Nanomaterial-Based Biosensors for SARS-CoV-2 and Future Epidemics

Letter Medicine, General & Internal

Serological testing for SARS-CoV-2: Advancements and future challenges

Harry Alexopoulos et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2023)

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Letter Medicine, General & Internal

Reliability of SARS-CoV-2 serological testing for influencing public health policies: A reappraisal

Giuseppe Lippi et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2023)

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Article Chemistry, Analytical

A systematic review of the advancement on colorimetric nanobiosensors for SARS-CoV-2 detection

Leticia Tessaro et al.

Summary: This article introduces the application of colorimetric biosensors in detecting the novel coronavirus. By collecting and analyzing relevant literature data, researchers found that gold nanoparticles were the most commonly used nanomaterials. Furthermore, they demonstrated the advantages of point-of-care diagnostic devices as a fast and cost-effective alternative, and presented the highlights of colorimetric biosensors developed for swabs, surgical masks, and lateral flow immunoassays.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2023)

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Article Nanoscience & Nanotechnology

Simultaneously ultrasensitive and quantitative detection of influenza A virus, SARS-CoV-2, and respiratory syncytial virus via multichannel magnetic SERS-based lateral flow immunoassay

Zhenzhen Liu et al.

Summary: In this study, a portable immunoassay based on SERS technology was proposed for simultaneous detection of multiple respiratory viruses. The method utilizes magnetic SERS tags for direct enrichment and capture of target viruses, eliminating the need for sample pretreatment and improving detection sensitivity. Experimental verification on throat swab samples demonstrated the potential of the method for early and rapid differential diagnosis of respiratory viruses.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2023)

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Article Biochemical Research Methods

Colorimetric and Raman dual-mode lateral flow immunoassay detection of SARS-CoV-2 N protein antibody based on Ag nanoparticles with ultrathin Au shell assembled onto Fe3O4 nanoparticles

Jingwen Li et al.

Summary: In this study, a novel magnetic-Raman-colorimetric nanoparticle was developed for highly sensitive detection of SARS-CoV-2 nucleocapsid protein antibodies. The method exhibited high accuracy, sensitivity, and reproducibility, and could differentiate different serum samples. This approach is valuable for evaluating disease processes and guiding treatment.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2023)

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Review Chemistry, Multidisciplinary

Biosensing with Fluorescent Carbon Nanotubes

Julia Ackermann et al.

Summary: Biosensors are important tools in modern basic research and biomedical diagnostics. NIR fluorescent molecular sensors based on SWCNTs have great potential in analyte detection, and the research on chemical design strategies and molecular recognition contributes to their further development.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biochemistry & Molecular Biology

Carbon nanotube field-effect transistor (CNT-FET)-based biosensor for rapid detection of SARS-CoV-2 (COVID-19) surface spike protein S1

Mazin A. Zamzami et al.

Summary: A fast, easy-to-use, low-cost, and quantitative electrochemical biosensor based on CNT-FET has been developed for quick and accurate detection of SARS-CoV-2 S1 antigen in fortified saliva samples. The biosensor exhibits high sensitivity, selectivity, and can save time, making it a valuable platform for rapid detection of SARS-CoV-2 S1 antigen from patient saliva.

BIOELECTROCHEMISTRY (2022)

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Article Biophysics

Gold nanoparticle based plasmonic sensing for the detection of SARS-CoV-2 nucleocapsid proteins

Kamyar Behrouzi et al.

Summary: This article introduces a virus detection scheme based on LSPR principle with gold nanoparticles aggregation, which can provide observable results by the naked eye in 5 minutes with a LOD of 150 ng/ml for N proteins. A comprehensive numerical model is developed to identify key parameters, and the linear relationship between a defined parameter and N protein concentrations is found to be useful for quantitative detection of the virus.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Medicine, General & Internal

Estimate false-negative RT-PCR rates for SARS-CoV-2. A systematic review and meta-analysis

Valentina Pecoraro et al.

Summary: A systematic review found that up to 58% of COVID-19 patients may have initial false-negative RT-PCR results, highlighting the need for a correct diagnostic strategy. Additionally, the rate of misdiagnosis may increase with higher disease prevalence.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Virology

Detection of SARS-CoV-2 variants by Abbott molecular, antigen, and serological tests

Mary A Rodgers et al.

JOURNAL OF CLINICAL VIROLOGY (2022)

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Article Materials Science, Multidisciplinary

Smart and emerging nanomaterials-based biosensor for SARS-CoV-2 detection

Kshitij R. B. Singh et al.

Summary: This article provides an overview of COVID-19, including its biomarkers, current diagnostic techniques, and emerging smart nanomaterials-based biosensing approaches, as well as discussing the future perspectives of biosensing technologies for SARS-CoV-2 diagnosis.

MATERIALS LETTERS (2022)

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Article Biochemistry & Molecular Biology

Colorimetric and Electrochemical Methods for the Detection of SARS-CoV-2 Main Protease by Peptide-Triggered Assembly of Gold Nanoparticles

Yunxiao Feng et al.

Summary: In this study, a label-free peptide substrate was used to induce the aggregation of AuNPs for visual analysis of Mpro activity. Co-assembly of AuNPs and peptide on an electrode surface allowed for the development of a simple and sensitive electrochemical method for detecting Mpro in serum samples.

MOLECULES (2022)

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Article Chemistry, Multidisciplinary

SARS-CoV-2 Quantum Sensor Based on Nitrogen-Vacancy Centers in Diamond

Changhao Li et al.

Summary: A molecular transducer based on NV centers has been proposed to convert SARS-CoV-2 RNA into magnetic noise signal for optical readout. This sensor demonstrates high sensitivity, low false negative rate, and fast detection of the virus.

NANO LETTERS (2022)

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Review Environmental Sciences

Minimizing errors in RT-PCR detection and quantification of SARS-CoV-2 RNA for wastewater surveillance

Warish Ahmed et al.

Summary: Monitoring pathogens like SARS-CoV-2 in wastewater using RT-PCR is effective for public health information, but there is a lack of standardized protocols for wastewater surveillance. Key strategies for improving accuracy include QA/QC measures, representative sampling, virus concentration, and clear data interpretation guidelines.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Virology

A Community Study of SARS-CoV-2 Detection by RT-PCR in Saliva: A Reliable and Effective Method

Filippo Fronza et al.

Summary: Efficient and wide-scale testing for SARS-CoV-2 is crucial for monitoring infection rates in the community. This study used a novel saliva collection device and found that saliva testing performed well in symptomatic individuals but showed a discordance in samples from convalescent subjects. It was equally effective as nasopharyngeal swabs for contact tracing in asymptomatic individuals.

VIRUSES-BASEL (2022)

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Review Virology

A structural view of the SARS-CoV-2 virus and its assembly

Nathan J. Hardenbrook et al.

