4.7 Article

Automated solid phase DNA extraction on a lab-on-a-disc with two-degrees of freedom instrumentation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Analytical

Plant pathogen detection on a lab-on-a-disc using solid-phase extraction and isothermal nucleic acid amplification enabled by digital pulse-actuated dissolvable film valves

Rohit Mishra et al.

Summary: Due to its ruggedness, portability, rapid processing times, and ease-of-use, centrifugal microfluidic systems have gained significant academic and commercial interest in the past decade. The LoaD platform offers the advantage of automating laboratory unit operations (LUOs) and requires only a low-cost spindle motor, making it a portable and accessible platform. A novel flow control scheme is proposed, which enables automation of multi-step assays with high reliability and full temporal control.

ANALYTICA CHIMICA ACTA (2023)

Article Multidisciplinary Sciences

Digital process control of multi-step assays on centrifugal platforms using high-low-high rotational-pulse triggered valving

Philip L. Early et al.

Summary: Due to the automation capabilities of centrifugal microfluidic systems, they have gained significant interest in industry and academia over the past 25 years. These systems, also known as Lab-on-a-Disc platforms, are primarily used for decentralized bioanalytical point-of-use/point-of-care testing. Flow control plays a crucial role in coordinating multi-step/multi-reagent assay formats on these platforms. Traditional flow control methods, such as capillary burst valves, have been replaced by programmable rotational pulse actuated valves, which use digital pulsing to improve flow control. In this work, High-Low-High (HLH) pulse-actuated valves are introduced for high spin-rate operations, such as blood centrifugation. The combination of HLH valves with Low-High-Low (LHL) valves is used to implement a time-dependent liquid handling protocol for a liver function test panel.

PLOS ONE (2023)

Article Chemistry, Analytical

Modular design of centrifugal microfluidic system and its application in nucleic acid screening

Gangpei Cai et al.

Summary: Modular integration of functional components on the chip and real-time alteration in the force direction of droplets optimizes centrifugal microfluidic systems and allows for passive components, compact modules, and high-throughput control. A novel centrifugal microfluidic system is introduced to improve chip control freedom and accuracy while facilitating the design and addition of passive functional components. The system is modularized to shorten design and optimization cycles and achieve chip reusability and multi-threaded control. Testing the nucleic acid purification and detection reactions on the modular chip verifies its feasibility for high-throughput nucleic acid screening.

TALANTA (2023)

Article Chemistry, Analytical

Siphon-Controlled Automation on a Lab-on-a-Disc Using Event-Triggered Dissolvable Film Valves

Brian D. Henderson et al.

Summary: The centrifugal microfluidic Lab-on-a-Disc platform combines event-triggered dissolvable film valves with a centrifugo-pneumatic siphon structure to control and time the release and incubations of samples/reagents/wash buffers through changes in disc spin-speed. This platform is suitable for integrating and automating chemiluminescent immunoassay for detection of C-reactive protein marker, with a limit of detection of 44.87 ng mL(-1) and limit of quantitation of 135.87 ng mL(-1).

BIOSENSORS-BASEL (2021)

Article Biochemical Research Methods

Ferrowax microvalves for fully automated serial dilution on centrifugal microfluidic platforms

Soohyun Kim et al.

Summary: A new centrifugal microfluidic system utilizing ferrowax microvalves has achieved fully automated serial dilutions, with excellent accuracy in a wide dynamic range of up to six orders of magnitude. The overall serial dilution process, including diluent addition, mixing, and product transfer steps, is completed very rapidly within 5 minutes.

BIOTECHNOLOGY JOURNAL (2021)

Review Engineering, Chemical

Biosensing on the Centrifugal Microfluidic Lab-on-a-Disc Platform

Celina M. Miyazaki et al.

PROCESSES (2020)

Article Biochemical Research Methods

Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices

M. Shane Woolf et al.

LAB ON A CHIP (2020)

Article Engineering, Multidisciplinary

Siphon-Induced Droplet Break-Off for Enhanced Mixing on a Centrifugal Platform

Robert Burger et al.

INVENTIONS (2020)

Review Nanoscience & Nanotechnology

Active pumping and control of flows in centrifugal microfluidics

Liviu Clime et al.

MICROFLUIDICS AND NANOFLUIDICS (2019)

Article Biophysics

Integrated LAMP and immunoassay platform for diarrheal disease detection

Christopher R. Phaneuf et al.

BIOSENSORS & BIOELECTRONICS (2018)

Review Chemistry, Multidisciplinary

The potential of paper-based diagnostics to meet the ASSURED criteria

Suzanne Smith et al.

RSC ADVANCES (2018)

Article Chemistry, Analytical

Baking Powder Actuated Centrifugo-Pneumatic Valving for Automation of Multi-Step Bioassays

David J. Kinahan et al.

MICROMACHINES (2016)

Review Chemistry, Multidisciplinary

Centrifugal microfluidic platforms: advanced unit operations and applications

O. Strohmeier et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Chemistry, Analytical

Centrifugal Microfluidic System for Nucleic Acid Amplification and Detection

Baogang Miao et al.

SENSORS (2015)

Article Nanoscience & Nanotechnology

Solvent-selective routing for centrifugally automated solid-phase purification of RNA

Nikolay Dimov et al.

MICROFLUIDICS AND NANOFLUIDICS (2015)

Article Nanoscience & Nanotechnology

Spin coating of hydrophilic polymeric films for enhanced centrifugal flow control by serial siphoning

Maria Kitsara et al.

MICROFLUIDICS AND NANOFLUIDICS (2014)

Article Biochemical Research Methods

Simple, distance-based measurement for paper analytical devices

David M. Cate et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Centrifugo-pneumatic valving utilizing dissolvable films

Robert Gorkin et al.

LAB ON A CHIP (2012)

Article Biochemical Research Methods

Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform

Kameel Abi-Samra et al.

LAB ON A CHIP (2011)

Review Biochemical Research Methods

Nucleic acid extraction techniques and application to the microchip

Carol W. Price et al.

LAB ON A CHIP (2009)

Article Nanoscience & Nanotechnology

Analysis and experiment of capillary valves for microfluidics on a rotating disk

Jerry M. Chen et al.

MICROFLUIDICS AND NANOFLUIDICS (2008)