Association of the Triglyceride-Glucose Index With Risk of Alzheimer's Disease: A Prospective Cohort Study

Article Cardiac & Cardiovascular Systems

Triglyceride-glucose index and common carotid artery intima-media thickness in patients with ischemic stroke

Mengyuan Miao et al.

Summary: This study found an association between TyG index and carotid atherosclerosis in patients with ischemic stroke, suggesting that TyG could be a promising marker for atherosclerosis.

CARDIOVASCULAR DIABETOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Li-Chan Tao et al.

Summary: This review summarizes the history of the use of the TyG index as a surrogate marker for insulin resistance (IR) and explores its application value in various types of cardiovascular disease (CVD), as well as the potential limitations of using this index as a predictor for cardiovascular events. The aim is to provide more extensive and precise supporting evidence to improve its application value in CVD.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure

Rong Huang et al.

Summary: This retrospective study of 932 ADHF patients showed that elevated TyG index was independently associated with poor prognosis and could be used for risk stratification. The highest TyG tertile was significantly associated with increased risk of all-cause death, CV death, and MACCEs.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Relationship of cumulative exposure to the triglyceride-glucose index with ischemic stroke: a 9-year prospective study in the Kailuan cohort

Xianxuan Wang et al.

Summary: This study evaluated the association between cumulative TyG index exposure and the risk of ischemic stroke, and found that a high cumulative TyG index is associated with a higher risk of ischemic stroke.

CARDIOVASCULAR DIABETOLOGY (2022)

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Review Biochemistry & Molecular Biology

Type 2 Diabetes Mellitus and Alzheimer's Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets

Rim Hamze et al.

Summary: The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly with the aging of the population. There is a strong association between type 2 diabetes and an increased risk of dementia. The amyloid cascade, altered glucose metabolism, and insulin signaling may play key roles in the pathophysiology of Alzheimer's disease. Impaired insulin and IGF-1 signaling, as well as GSK3 beta and DYRK1A, could be potential therapeutic targets for both diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis

Xiao Liu et al.

Summary: This meta-analysis found that a higher TyG index is associated with increased incidence of coronary artery disease, myocardial infarction, and composite cardiovascular disease in the general population. However, there is no association between the TyG index and mortality. There is a potential linear association between the TyG index and the risk of coronary artery disease and composite cardiovascular disease incidence. Further studies are needed to confirm these findings, especially in non-Asians.

CARDIOVASCULAR DIABETOLOGY (2022)

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Review Clinical Neurology

Shared pathophysiology: Understanding stroke and Alzheimer's disease

Sai Sriram et al.

Summary: This critical review examines the shared vascular risk factors between Alzheimer's disease and stroke, as well as their pathophysiology and interplay. The review highlights areas that require further investigation and discusses the potential of targeting secondary mechanisms early in treatment options.

CLINICAL NEUROLOGY AND NEUROSURGERY (2022)

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Article Clinical Neurology

2022 Alzheimer's disease facts and figures

Joseph Gaugler et al.

Summary: This article discusses the impact of Alzheimer's disease on public health, including its incidence, prevalence, mortality and morbidity rates, healthcare costs and caregivers' burden. It also addresses the perspectives of consumers and primary care physicians on mild cognitive impairment (MCI) and the need for improved awareness, diagnosis, and treatment. The article emphasizes the increasing number of individuals living with Alzheimer's and the challenges faced by caregivers and healthcare providers, particularly during the COVID-19 pandemic.

ALZHEIMERS & DEMENTIA (2022)

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Review Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

Alberto Serrano-Pozo et al.

Summary: The APOE ε4 allele and ε2 allele are respectively the strongest genetic risk factor and protective factor for Alzheimer's disease. While therapies targeting APOE are currently unavailable, recent research has expanded our understanding of APOE pathogenesis to include multiple pathological processes, offering valuable insights for therapy development.

LANCET NEUROLOGY (2021)

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Article Medicine, General & Internal

Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study

Yun Kyung Cho et al.

Summary: The study revealed that TyG-WC index is a better predictor for coronary artery calcification progression, with incidence rates increasing with higher TyG-WC quartiles. Patients in the highest TyG-WC quartile had a higher prevalence rate compared to those in the lowest quartile.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Clinical Neurology

Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study

Samia C. Akhter-Khan et al.

Summary: The study found that persistent loneliness in mid-life is associated with a higher risk of dementia and Alzheimer's disease, while recovering from loneliness suggests lower dementia risk.

ALZHEIMERS & DEMENTIA (2021)

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Article Cardiac & Cardiovascular Systems

Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study

Shujie Wang et al.

Summary: The study found that compared to HOMA-IR, the TyG index is independently and more strongly associated with arterial stiffness in patients with T2D. Seemingly unrelated regression estimation analysis and multivariable logistic analyses showed that the TyG index was positively associated with the prevalence of increased arterial stiffness, especially in older patients with a longer duration of diabetes and poor glycaemic control. Subgroup analyses revealed a more significant association between the TyG index and arterial stiffness in specific patient populations.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Triglyceride-glucose index is associated with in-stent restenosis in patients with acute coronary syndrome after percutaneous coronary intervention with drug-eluting stents

Yong Zhu et al.