Summary: In this review, the authors summarize the structural work on SARS-CoV-2 virus and its cellular assembly process, highlighting important findings that have significantly impacted the protection and treatment of emerging viral infections.

CURRENT OPINION IN VIROLOGY (2022)

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Article Medicine, General & Internal

Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: A multi-centre clinical evaluation

Lisa J. Krueger et al.

Summary: This study evaluated the clinical performance and ease-of-use of seven SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs). The results showed high sensitivity and specificity of the Ag-RDTs, especially in early-stage disease and individuals with high viral loads. The tests from Mologic, Bionote, and Standard Q demonstrated good usability.

EBIOMEDICINE (2022)

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Article Microbiology

SARS-CoV-2 N Gene G29195T Point Mutation May Affect Diagnostic Reverse Transcription-PCR Detection

Karrie K. K. Ko et al.

Summary: This study reveals a previously unreported mutation in the N gene of SARS-CoV-2, which may render certain commercial tests unable to accurately detect the virus, highlighting the importance of real-time surveillance of viral variants.

MICROBIOLOGY SPECTRUM (2022)

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Article Medicine, General & Internal

Diagnostic accuracy of rapid point-of-care tests for diagnosis of current SARS-CoV-2 infections in children: a systematic review and meta-analysis

Naomi Fujita-Rohwerder et al.

Summary: This study systematically assessed the diagnostic accuracy of rapid point-of-care tests for current SARS-CoV-2 infections in children under real-life conditions. The results showed significant variation in the performance of antigen tests in pediatric populations, with low diagnostic sensitivity. Further research and improvement are needed in this area.

BMJ EVIDENCE-BASED MEDICINE (2022)

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Article Biophysics

Aptamer-based electrochemical biosensor for rapid detection of SARS-CoV-2: Nanoscale electrode-aptamer-SARS-CoV-2 imaging by photo-induced force microscopy

Juan Carlos Abrego-Martinez et al.

Summary: Quick and accurate diagnosis of the COVID-19 is crucial in stopping the spread of the virus. The development of an aptamer-based biosensor on a screen-printed carbon electrode platform shows promise in providing rapid and sensitive detection of SARS-CoV-2, offering a potential solution to the current challenges in COVID-19 diagnosis.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

A rapid RNA extraction-free lateral flow assay for molecular point-of-care detection of SARS-CoV-2 augmented by chemical probes

Ketan Dighe et al.

Summary: The COVID-19 pandemic has highlighted the shortcomings in healthcare systems globally when it comes to rapid and accurate diagnosis. This study introduces a lateral flow strip-based RNA extraction and amplification-free nucleic acid test (NAT) for the rapid diagnosis of COVID-19 cases. The assay demonstrates high accuracy and specificity.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Biophysics

Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterials

Soo Hyun Lee et al.

Summary: In this study, a sensitive and selective detection of RBD peptides in SARS-CoV-2 and SARS-CoV was achieved using a terahertz time-domain spectroscopy system and metamaterial-based sensing chips, with successful discrimination between the two viruses.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Electrochemistry

Electrochemical Biosensor for the Detection of SARS-CoV-2 Main Protease and Its Inhibitor Ebselen

Qiongyu Zhang et al.

Summary: This study presents an electrochemical method for detecting SARS-CoV-2 major protease (Mpro). The method utilizes ferrocene-labeled peptide substrates immobilized on gold nanoparticles-modified electrodes. The effectiveness of the method in analyzing Mpro was investigated, and it was successfully used to evaluate the inhibition efficiency of a known inhibitor.

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2022)

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Review Chemistry, Analytical

Development of QDs-based nanosensors for heavy metal detection: A review on transducer principles and in-situ detection

Xinyi Wang et al.

Summary: This review discusses the application of quantum dots-based nanosensors in the detection of heavy metal ions. The stability of the sensors is improved by optimizing the assembly strategies and adding reference substances. The use of quantum dots in optical and electrochemical sensors is highlighted, as well as their integration with portable devices for practical detection in complex environments. The deficiencies and future challenges are also discussed.

TALANTA (2022)

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Review Environmental Sciences

Quantum dots based sensitive nanosensors for detection of antibiotics in natural products: A review

Mohammad Mehdi Sabzehmeidani et al.

Summary: This study focuses on the prompt and accurate detection of residual antibiotics in food products using zero-dimensional fluorescent probes, discussing trends in carbon and metal based QDs preparation and modification. It explores the diverse application of QDs in various detection systems and their different optical properties for detecting a wide range of antibiotics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Materials Science, Multidisciplinary

Tryptophan capped gold-aryl nanoparticles for energy transfer study with SARS-CoV-2 spike proteins

Javad B. M. Parambath et al.

Summary: Current research has focused on developing gold nanomaterials and methods for detecting the spike protein of SARS-CoV-2. The study found a strong binding affinity between the spike protein and tryptophan immobilized on gold-carbon nanoparticles, and used fluorescence quenching for detection.

SOFT MATERIALS (2022)

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Article Spectroscopy

Turn -on FRET-based cysteine sensor by sulfur-doped carbon dots and Au nanoparticles decorated WS2 nanosheet

Ensiyeh Mirsadoughi et al.

Summary: This article introduces a fluorescence resonance energy transfer (FRET) system for detecting cysteine, and optimizes the pH, temperature, and time to achieve good detection performance. The method can rapidly and sensitively detect the concentration of cysteine in human blood serum.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

Development of colorimetric sensors based on gold nanoparticles for SARS-CoV-2 RdRp, E and S genes detection

Ciro Rodriguez Diaz et al.

Summary: This article presents a colorimetric sensor based on gold nanoparticles for the detection of SARS-CoV-2 sequences. The sensor is fast, reliable, and easily scalable, with the ability to detect target sequences within 15 minutes. The efficiency and selectivity of detection are evaluated using synthetic samples, infected cells, and patient samples. The system's sensitivity is enhanced through an affordable amplification approach, enabling the detection of high and medium viral loads. The proposed approach is valuable for facilities with limited resources due to its ease of use, stability, and minimal equipment requirements.

TALANTA (2022)

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Review Biotechnology & Applied Microbiology

Gold Nanoparticles Based Optical Biosensors for Cancer Biomarker Proteins: A Review of the Current Practices

Jinghua Tai et al.

Summary: Gold nanoparticles play an important role in biomedical research and can be used to fabricate optical biosensors, improving the sensitivity and specificity of detection devices. These sensors based on gold nanoparticles have the potential for cancer protein detection.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Chemistry, Analytical

Label-Free LSPR-Vertical Microcavity Biosensor for On-Site SARS-CoV-2 Detection

Yuqiao Zheng et al.

