4.8 Article

Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

RNA therapeutics in the clinic

Alexander Curreri et al.

Summary: RNA therapeutics are actively studied for their potential as a therapeutic modality in both preclinical and clinical studies. With the ongoing COVID-19 pandemic, they have gained significant attention and are widely discussed. Since their first approval in 1998, research on RNA therapeutics has advanced to explore new therapeutic targets and delivery strategies to improve their safety and effectiveness. This review provides an overview of currently approved RNA therapeutics, their mechanisms of action, and strategies for enhancing their clinical use. It also analyzes ongoing clinical trials and discusses the challenges and potential strategies for clinical translation.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

Review Pharmacology & Pharmacy

Nanobiotechnology-Enabled mRNA Stabilization

He Xian et al.

Summary: mRNA technology has gained significant attention for its therapeutic potential, but stabilizing mRNA molecules is crucial for its widespread applications. This review focuses on the recent progress in nanobiotechnology-enabled strategies for stabilizing mRNA and improving delivery. It introduces the factors that destabilize mRNA and reviews the molecular and nanotechnology approaches for mRNA stabilization. The impact of formulation processing on mRNA stability, including freezing and lyophilization, and the challenges and future directions are also discussed.

PHARMACEUTICS (2023)

Article Biochemistry & Molecular Biology

Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells

Chien-Yu Lin et al.

Summary: Liver fibrosis is characterized by excessive accumulation of ECM in the liver due to chronic injuries and inflammation. In this study, researchers modified a small peptide-based siRNA nanocomplex with an IGF2R-specific peptide to achieve HSC-specific drug delivery. The modified nanocomplex showed higher specificity for activated HSCs and could potentially be used for the treatment of liver fibrosis.

BIOMOLECULES (2023)

Article Chemistry, Multidisciplinary

An Encodable Scaffold for Sequence-Specific Recognition of Duplex RNA

Jonathan G. Kwok et al.

Summary: RNA folds into diverse secondary and tertiary structures, making it difficult to develop ligands that can specifically target it. In this study, the researchers aimed to develop ligands for dsRNA segments by analyzing high-resolution structures of DNA and RNA. They found that the helical motifs in bZIP/bHLH proteins were not ideal for binding dsRNA major grooves. Through reengineering the leucine zipper motifs with synthetic crosslinkers, they successfully designed a synthetic crosslinked helix fork (CHF) as a proteomimetic scaffold for targeting dsRNA.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Review Genetics & Heredity

Drug delivery systems for RNA therapeutics

Kalina Paunovska et al.

Summary: This article provides an overview of the importance of RNA-based gene therapy and describes the molecular mechanisms of RNA therapies and different drug delivery systems. It also discusses the path from preclinical research to clinical approval for these therapies.

NATURE REVIEWS GENETICS (2022)

Article Biochemistry & Molecular Biology

Current Advances in RNA Therapeutics for Human Diseases

Hannah Zogg et al.

Summary: DNA and RNA were recognized as the genetic code containing necessary information for cell functioning. The discovery of non-coding RNAs, such as microRNAs, created new opportunities for treating human diseases. However, the instability of RNA and the ambiguous results of clinical trials pose challenges for RNA therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

RNA-Binding Macrocyclic Peptides

Sunit Pal et al.

Summary: The use of cyclic peptides to target RNA provides potential therapeutic options, and lessons learned from past examples can guide the development of novel potent and selective ligands.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Review Microbiology

Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance

Zane T. Laughlin et al.

Summary: This article briefly introduces the structures, biosynthesis, and applications of tuberactinomycins in the treatment of tuberculosis. Recent studies on their action on the ribosome and resistance mechanisms are also discussed. Finally, future applications of these drugs are considered after their removal from the List of Essential Medicines.

FRONTIERS IN MICROBIOLOGY (2022)

Article Pharmacology & Pharmacy

Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability

Mariko Kamiya et al.

Summary: This study evaluated the effects of temperature, cryoprotectants, vibration, light exposure, and syringe aspiration on the physicochemical properties of mRNA-LNPs. It was found that storage at -80 degrees C without a cryoprotectant caused a decrease in protein expression. Similar changes were observed with exposure to vibration and light under certain conditions.

PHARMACEUTICS (2022)

Review Genetics & Heredity

RNA-binding proteins in human genetic disease

Fatima Gebauer et al.

Summary: RNA-binding proteins (RBPs) are key effectors of gene expression, and their malfunction leads to various diseases. RBPs play important roles in human genetic disorders, with emerging therapeutic interventions targeting RBPs.

NATURE REVIEWS GENETICS (2021)

Article Biochemistry & Molecular Biology

Constrained peptides mimic a viral suppressor of RNA silencing

Arne Kuepper et al.

Summary: The design of high-affinity, RNA-binding ligands is challenging due to structural properties of RNA and lack of well-defined binding pockets. Peptide-derived molecules show promise as alternative scaffolds, but are limited by lack of design principles and bio-stability. Constrained alpha-helical peptides, like the one derived from TAV2b, show potential in mimicking RNA-binding proteins for the design of bioactive RNA-targeting ligands.

NUCLEIC ACIDS RESEARCH (2021)

Article Chemistry, Multidisciplinary

Synergistic DNA- and Protein-Based Recognition Promote an RNA-Templated Bio-orthogonal Reaction

Niall M. McLoughlin et al.

