision-making processes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Impact of nasal polyps on endotype and phenotype in patients with moderate to severe asthma

Rory Chan et al.

Summary: Patients with asthma with nasal polyps (AwNPs) show significant differences in type 2 biomarkers, lung function, and asthma control compared to those with asthma alone (A). AwNPs patients have higher levels of PBE and FeNO, suggesting better asthma control despite the presence of nasal polyps.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Otorhinolaryngology

The SWI/SNF complex in eosinophilic and non eosinophilic chronic rhinosinusitis

Katarzyna Kowalik et al.

Summary: The study found that BEC and HPEC were negatively correlated with all SWI/SNF subunits. HPEC and BEC were positively correlated with clinical findings (L-M and SNOT-22), while SWI/SNF was negatively correlated with clinical findings in eCRS.

ACTA OTORHINOLARYNGOLOGICA ITALICA (2021)

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Article Otorhinolaryngology

Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis

Naweed Chowdhury et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2019)

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Type 2 biomarkers and quality of life in chronic rhinosinusitis with nasal polyps

相关参考文献

CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis

EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: Definitions and management

Impact of nasal polyps on endotype and phenotype in patients with moderate to severe asthma

The SWI/SNF complex in eosinophilic and non eosinophilic chronic rhinosinusitis

Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality-of-life measures in chronic rhinosinusitis

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