Summary: In this study, a vertical microcavity and localized surface plasmon resonance hybrid biosensor was proposed for high-throughput detection of SARS-CoV-2. The simulation and experimental results showed that nanoporous gold (NPG) deposited sensors performed better in resonance quality and sensitivity compared to gold-deposited and pure microcavity sensors. The pre-clinical validation demonstrated that 40% porosity NPG sensors had the highest sensitivity for SARS-CoV-2 pseudovirus in artificial saliva. The proposed automatic biosensing system showed potential for on-site coronavirus detection with sufficient sensitivity by delivering results of 100 samples within 30 minutes.

BIOSENSORS-BASEL (2022)

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Review Nanoscience & Nanotechnology

Magnetic nanoparticles and magnetic particle spectroscopy-based bioassays: a 15 year recap

Kai Wu et al.

Summary: This article firstly summarizes the design and application of nanoparticles in the field of medicine, with a focus on the development of magnetic particle spectroscopy (MPS) as an independent platform in biomedical applications. The mechanisms and applications of different MPS platforms are discussed, and the applications of MPS in disease diagnosis, food safety, drug screening, etc. are introduced. Finally, the rapid development of MPS in the first 15 years is commented on, and the prospects and challenges faced by portable MPS devices in the growing demand for fast, inexpensive, and easy-to-use biometric techniques are discussed.

NANO FUTURES (2022)

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Article Chemistry, Physical

Frequency and Amplitude Optimizations for Magnetic Particle Spectroscopy Applications

Vinit Kumar Chugh et al.

Summary: Magnetic particle spectroscopy (MPS) is a bioassay technique based on magnetic nanoparticles that has various applications in disease diagnosis, foodborne pathogen detection, and virus detection. This study systematically investigates the effect of alternating magnetic field frequencies and amplitudes on the response of single- and multicore magnetic nanoparticles. The results suggest that different MPS modalities are suitable for different types of bioassays, and sensitivity can be improved by selecting appropriate frequencies and amplitudes.

JOURNAL OF PHYSICAL CHEMISTRY C (2022)

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Article Engineering, Environmental

FRET-based hACE2 receptor mimic peptide conjugated nanoprobe for simple detection of SARS-CoV-2

Byunghoon Kang et al.

Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a global pandemic of coronavirus disease (COVID-19). Early diagnosis, isolation, and prevention are crucial due to the lack of specific antiviral drugs and the emergence of viral variants. Researchers have developed a new fluorescence detection method that can accurately detect SARS-CoV-2 in a short period of time with a low detection limit.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Microbiology

Advanced Molecular and Immunological Diagnostic Methods to Detect SARS-CoV-2 Infection

John Charles Rotondo et al.

Summary: COVID-19 emerged in late 2019 in China and quickly spread across the globe, causing significant impacts. Over the past 2 years, there have been important advancements in prevention and diagnosis, such as the development of effective vaccines and high sensitivity diagnostic kits.

MICROORGANISMS (2022)

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Article Chemistry, Analytical

Magnetic/fluorescent dual-modal lateral flow immunoassay based on multifunctional nanobeads for rapid and accurate SARS-CoV-2 nucleocapsid protein detection

Zihao Xie et al.

Summary: A novel magnetic/fluorescent dual-modal lateral flow immunoassay has been developed for the rapid and accurate diagnosis of SARS-CoV-2 nucleocapsid protein. This method combines the advantages of magnetic and fluorescent signals, resulting in high sensitivity and accuracy, and shows potential for early-stage diagnosis.

ANALYTICA CHIMICA ACTA (2022)

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Article Multidisciplinary Sciences

Real-time COVID-19 detection via graphite oxide-based field-effect transistor biosensors decorated with Pt/Pd nanoparticles

Asma Wasfi et al.

Summary: The rapid spread of the COVID-19 virus and the lack of specific treatment emphasize the need for accurate and early diagnosis. A graphene oxide-based field-effect transistor (GO-FET) biosensor has been developed for real-time detection of the COVID-19 spike protein antigen. The biosensor shows high specificity and sensitivity to COVID-19 spike protein, and the limit of detection is 1 fg/mL. This promising biosensor could greatly contribute to COVID-19 diagnosis.

SCIENTIFIC REPORTS (2022)

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Review Chemistry, Multidisciplinary

Review on LSPR assisted photocatalysis: effects of physical fields and opportunities in multifield decoupling

Sijia Lv et al.

Summary: This study reviews the influence mechanism of optical, electric, magnetic, and thermal physical fields on the photocatalytic efficiency of LSPR systems and analyzes the research bottlenecks in this field. The potential of different numerical simulation methods is also discussed. However, the function mechanism of LSPR is still not well understood.

NANOSCALE ADVANCES (2022)

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Review Medicine, General & Internal

Effectiveness of tests to detect the presence of SARS-CoV-2 virus, and antibodies to SARS-CoV-2, to inform COVID-19 diagnosis: a rapid systematic review

David Jarrom et al.

Summary: This systematic review aims to evaluate the clinical effectiveness of tests for diagnosing COVID-19 through the detection of SARS-CoV-2 virus and antibodies. It highlights the uncertainties regarding the effectiveness of these tests and emphasizes the need for further research on disease management and virus testing strategies.

BMJ EVIDENCE-BASED MEDICINE (2022)

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Article Allergy

Accuracy of serological testing for SARS-CoV-2 antibodies: First results of a large mixed-method evaluation study

Daniel Brigger et al.

Summary: This study compared the diagnostic accuracy of serological immunoassays targeting different proteins of SARS-CoV-2 and found that ELISAs targeting RBD and S1 protein have high sensitivity and specificity. Additionally, most SARS-CoV-2 positive individuals showed neutralizing activity against the live virus. Further evaluation in studies verifying diagnostic accuracy and protective immunity against SARS-CoV-2 is warranted.

ALLERGY (2021)

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Article Infectious Diseases

Pitfalls in SARS-CoV-2 PCR diagnostics

Kerstin Wernike et al.

Summary: To ensure the accuracy of PCR testing, thorough pre-testing of reagents is necessary to avoid contaminations leading to false-positive results and to improve positive predictive value in low-prevalence situations.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

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Article Chemistry, Physical

Ultra-sensitive and fast optical detection of the spike protein of the SARS-CoV-2 using AgNPs/SiNWs nanohybrid based sensors

Kais Daoudi et al.

Summary: The study focused on developing a SERS sensor to detect the SARS-CoV-2 spike protein, using silicon nanowires (SiNWs) substrate and plasmonic silver nanoparticles (AgNPs) decoration to enhance sensing. The results indicated promising potential for SERS as an innovative tool in early infection diagnosis.

SURFACES AND INTERFACES (2021)

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Review Chemistry, Analytical

A Review of THz Technologies for Rapid Sensing and Detection of Viruses including SARS-CoV-2

Naznin Akter et al.