Summary: The triglyceride-glucose (TyG) index is positively associated with in-stent restenosis (ISR) after drug-eluting stent (DES) implantation in patients with acute coronary syndrome (ACS). Higher TyG index is related to higher prevalence of DES-ISR in ACS patients.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Impact of triglyceride-glucose index on long-term cardiovascular outcomes in patients with myocardial infarction with nonobstructive coronary arteries

Side Gao et al.

Summary: The TyG index is associated with the risk of major adverse cardiovascular events in MINOCA patients, with higher levels of TyG index indicating a poorer prognosis. There is a positive correlation between prognosis and TyG index levels, and the TyG index also has a moderate predictive value for future cardiovascular events.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

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Correction Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches (vol 20, pg 68, 2021)

Alberto Serrano-Pozo et al.

LANCET NEUROLOGY (2021)

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Article Clinical Neurology

Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers

Megan M. Bernath et al.

NEUROLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

Le Wang et al.

CARDIOVASCULAR DIABETOLOGY (2020)

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Article Clinical Neurology

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia A Randomized Clinical Trial

Suzanne Craft et al.

JAMA NEUROLOGY (2020)

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Article Endocrinology & Metabolism

Central nervous pathways of insulin action in the control of metabolism and food intake

Stephanie Kullmann et al.

Lancet Diabetes & Endocrinology (2020)

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Article Clinical Neurology

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

Derek Kellar et al.

LANCET NEUROLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Minghui Li et al.

CARDIOVASCULAR DIABETOLOGY (2020)

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Article Medicine, General & Internal

The State of US Health, 1990-2016 Burden of Diseases, Injuries, and Risk Factors Among US States

Ali H. Mokdad et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Review Clinical Neurology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold et al.

NATURE REVIEWS NEUROLOGY (2018)

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Review Immunology

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Yang Shi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Medicine, General & Internal

The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents

Shinje Moon et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2017)

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Article Multidisciplinary Sciences

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Simon M. Laws et al.

SCIENTIFIC REPORTS (2017)

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Review Physiology

BRAIN INSULIN RESISTANCE AT THE CROSSROADS OF METABOLIC AND COGNITIVE DISORDERS IN HUMANS

Stephanie Kullmann et al.

PHYSIOLOGICAL REVIEWS (2016)

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Article Clinical Neurology

Insulin resistance predicts brain amyloid deposition in late middle-aged adults

Auriel A. Willette et al.

ALZHEIMERS & DEMENTIA (2015)

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Article Cardiac & Cardiovascular Systems

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

Rahul S. Desikan et al.

CIRCULATION (2015)

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Article Biochemistry & Molecular Biology

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease

Dimitrios Kapogiannis et al.

FASEB JOURNAL (2015)

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Review Neurosciences

Hippocampal insulin resistance and cognitive dysfunction

Geert Jan Biessels et al.

NATURE REVIEWS NEUROSCIENCE (2015)

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Article Clinical Neurology

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease

Auriel A. Willette et al.

JAMA NEUROLOGY (2015)

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Review Neurosciences

Common Mechanisms of Alzheimer's Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration

Brandon P. Lucke-Wold et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

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Article Neurosciences

Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia

Amy Claxton et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

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Article Clinical Neurology

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies

Mark Yarchoan et al.

ACTA NEUROPATHOLOGICA (2014)

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Review Pharmacology & Pharmacy

Brain metabolic dysfunction at the core of Alzheimer's disease

Suzanne M. de la Monte et al.

BIOCHEMICAL PHARMACOLOGY (2014)

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Review Chemistry, Multidisciplinary

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

Scott A. Yuzwa et al.

CHEMICAL SOCIETY REVIEWS (2014)

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Article Medicine, General & Internal

Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index

C. Irace et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2013)

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Article Endocrinology & Metabolism

Hypoglycemia Aggravates Critical Illness-Induced Neurocognitive Dysfunction

Thomas Duning et al.

DIABETES CARE (2010)

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Article Clinical Neurology

Insulin metabolism and the risk of Alzheimer disease The Rotterdam Study

E. M. C. Schrijvers et al.

NEUROLOGY (2010)

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Article Medicine, Research & Experimental

The Product of Fasting Glucose and Triglycerides As Surrogate for Identifying Insulin Resistance in Apparently Healthy Subjects

Luis E. Simental-Mendía et al.

Metabolic Syndrome and Related Disorders (2008)

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Article Clinical Neurology

Intranasal insulin improves cognition and modulates β-amyloid in early AD

M. A. Reger et al.

NEUROLOGY (2008)

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Association of the Triglyceride-Glucose Index With Risk of Alzheimer's Disease: A Prospective Cohort Study

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