Summary: Peptide-DNA conjugates designed for binding with RNA through Watson-Crick base pairing combined with peptide-mediated major groove recognition represent a structure-based approach to novel biomolecular assemblies. By designing two distinct conjugate families with tunable binding characteristics for adjacent binding to a specific RNA sequence, a ternary complex is formed. The proximity of peptide elements in the complex enables an RNA-templated click reaction, introducing a new approach for functional biomolecular assemblies.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

Review Pharmacology & Pharmacy

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Linde Schoenmaker et al.

Summary: The current mRNA-lipid nanoparticle COVID-19 vaccines require storage at low temperatures due to instability. Improving mRNA nucleotide composition, understanding the impact of mRNA environment within LNPs, and exploring drying techniques can enhance vaccine stability.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biotechnology & Applied Microbiology

The Limitless Future of RNA Therapeutics

Tulsi Ram Damase et al.

Summary: Recent advances in RNA technology have enabled the development of RNA-based therapeutics, which are cost-effective, relatively simple to manufacture, and can target previously undruggable pathways. These drugs have the potential to change the standard of care for many diseases and actualize personalized medicine. Challenges and advantages associated with RNA-based drugs are discussed along with various approaches for RNA delivery.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Review Biotechnology & Applied Microbiology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Namit Chaudhary et al.

Summary: mRNA vaccines have been established as a rapid, effective, and safe approach for protecting individuals from infectious diseases, especially during the COVID-19 pandemic. Further research is needed to optimize mRNA vaccine design, delivery, and applications for a range of infectious diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Review Pharmacology & Pharmacy

Protamine-Based Strategies for RNA Transfection

Natalia Teresa Jarzebska et al.

Summary: Protamine is a natural cationic peptide mixture used for heparin neutralization and slow-release insulin formulations. It is also employed for cellular delivery of nucleic acids. Protamine plays a dual role in RNA stabilization, protecting against degradation and enhancing cell penetration.

PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

The emerging role of RNA modifications in the regulation of mRNA stability

Sung Ho Boo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

The structural basis for inhibition of ribosomal translocation by viomycin

Ling Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

A large-scale binding and functional map of human RNA-binding proteins

Eric L. Van Nostrand et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

Role of Glutathione in Cancer: From Mechanisms to Therapies

Luke Kennedy et al.

BIOMOLECULES (2020)

Review Biochemistry & Molecular Biology

Therapeutic siRNA: state of the art

Bo Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Chemistry, Organic

Sequence-Specific DNA Recognition with Designed Peptides

Sonia Boga et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Protein-RNA interactions: structural characteristics and hotspot amino acids

Dennis M. Krueger et al.

Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

Review Biochemistry & Molecular Biology

SICLOPPS cyclic peptide libraries in drug discovery

Ali Tavassoli

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2

Nicola De Franceschi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

Molecular mechanism of viomycin inhibition of peptide elongation in bacteria

Mikael Holm et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Reduced stability and intracellular transport of dsRNA contribute to poor RNAi response in lepidopteran insects

Jayendra Nath Shukla et al.

RNA BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2

Nicola De Franceschi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Oncology

MicroRnA Targeting to Modulate Tumor Microenvironment

Praneeth R. Kuninty et al.

FRONTIERS IN ONCOLOGY (2016)

Review Biochemistry & Molecular Biology

Hydrocarbon Stapled Peptides as Modulators of Biological Function

Philipp M. Cromm et al.

ACS CHEMICAL BIOLOGY (2015)

Review Chemistry, Multidisciplinary

Peptides Come Round: Using SICLOPPS Libraries for Early Stage Drug Discovery

Katherine R. Lennard et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

Review Microbiology

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Daniel N. Wilson

NATURE REVIEWS MICROBIOLOGY (2014)

Review Chemistry, Multidisciplinary

Bioreducible Polymers for Gene Silencing and Delivery

Sejin Son et al.

ACCOUNTS OF CHEMICAL RESEARCH (2012)

Article Biotechnology & Applied Microbiology

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Benjamin Petsch et al.

NATURE BIOTECHNOLOGY (2012)

Article Microbiology

Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

Rashid Akbergenov et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Biotechnology & Applied Microbiology

Poly(oligo-D-arginine) With Internal Disulfide Linkages as a Cytoplasm-sensitive Carrier for siRNA Delivery

Young-Wook Won et al.

MOLECULAR THERAPY (2011)

Article Biochemical Research Methods

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Young-Woo Kim et al.

NATURE PROTOCOLS (2011)

Article Chemistry, Organic

gamma-AApeptides bind to RNA by mimicking RNA-binding proteins

Youhong Niu et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein

Akiko Eguchi et al.

NATURE BIOTECHNOLOGY (2009)

Article Biochemistry & Molecular Biology

Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b

Hong-Ying Chen et al.

EMBO REPORTS (2008)

Review Biochemical Research Methods

Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions

Lance M. Hellman et al.

NATURE PROTOCOLS (2007)

Review Biochemistry & Molecular Biology

RNAi therapeutics: a potential new class of pharmaceutical drugs

David Bumcrot et al.

NATURE CHEMICAL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

TAR RNA recognition by a cyclic peptidomimetic of Tat protein

TC Leeper et al.

BIOCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Thermal difference spectra: a specific signature for nucleic acid structures

JL Mergny et al.

NUCLEIC ACIDS RESEARCH (2005)

Review Biochemistry & Molecular Biology

The role of glutathione in cancer

GK Balendiran et al.

CELL BIOCHEMISTRY AND FUNCTION (2004)

Article Biochemical Research Methods

Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers

DL McKenzie et al.

BIOCONJUGATE CHEMISTRY (2000)