Summary: Terahertz technology-based biosensors offer new possibilities for virus detection, allowing for low-cost, non-invasive, and rapid testing. Traditional virus detection methods have limitations, and terahertz technology has the potential to address these shortcomings.

BIOSENSORS-BASEL (2021)

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Article Chemistry, Analytical

Conventional PCR assisted single-component assembly of spherical nucleic acids for simple colorimetric detection of SARS-CoV-2

Abbas Karami et al.

Summary: A colorimetric strategy based on gold nanoparticle assembly was developed for visual detection of SARS-CoV-2 RNA PCR products, simplifying the testing process and providing clear differentiation between positive and negative cases in post-PCR colorimetric test. The strategy rivals real-time PCR in sensitivity when evaluating samples from laboratory-confirmed cases of SARS-CoV-2 infection.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Multidisciplinary

Low-Cost Optodiagnostic for Minute-Time Scale Detection of SARS-CoV-2

Andre Lopes Ferreira et al.

Summary: The COVID-19 pandemic has widened the health equity gap in society, disproportionately affecting disadvantaged populations. A low-cost rapid testing device called COLOR can detect SARS-CoV-2 within 5 minutes, providing a solution for high-frequency testing in low-resource communities.

ACS NANO (2021)

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Article Chemistry, Analytical

Label-free detection of SARS-CoV-2 Spike S1 antigen triggered by electroactive gold nanoparticles on antibody coated fluorine-doped tin oxide (FTO) electrode

Akanksha Roberts et al.

Summary: A novel immunosensor for detecting the spike protein of the coronavirus was reported, showing high sensitivity and stability under optimized conditions for detecting very low levels of the virus protein in standard buffer. This immunosensor could serve as a rapid, specific, and sensitive diagnostic tool for detecting traces of the coronavirus spike antigen in clinical samples.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Analytical

Colorimetric and electrochemical detection of SARS-CoV-2 spike antigen with a gold nanoparticle-based biosensor

Erman Karakus et al.

Summary: The article introduces a method for colorimetric and electrochemical detection of the SARS-CoV-2 spike antigen using gold nanoparticle-based biosensors, with a high detection sensitivity of 48 ng/mL. The method is rapid, simple, and highly specific for the detection of the SARS-CoV-2 spike antigen.

ANALYTICA CHIMICA ACTA (2021)

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Review Chemistry, Multidisciplinary

A Review of Piezoelectric and Magnetostrictive Biosensor Materials for Detection of COVID-19 and Other Viruses

Fumio Narita et al.

Summary: This article reviews the current state of research on biosensor materials for virus detection, including a general description of virus detection principles, a critique of experimental work on various virus sensors, and a summary of their detection limitations.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Simultaneous Dual-Gene Diagnosis of SARS-CoV-2 Based on CRISPR/Cas9-Mediated Lateral Flow Assay

Erhu Xiong et al.

Summary: The newly developed method can simultaneously detect two SARS-CoV-2 genes in a single test, showing high sensitivity and accuracy, providing a more accurate and convenient pathway for COVID-19 diagnosis in low-resource regions.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Medicine, General & Internal

The Proportion of SARS-CoV-2 Infections That Are Asymptomatic A Systematic Review

Daniel P. Oran et al.

Summary: Available data suggests that at least one third of SARS-CoV-2 infections are asymptomatic. Longitudinal studies indicate that nearly three quarters of individuals who test positive via PCR but show no symptoms at the time of testing will remain asymptomatic. Control strategies for COVID-19 need to be adjusted considering the prevalence and transmission risk of asymptomatic SARS-CoV-2 infections.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Biophysics

One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device

Liping Huang et al.

Summary: The rapid, accurate, and convenient detection of SARS-CoV-2 virus is crucial in controlling the ongoing global pandemic. A new method developed allows for rapid and direct optical measurement of virus particles with minimal sample preparation, showing promise for quick adoption in clinical and resource-limited settings.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Biophysics

Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy

Enja Laureen Roesch et al.

Summary: This study demonstrates a diagnostic assay for the detection of pathogen-specific nucleic acids based on magnetic nanoparticles, which allows for rapid and accurate detection of various nucleic acids. DNA can be detected at a concentration as low as 500 pM, and RNA, SARS-CoV-2-specific DNA, and saliva can also be used as sample media for accurate testing.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Microbiology

Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point-of-Care Testing

Steven E. Conklin et al.

Summary: This study compared the performance of 15 different lateral flow POCTs for detecting SARS-CoV-2-specific antibodies and found variations in sensitivity and specificity. Additionally, the study observed differences in the timing of appearance of IgM and IgG bands.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Chemistry, Physical

Porous Au@Pt nanoparticles with superior peroxidase-like activity for colorimetric detection of spike protein of SARS-CoV-2

Zhao Fu et al.

Summary: A novel colorimetric assay for detecting the spike (S1) protein of SARS-CoV-2 was developed based on the peroxidase-like activity of Au@Pt nanoparticles, showing rapidness, easy operation, and high sensitivity. The Au@Pt nanoparticles were fabricated using a seed-mediated growth approach, resulting in enhanced catalysis attributed to the porous nanostructure and electron-rich Pt shells, enabling a switch in the catalytic pathway.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Toward Rapid and Sensitive Detection of SARS-CoV-2 with Functionalized Magnetic Nanoparticles

Jing Zhong et al.

Summary: The outbreak of SARS-CoV-2 poses a threat to global medical systems and economies, highlighting the urgent need for rapid and sensitive diagnostics. Homogeneous biosensing based on magnetic nanoparticles shows promise for detecting biomolecules quickly and with high sensitivity.

ACS SENSORS (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Michael A. Johansson et al.

Summary: The study suggests that more than half of COVID-19 transmission may come from asymptomatic individuals, highlighting the importance of measures beyond identifying and isolating symptomatic cases in controlling the spread of the virus.

JAMA NETWORK OPEN (2021)

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Article Chemistry, Analytical

Rapid One-Pot Detection of SARS-CoV-2 Based on a Lateral Flow Assay in Clinical Samples

Chao Zhang et al.

Summary: This study developed a rapid detection method for SARS-CoV-2, with the entire sample-to-result workflow taking less than 40 minutes. The method achieved 100% accuracy compared to PCR-based assays, offering a potential universal platform for rapid and point-of-care detection of emerging infectious diseases.

ANALYTICAL CHEMISTRY (2021)

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Article Biophysics

Botulinum toxin as an ultrasensitive reporter for bacterial and SARS-CoV-2 nucleic acid diagnostics

Fengge Song et al.

Summary: The detection strategy utilizes BoNT/A LC activated complex assay, nanoparticle hybridization system, and Fluorescence Resonance Energy Transfer technology to achieve high sensitivity in pathogenic microorganism detection, providing a simple instrument-free colorimetric tool for global public health emergencies.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Biochemistry & Molecular Biology

Carbon Nanotubes, Graphene, and Carbon Dots as Electrochemical Biosensing Composites

Raja Ram Pandey et al.

