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S. Vamsee Raju et al.
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Mark J. Turner et al.
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R. Venkatasamy et al.
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Nancy K. Leidy et al.
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Andrea Gershon et al.
JAMA INTERNAL MEDICINE (2013)
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J. Milara et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2011)
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John R. Hurst et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
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Leonardo M. Fabbri et al.
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Peter M. A. Calverley et al.
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Victoria Boswell-Smith et al.
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The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C4-induced contractions in passively sensitized human airways
DT Schmidt et al.
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