期刊
ANALYTICA CHIMICA ACTA
卷 1275, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aca.2023.341562
关键词
Cultural heritage; Proteinaceous binders; Simultaneous detection; Microfluidic device; Electrochemical immunosensor
The aging of proteinaceous binders can cause diseases such as flaking, cracks, and peeling in cultural relics. Timely identification of binders is beneficial for the restoration of diseased cultural relics. A portable electrochemical microfluidic device was developed for simultaneous detection of casein, ovalbumin, and peach gum binders. The proposed technology achieved miniaturization, portability, and reagent-saving goals, with excellent performance in terms of detection limits and acceptable anti-interference ability, stability, and storage capacity.
The aging of the proteinaceous binders will cause the cultural relics to suffer from diseases such as flaking, cracks, and even peeling. Identifying the type of binders in a timely manner is conducive to restore diseased cultural relics. High-throughput and portable detection system are of great significance for researching cultural relic materials on the archaeological site. Therefore, in this work, a portable electrochemical microfluidic device for the simultaneous detection of casein, ovalbumin, and peach gum binders was developed. The proposed electrochemical immunosensor technology integrated with microfluidic device achieve the goals of miniaturization, portability and reagent-saving. For casein, ovalbumin and peach gum, excellent performance was obtained in terms of their limits of detection (LOD) at 0.237, 0.507, and 0.403 ng mL-1 (S/N = 3), respectively. In addition, the microfluidic sensing platform exhibited acceptable anti-interference ability, stability, and storage capacity. In order to evaluate the practical application value, the proposed microfluidic sensing device was applied for detecting eight archaeological samples from different historic sites. This work demonstrates great potential for high-throughput, portable detection of cultural relic proteinaceous binder materials.
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