Summary: Carbon nanomaterials are extensively used in electrochemical sensing composites due to their unique properties, however, their long-term ecological fate remains unknown. Graphene and carbon dots are more biodegradable compared to carbon nanotubes, and design elements such as Coulombic attraction and specific atoms as tethering points are crucial for electrocatalytic performance.

MOLECULES (2021)

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Article Chemistry, Multidisciplinary

Ultrasensitive Detection of SARS-CoV-2 Antibody by Graphene Field-Effect Transistors

Hua Kang et al.

Summary: The development of a graphene field-effect transistor (g-FET) biosensor has enabled ultrasensitive detection of SARS-CoV-2 antibodies with rapid and precise diagnosis capabilities. This technology holds great promise in future prevention and control of other epidemic outbreaks.

NANO LETTERS (2021)

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Article Microbiology

Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts

Nira R. Pollock et al.

Summary: The study evaluated the performance of the Abbott BinaxNOW COVID-19 Ag card in a community testing site and found high sensitivity in newly symptomatic adults, but lower sensitivity in children and asymptomatic individuals, revealing potential limitations of the BinaxNOW test.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Chemistry, Physical

Aptamer Conjugated Gold Nanostar-Based Distance-Dependent Nanoparticle Surface Energy Transfer Spectroscopy for Ultrasensitive Detection and Inactivation of Corona Virus

Avijit Pramanik et al.

Summary: In this study, a rapid diagnostic method for specific SARS-CoV-2 antigens and pseudotyped viruses was demonstrated using Rhodamine 6G dye conjugated DNA aptamer-attached gold nanostars. Additionally, it was shown that DNA aptamer-attached GNSs can prevent virus infection by inhibiting receptor binding and destroying the virus membrane.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2021)

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Article Biochemical Research Methods

Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit

Alexander Kruettgen et al.

Summary: The study found that the specificity of the SARS-CoV-2 Rapid Antigen Test is higher than its sensitivity, with high accuracy for samples with a cycle threshold of less than 25. It is suitable for differentiating contagious and non-contagious SARS-CoV-2 patients.

JOURNAL OF VIROLOGICAL METHODS (2021)

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Article Infectious Diseases

Scaling up COVID-19 rapid antigen tests: promises and challenges

Rosanna W. Peeling et al.

Summary: WHO recommends antigen-detection rapid diagnostic tests (Ag-RDTs) with at least 80% sensitivity and 97% specificity for patients with symptoms consistent with COVID-19. Ag-RDTs may show high false negative rates after the acute phase, suggesting the need for a combination of molecular and serological tests. In low prevalence settings and situations where infection needs to be ruled out, Ag-RDTs with high negative predictive values can be used confidently, but high false positive rates in low prevalence areas require further confirmation.

LANCET INFECTIOUS DISEASES (2021)

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Article Chemistry, Multidisciplinary

Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors

Rebecca L. Pinals et al.

Summary: Developing tools for rapid and accessible diagnosis of actively infected individuals, a SWCNT-based sensor functionalized with ACE2 was introduced for rapid SARS-CoV-2 detection. The sensor exhibited a robust 2-fold fluorescence increase within 90 minutes of exposure to the virus spike protein, showing potential for practical application in diagnostic settings. The study demonstrated the stability and sensing capacity of the ACE2-SWCNT nanosensors in various mediums, highlighting their potential as a rapid optical tool for COVID-19 detection.

NANO LETTERS (2021)

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Review Chemistry, Physical

Diagnostics for SARS-CoV-2 infections

Bhavesh D. Kevadiya et al.

Summary: The outbreak of SARS-CoV-2 causing COVID-19 has led to diverse and severe symptoms, making accurate diagnosis a key challenge. Rapid diagnosis and treatment measures are crucial in controlling the spread of the virus. The development of diagnostic tools, including nanomaterial-based ones, is essential in the fight against the pandemic.

NATURE MATERIALS (2021)

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Article Multidisciplinary Sciences

Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests

Mitsuru Wakita et al.

Summary: The study evaluated the performance of five COVID-19 antibody detection tests on serum samples from Japanese COVID-19 patients at different time points. The Elecsys and immunochromatography kits showed varying sensitivity and specificity in detecting antibodies in patients with different severity of COVID-19. Current antibody detection tests may be more suitable for short-term epidemiological studies.

PLOS ONE (2021)

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Article Chemistry, Analytical

SERS-based lateral flow immunoassay for sensitive and simultaneous detection of anti-SARS-CoV-2 IgM and IgG antibodies by using gap-enhanced Raman nanotags

Shiliang Chen et al.

Summary: The newly developed SERS-based LFIA strip using GERTs achieved highly sensitive detection of anti-SARS-CoV-2 IgM and IgG, with detection limits 100 times lower compared to conventional LFIA strips, improving the accuracy and reliability of early diagnosis.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Nanoparticle transfer biosensors for the non-invasive detection of SARS-CoV-2 antigens trapped in surgical face masks

Andreu Vaquer et al.

Summary: The detection of SARS-CoV-2 antigens in respiratory tract samples has become a common method for screening new infections. A new non-invasive COVID-19 diagnosis approach using mobile biosensors to detect viral antigens trapped in surgical face masks worn by patients has demonstrated high sensitivity and specificity, making it ideal for mass screening.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Development of an ultrasensitive fluorescent immunochromatographic assay based on multilayer quantum dot nanobead for simultaneous detection of SARS-CoV-2 antigen and influenza A virus

Chongwen Wang et al.

Summary: The study developed a two-channel fluorescent immunochromatographic assay for early diagnosis of SARS-CoV-2 and FluA, achieving simultaneous detection within 15 minutes with high sensitivity and stability.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Sensitive and rapid on-site detection of SARS-CoV-2 using a gold nanoparticle-based high-throughput platform coupled with CRISPR/Cas12-assisted RT-LAMP

Yaqin Zhang et al.

Summary: The development of a gold nanoparticle-based visual assay combined with CRISPR/Cas12a-assisted RT-LAMP for rapid and sensitive detection of SARS-CoV-2 shows promise in improving COVID-19 screening efforts. This method is easy to operate and has high-throughput testing capability, with potential applications in screening suspected individuals in various settings.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples

Haifeng Liu et al.

Summary: This study reported a surface-enhanced Raman scattering-based lateral flow immunoassay method for the high sensitivity simultaneous detection of anti-SARS-CoV-2 IgM/IgG. The method utilized custom SERS tags and dual layers of Raman dye, with signal intensities easily recorded by a portable Raman instrument for high sensitivity analysis. Validation on samples from COVID-19 patients and healthy individuals showed high accuracy and specificity.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

A multi-target lateral flow immunoassay enabling the specific and sensitive detection of total antibodies to SARS COV-2

Simone Cavalera et al.

