Ratiometric near-infrared upconversion fluorescence sensor for selectively detecting and imaging of Al3+

Near-infrared (NIR) fluorescent probes provide extremely sensitive Al3+ detection for human health purposes. This research develops novel Al3+ response molecules (HCMPA) and NIR upconversion fluorescent nanocarriers (UCNPs), which respond to Al3+ through ratio NIR fluorescence. UCNPs improve photobleaching and visible light lack in specific HCMPA probes. Additionally, UCNPs are capable of ratio response, which will further enhance signal accuracy. The NIR ratiometric fluorescence sensing system has been successfully used to detect Al3+ within the range 0.1-1000 nM with an accuracy limit of 0.06 nM. Alternatively, a NIR ratiometric fluorescence sensing system integrated with a specific molecule can image Al3+ within cells. This study demonstrates that a NIR fluorescent probe is an effective and highly stable method of measuring Al3+ in cells.

Automated summary

Near-infrared (NIR) fluorescent probes offer highly sensitive detection of Al3+ for human health purposes. This study introduces new Al3+ response molecules (HCMPA) and NIR upconversion fluorescent nanocarriers (UCNPs) that respond to Al3+ through ratio NIR fluorescence. The use of UCNPs improves photobleaching and addresses the lack of visible light in specific HCMPA probes. The NIR ratiometric fluorescence sensing system successfully detects Al3+ within the range of 0.1-1000 nM with an accuracy limit of 0.06 nM.