4.7 Review

Review: Early and late determinants of puberty in ruminants and the role of nutrition

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Article Genetics & Heredity

Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans

A. Kemal Topaloglu et al.

Summary: Metabolism plays a role in determining puberty and fertility, with NHLH2 identified as a key molecule linking metabolism and puberty. Research on a mouse model with pubertal failure and late-onset obesity, as well as obese patients with NHLH2 gene variations, highlights the critical role of NHLH2 in human puberty and body weight control.

HUMAN GENETICS (2022)

Review Endocrinology & Metabolism

Development of the gonadotropin-releasing hormone system

Anne H. Duittoz et al.

Summary: This review provides an overview of the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, highlighting the transcriptional regulation of the Gnrh1 gene, the prenatal development of the GnRH1 system in rodents and humans, and the paracrine and synaptic communication during migration of the GnRH cells.

JOURNAL OF NEUROENDOCRINOLOGY (2022)

Article Agriculture, Dairy & Animal Science

Gene co-expression networks contributing to reproductive development in Holstein-Friesian bull calves

K. Keogh et al.

Summary: This study conducted gene co-expression analyses on the HPT and adipose tissues of bull calves fed different levels of nutrition, and identified co-expressed gene networks associated with metabolic status, reproductive development, and testicular development markers. These networks were also significantly associated with biological pathways related to energy production, cellular growth and proliferation, GnRH signaling, and cholesterol biosynthesis.

ANIMAL (2022)

Article Pharmacology & Pharmacy

A Putative New Melatonin Binding Site in Sheep Brain, MTx: Preliminary Observations and Characteristics

Preety Shabajee-Alibay et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

Review Endocrinology & Metabolism

Broadening the role of osteocalcin in the hypothalamic-pituitary-gonadal axis

Chang Shan et al.

Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.

JOURNAL OF ENDOCRINOLOGY (2021)

Review Genetics & Heredity

Genetic Features of Reproductive Traits in Bovine and Buffalo: Lessons From Bovine to Buffalo

Baoshun Shao et al.

Summary: This review classified and summarized reproductive traits of bovine and buffalo, including heritability estimates, molecular markers, and genomic selection. There were wide differences in heritability estimates for reproductive traits among different populations.

FRONTIERS IN GENETICS (2021)

Article Pediatrics

Peripheral Precocious Puberty of Ovarian Origin in a Series of 18 Girls: Exome Study Finds Variants in Genes Responsible for Hypogonadotropic Hypogonadism

Raja Brauner et al.

Summary: In this study on peripheral precocious puberty of ovarian origin, exome sequencing identified potential pathogenic variants in genes associated with hypogonadotropic hypogonadism in half of the patients. Further functional studies and research on other cohorts are recommended to establish the causality of these variants.

FRONTIERS IN PEDIATRICS (2021)

Article Agriculture, Dairy & Animal Science

Effect of plane of nutrition during the first 12 weeks of life on growth, metabolic and reproductive hormone concentrations, and testicular relative mRNA abundance in preweaned Holstein Friesian bull calves

Stephen P. Coen et al.

Summary: The study examined the impact of nutrition in the first 12 weeks of life on testicular and sexual development in bull calves. Results showed that offering a high plane of nutrition not only improved growth and metabolic status, but also advanced testicular development for precocious sexual maturation.

JOURNAL OF ANIMAL SCIENCE (2021)

Article Multidisciplinary Sciences

A high plane of nutrition during early life alters the hypothalamic transcriptome of heifer calves

Jose M. Sanchez et al.

Summary: The study revealed that increased nutrition intake during early calfhood can affect gene expression in the hypothalamus, potentially leading to early sexual development in heifers, with stress-signaling pathways being among the most affected.

SCIENTIFIC REPORTS (2021)

Review Agriculture, Dairy & Animal Science

Overcoming neuroendocrine and metabolic barriers to puberty: the role of melatonin in advancing puberty in ewe lambs

K. R. Pool et al.

DOMESTIC ANIMAL ENDOCRINOLOGY (2020)

Article Biochemistry & Molecular Biology

Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction

Charlotte Vanacker et al.