Summary: This new rapid test can accurately detect the total antibody response to SARS CoV-2 infection, with high diagnostic specificity and sensitivity, and can detect infection earlier.

TALANTA (2021)

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Article Chemistry, Analytical

A silver@gold nanoparticle tetrahedron biosensor for multiple pesticides detection based on surface-enhanced Raman scattering

Yuxiao Lu et al.

Summary: This study constructed a nano-tetrahedron using DNA and Ag@Au nanoparticles to achieve simultaneous detection of multiple pesticides with high sensitivity and low detection limit. The proposed method was verified to be accurate and practical for practical applications.

TALANTA (2021)

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Review Chemistry, Analytical

Functionalized gold nanomaterials as biomimetic nanozymes and biosensing actuators

Liu Liu et al.

Summary: This article reviews the recent advances of functionalized Au NMs in the past decade, summarizes their multiple applications in biomimic catalysis and biosensing, and proposes possible outlooks for the design and applications of functionalized Au NMs in the future.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Medicine, General & Internal

SARS- CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

Maya Moshe et al.

Summary: The study evaluated the performance of new lateral flow immunoassays (LFIAs) for detecting SARS-CoV-2 antibodies in a national COVID-19 seroprevalence program. Seven LFIAs showed sensitivity ranging from 69% to 100% and specificity from 98.6% to 100%. One LFIA was identified with suitable clinical performance for potential inclusion in seroprevalence studies, but none showed superior performance for routine clinical use compared to the current LFIA.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Ecology

ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species

Huan Yan et al.

Summary: The study shows significant variability in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Many bat species may not be potential hosts for these viruses, and there is no correlation between proximity to humans and likelihood of being natural hosts.

NATURE ECOLOGY & EVOLUTION (2021)

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Article Multidisciplinary Sciences

A SARS-CoV-2 antigen rapid diagnostic test for resource limited settings

Erica Frew et al.

Summary: To address the challenges posed by the novel coronavirus, a cost-effective and rapid SARS-CoV-2 antigen test has been developed, capable of identifying the presence of the virus in patient anterior nares swab samples with high sensitivity and no requirement for equipment or laboratory infrastructure.

SCIENTIFIC REPORTS (2021)

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Article Nanoscience & Nanotechnology

Rational Engineering of the DNA Walker Amplification Strategy by Using a Au@Ti3C2@PEI-Ru(dcbpy)32+ Nanocomposite Biosensor for Detection of the SARS-CoV-2 RdRp Gene

Bo Yao et al.

Summary: A novel Au@Ti3C2@PEI-Ru(dcbpy)(3)(2+) nanocomposite-based ECL biosensor was designed for the sensitive detection of the SARS-CoV-2 RdRp gene. The sensor showed a wide detection range and a low limit of detection, indicating its great potential for clinical medical applications. The use of a DNA walker amplification strategy also showed promising results for other detection methods.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Virology

Structure of SARS-CoV-2 spike protein

Jun Zhang et al.

Summary: The COVID-19 pandemic, caused by SARS-CoV-2, has led to millions of deaths and devastating socio-economic consequences worldwide. Understanding the structure-function relationships of viral proteins and host factors is crucial for developing intervention strategies. The trimeric spike protein is a key target for diagnostics, therapeutics, and vaccines, and rapid progress in its structural biology has advanced our understanding of the viral entry process.

CURRENT OPINION IN VIROLOGY (2021)

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Article Chemistry, Analytical

Rapid and sensitive triple-mode detection of causative SARS-CoV-2 virus speci fi c genes through interaction between genes and nanoparticles

Yakun Gao et al.

Summary: This article introduces a triple-mode biosensor based on AuNPs, which can rapidly and selectively detect viral RNA, achieving femtomole level detection limits in absorbance, fluorescence, and SERS modes. The sensor effectively minimizes false negative/positive readings of SARS-CoV-2.

ANALYTICA CHIMICA ACTA (2021)

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Article Electrochemistry

An electrochemical dual-aptamer biosensor based on metal-organic frameworks MIL-53 decorated with Au@Pt nanoparticles and enzymes for detection of COVID-19 nucleocapsid protein

Jinju Tian et al.

Summary: An electrochemical dual-aptamer biosensor was developed for the detection of SARS-CoV-2 nucleocapsid protein, showing high sensitivity and specificity, with great potential for early diagnosis of the virus.

ELECTROCHIMICA ACTA (2021)

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Article Virology

Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR

Flaminia Olearo et al.

Summary: This study evaluated the analytic performance and handling of four rapid Antigen Point of Care Tests, showing acceptable sensitivity and specificity in high viral load samples but a risk of contamination. Careful consideration is needed before clinical implementation due to lower sensitivity compared to RT-qPCR.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Review Infectious Diseases

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis

Nicole Ngai Yung Tsang et al.

Summary: This study systematically compared the diagnostic performance of different clinical specimen collection methods for SARS-CoV-2 infection. Pooled nasal and throat swabs showed the highest sensitivity and positive predictive value, while saliva and nasal swabs also demonstrated good diagnostic performance. Throat swabs had a significantly lower sensitivity and positive predictive value and were not recommended for diagnosis. Self-collection for pooled nasal and throat swabs and nasal swabs did not affect diagnostic accuracy.

LANCET INFECTIOUS DISEASES (2021)

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Review Chemistry, Physical

Graphene quantum dot-based electrochemical biosensing for early cancer detection

Tanveer A. Tabish et al.

Summary: The electrochemical biosensing systems coupled with graphene quantum dots have shown great potential for cancer diagnostic strategies, especially in identifying early tumorigenesis changes and detecting ultralow concentrations of biomarkers for distinguishing normal and malignant cells. Graphene quantum dots, with their comparable size to biomolecules, provide an ideal platform for studying proteins, cells, and viruses.

CURRENT OPINION IN ELECTROCHEMISTRY (2021)

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Review Genetics & Heredity

Testing at scale during the COVID-19 pandemic

Tim R. Mercer et al.

Summary: The assembly and publication of the SARS-CoV-2 genome in January 2020 allowed for immediate development of tests and led to the largest global testing programme in history. Despite efforts to control the spread, widespread community transmission of the virus has become entrenched in many countries, necessitating population-scale testing to identify and isolate infected individuals. Testing plays a crucial role in the response to the COVID-19 pandemic and is likely to continue to be vital in public health.

NATURE REVIEWS GENETICS (2021)

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Article Chemistry, Analytical

Paper-Based Test for Rapid On-Site Screening of SARS-CoV-2 in Clinical Samples

Wen Ren et al.

