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Article
Chemistry, Multidisciplinary
Deep Sekhar Biswas et al.
Summary: By studying the FRET phenomenon between fluorescent organic nanoparticles, it is found that the efficiency does not follow the Forster law and can achieve high efficiency at long distances. This opens up the possibility of using advanced optical nanomaterials for amplified FRET-based biosensing.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Dongliu Xiang et al.
Summary: A versatile detection technique was developed using magnetic beads, barcoded DNA strands released from gold nanoparticles, and exonuclease III cyclic cleavage-assisted signal amplification. This technique was integrated into a microfluidic chip with multiple chambers and the mixing was achieved by acoustic vibration from a portable sonic toothbrush. The detection limits of three different targets were successfully demonstrated, and this platform is expected to be developed into an automatic sample-to-answer device.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Yudong Sun et al.
Summary: Rapid, low-cost, and user-friendly methods for nucleic acid detection are urgently needed. Here, a miniaturized and convenient photoelectrochemical biosensor array (PEBA) platform was developed for multiplexing and simultaneous detection of nucleic acid. The platform demonstrated high sensitivity and a linear range for HPV genotyping, and achieved a concordance result of 97.5% when compared with commercial kits in evaluation with clinical samples. The PEBA platform has potential applications in biomedicine analysis and clinical healthcare diagnosis.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Yin Zhao et al.
Summary: Fast and simplified detection of HPV using a microfluidic dual-droplet device (M-D3) was developed. The device combined the CRISPR-Cas12a system and multiplexed recombinase polymerase amplification (RPA) assay to simultaneously detect HPV16 and HPV18. The M-D3 platform demonstrated high sensitivity and specificity in detecting HPV DNA, allowing on-chip detection within 30 minutes. The platform was validated using clinical patient samples with HPV infection risk, showing promising results in terms of sensitivity and specificity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lifang Pang et al.
Summary: In this study, smart up/downconversion nanomachines were constructed by modifying DNA logic circuits on nanoparticles, enabling precise and efficient photodynamic therapy (PDT) for target tumors using near-infrared light. The biodistribution of the nanomachines in vivo could be visualized using NIR-II fluorescence imaging, contributing to precise PDT. This work provides new insights into the development of precise and highly efficient PDT systems.
Article
Chemistry, Multidisciplinary
Wen Yi Lv et al.
Summary: A weak-inputs-strong-outputs strategy was proposed to guide the construction of sensitive logic nanodevices by coupling an input-induced reversible DNA computing platform with a signal amplifier based on hybridization chain reaction. The newly formed logic nanodevices have good sensitivity to weak input signals and can perform various logic operations in a dilute solution medium.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yaquan Liang et al.
Summary: The electrochemical reduction signal of graphene oxide nanocolloids is inhibited when they form non-covalent interactions with single stranded DNA oligonucleotides. The decrease in reduction current intensity is highly influenced by the nucleobase sequence and can be directly correlated to the specific DNA homo-oligonucleotide.
CHEMICAL COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mykhaylo Usyk et al.
Summary: Burk et al. developed an algorithm called molBV, which uses the 16S rRNA gene to diagnose bacterial vaginosis (BV) and predict the progression of human papillomavirus infection to cervical pre-cancer. They found that an increase in BV activity directly predicts the clearance of high-risk HPV infection, and also identified an alternative inflammatory BV signature associated with infection progression.
NATURE COMMUNICATIONS
(2022)
Article
Biophysics
Shengyu Chen et al.
Summary: MicroRNAs (miRNAs) play a crucial role in regulating cellular activities, and their abnormal expression is associated with various diseases, especially cancer. However, detecting the copy numbers of different miRNAs in single cells accurately remains challenging. In this study, researchers proposed an intracellular multivariate signal amplification strategy and established an ultrasensitive single-cell analysis method for quantifying the absolute copy numbers of multiple miRNAs in a single cell simultaneously. They successfully analyzed the distribution of miRNA-21 and miRNA-141 copy numbers in different types of cells, revealing distinct expression characteristics in cancer cells. These findings provide insights into cell-to-cell heterogeneity and the relationship between miRNAs and different types of cancer at the single-cell level.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Lin Ling Zheng et al.
