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Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2023)

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Article Biochemistry & Molecular Biology

Human Xylosyltransferase I-An Important Linker between Acute Senescence and Fibrogenesis

Vanessa Schmidt et al.

Summary: The human xylosyltransferase isoform XT-I is involved in proteoglycan biosynthesis and is associated with fibrosis. In this study, it was found that XT-I expression was suppressed in acute senescent proto-myofibroblasts, leading to reduced extracellular matrix remodeling. The findings suggest that XT-I plays an important role in the switch between physiological and pathological wound healing.

BIOMEDICINES (2023)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases

He-Jin Lee et al.

Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by neuronal loss, protein aggregation, and chronic inflammation. Aging is a critical risk factor for these diseases, but the mechanism is not well understood. Cellular senescence, which involves changes in cellular phenotypes and increased secretion of certain molecules, is discussed in this review as a contributing factor to brain aging and neurodegenerative diseases. The potential of senescence modifiers and senolytics in treating these diseases is also explored.

JOURNAL OF MOLECULAR BIOLOGY (2023)

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Article Cell Biology

Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations

Katarzyna Malgorzata Kwiatkowska et al.

Summary: The aim of this study was to characterize DNA methylation patterns in replicative and induced senescence in different human cell types. Three epigenetic signatures were identified: cell type- and treatment-specific signature, cell type-specific senescence-related signature, and cell type-transversal replicative senescence-related signature. Cluster analysis revealed distinct DNA methylation patterns in replicative senescent cells, and enrichment in pathways related to the nervous system was shown. Despite no statistically significant evidence of age acceleration, a trend of increased biological age in replicative senescent cultures of all three cell types was observed. This work highlights the heterogeneity of senescent cells and their impact on tissue homeostasis.

CELLS (2023)

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Article Cell Biology

Absence of HDAC3 by Matrix Stiffness Promotes Chromatin Remodeling and Fibroblast Activation in Idiopathic Pulmonary Fibrosis

Fernanda Toscano-Marquez et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease characterized by progressive and irreversible lung scarring associated with fibroblast activation. This study investigates the role of HDAC3, a histone deacetylase, in chromatin remodeling and gene expression in IPF-derived fibroblasts. The results show that HDAC3 is decreased in the nucleus of IPF fibroblasts and its inhibition leads to increased expression of profibrotic genes. The study also suggests that matrix stiffness, mimicked by hydrogels, promotes the loss of nuclear HDAC3 and worsens the fibrotic microenvironment. These findings indicate that HDAC3 could be a potential target for therapeutic interventions in IPF.

CELLS (2023)

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Article Cell Biology

Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro

Erik Brauer et al.

Summary: Tissue formation and healing require cell proliferation, migration, extracellular matrix production, and tensioning. Cellular senescence has been found to modulate cell mechanics and extracellular matrix expression, affecting tissue stiffness and contraction. This study highlights the active mechanical role of cellular senescence in tissue formation and emphasizes the importance of a functional extracellular matrix network.

AGING CELL (2023)

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Review Biochemistry & Molecular Biology

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities

Prashanta Silwal et al.

Summary: Cellular senescence is closely related to aging and age-related disorders. Senescent cells overproduce inflammatory and catabolic factors, leading to tissue degeneration. Chronic accumulation of senescent cells is associated with intervertebral disc degeneration (IDD) in aging populations.

BIOMOLECULES (2023)

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Article Geriatrics & Gerontology

The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells

Fariba Nosrati et al.

Summary: Tissue fibrosis is a common issue in organ aging, caused by the chronic accumulation of senescent cells. Fibroblasts, especially in the skin, play a crucial role in fibrosis by proliferating and depositing excessive extracellular matrix (ECM). This study aims to investigate the influence of senescent fibroblasts and their secretome on dermal fibrosis. The results show that senescent fibroblasts have the potential to be profibrotic, but their secretome failed to induce a fibrotic response in non-senescent cells, contrary to studies on lung fibroblasts.

BIOGERONTOLOGY (2023)

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Article Cell Biology

Human senescent fibroblasts trigger progressive lung fibrosis in mice

Fernanda Hernandez-Gonzalez et al.

Aging-US (2023)

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Article Cell & Tissue Engineering

Synergistic Effect of miR-200 and Young Extracellular Matrix-based Bio-scaffolds to Reduce Signs of Aging in Senescent Fibroblasts

Georgia Pennarossa et al.