Summary: A highly sensitive magnetic-focus-enhanced lateral flow assay (mLFA) was proposed for the detection of SARS-CoV-2, allowing the recognition of very low concentrations of the virus particles. This method utilizes magnetic focus enhancement and horseradish peroxidase (HRP) amplification to achieve highly sensitive technology for the recognition of SARS-CoV-2.

BIOSENSORS-BASEL (2021)

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Review Chemistry, Analytical

Carbon Nanotube (CNT)-Based Biosensors

David C. Ferrier et al.

Summary: Recent advances in carbon nanotubes (CNTs) for sensors and biosensors have been discussed, with various applications developed but still facing challenges in integration and industrial scale fabrication.

BIOSENSORS-BASEL (2021)

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Article Anesthesiology

Economic impact of COVID-19 pandemic on healthcare facilities and systems: International perspectives

Alan D. Kaye et al.

Summary: The COVID-19 pandemic has had a significant financial impact on international hospitals and healthcare facilities, causing them to face major financial challenges. It has also exposed deficiencies in pandemic preparedness in healthcare institutions globally, prompting the development of new essential plans.

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2021)

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Article Multidisciplinary Sciences

Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers

Alice Berger et al.

Summary: This study validated two widely available commercial Ag-RDTs, both meeting WHO criteria of >= 80% sensitivity and >= 97% specificity. Although less sensitive than RT-PCR, these assays could be beneficial due to their rapid results, ease of use, and independence from existing laboratory structures. Testing criteria focusing on patients with typical symptoms in their early symptomatic period onset could further increase diagnostic value.

PLOS ONE (2021)

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Editorial Material Multidisciplinary Sciences

SARS-CoV-2 transmission without symptoms

Angela L. Rasmussen et al.

SCIENCE (2021)

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Article Chemistry, Analytical

Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum

Muhammad Muhammad et al.

Summary: This study successfully developed a label-free biosensor for detecting interleukin-6 and achieved quantitative evaluation in a low concentration range. The research indicates that the aptamer-based SERS biosensor can be a promising tool for quick and convenient medical diagnosis applications.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Analytical

A review of aptamer-based SERS biosensors: Design strategies and applications

Muhammad Muhammad et al.

Summary: This review summarizes the general working strategies and different sensor designs of aptamer-based SERS biosensors, which include using aptamer conformational change or various extrinsic Raman reporters. The advantages, applications, and perspectives of these sensors are also discussed.

TALANTA (2021)

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Article Chemistry, Analytical

Anti-SARS-CoV-2 IgG and IgM detection with a GMR based LFIA system

Qiaoge Bayin et al.

Summary: The study introduces a novel lateral flow immunoassay method based on superparamagnetic nanoparticles and giant magnetoresistance sensing system for simultaneous quantitative detection of anti-SARS-CoV-2 immunoglobulin M and G. This method offers advantages in cost-effectiveness, time efficiency, and ease of operation.

TALANTA (2021)

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Article Microbiology

Development of Fast and Portable Frequency Magnetic Mixing-Based Serological SARS-CoV-2-Specific Antibody Detection Assay

Jan Pietschmann et al.

Summary: The emergence of novel coronavirus in China in December 2019 led to a global pandemic, where vaccination is expected to provide containment of the virus. To better detect antibodies, a novel and rapid serological magnetic immunodetection (MID) point-of-care (PoC) assay was developed, giving qualitative and semiquantitative results of SARS-CoV-2-specific antibody levels in patient's sera within a short time.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Nanoscience & Nanotechnology

One-Step, Wash-free, Nanoparticle Clustering-Based Magnetic Particle Spectroscopy Bioassay Method for Detection of SARS-CoV-2 Spike and Nucleocapsid Proteins in the Liquid Phase

Kai Wu et al.

Summary: Amid the ongoing global COVID-19 pandemic, there is a growing demand for accessible, easy-to-use, rapid, inexpensive, and highly accurate diagnostic tools. Traditional diagnostic methods may be too slow and cumbersome for effective disease surveillance and control. Therefore, developing a rapid, one-step, user-friendly, and high-accuracy diagnostic platform is crucial for future epidemic control.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Epitope-Functionalized Gold Nanoparticles for Rapid and Selective Detection of SARS-CoV-2 IgG Antibodies

Tedrick Thomas Salim Lew et al.

Summary: The study developed a colorimetric serological assay to detect SARS-CoV-2 IgG in patients' plasma using short antigenic epitopes conjugated to gold nanoparticles. The specific bivalent binding between SARS-CoV-2 antibodies and epitope-functionalized AuNPs triggers nanoparticle aggregation, allowing for rapid and distinct detection of SARS-CoV-2 infection in clinical samples.

ACS NANO (2021)

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Article Chemistry, Analytical

Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors

Adrianna N. Masterson et al.

Summary: The diagnostic test presented is capable of accurately detecting multiple biomarkers of COVID-19 on a single platform, with high specificity, sensitivity, positive predictive value, and negative predictive value. It enables direct quantitative measurement of antibodies in plasma with high confidence and has potential applications beyond the current pandemic.

ANALYTICAL CHEMISTRY (2021)

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Article Biophysics

Rapid and unamplified identification of COVID-19 with morpholino-modified graphene field-effect transistor nanosensor

Jiahao Li et al.

Summary: A rapid and unamplified nanosensing platform for detecting SARS-CoV-2 RNA in human throat swab specimens was developed, showing high sensitivity and rapid response. The sensor could accurately differentiate healthy individuals from infected individuals and had strong agreement with RT-PCR results.

BIOSENSORS & BIOELECTRONICS (2021)

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Review Chemistry, Inorganic & Nuclear

Surface functionalization - The way for advanced applications of smart materials

Karolina Wieszczycka et al.

Summary: This review discusses the latest innovations and trends in surface functionalization of various nanomaterials, focusing on smart materials fabrication protocols and challenges in improving their performance. Attention is given to the properties enhancement of polymer, silica, inorganic, and hybrid nanomaterials, as well as their potential applications in multiple fields.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Medicine, General & Internal

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection: One year later

Fabio Angeli et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2021)

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Article Chemistry, Physical

Magnetic Particle Spectroscopy with One-Stage Lock-In Implementation for Magnetic Bioassays with Improved Sensitivities

Vinit Kumar Chugh et al.

Summary: Magnetic particle spectroscopy (MPS) is a highly sensitive and versatile sensing technique for quantitative bioassays, utilizing the dynamic magnetic responses of magnetic nanoparticles (MNPs) to detect target analytes. An MPS system with a one-stage lock-in design enhances sensitivity and can be applied for detecting various analytes such as viruses and toxins.

JOURNAL OF PHYSICAL CHEMISTRY C (2021)

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Article Chemistry, Multidisciplinary

Efficient and Versatile Application of Fluorescence DNA-Conjugated CdTe Quantum Dots Nanoprobe for Detection of a Specific Target DNA of SARS Cov-2 Virus

Ghasem Rezanejade Bardajee et al.

