Ameliorating Effects of Curcumin on Testicular Cancer

In the young men's population, testicular cancer (TC) is characterized as one of the main causes of morbidity and mortality around the world. This cancer is mainly divided into germ cell and nongerm cell types and manifests different signs and symptoms, like bone pain, nausea, lower back pain, and anorexia. Also, TC is associated with serious conditions, such as urogenital disorders, infertility, cardiovascular diseases, and solid tumors. Unfortunately, common remedies for TC, including chemotherapy and surgery, have not provided a promising outlook due to their adverse effects on life quality. Ergo, finding a new therapeutic candidate with high effectiveness and low detrimental impacts is indispensable. Newly, herbal remedies have attracted much interest because of their potential to improve diverse diseases, like cancer. In this context, increasing evidence indicated that curcumin, as a polyphenol compound originating from the plant Curcuma longa, has beneficial effects for treating TC. Hence, in this narrative review, we aimed to review documents showing the therapeutic potential of this herbal candidate against TC.

Automated summary

Testicular cancer is a major cause of morbidity and mortality in young men worldwide, with different symptoms and associations with other serious conditions. Traditional treatments such as chemotherapy and surgery have limited effectiveness and negative impacts on life quality. Therefore, finding a new therapeutic candidate is crucial. Herbal remedies, including curcumin from Curcuma longa, have shown promise in treating testicular cancer.