Summary: Aging is a complex process that leads to a decline in physiological functions and increased mortality risk. Research has shown that the miR-200 family can induce a plastic state in skin cells of older individuals, which improves cellular and aging characteristics. Additionally, maintaining a suitable young microenvironment can stabilize the rejuvenating effects of miR-200.

STEM CELL REVIEWS AND REPORTS (2023)

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Article Engineering, Biomedical

Targeting extracellular matrix glycation to attenuate fibroblast activation

Minjeong Jang et al.

Summary: In this study, the researchers found that accumulated AGEs in the ECM can alter the phenotype of fibroblast within a three-dimensional collagen matrix, leading to the acquisition of a cancer-associated fibroblast (CAF)-like phenotype. These effects can be blocked by neutralizing antibodies against the AGE receptor (RAGE) or by inhibiting focal adhesion signaling. In addition, an AGE cross-link breaker called ALT-711 can reduce the transformation of fibroblasts into the CAF-like phenotype. Decreased matrix stiffness also attenuates fibroblast activation. These findings suggest potential therapeutic strategies targeting non-enzymatic ECM glycation to regulate fibroblast activation.

ACTA BIOMATERIALIA (2022)

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Review Biochemistry & Molecular Biology

The Proteolysis of ECM in Intervertebral Disc Degeneration

Huaizhen Liang et al.

Summary: Intervertebral disc degeneration (IDD) is a common pathological process that leads to lower back pain. Understanding the molecular mechanisms involved in disc degeneration is crucial for the development of lumbar disc intervention strategies. This article explores the relationship between the intervertebral disc and the extracellular matrix (ECM), as well as the role of ECM proteolysis in the degenerative process. Targeting proteases associated with ECM proteolysis could be an effective intervention approach for IDD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Correction Cell Biology

Evaluation of senescent cells in intervertebral discs by lipofuscin staining (vol 199, 111564, 2021)

Dimitris Veroutis et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

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Article Oncology

Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors

Seiichiro Ishihara et al.

Summary: Matrix stiffness is critical for cancer progression, regulated by transcription factors. Stiff extracellular matrices trigger mechanotransduction, influencing cancer and stromal cells. YAP/TAZ transcription factors respond to matrix stiffness and play a crucial role.

CANCERS (2022)

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Article Medicine, Research & Experimental

Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultraviolet-induced photoaging

Haesoo Kim et al.

Summary: Photoaging is primarily caused by UV radiation, resulting in increased secretion of matrix metalloproteinases (MMPs) and collagen degradation. Our study reveals the critical role of senescent cells in photoaging and suggests that senolytic agents can attenuate photoaging and serve as potential strategies for its treatment.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways

Jiongbiao Zhong et al.

Summary: This study investigates the effects of ionizing radiation on cellular senescence and matrix catabolism in the annulus fibrosus. The results suggest that radiation-induced cellular senescence can contribute to matrix degradation, which may have adverse effects on spinal health.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration

Jinna Wu et al.

Summary: Abnormal mechanical load is a significant risk factor for intervertebral disc degeneration (IDD) and cellular senescence plays a crucial role in this process. This study reveals the molecular mechanism underlying mechano-induced cellular senescence and IDD progression, highlighting the positive feedback loop between NF-kappa B and periostin. Additionally, neutralizing antibodies against periostin can interrupt this loop.

MOLECULAR THERAPY (2022)

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Article Cell Biology

BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study

Guang-Zhi Zhang et al.

Summary: Intervertebral disc degeneration (IDD) is a common chronic muscle degeneration disease. This study found that inhibiting BRD4 can reduce cell senescence and apoptosis in intervertebral discs, providing a potential therapeutic target for IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Engineering, Biomedical

Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering

Xuewei Zhang et al.

Summary: The application of decellularized extracellular matrix (dECM) scaffolds holds enormous potential for tissue regeneration. These scaffolds provide an optimal non-immune environment with native three-dimensional structures and bioactive components, making them an ideal choice for regenerating functional organs/tissues, especially when combined with stem cells.

BIOACTIVE MATERIALS (2022)

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Article Geriatrics & Gerontology

Elevated skin senescence in young mice causes delayed wound healing

Rex Jeya Rajkumar Samdavid Thanapaul et al.

Summary: The influence of cellular senescence on wound healing is still not fully understood. This study demonstrates that elevated skin senescence can delay wound healing and result in sustained senescence after healing.

GEROSCIENCE (2022)

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Review Biotechnology & Applied Microbiology

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Yuhao Wu et al.