Summary: This study utilized a fluorescence quantum dots-DNA nanosensor for efficient detection of specific DNA or RNA from the SARS Cov-2 virus, providing a simple, highly sensitive, selective, and rapid approach through FRET experiment and forming a classic sandwich structure.

LANGMUIR (2021)

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Article Chemistry, Analytical

Voltammetric-based immunosensor for the detection of SARS-CoV-2 nucleocapsid antigen

Shimaa Eissa et al.

Summary: A label-free square wave voltammetry-based biosensing platform for detecting SARS-CoV-2 in nasopharyngeal samples was developed with high sensitivity and selectivity. The biosensor demonstrated successful detection of the SARS-CoV-2 virus in clinical samples, showing a good correlation with RT-PCR cycle threshold values.

MICROCHIMICA ACTA (2021)

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Review Chemistry, Analytical

A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus

Nadiah Ibrahim et al.

Summary: The emergence of deadly human coronaviruses, as well as other viral diseases, has caused millions of deaths worldwide. Nanomaterials-based biosensors have shown great potential for early and rapid detection of human viral diseases, providing a new strategy for containment and treatment.

SENSORS (2021)

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Article Chemistry, Analytical

Development of a rapid and sensitive quantum dot nanobead-based double-antigen sandwich lateral flow immunoassay and its clinical performance for the detection of SARS-CoV-2 total antibodies

Yaofeng Zhou et al.

Summary: The study successfully developed highly luminescent quantum dot nanobeads for rapid and accurate measurement of total antibody concentrations in the population, which is crucial for combating the COVID-19 pandemic.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Magnetic graphene quantum dots facilitate closed-tube one-step detection of SARS-CoV-2 with ultra-low field NMR relaxometry

Yongqiang Li et al.

Summary: The use of a magnetic GQDs-based probe coupled with ULF NMR enables rapid, safe, and sensitive detection of SARS-CoV-2, improving efficiency and reducing the risk of infection for testers.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Medicine, General & Internal

Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis

Lukas E. Brummer et al.

Summary: A systematic review and meta-analysis was conducted to evaluate the clinical accuracy of commercially available Ag-RDTs for SARS-CoV-2. The study found that Ag-RDTs can detect the vast majority of infected individuals in the early phase of the disease and those with high viral load, making them valuable diagnostic tools. However, concerns were raised regarding bias across datasets and the need for standardization in conducting and reporting clinical accuracy studies for improved comparability and data utilization.

PLOS MEDICINE (2021)

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Article Chemistry, Multidisciplinary

SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

Elena Zavyalova et al.

Summary: This paper presents a SERS-aptasensor based on colloidal solutions for rapid and specific quantitative determination of the SARS-CoV-2 virus, distinguishing it from other respiratory viruses. Existing SERS-based aptasensors for virus detection often lack quantification or are complex and costly in their design and implementation.

NANOMATERIALS (2021)

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Letter Microbiology

Identification of Novel Mutations in the N Gene of SARS-CoV-2 That Adversely Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR

Rashedul Hasan et al.

MICROBIOLOGY SPECTRUM (2021)

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Review Medicine, General & Internal

PCR performance in the SARS-CoV-2 Omicron variant of concern?

Cesar M. J. A. Metzger et al.

Summary: The new SARS-CoV-2 Omicron variant has been declared a Variant of Concern due to important mutations in the viral spike protein, especially in the receptor-binding domain. The spread of this variant is being investigated with the first cases detected in Switzerland. Questions have been raised about the effectiveness of PCR assays and specific features for identifying Omicron samples, with guidance provided in this minireview.

SWISS MEDICAL WEEKLY (2021)

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Review Biotechnology & Applied Microbiology

A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection

Leticia Tessaro et al.

Summary: Various morphologies and transducer types have significant impacts on the sensitivity and detection limit of AuNPs, with authors reporting a wide variation in LOD based on morphology and transducer type. While no direct relationship between AuNP size and LOD was noted, spherical AuNPs with an average diameter ranging from 10 to 100 nm, particularly particles with an average diameter of 80 nm showed better results.

SENSORS AND ACTUATORS REPORTS (2021)

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Article Chemistry, Multidisciplinary

Detection of SARS-CoV-2 and its S and N proteins using surface enhanced Raman spectroscopy

John Eder Sanchez et al.

Summary: The COVID-19 pandemic highlighted the importance of accurate and rapid virus testing. The use of Surface Enhanced Raman Spectroscopy (SERS) with novel nanomaterials can provide distinct spectroscopic signatures of the SARS-CoV-2 virus, offering a fast, inexpensive, and reliable clinical testing method. Additionally, SERS can be utilized for analyzing structural changes in virus proteins, showcasing the application of nanotechnology in health and social issues.

RSC ADVANCES (2021)

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Article Chemistry, Multidisciplinary

CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2

Yiren Cao et al.

Summary: The trans-cleavage activity of target-activated CRISPR/Cas12a released an RNA crosslinker from a molecular transducer, aiding in the assembly of gold nanoparticles. Integration of the molecular transducer with isothermal amplification and CRISPR/Cas12a allowed for visual detection of the N gene and E gene of SARS-CoV-2 in 45 minutes.

CHEMICAL COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

SERS Based Lateral Flow Immunoassay for Point-of-Care Detection of SARS-CoV-2 in Clinical Samples

Shalu Yadav et al.

Summary: The ongoing COVID-19 pandemic has created a significant burden on the global healthcare system, necessitating a rapid, user-friendly, and cost-effective on-site monitoring system for diagnosis. This review discusses the integration of SERS with LFIA for quantitative analysis of SARS-CoV-2 as a solution to the limitations of existing methods.

ACS APPLIED BIO MATERIALS (2021)

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Review Biochemical Research Methods

DNA-Functionalized Plasmonic Nanomaterials for Optical Biosensing

Yuanyuan Tian et al.

BIOTECHNOLOGY JOURNAL (2020)

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Article Chemistry, Analytical

Frster resonance energy transfer?what can we learn and how can we use it?

Herbert Schneckenburger

METHODS AND APPLICATIONS IN FLUORESCENCE (2020)

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Article Medical Laboratory Technology

Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia

Daniel K. W. Chu et al.

CLINICAL CHEMISTRY (2020)

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Article Virology

Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis

Zhengtu Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

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Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

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Review Chemistry, Analytical

Resonance energy transfer to gold nanoparticles: NSET defeats FRET

Chi Chen et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection

Guangyu Qiu et al.

ACS NANO (2020)

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Article Biochemistry & Molecular Biology

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

Junwen Luan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Letter Cardiac & Cardiovascular Systems

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

Liang Chen et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Article Microbiology

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CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

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Letter Gastroenterology & Hepatology

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