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Review
Chemistry, Physical
Qi Meng et al.
Summary: Programmed cell death (PCD) and immunogenic cell death (ICD) are important mechanisms in cancer therapy, and understanding their relationship is significant for tumor treatments. This review describes the interrelationship between PCD and ICD using nanomedicines as examples. It provides an overview of PCD patterns, explores the link between apoptosis and ICD, introduces non-apoptotic signaling pathways and their relationship with ICD, and summarizes the potential application of PCD and ICD in the development of new nanomaterials. The review aims to deepen understanding, extend biomedical applications, and promote progress in clinical tumor therapy.
Article
Engineering, Biomedical
Yang Lu et al.
Summary: Cancer immunotherapy is enhanced by inducing immunogenic cell death (ICD) and regulating tumor metabolism using a self-assembling nano-dot PLNR840, which contains a near-infrared photothermal agent and lactate oxidase (LOX). This strategy effectively improves the immune status and antitumor effect in mouse models of breast cancer and hepatocellular carcinoma.
Article
Chemistry, Multidisciplinary
Binbin Ding et al.
Summary: Researchers discovered that ZIF-8 nanoparticles can induce pyroptosis, a form of cell death, through a caspase-1/gasdermin D (GSDMD)-dependent pathway. This cell death process is accompanied by necrosis and immunogenic cell death (ICD), which triggers an immune response. Furthermore, loading a mitochondrial depolarizing agent, CCCP, into ZIF-8 nanoparticles enhances the pyroptosis process. The modified F127-ZIF-8(CCCP) nanoparticles activate anti-tumor immune response and reshape the tumor microenvironment, leading to effective tumor growth inhibition. This study advances the biomedical applications of ZIF-8 and offers insights into pyroptosis-induced cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Medicinal
Jun-Kyu Byun
Summary: Tumor development is affected by circulating metabolites, with elevated levels of lactic acid and low levels of glucose and glutamine. Lactic acid, a major circulating carbon metabolite produced by tumors, regulates energy metabolism and cancer cell signaling pathways. Recent studies have identified the pro-tumorigenic action of lactic acid and propose targeting its metabolism as a therapeutic strategy for anti-cancer therapy.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Physical
Binbin Ding et al.
Summary: A new concept of pyroptosis adjuvants (PTAVs) for tumor immunotherapy is proposed, which can generate reactive oxygen species (ROS) to activate the immune response. The PTAVs show effective inhibition of tumor growth and pulmonary metastasis.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yang Li et al.
Summary: Ion-interference therapy using ions to disrupt intracellular biological processes shows promise as a potential cancer treatment. In this study, NaCl nanocrystals were skillfully delivered to tumor cells and explosively released Na+/Cl- by using virus-mimicking and glutathione-responsive nanomaterials. This strategy effectively inhibited tumor growth by inducing cell swelling, reactive oxygen species generation, and depletion of glutathione.
Article
Chemistry, Multidisciplinary
Lingxiao Zhang et al.
Summary: This study demonstrates that weakly alkaline layered double hydroxide nanoparticles (LDH NPs) can remodel the suppressive tumor immune microenvironment (TIME) and enhance antitumor immune responses, showing promising potential for solid tumor immunotherapy.
Article
Chemistry, Multidisciplinary
Pan Zheng et al.
Summary: Researchers have developed a pyroptosis inducer for cancer immunotherapy by inducing mitochondrial Ca2+ overload. The inducer triggers robust immune responses, effectively suppressing tumor proliferation and lung metastasis, providing new strategies and inspiration for pyroptosis-mediated cancer treatments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Zhu Li et al.
Summary: In this study, a smart micelle system was developed using an amphiphilic copolymer to encapsulate manganese zinc sulfide nanoparticles and triggered release by near infrared light. The micelles effectively enhanced reactive oxygen species generation, leading to immunogenic cell death and improved antitumor immunity in melanoma.
Review
Chemistry, Multidisciplinary
Zheng Zhang et al.
Summary: Pyroptosis, a form of programmed cell death, can remodel the tumor immune microenvironment and enhance therapeutic efficiency of malignant tumors, especially when augmented by nanomedicine. The application of nanotechnology in potentiate pyroptosis for cancer treatment shows promise in accelerating clinical translation.
Article
Engineering, Environmental
Pan Zheng et al.
Summary: The study revealed that high concentration of zinc oxide can effectively induce pyroptosis and has a better immune activation effect than apoptosis induced by low concentration of zinc oxide.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tao Yu et al.
Summary: Metabolic reprogramming is a key factor in the competition between cancer cells and immune cells in the tumor microenvironment. Therapeutic strategies targeting the metabolic dependence of cancer cells can restore anti-tumor responses of T cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Honggang Xiong et al.
Summary: The study highlights the importance of epigenetic alterations and immunosuppressive factors in limiting T cell activation in the tumor microenvironment. The newly designed tumor microenvironment-inspired prodrug nanomicelle releases active substances that inhibit tumor growth by promoting pyroptosis, ultimately enhancing the efficiency of immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Linan Shi et al.
Summary: A novel nanoplatform was developed in this study, which can achieve high-efficient tumor-specific catalytic anticancer treatment in acidic tumor microenvironments through a cyclic amplification strategy, leading to enhanced Fenton-like reaction. Ultimately, this smart nanoplatform enables self-boosting generation of reactive oxygen species (ROS), inducing strong intracellular oxidative stress, and resulting in substantial anticancer outcomes in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Binbin Ding et al.
Summary: This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy, which can release ions to induce intracellular osmotic imbalance and trigger cell death mechanisms. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity, inhibiting tumor growth and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Pan Zheng et al.
Summary: This study developed an acid-sensitive nanoparticle ((CaCUR)-Ca-PEG) that induces mitochondrial Ca2+ overload and acts as an ICD inducer in improved cancer therapy. Combination with ultrasound (US) enhances the ICD effect, showing promising therapeutic and diagnostic properties.
Article
Multidisciplinary Sciences
McLane J. Watson et al.
Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.
Article
Chemistry, Multidisciplinary
Yao Xiao et al.
Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.
Review
Biochemistry & Molecular Biology
Catarina Roma-Rodrigues et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Multidisciplinary
Wen Jiang et al.
ADVANCED MATERIALS
(2019)
Review
Oncology
Karen G. de la Cruz-Lopez et al.
FRONTIERS IN ONCOLOGY
(2019)
Review
Chemistry, Multidisciplinary
Yu Mi et al.
Article
Oncology
Nicoletta Caronni et al.
Review
Multidisciplinary Sciences
Antoni Ribas et al.
Article
Oncology
Suzanne L. Topalian et al.
Article
Biochemistry & Molecular Biology
Anthony Rongvaux et al.
Article
Multidisciplinary Sciences
Oscar R. Colegio et al.
Review
Immunology
Suzanne L. Topalian et al.
CURRENT OPINION IN IMMUNOLOGY
(2012)
Review
Pharmacology & Pharmacy
Suveera Dhup et al.
CURRENT PHARMACEUTICAL DESIGN
(2012)
Review
Multidisciplinary Sciences
Matthew G. Vander Heiden et al.
Article
Hematology
Karin Fischer et al.
Article
Hematology
E Gottfried et al.