Summary: In this article, the involvement of senescence in intervertebral disc degeneration (IVDD) is reviewed, and the potential of senolytics in eliminating senescent disc cells and alleviating IVDD is discussed. A table listing potential drugs for IVDD therapy is also provided.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Dermatology

Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin

Ewa Markiewicz et al.

Summary: This study aimed to define the potential targets for screening and validation of anti-glycation activity of novel cosmetic candidates from natural products and to provide a plausible mechanism for their anti-aging potential based on 3D skin models. The findings suggest that glycation can result in age-related alterations in the structural and cellular organizations of the skin, which can be restored by Resveratrol derivatives.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2022)

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Article Oncology

Nucleus pulposus cell senescence is regulated by substrate stiffness and is alleviated by LOX possibly through the integrin β1-p38 MAPK signaling pathway

Runze Zhao et al.

Summary: In this study, the effect of matrix stiffness on nucleus pulposus (NP) cell senescence was investigated using polyvinyl alcohol (PVA) hydrogel with different stiffness to mimic the matrix stiffness of normal and degenerated NP tissue. The results showed that increased matrix stiffness induced NP cell senescence and increased cellular Young's modulus, possibly through upregulation of integrin beta 1 and p38 MAPK. Restoration of extracellular matrix synthesis inhibited the matrix stiffness-induced senescence of NP cells. These findings provide new insights into the pathological mechanism of intervertebral disc degeneration.

EXPERIMENTAL CELL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration

Matthew J. Kibble et al.

Summary: Back pain, caused by degeneration of the intervertebral discs, is a leading cause of disability worldwide. Understanding the different extracellular matrix cues is crucial for designing effective cellular and regenerative therapies. Omics technologies and modern biofabrication techniques can be used to study matrix molecules and growth factors in disc models, guiding the drivers of healthy cell phenotype and differentiation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Decreased differentiation capacity and altered expression of extracellular matrix components in irradiation-mediated senescent human breast adipose-derived stem cells

Adamantia Papadopoulou et al.

Summary: This study found that ionizing radiation can cause premature senescence in human breast adipose-derived stem cells (ASCs), leading to decreased differentiation potential and specific changes associated with a permissive environment for tumor growth.

IUBMB LIFE (2022)

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Article Cell Biology

Aging Fibroblasts Adversely Affect Extracellular Matrix Formation via the Senescent Humoral Factor Ependymin-Related Protein 1

Kento Takaya et al.

Summary: The secretion of EPDR1 by senescent cells affects nearby fibroblasts and has negative effects on matrix production in the dermis, suggesting potential candidate targets for the development of skin anti-aging therapies.

CELLS (2022)

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Review Oncology

Cellular senescence and the tumour microenvironment

Masaki Takasugi et al.

Summary: The senescence-associated secretory phenotype (SASP) produced by senescent cells can remodel the tumor microenvironment and have both suppressive and promoting effects on tumor development, depending on cell type and context-dependency.

MOLECULAR ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration

Xiangheng Dai et al.

Summary: This study found that AOPPs induce senescence in AF cells through a NOX4-dependent and MAPK-mediated pathway, thereby accelerating IVDD.

PEERJ (2022)

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Article Cell Biology

Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice

Dan-Lin Zheng et al.

Summary: This study aimed to clarify the mechanism of atrial fibrillation (AF) susceptibility in diabetes mellitus (DM) patients. Increased levels of p16 and Rb proteins in the atrium of diabetic mice were found to be associated with increased AF susceptibility. Advanced glycation end products (AGEs) accelerated atrial electrical remodeling and cellular senescence, leading to increased AF susceptibility through activation of the p16/Rb pathway. Inhibition of the receptor for AGEs (RAGE) or the p16/Rb pathway may be a potential therapeutic target for AF in diabetes.

AGING CELL (2022)

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Article Pharmacology & Pharmacy

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

Kaj E. C. Blokland et al.

Summary: This study investigated the impact of increased stiffness on senescence and fibrosis markers in primary human lung fibroblasts, showing that fibroblasts cultured on stiffer matrices exhibit higher YAP nuclear translocation and RANKL secretion, as well as increased expression of fibrosis-related genes like ACTA2 and COL1A1.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Genetics & Heredity

Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway

Hao Li et al.

Summary: Senescent fibroblasts activate cancer-associated fibroblast (CAF) phenotype through the Stat3 pathway, promoting the migration and invasion of lung cancer cells.