Summary: We report a sensitive nanoprobe for live-cell imaging using quantum dots and BH-2 loaded gold nanoparticles assembled through a molecular beacon. This nanoprobe achieves nanometal surface energy transfer and Fo·ster resonance energy transfer, significantly enhancing the energy transfer efficiency. The nanoprobe demonstrates strong photostability and has been successfully used to record the spatiotemporal distribution and dynamics of genomic RNA in live cells.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Liyuan Zhou et al.
Summary: This study investigates the molecular mechanisms of cervical carcinogenesis caused by HPV DNA integration into the human genome. By analyzing 16 HPV16-positive cervical tumors, the authors identify distinct integration types, structural variations, and potential driver genes. The findings provide insights into the role and mechanism of HPV integration in cervical cancer.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Chunxu Lv et al.
Summary: This study designs a multifunctional nanoplatform to treat cancer by regulating intracellular ions and causing cell death, which shows promising efficacy in tumor suppression.
Article
Engineering, Biomedical
Huanhuan Sun et al.
Summary: This study presents a stable DNA tetrahedra-gold nanoclusters (DT/AuNCs) nanohybrid for stimuli-responsive tumor imaging and gene-chemo therapy. The DT/AuNCs exhibit sequential response to legumain-TK1 mRNA & glutathione, leading to combined gene silencing and chemo-therapy. The nanohybrids significantly improve the stability and therapeutic efficiency compared to naked DNA tetrahedra.
Article
Biophysics
Ling Liang et al.
Summary: In this study, a two-dimensional DNA walking nanomachine with high working efficiency and low cost was easily assembled using GO as the working platform. The nanomachine showed simple operation, high cost-performance ratio, and low background signal, making it highly promising for biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Jiaoli Wang et al.
Summary: Visualizing intracellular microRNA (miRNA) is important for understanding its role in disease development. This study presents a size-controllable and self-assembled DNA nanosphere that uses ATP-fueled dissociation for amplified miRNA imaging in live cells and mice. The nanosphere, composed of Y-shaped DNA monomers, can be easily controlled in size and shows fair cell penetration, stability, and sensitivity for detecting miRNA expression in cancer cells and mice.
Article
Chemistry, Analytical
Mengying Ye et al.
Summary: In this study, a photoactivatable membrane-oriented HCR system was designed to achieve amplification imaging through self-assembly initiated by a photoactivated initiator probe. Based on imaging of specific surface proteins, our system demonstrated high efficiency and accuracy in differentiating between plasma samples from breast cancer patients and healthy donors.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Shengyu Chen et al.
Summary: Single-cell protein analysis is crucial for understanding cellular heterogeneity and biology. This study proposes an intracellular multicomponent synchronous DNA-walking strategy for quantifying multiple tumor-associated proteins simultaneously in a single cell. By amplifying the signals of nucleolin and thymidine kinase 1 using a nanoprobe based on a DNA walker, the absolute quantification of these proteins in single cells was achieved. The results demonstrate the overexpression of nucleolin and thymidine kinase 1 in liver cancer cells compared to normal hepatocytes.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Wenchan Deng et al.
Summary: This study reports a toehold-exchange translator and translator-mediated DNAzyme motor systems that enable sensitive responses to various nucleic acid targets using the same DNAzyme motor without requiring redesign. The translator efficiently converts nucleic acid targets into specific output DNA, activating the DNAzyme motor and enabling autonomous movement. By adjusting the target-binding region of the translator, the same DNAzyme motor system can respond to multiple nucleic acid targets. The study also demonstrates the construction and operation of four logic gates using the translator and DNAzyme motor, enhancing the biosensing applications of DNA motors.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Chunhuan Xu et al.
Summary: A novel DNA machine-based approach for absolute quantification of mRNA in individual cells is presented. This method provides important insights into cellular function and has great research and diagnostic value.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Huimin Wang et al.