EMBO JOURNAL (2020)

Review Endocrinology & Metabolism

Minipuberty of human infancy - A window of opportunity to evaluate hypogonadism and differences of sex development?

Christoffer Hojrup Renault et al.

ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2020)

Article Multidisciplinary Sciences

Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty

Ravinder Anand-Ivell et al.

PLOS ONE (2019)

Review Endocrinology & Metabolism

Melatonin as a Hormone: New Physiological and Clinical Insights

Jose Cipolla-Neto et al.

ENDOCRINE REVIEWS (2018)

Article Developmental Biology

Early onset of puberty in cattle: implications for gamete quality and embryo survival

D. A. Kenny et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2018)

Article Endocrinology & Metabolism

Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty

Andrew Dauber et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Endocrinology & Metabolism

No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe

C. Decourt et al.

ENDOCRINOLOGY (2016)

Article Agriculture, Dairy & Animal Science

Relationships among Puberty, Muscle and Fat, and Liveweight Gain during Mating in Young Female Sheep

C. A. Rosales Nieto et al.

REPRODUCTION IN DOMESTIC ANIMALS (2015)

Article Agriculture, Dairy & Animal Science

Optimising reproductive performance of beef cows and replacement heifers

M. G. Diskin et al.

ANIMAL (2014)

Article Endocrinology & Metabolism

Melatonin from Cerebrospinal Fluid but Not from Blood Reaches Sheep Cerebral Tissues Under Physiological Conditions

C. Legros et al.

JOURNAL OF NEUROENDOCRINOLOGY (2014)

Article Biology

Sex-specific processing of social cues in the medial amygdala

Joseph F. Bergan et al.

Article Agriculture, Dairy & Animal Science

The IGF1 pathway genes and their association with age of puberty in cattle

Marina R. S. Fortes et al.

ANIMAL GENETICS (2013)

Article Endocrinology & Metabolism

Evidence That Dopamine Acts via Kisspeptin to Hold GnRH Pulse Frequency in Check in Anestrous Ewes

Robert L. Goodman et al.

ENDOCRINOLOGY (2012)

Review Endocrinology & Metabolism

Recent Secular Trends in Pubertal Timing: Implications for Evaluation and Diagnosis of Precocious Puberty

Kaspar Sorensen et al.

HORMONE RESEARCH IN PAEDIATRICS (2012)

Article Biochemistry & Molecular Biology

Endocrine Regulation of Male Fertility by the Skeleton

Franck Oury et al.

Article Agriculture, Dairy & Animal Science

A single nucleotide polymorphism-derived regulatory gene network underlying puberty in 2 tropical breeds of beef cattle

M. R. S. Fortes et al.

JOURNAL OF ANIMAL SCIENCE (2011)

Article Medicine, Research & Experimental

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

Jose Donato et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Cell Biology

Seasonal breeding as a neuroendocrine model for puberty in sheep

Jeremy T. Smith et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)

Article Agriculture, Dairy & Animal Science

Neuroendocrine and Genetic Control of Seasonal Reproduction in Sheep and Goats

P. Chemineau et al.

REPRODUCTION IN DOMESTIC ANIMALS (2010)

Review Endocrinology & Metabolism

Evidence that RF-amide related peptides are inhibitors of reproduction in mammals

Iain J. Clarke et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2009)

Article Medicine, General & Internal

A GPR54-activating mutation in a patient with central precocious puberty

Milena Gurgel Teles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Endocrinology & Metabolism

Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies

Tiziana Cogliati et al.

MOLECULAR ENDOCRINOLOGY (2007)

Article Agriculture, Dairy & Animal Science

Genetic analysis of NHLH2 and its putative role in bovine body weight control

K. M. Brennan et al.

ANIMAL GENETICS (2006)

Article Agriculture, Dairy & Animal Science

Role of leptin in the regulation of gonadotropin secretion in farm animals

CR Barb et al.

ANIMAL REPRODUCTION SCIENCE (2004)

Article Multidisciplinary Sciences

Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54

N de Roux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Psychology, Developmental

Growth at puberty

AD Rogol et al.

JOURNAL OF ADOLESCENT HEALTH (2002)