GENES (2022)

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Article Materials Science, Biomaterials

The impact of matrix age on intervertebral disc regeneration

Morena Francesca Fiordalisi et al.

Summary: This study evaluated the impact of extracellular matrix (ECM) donor age on intervertebral disc (IVD) regeneration/degeneration and found that younger ECM scaffolds have better repopulation efficiency and the ability to restore a functional IVD microenvironment.

BIOMATERIALS ADVANCES (2022)

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Article Chemistry, Analytical

Shotgun proteomics of extracellular matrix in late senescent human dermal fibroblasts reveals a down-regulated fibronectin-centered network

Kun Cho et al.

Summary: Extracellular matrix (ECM) proteins are crucial for cell growth and differentiation. Comparison of proteomes between young and late senescent human dermal fibroblasts (HDFs) showed differential expression of ECM proteins. A protein-protein interaction network centered around FN1 was constructed using Ingenuity Pathways Analysis. Immunoblot analysis confirmed the differential protein levels of FN1, VTN, APOB, and HTRA1. The findings suggest that the aging process in HDFs involves impaired regulation of FN1 and altered interaction with neighboring proteins.

JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration

Jianle Wang et al.

Summary: A novel circular RNA molecule, circKIF18A, has been found to protect spinal cells from premature aging, offering a potential therapeutic target for intervertebral disc degeneration (IVDD).

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Article Engineering, Biomedical

Effect of cellular and ECM aging on human iPSC-derived cardiomyocyte performance, maturity and senescence

S. Gulberk Ozcebe et al.

Summary: Young cardiac extracellular matrix promotes cell proliferation and drug responsiveness, while aged ECM accelerates aging phenotype and impairs cardiac function.

BIOMATERIALS (2021)

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Article Cell Biology

Promises and challenges of senolytics in skin regeneration, pathology and ageing

Vera Pils et al.

Summary: Research in the past two decades has identified the crucial role of cellular senescence in skin physiology and pathology. Senescent cells have been found in various skin conditions, and strategies to prevent or reduce senescent burden in the skin could benefit the aging population. Senolytic drugs, which specifically eliminate senescent cells, are being studied for potential clinical use in treating skin aging and diseases.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Review Dermatology

Connective Tissue and Fibroblast Senescence in Skin Aging

Meinhard Wlaschek et al.

Summary: The accumulation of senescent dermal fibroblasts and damage to macromolecules inside and outside fibroblasts are key factors in skin aging. In addition, the failure of NK cells to adequately remove senescent fibroblasts leads to the release of harmful factors impacting skin aging. This review also highlights the importance of the plasticity of dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix, and the depletion of fibroblast subsets on skin homeostasis and aging.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Cell Biology

Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

Bingjin Wang et al.

Summary: The study reveals the role of Piezo1 in human NP cells under ECM stiffness, leading to oxidative stress and ER stress, and exacerbating cellular senescence and apoptosis. Inhibition of Piezo1 can alleviate these effects, and silencing Piezo1 may ameliorate IDD and decrease the elasticity modulus of rat NP tissues.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Multidisciplinary Sciences

Extracellular matrix and cellular senescence in venous leg ulcers

Debbie X. E. Lim et al.

Summary: The study found a strong correlation between the presence of senescent cells and decreased collagen area in human chronic wounds, aiding in predicting healing trajectory of wounds; higher levels of senescent cells were found in male venous leg ulcer patients, while those under 60 years old with wounds persisting for over 24 months had the lowest levels of collagen.Dispensing method founded by Wang et al. requires less effort and cost and is highly accurate when it comes to protein liquid handling.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration

Jingyu Ding et al.

Aging-US (2021)

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Article Cell & Tissue Engineering

Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts

Xiangnan Zhao et al.

Summary: The study demonstrated that chitosan hydrogel-encapsulated extracellular vesicles (EVs) could effectively rejuvenate aging dermal fibroblasts by promoting cell proliferation, enhancing ECM protein synthesis, and inhibiting MMPs overexpression. Furthermore, subcutaneous injection of CS-EVs in a mouse model significantly delayed skin aging processes, showcasing the potential of this novel therapeutic approach for rejuvenating aging skin.

STEM CELL RESEARCH & THERAPY (2021)

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Article Oncology

Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts

Eleni Mavrogonatou et al.

Summary: Ionizing radiation for breast cancer can lead to premature senescence of stromal fibroblasts, characterized by the down-regulation of decorin. Growth factors like bFGF and VEGF play critical roles in this regulation. Autophagy activation can increase decorin levels, while impaired autophagy is implicated in decorin reduction.