Summary: This article introduces a new isothermal nucleic acid amplification technique, which can achieve miRNA amplification detection through reasonable probe design, avoiding the increase in cost and operation steps caused by temperature changes or the addition of additional reagents.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Yiren Cao et al.
Summary: The study found that in MNAzymes, the split location and secondary structure of DNAzymes can affect their catalytic activity in multi-step cleavage, with the split location between the seventh cytosine and the eighth thymine of the catalytic core region and the four-arm structure yielding the optimum catalytic activity. The optimized MNAzymes with binding-induced DNA assembly can be used for sensitive protein detection.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Arun Richard Chandrasekaran et al.
Summary: Molecular biomarkers are crucial in clinical settings and research labs, with the challenge of detecting multiple biomarkers providing a comprehensive overview. Programmable DNA nanoswitches enable the multiplexed detection of up to 6 biomarkers simultaneously, showcasing the potential for diverse biomolecular detection in a single assay.
Article
Chemistry, Analytical
Jiasi Wang et al.
Summary: Cervical cancer is a leading cause of cancer deaths among women in developing countries, highlighting the need for a rapid and low-cost HPV detection method for screening. The dLAMP assay and self-digitization chip demonstrated reliable genotyping and quantitative detection of 14 high-risk HPVs, showing potential for simple, rapid, and cost-effective diagnosis of HPV infection.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chi Yao et al.
Summary: A DNA network containing polyvalent multimodules was developed for specific isolation and incubation of T cells, achieving efficient isolation with high purity and low cell damage. Complementary sequences facilitated the formation of the DNA network and cutting sites for responsive release of T cells and immune adjuvants, showing potential for localized immunotherapy in tumor lesions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Medicine, General & Internal
Milena Falcaro et al.
Summary: A study in England found a significant reduction in cervical cancer and CIN3 incidence in young women after the introduction of the HPV immunisation programme, especially in those vaccinated at age 12-13. The programme has successfully almost eliminated cervical cancer in women born since September 1, 1995.
Letter
Medicine, General & Internal
Miriam Cremer et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Alejandra Garcia et al.
Summary: HPV infection is a necessary factor for the development of cervical cancer, and viral oncoproteins E6 and E7 play central roles in the carcinogenic process. Studies have shown that certain HPV subtypes use unique mechanisms for translating E6/E7 in cervical tumors, shedding light on the mechanism of cancer development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Jixue Weng et al.
Summary: Cervical cancer is a significant cause of death in women, with HPV typing being crucial for diagnosis and control. The Multi-Vision method, utilizing closed-tube PCR, offers high specificity and sensitivity for typing various HPV types, making it a useful tool for HPV detection in resource-limited regions.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qian Chen et al.
Summary: The development of a renal-accumulating DNA nanodevice in this study offers promising protection for acute kidney injury patients in different stages, with potential for providing durable and pathogenic treatment for kidney dysfunction based on the pathophysiological events caused by ischemia-reperfusion.
Article
Chemistry, Multidisciplinary
Lei Mou et al.
Summary: The study developed a droplet-based digital microfluidic hybridization assay for direct nucleic acid detection with attomolar sensitivity, providing a clinically useful method for detecting HPV without amplification.
Article
Chemistry, Multidisciplinary
Ke Ma et al.
Summary: This study demonstrates a new nanomaterial for in vivo diagnosis and therapy of liver tumors, which has good biocompatibility and high selectivity, and performs well both in vitro and in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biophysics
Hojeong Shin et al.
Summary: The authors developed a graphene oxide-based system called GOViRA for real-time monitoring of intracellular viral RNA levels, providing a potential tool for discovering new antiviral compounds. Through high-throughput screening, they identified a drug called ulipristal as a potent inhibitor against DENV infection.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Xiaoyu Zhao et al.
Summary: The study developed a microfluidic detection system for diagnosing high-risk HPV with good detection performance. The system integrates nucleic acid purification, isothermal amplification, and real-time fluorescence detection, offering automated and rapid diagnosis with broad potential for resource-limited settings.
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Paul A. Cohen et al.
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Biwu Liu et al.
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