CANCERS (2021)

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Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Moises Selman et al.

Summary: Ageing is a complex biological process involving multiple factors that lead to a decline in physiological functions and an increased risk of chronic diseases. Inflammageing and fibrotic pathways play key roles in age-related morbidities and the accumulation of extracellular matrix in the elderly. The concept of Fibroageing suggests that stiff ECM and activation of fibrotic positive feedback loops contribute to various age-related alterations.

AGEING RESEARCH REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Cellular Senescence in Lung Fibrosis

Fernanda Hernandez-Gonzalez et al.

Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells

Rongjin Luo et al.

Summary: This study highlights the crucial role of FAM134B-mediated ER-phagy in apoptosis and senescence induced by AGEs in intervertebral disc cells by modulating intracellular ROS accumulation. Overexpression of FAM134B can alleviate these effects, while knockdown exacerbates them. Targeting FAM134B-mediated ER-phagy could be a promising therapeutic strategy for IDD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM

Kaj E. C. Blokland et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease with age being a major risk factor. Research suggests that ECM deposited by IPF fibroblasts does not induce cellular senescence, but rather leads to upregulation of proinflammatory and profibrotic cytokines, potentially contributing to the progression of fibrosis.

CELLS (2021)

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Article Cell & Tissue Engineering

INTEGRIN-MEDIA TED INTERACTIONS WITH A LAMININ- PRESENTING SUBSTRATE MODULATE BIOSYNTHESIS AND PHENOTYPIC EXPRESSION FOR CELLS OF THE HUMAN NUCLEUS PULPOSUS

J. Speer et al.

Summary: The study identified integrin alpha 3 as a key regulator in mediating interactions between degenerative NP cells and laminin-111, with blocking this integrin resulting in decreased cell attachment, reduced expression of phenotypic markers, and alterations in cytoskeletal organization. Additionally, integrin alpha 3 plays a critical role in how NP cells sense and alter phenotype in response to culture upon laminin.

EUROPEAN CELLS & MATERIALS (2021)

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Review Oncology

The role of senescence in cancer development

Eleni Mavrogonatou et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Article Geriatrics & Gerontology

The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging

Collin Yves Ewald

GERONTOLOGY (2020)

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Article Cell Biology

Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype

Deepraj Ghosh et al.

JOURNAL OF CELL SCIENCE (2020)

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Article Physiology

Link between increased cellular senescence and extracellular matrix changes in COPD

Roy R. Woldhuis et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Article Oncology

Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles

Liu Han et al.

CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

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Article Biology

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

Hui Che et al.

ELIFE (2020)

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Review Biochemistry & Molecular Biology

The ECM path of senescence in aging: components and modifiers

Naama Levi et al.

FEBS JOURNAL (2020)

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Article Multidisciplinary Sciences

Fibroblast rejuvenation by mechanical reprogramming and redifferentiation

Bibhas Roy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Biotechnology & Applied Microbiology

Extracellular Matrix From Decellularized Wharton's Jelly Improves the Behavior of Cells From Degenerated Intervertebral Disc

Letizia Penolazzi et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Geriatrics & Gerontology

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts

Adamantia Papadopoulou et al.

BIOGERONTOLOGY (2020)

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Review Cell Biology

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Alexander Fedintsev et al.

AGEING RESEARCH REVIEWS (2020)

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Review Medicine, Research & Experimental

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

Kaj E. C. Blokland et al.

CLINICAL SCIENCE (2020)

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Article Biology

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Hosni Cherif et al.

ELIFE (2020)

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Article Geriatrics & Gerontology

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

Regina Weinmuellner et al.

NPJ AGING AND MECHANISMS OF DISEASE (2020)

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Article Biochemistry & Molecular Biology

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

Eleni Mavrogonatou et al.

MATRIX BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype

Rekha Jakhar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, General & Internal

Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro

Hosni Cherif et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Niche stiffness underlies the ageing of central nervous system progenitor cells

Michael Segel et al.

NATURE (2019)

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Article Cell Biology

Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release

Yingchao Han et al.

AGING-US (2019)

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Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

CELL (2019)

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Article Geriatrics & Gerontology

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

Christina Lee Chung et al.

GEROSCIENCE (2019)

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Article Biochemistry & Molecular Biology

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

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Senescent Fibroblasts Promote Neoplastic Transformation of Partially Transformed Ovarian Epithelial Cells in a Three-dimensional Model of Early Stage Ovarian Cancer

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